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Anemia, Hypochromic
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
Anemia, Hypochromic
ClpC1, an ATP-dependent Clp protease in plastids, is involved in iron homeostasis in Arabidopsis leaves.
Anemia, Hypochromic
Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.
Blindness
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
Dehydration
A nuclear gene, erd1, encoding a chloroplast-targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up-regulated during senescence in Arabidopsis thaliana.
Hypersensitivity
Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms.
Infections
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus.
Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Infections
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.
Infections
Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis.
Infections
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Infections
Dual RNA-seq in Streptococcus pneumoniae Infection Reveals Compartmentalized Neutrophil Responses in Lung and Pleural Space.
Infections
Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival.
Infections
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Infections
Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne.
Infections
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Infections
Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis.
Infections
Recent advances in Clp protease modulation to address virulence, resistance and persistence of MRSA infection.
Infections
Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.
Infections
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Infections
The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages.
Infections
The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections.
Infections
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
Infections
The development of small-molecule modulators for ClpP protease activity.
Infections
The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa.
Infections
Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology.
Infertility
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
Leprosy
Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins.
Leukemia, Myeloid, Acute
The role of mitochondrial proteases in leukemic cells and leukemic stem cells.
Liver Cirrhosis, Biliary
Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Antibodies to Clp protease in primary biliary cirrhosis: possible role of a mimicking T-cell epitope.
Liver Diseases
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Malaria
A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development.
Malaria
A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents.
Malaria
Bayesian analysis of new and old malaria parasite DNA sequence data demonstrates the need for more phylogenetic signal to clarify the descent of Plasmodium falciparum.
Malaria
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).
Malaria
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Malaria, Avian
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Neoplasms
Contribution of the Clp Protease to Bacterial Survival and Mitochondrial Homoeostasis.
Neoplasms
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Neoplasms
Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells.
Neoplasms
Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer.
Neoplasms
Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers.
Neoplasms
The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.
Neuroblastoma
Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53.
Parasitic Diseases
A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential antileishmanial drug candidate.
Persistent Infection
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Plant Diseases
Antagonistic Regulation by CPN60A and CLPC1 of TRXL1 that Regulates MDH Activity Leading to Plant Disease Resistance and Thermotolerance.
Pneumococcal Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Pneumococcal Infections
Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP.
Pneumococcal Infections
Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in Mice.
Pneumococcal Infections
Mucosal immunization with caseinolytic protease X elicited cross-protective immunity against pneumococcal infection in mice.
Pneumococcal Infections
Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice.
Pneumonia
The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia.
Pneumonia, Staphylococcal
The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia.
Sepsis
Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.
Sexually Transmitted Diseases
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
Sexually Transmitted Diseases
The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci.
Staphylococcal Infections
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Starvation
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
Starvation
Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli.
Starvation
Inter- and intramolecular regulation of protein depupylation in Mycobacterium smegmatis.
Starvation
Mycobacterium smegmatis MSMEG_0129 is a nutrition-associated regulator that interacts with CarD and ClpP2.
Starvation
Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease.
Starvation
Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli.
Starvation
Role of the response regulator RssB in sigma recognition and initiation of sigma proteolysis in Escherichia coli.
Starvation
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
Tuberculosis
A ClpP protein model as tuberculosis target for screening marine compounds.
Tuberculosis
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Tuberculosis
An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Tuberculosis
Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1.
Tuberculosis
Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase.
Tuberculosis
Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.
Tuberculosis
Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.
Tuberculosis
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.
Tuberculosis
Cleavage specificity of Mycobacterium tuberculosis ClpP1P2 protease and identification of novel peptide substrates and boronate inhibitors with anti-bacterial activity.
Tuberculosis
Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis.
Tuberculosis
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Tuberculosis
Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Tuberculosis
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Tuberculosis
Delving Into the Functional Meaning of Phenotypic Variation in Mycobacterial Persistence: Who Benefits the Most From Programmed Death of Individual Cells?
Tuberculosis
Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis.
Tuberculosis
Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China.
Tuberculosis
Gift from Nature: Cyclomarin?A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Tuberculosis
High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.
Tuberculosis
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Tuberculosis
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.
Tuberculosis
Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.
Tuberculosis
Mutation analysis of the interactions between Mycobacterium tuberculosis caseinolytic protease C1 (ClpC1) and ecumicin.
Tuberculosis
Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Tuberculosis
Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease.
Tuberculosis
Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation.
Tuberculosis
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function.
Tuberculosis
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Tuberculosis
Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.
Tuberculosis
Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis.
Tuberculosis
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Tuberculosis
Species variation in ATP-dependent protein degradation: protease profiles differ between mycobacteria and protease functions differ between Mycobacterium smegmatis and Escherichia coli.
Tuberculosis
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
Tuberculosis
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.
Tuberculosis
Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.
Tuberculosis
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.
Tuberculosis
The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
Tuberculosis
The C-terminus of ClpC1 of Mycobacterium tuberculosis is crucial for its oligomerization and function.
Tuberculosis
The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum.
Tuberculosis
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo.
Tuberculosis
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Tuberculosis
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
Tuberculosis
The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini.
Tuberculosis
Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities.
Tuberculosis
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
Tuberculosis
[Prediction and Analysis of Epitopes in clpP2 of Mycobacterium tuberculosis].
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Porankiewicz, J.; Wang, J.; Clarke, A.K.
New insights into the ATP-dependent Clp protease: Escherichia coli and beyond
Mol. Microbiol.
32
449-458
1999
Aquifex aeolicus (O67357), Arabidopsis thaliana (P56772), Arabidopsis thaliana (Q787X4), Bacillus subtilis (P80244), Bordetella pertussis, Borreliella burgdorferi (O51698), Caenorhabditis elegans (Q27539), Caulobacter vibrioides (B8GX16), Chlamydia trachomatis (P38002), Chlamydomonas moewusii (P42379), Chlamydomonas reinhardtii (P42380), Chlorella vulgaris (P56317), Chlorobaculum tepidum, Clostridium acetobutylicum, Cyanophora paradoxa (Q36863), Deinococcus radiodurans, Enterococcus faecalis, Epifagus virginiana (P30063), Escherichia coli, Fritillaria agrestis (O49081), Haemophilus influenzae (P43867), Helicobacter pylori, Homo sapiens (Q16740), Lactococcus lactis (Q9ZAB0), Listeria monocytogenes, Marchantia polymorpha (P12208), Mus musculus (O88696), Mycobacterium tuberculosis (P9WPC5 and P9WPC3), Mycobacterium tuberculosis H37Rv (P9WPC5 and P9WPC3), Myxococcus xanthus, Nicotiana tabacum (P12210), Oryza sativa (P0C312), Paracoccus denitrificans (P54414), Pinus contorta (P36387), Pinus thunbergii (P41609), Populus tremula, Porphyromonas gingivalis, Pseudomonas aeruginosa, Rhodobacter capsulatus, Salmonella enterica subsp. enterica serovar Typhimurium, Shewanella putrefaciens, Solanum lycopersicum (Q42886), Streptococcus pyogenes, Streptococcus salivarius (P36398), Streptomyces coelicolor, Synechococcus sp., Synechococcus sp. (O34125), Synechococcus sp. (P54415), Synechocystis sp. (P54416), Synechocystis sp. (P74467), Synechocystis sp. (Q59993), Treponema pallidum (O84003), Triticum aestivum (P24064), Yersinia enterocolitica (O30612), Yersinia enterocolitica (Q60107), Zea mays (P12340)
brenda
Yu, A.Y.; Houry, W.A.
ClpP: a distinctive family of cylindrical energy-dependent serine proteases
FEBS Lett.
581
3749-3757
2007
Streptococcus pneumoniae, Escherichia coli, Homo sapiens, Mycobacterium tuberculosis, Plasmodium falciparum
brenda
Hansen, J.; Corydon, T.J.; Palmfeldt, J.; Duerr, A.; Fontaine, B.; Nielsen, M.N.; Christensen, J.H.; Gregersen, N.; Bross, P.
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13)
Neuroscience
153
474-482
2008
Homo sapiens (Q16740)
brenda
Zhang, Y.; Maurizi, M.R.
Mitochondrial ClpP activity is required for cisplatin resistance in human cells
Biochim. Biophys. Acta
1862
252-264
2016
Homo sapiens (Q16740)
brenda
3.4.21.92 Endopeptidase Clp
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
