Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.21.89 - Signal peptidase I

for references in articles please use BRENDA:EC3.4.21.89
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.89 Signal peptidase I
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
UNIPROT: Q15005 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Cleavage of hydrophobic, N-terminal signal or leader sequences
Synonyms
signal peptidase, leader peptidase, spase, protease iv, signal peptidase i, spase i, type i signal peptidase, leader proteinase, plsp1, sec11, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Bacterial leader peptidase 1
-
-
-
-
Escherichia coli leader peptidase
-
-
-
-
Eukaryotic signal peptidase
-
-
-
-
Eukaryotic signal proteinase
-
-
-
-
HOSP
-
-
-
-
Leader peptidase
-
-
-
-
Leader peptidase I
-
-
-
-
Leader peptide hydrolase
-
-
-
-
Leader proteinase
-
-
-
-
Peptidase, signal
-
-
-
-
Pilin leader peptidase
-
-
-
-
Prokaryotic leader peptidase
-
-
-
-
Prokaryotic signal peptidase
-
-
-
-
Prokaryotic signal proteinase
-
-
-
-
Propeptidase
-
-
-
-
Proteinase, eukaryotic signal
-
-
-
-
Proteinase, signal
-
-
-
-
PuIO prepilin peptidase
-
-
-
-
Signal peptidase
-
-
-
-
Signal peptide hydrolase
-
-
-
-
Signal peptide peptidase
-
-
-
-
Signalase
-
-
-
-
SPC
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
65979-36-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
signal peptides from preproteins + H2O
mature proteins
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
signal peptides from preproteins + H2O
mature proteins
show the reaction diagram
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
human
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SPCS2_HUMAN
226
0
25003
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dalbey, R.E.; Lively, M.O.; Bron,S.; Van Diijl, J.M.
The chemistry and enzymology of the type I signal peptidases
Protein Sci.
6
1129-1138
1997
Bacillus amyloliquefaciens, [Bacillus] caldolyticus, Bacillus subtilis, Bacillus licheniformis, Bradyrhizobium japonicum, Saccharomyces cerevisiae, Canis lupus familiaris, Gallus gallus, Escherichia coli, Haemophilus influenzae, Methanocaldococcus jannaschii, Staphylococcus aureus, Mycobacterium tuberculosis, no activity in Mycoplasma genitalium, Phormidium laminosum, Pseudomonas fluorescens, Rana sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Caenorhabditis elegans (P34525), Schizosaccharomyces pombe (Q10259), Homo sapiens (Q15005), Rhodobacter capsulatus (Q52697)
Manually annotated by BRENDA team