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Information on EC 3.4.21.89 - Signal peptidase I and Organism(s) Mycobacterium tuberculosis and UniProt Accession P9WKA1

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.89 Signal peptidase I
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Select one or more organisms in this record: ?
This record set is specific for:
Mycobacterium tuberculosis
UNIPROT: P9WKA1 not found.
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Word Map
The taxonomic range for the selected organisms is: Mycobacterium tuberculosis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Cleavage of hydrophobic, N-terminal signal or leader sequences
Synonyms
signal peptidase, leader peptidase, spase, protease iv, signal peptidase i, spase i, type i signal peptidase, leader proteinase, plsp1, sec11, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Bacterial leader peptidase 1
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-
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Escherichia coli leader peptidase
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-
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Eukaryotic signal peptidase
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-
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Eukaryotic signal proteinase
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-
-
-
HOSP
-
-
-
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Leader peptidase
-
-
-
-
Leader peptidase I
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-
-
-
Leader peptide hydrolase
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-
-
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Leader proteinase
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-
-
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Peptidase, signal
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-
-
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Pilin leader peptidase
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-
-
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Prokaryotic leader peptidase
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-
-
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Prokaryotic signal peptidase
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-
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Prokaryotic signal proteinase
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-
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Propeptidase
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-
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Proteinase, eukaryotic signal
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-
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Proteinase, signal
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-
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PuIO prepilin peptidase
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-
-
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Signal peptidase
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-
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Signal peptide hydrolase
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-
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Signal peptide peptidase
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-
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Signalase
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-
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SPC
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-
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type I signal peptidase
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
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-
CAS REGISTRY NUMBER
COMMENTARY hide
65979-36-4
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
signal peptides from preproteins + H2O
mature proteins
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
signal peptides from preproteins + H2O
mature proteins
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one
overexpression of lepB reduces the susceptibility of Mycobacterium tuberculosis to 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one, and downregulation results in increased susceptibility. Treatment with 1-(2,5-dichlorophenyl)-3-(dimethylamino)propan-1-one leads to a rapid loss of viability and cell lysis. The compound has increased potency in nonreplicating cells, causing a reduction in viable cell numbers below the detection limit after 24 h
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
gene is essential, and reduced lepB expression is detrimental to growth
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
32000
-
deduced from DNA sequence
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K174A
mutation is lethal
S94A
mutation is lethal
S96A
mutation is lethal
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dalbey, R.E.; Lively, M.O.; Bron,S.; Van Diijl, J.M.
The chemistry and enzymology of the type I signal peptidases
Protein Sci.
6
1129-1138
1997
Bacillus amyloliquefaciens, [Bacillus] caldolyticus, Bacillus subtilis, Bacillus licheniformis, Bradyrhizobium japonicum, Saccharomyces cerevisiae, Canis lupus familiaris, Gallus gallus, Escherichia coli, Haemophilus influenzae, Methanocaldococcus jannaschii, Staphylococcus aureus, Mycobacterium tuberculosis, no activity in Mycoplasma genitalium, Phormidium laminosum, Pseudomonas fluorescens, Rana sp., Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Caenorhabditis elegans (P34525), Schizosaccharomyces pombe (Q10259), Homo sapiens (Q15005), Rhodobacter capsulatus (Q52697)
Manually annotated by BRENDA team
Ollinger, J.; OMalley, T.; Ahn, J.; Odingo, J.; Parish, T.
Inhibition of the sole type I signal peptidase of Mycobacterium tuberculosis is bactericidal under replicating and nonreplicating conditions
J. Bacteriol.
194
2614-2619
2012
Mycobacterium tuberculosis (P9WKA1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKA1)
Manually annotated by BRENDA team