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Disease on EC 3.4.21.78 - granzyme A and Organism(s) Homo sapiens and UniProt Accession P51124

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
The role of TSP-1 on decidual macrophages involved in the susceptibility to unexplained recurrent spontaneous abortion.
Acquired Immunodeficiency Syndrome
Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.
Acute Chest Syndrome
Association of plasma CD40L with acute chest syndrome in sickle cell anemia.
Acute Kidney Injury
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury.
Reduction of natural killer and natural killer T cells is not protective in cisplatin-induced acute renal failure in mice.
Acute Lung Injury
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice.
Adenocarcinoma
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
The effect of thrombospondin-1 and TGF-beta 1 on pancreatic cancer cell invasion.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
[Relationship between changes of serum concentrations of antiangiogenic factors and disease progression in patients of pancreatic carcinoma]
Adenocarcinoma of Lung
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
Adenocarcinoma, Follicular
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity.
Adenoma
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Airway Obstruction
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Alzheimer Disease
Amyloid-? inhibits thrombospondin 1 release from cultured astrocytes: effects on synaptic protein expression.
Anemia
Disturbance of plasma and platelet thrombospondin levels in sickle cell disease.
Anemia, Hemolytic
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Anemia, Sickle Cell
Disturbance of plasma and platelet thrombospondin levels in sickle cell disease.
Relationship of Thrombospondin 1 to von Willebrand Factor and ADAMTS-13 in Sickle Cell Disease Patients of Arab Ethnicity.
Aneurysm, Dissecting
Thrombospondin 1 Is Increased in the Aorta and Plasma of Patients With Acute Aortic Dissection.
Aortic Aneurysm
Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix.
Aortic Valve Stenosis
Thrombospondins, potential drug targets for cardiovascular diseases.
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Arthritis
Effects of thrombospondin-1 on disease course and angiogenesis in rat adjuvant-induced arthritis.
Granzyme A contributes to inflammatory arthritis through stimulation of osteoclastogenesis.
Arthritis, Experimental
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
Arthritis, Rheumatoid
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis.
Perforin and granzyme A expression identifying cytolytic lymphocytes in rheumatoid arthritis.
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA).
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Tumor Necrosis Factor Inhibition Modulates Thrombospondin-1 Expression in Human Inflammatory Joint Disease through Altered NR4A2 Activity.
Asbestosis
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS.
Asthma
Granule Cytotoxic Activity and Oxidative DNA Damage in Smoking and Nonsmoking Patients With Asthma.
Increased angiogenic factors in exhaled breath condensate of children with severe asthma - New markers of disease progression?
Natural killer cell-mediated inflammation resolution is disabled in severe asthma.
TIPE2 is negatively correlated with tissue factor and thrombospondin-1 expression in patients with bronchial asthma.
Astrocytoma
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
Atherosclerosis
C3 and alternative pathway components are associated with an adverse lipoprotein subclass profile: The CODAM study.
Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.
Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries.
Increased expression of thrombospondin-1 in vessel wall of diabetic Zucker rat.
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases.
Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase.
Thrombospondin-1 is elevated with both intimal hyperplasia and hypercholesterolemia.
Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia.
Thrombospondins, potential drug targets for cardiovascular diseases.
TSP-1 (Thrombospondin-1) Deficiency Protects ApoE-/- Mice Against Leptin-Induced Atherosclerosis.
[The role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells]
Atypical Hemolytic Uremic Syndrome
A user's guide to the interactive Web database of factor H-associated hemolytic uremic syndrome.
Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome.
Postoperative thrombotic thrombocytopenic purpura in an infant: case report and literature review.
[Clinical characteristies of atypical hemolytie uremic syndrome associated with H factor antibody in children].
Brain Diseases
Granzyme A Participates in the Pathogenesis of Infection-Associated Acute Encephalopathy.
Brain Injuries
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Type IV collagen induces expression of thrombospondin-1 that is mediated by integrin alpha1beta1 in astrocytes.
Brain Injuries, Traumatic
Plasma thrombospondin-1 and clinical outcomes in traumatic brain injury.
Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice.
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Brain Neoplasms
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Breast Neoplasms
ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells.
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Calcitriol reduces thrombospondin-1 and increases vascular endothelial growth factor in breast cancer cells: Implications for tumor angiogenesis.
CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Decrease of let-7f in low-dose metronomic Paclitaxel chemotherapy contributed to upregulation of thrombospondin-1 in breast cancer.
Differential proteomic analysis of late-stage and recurrent breast cancer from formalin-fixed paraffin-embedded tissues.
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Estradiol down-regulates CD36 expression in human breast cancer cells.
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Evidence of a bi-phasic effect of thrombospondin-1 on angiogenesis.
Fibroblast growth factor 8 induced downregulation of thrombospondin 1 is mediated by the MEK/ERK and PI3K pathways in breast cancer cells.
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy.
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.
Histopathology and clinical assessment correlate with the cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumors.
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Inhibition of breast cancer progression by an antibody to a thrombospondin-1 receptor.
Pharmacogenetic interaction analysis of VEGFR-2 and IL-8 polymorphisms in advanced breast cancer patients treated with paclitaxel and bevacizumab.
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis.
Role of urokinase plasminogen activator receptor in thrombospondin 1-mediated tumor cell invasion.
Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2.
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer.
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Thrombospondin-1 and transforming growth factor-beta l promote breast tumor cell invasion through up-regulation of the plasminogen/plasmin system.
Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Bronchopulmonary Dysplasia
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Calcinosis
The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.
Calciphylaxis
The involvement of matrix glycoproteins in vascular calcification and fibrosis: an immunohistochemical study.
Carcinogenesis
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Further characterization of BC3H1 myogenic cells reveals lack of p53 activity and underexpression of several p53 regulated and extracellular matrix-associated gene products.
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Microvessel density and regulators of angiogenesis in malignant and nonmalignant prostate tissue.
The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma.
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Carcinoma
Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features.
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
Extraction of RNA from archival tissues and measurement of thrombospondin-1 mRNA in normal, dysplastic, and malignant oral tissues.
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines.
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
The expression and underlying angiogenesis effect of DPC4 and VEGF on the progression of cervical carcinoma.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas.
Carcinoma in Situ
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Carcinoma, Ductal
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Carcinoma, Hepatocellular
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Carcinoma, Intraductal, Noninfiltrating
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Carcinoma, Mucoepidermoid
Correlation between the expression of thrombospondin-1 and neovascularization in mucoepidermoid carcinoma.
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
[Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma]
[The expression of inhibitor-1 of DNA binding/differentiation-1 and thrombospondin-1 in mucoepidermoid carcinoma of different malignant degree]
Carcinoma, Non-Small-Cell Lung
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Carcinoma, Papillary
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells.
Carcinoma, Renal Cell
pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines.
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Carcinoma, Squamous Cell
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix.
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Cardiomegaly
Thrombospondin-4 expression is rapidly upregulated by cardiac overload.
Thrombospondins, potential drug targets for cardiovascular diseases.
Cardiovascular Diseases
Association of Plasma Thrombospondin-1 Level with Cardiovascular Disease and Mortality in Hemodialysis Patients.
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Cataract
Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation.
Cerebral Hemorrhage
Elevated cerebrospinal fluid levels of thrombospondin-1 correlate with adverse clinical outcome in patients with aneurysmal subarachnoid hemorrhage.
Cervical Intraepithelial Neoplasia
Thrombospondin-1 acts as a fence to inhibit angiogenesis that occurs during cervical carcinogenesis.
Chikungunya Fever
RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
Cholangiocarcinoma
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
Cholera
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
Choroidal Neovascularization
Production and accumulation of thrombospondin-1 in human retinal pigment epithelial cells.
Thrombospondin-1 expression in RPE and choroidal neovascular membranes.
Chronic Periodontitis
Targeting TSP-1 decreased periodontitis by attenuating extracellular matrix degradation and alveolar bone destruction.
Chronic Urticaria
Endostatin and Thrombospondin-1 levels are increased in the sera of patients with chronic spontaneous urticaria.
Colitis
Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model.
Colitis, Ulcerative
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
Association Between Response to Etrolizumab and Expression of Integrin ?E and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis.
Colonic Neoplasms
Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells.
Effects of anti-miR-182 on TSP-1 expression in human colon cancer cells: there is a sense in antisense?
Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer.
Mechanisms of Platelet-Stimulated Colon Cancer Invasion: Role of Clusterin and Thrombospondin-1 in Regulation of the P38MAPK-MMP-9 Pathway.
Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer.
Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Colorectal Neoplasms
15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1.
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma.
Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Thrombospondin-1 Mimetic Agonist Peptides Induce Selective Death in Tumor Cells: Design, Synthesis, and Structure-Activity Relationship Studies.
Coma
Plasma thrombospondin-1 and clinical outcomes in traumatic brain injury.
Corneal Injuries
BMP-1 disrupts cell adhesion and enhances TGF-? activation through cleavage of the matricellular protein thrombospondin-1.
Corneal Neovascularization
c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1.
PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition.
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression.
Roles of thrombospondin-1 and -2 in regulating corneal and iris angiogenesis.
Thrombospondin 1 inhibits inflammatory lymphangiogenesis by CD36 ligation on monocytes.
Coronary Artery Disease
Higher plasma thrombospondin-1 levels in patients with coronary artery disease and diabetes mellitus.
COVID-19
Elevated Exhaustion Levels of NK and CD8+ T Cells as Indicators for Progression and Prognosis of COVID-19 Disease.
Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients.
Cowpox
Perforin is essential for control of ectromelia virus but not related poxviruses in mice.
Craniocerebral Trauma
Plasma thrombospondin-1 and clinical outcomes in traumatic brain injury.
Crohn Disease
CD47(Low) Status on CD4 Effectors Is Necessary for the Contraction/Resolution of the Immune Response in Humans and Mice.
Cysts
Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.
Dermatitis, Contact
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions.
Dermatomyositis
Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases: implications for cardiovascular risk.
Diabetes Complications
Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose.
Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications.
Diabetes Mellitus
Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus.
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Diabetes Mellitus, Type 1
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates.
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No.
Granzyme A-deficiency breaks immune tolerance and promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats.
Diabetic Angiopathies
Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice.
Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia.
Diabetic Cardiomyopathies
The role of thrombospondin-1-mediated TGF-?1 on collagen type III synthesis induced by high glucose.
Diabetic Nephropathies
Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.
Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-beta1 dependent and TGF-beta1 independent pathways.
Thrombospondin-1 is an endogenous activator of TGF-beta in experimental diabetic nephropathy in vivo.
Diabetic Neuropathies
Exercise and IGF-1 supplementation improve angiogenesis and angiogenic cytokines in a rat model of diabetes-induced neuropathy.
Diabetic Retinopathy
Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes.
Thrombospondin-1 is produced by retinal glial cells and inhibits the growth of vascular endothelial cells.
[Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]
[The changes of TSP-1 expression in the retina of STZ-induced rat diabetic mellitus model with pioglitazone]
Diphtheria
Hematopoietic stem cells are not direct cytotoxic targets of natural killer cells.
Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells.
Down Syndrome
Identification of novel direct transcriptional targets of glucocorticoid receptor.
Dry Eye Syndromes
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
Thrombospondin-1 as a Regulator of Corneal Inflammation and Lymphangiogenesis: Effects on Dry Eye Disease and Corneal Graft Immunology.
Thrombospondin-1 in ocular surface health and disease.
Dysentery
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.
Dysplastic Nevus Syndrome
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Ectromelia
Caspase-dependent inhibition of mousepox replication by gzmB.
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
Encephalomyelitis, Autoimmune, Experimental
Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes.
Endometrial Neoplasms
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
microRNAs related to angiogenesis are dysregulated in endometrioid endometrial cancer.
Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis.
Endometriosis
Expression of vascular endothelial growth factor and thrombospondin-1 mRNA in patients with endometriosis.
Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues.
microRNAs expression in endometriosis and their relation to angiogenic factors.
[Expression of vascular endothelial growth factor and thrombospondin-1 in the ectopic and eutopic endometrium of women with endometriosis]
Enteritis
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
Epilepsies, Partial
A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model.
Epilepsy
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus.
Serum Exosomal Proteins F9 and TSP-1 as Potential Diagnostic Biomarkers for Newly Diagnosed Epilepsy.
Epiretinal Membrane
Thrombospondin-1 is produced by retinal glial cells and inhibits the growth of vascular endothelial cells.
Erectile Dysfunction
Expression changes of transforming growth factor-beta1 and thrombospondin-1 in cavernous tissues of diabetic rats.
Fatty Liver
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Fibroadenoma
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Fibrosarcoma
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
[Inhibition of fibrosarcoma growth in mice by antibody against B cell epitope on mouse Toll-like receptor-2 extracellular domain]
Fragile X Syndrome
Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model.
Ganglioneuroma
Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma.
Genetic Diseases, Inborn
The thrombospondins.
Glaucoma
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-beta1 and dexamethasone in vitro.
Glioblastoma
Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.
Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant glioma cells.
Cell density regulates thrombospondin-1 production in malignant glioma cells.
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Downregulation of GFAP, TSP-1, and p53 in human glioblastoma cell line, U373MG, by IE1 protein from human cytomegalovirus.
Reverting the molecular fingerprint of tumor dormancy as a therapeutic strategy for glioblastoma.
Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells.
Glioma
Antisense-mediated reduction in thrombospondin-1 expression reduces cell motility in malignant glioma cells.
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors.
Correlation between TSP-1, TGF-? and PPAR-? expression levels and glioma microvascular density.
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Cytotoxic CD4(+) T cells are correlated with better prognosis in Han Chinese grade II and grade III glioma subjects and are suppressed by PD-1 signaling.
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
Participation of thrombospondin-1 in the activation of latent transforming growth factor-beta in malignant glioma cells.
Quantification of thrombospondin-1 secretion and expression of alphavbeta3 and alpha3beta1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells.
Glomerulonephritis
Differential expression of thrombospondin and cellular fibronectin during remodeling in proliferative glomerulonephritis.
Expression and clinical significance of thrombospondin-1 and plasminogen activator inhibitor-1 in patients with mesangial proliferative glomerulonephritis.
PDE-5 inhibition impedes TSP-1 expression, TGF-beta activation and matrix accumulation in experimental glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach.
Graft vs Host Disease
Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease.
Granuloma
[Granzymes A and B in pulmonary sarcoidosis (experimental study)]
Granulomatosis with Polyangiitis
Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study.
granzyme a deficiency
Granzyme A-deficiency breaks immune tolerance and promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency promotes angiotensin-II induced aneurysm in mice.
Sjögren's syndrome-like ocular surface disease in thrombospondin-1 deficient mice.
Sustained beta-cell dysfunction but normalized islet mass in aged thrombospondin-1 deficient mice.
Thrombospondin-1 contributes to slower aortic aneurysm growth by inhibiting maladaptive remodeling of extracellular matrix.
Thrombospondin-1 Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis.
Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy via TGF-?1 activation in mice.
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
TSP-1 (Thrombospondin-1) Deficiency Protects ApoE-/- Mice Against Leptin-Induced Atherosclerosis.
TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis.
TSP-1 in lung fibrosis.
[H Factor Deficiency: A Case with an Atypical Presentation].
Heart Diseases
Investigation of thrombospondin-1 and transforming growth factor-? expression in the heart of aging mice.
Heart Failure
Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling.
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure.
Thrombospondins, potential drug targets for cardiovascular diseases.
HELLP Syndrome
Circulating levels of thrombospondin-1 are decreased in HELLP syndrome.
Hemangioma
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma.
[Expression and significance of the proteins in TSP-1 and NF-?B signal pathways of infantile capillary hemangioma].
Hemorrhagic Fever with Renal Syndrome
Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.
Hemorrhagic Stroke
The Roles of Thrombospondins in Hemorrhagic Stroke.
Hepatitis C, Chronic
Gene expression of perforin and granzyme A in the liver in chronic hepatitis C: comparison with peripheral blood mononuclear cells.
Herpes Simplex
Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.
HIV Infections
Low levels of perforin expression in CD8+ T lymphocyte granules in lymphoid tissue during acute human immunodeficiency virus type 1 infection.
Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.
Hypercalcemia
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Hyperglycemia
Application of transcutaneous carbon dioxide improves capillary regression of skeletal muscle in hyperglycemia.
The effect of cilostazol on expression of thrombospondin-1 in diabetic retinopathy.
Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications.
Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia.
Hypersensitivity
The Angiogenesis Inhibitor Thrombospondin-1 Inhibits Acute Cutaneous Hypersensitivity Reactions.
Thrombospondin-1 in ocular surface health and disease.
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Hypertension
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril.
Hypertension, Pulmonary
Thrombospondin-1 null mice are resistant to hypoxia-induced pulmonary hypertension.
Hypotension
Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.
Idiopathic Interstitial Pneumonias
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Idiopathic Pulmonary Fibrosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Immunoglobulin G4-Related Disease
Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease.
Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis.
Infections
A novel and divergent role of granzyme A and B in resistance to helminth infection.
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection.
Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.
Binding of complement regulatory proteins to group A Streptococcus.
Caspase-dependent inhibition of mousepox replication by gzmB.
Characterization of cytotoxicity-related gene expression in response to virulent Marek's disease virus infection in the bursa of Fabricius.
Circulating concentrations of soluble granzyme A and B increase during natural and experimental Plasmodium falciparum infections.
Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand/Fas system.
Cutaneous leishmaniasis: co-ordinate expression of granzyme A and lymphokines by CD4+ T cells from susceptible mice.
Cytomegalovirus infection decreases expression of thrombospondin-1 and -2 in cultured human retinal glial cells: effects of antiviral agents.
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Differential Activation of Human Monocytes and Lymphocytes by Distinct Strains of Trypanosoma cruzi.
Ex vivo rectal explant model reveals potential opposing roles of Natural Killer cells and Marginal Zone-like B cells in HIV-1 infection.
Expression of activation and cytotoxic molecules by peripheral blood lymphocytes of patients with paracoccidioidomycosis.
Expression of cytotoxicity-associated genes in Marek's disease virus-infected chickens.
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.
Expression of perforin, granzyme A and Fas ligand mRNA in caecal tissues upon Eimeria tenella infection of naïve and immune chickens.
Extracellular granzyme A in amniotic fluid is elevated in the presence of sterile intra-amniotic inflammation in preterm prelabor rupture of membranes.
Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.
Granzyme A in Chikungunya and Other Arboviral Infections.
Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia.
Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.
Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes.
HIV virions and HIV infection in vitro are unaffected by human granzymes A and B.
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease.
Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis.
Longevity of T-cell memory following acute viral infection.
Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection.
Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.
RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation.
Stable RNA interference of host thrombospondin-1 blocks Trypanosoma cruzi infection.
The kinetics of CD4+ and CD8+ T-cell gene expression correlate with protection in Atlantic salmon (Salmo salar L) vaccinated against infectious pancreatic necrosis.
Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection.
Thrombospondin-1 Plays an Essential Role in Yes-Associated Protein Nuclear Translocation during the Early Phase of Trypanosoma cruzi Infection in Heart Endothelial Cells.
Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection.
Thrombospondin-1 Restricts Interleukin-36?-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection.
Influenza, Human
Costimulatory ligand 4-1BBL (CD137L) as an efficient adjuvant for human antiviral cytotoxic T cell responses.
Examination of influenza specific T cell responses after influenza virus challenge in individuals vaccinated with MVA-NP+M1 vaccine.
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Insulin Resistance
Thrombospondin 1 Suppresses Insulin Signaling in C2C12 Myotubes.
Intracranial Aneurysm
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Intracranial Hemorrhages
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Ischemic Stroke
Plasminogen deficiency causes reduced angiogenesis and behavioral recovery after stroke in mice.
Keratitis
Spontaneous bacterial keratitis in CD36 knockout mice.
Thrombospondin-1 in ocular surface health and disease.
Keratoacanthoma
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Leiomyoma
Expression of matricellular proteins in human uterine leiomyomas and normal myometrium.
Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.
Leishmaniasis, Cutaneous
Cutaneous leishmaniasis: co-ordinate expression of granzyme A and lymphokines by CD4+ T cells from susceptible mice.
Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis.
Leukemia
A secretable serine proteinase with highly restricted specificity from cytolytic T lymphocytes inactivates retrovirus-associated reverse transcriptase.
Adenovirus-mediated gene therapy with an antiangiogenic fragment of thrombospondin-1 inhibits human leukemia xenograft growth in nude mice.
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A.
Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.
Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.
Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
Thrombospondin-1 (TSP-1) and TSP-1-derived heparin-binding peptides induce promyelocytic leukemia cell differentiation and apoptosis.
Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3.
Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells.
Leukemia, Promyelocytic, Acute
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Leukopenia
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
Liver Cirrhosis
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Liver Diseases
Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor ? signal activation and liver regeneration after hepatectomy in an experimental model.
Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH).
Liver Failure, Acute
Thrombospondin-1 Exacerbates Acute Liver Failure and Hepatic Encephalopathy Pathology in Mice by Activating Transforming Growth Factor ?1.
Lung Diseases
Granzyme K: a novel mediator in acute airway inflammation.
Lung Diseases, Interstitial
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Lung Injury
A TSP-1 synthetic peptide inhibits bleomycin-induced lung fibrosis in mice.
Lung Neoplasms
Adoptive immunotherapy of lung cancer with immobilized anti-TCRgammadelta antibody-expanded human gammadelta T-cells in peripheral blood.
Decreased Thrombospondin-1 and Bone Morphogenetic Protein-4 Serum Levels as Potential Indices of Advanced Stage Lung Cancer.
Identification and validation of novel circulating biomarkers for early diagnosis of lung cancer.
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
[Expression of thrombospondin-1 and CD44 in human lung cancer tissues and their prognostic significance.]
Lupus Erythematosus, Systemic
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome.
Lymphatic Metastasis
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Lymphocytic Choriomeningitis
Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus.
Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes.
Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection.
Lymphoma
NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.
The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175.
Thrombospondin-1 (TSP-1) and Survivin (S) expression in non-Hogkin's lymphomas.
Lymphoma, B-Cell
Immune mediators in vitreous fluids from patients with vitreoretinal B-cell lymphoma.
Lymphoma, Non-Hodgkin
Sjögren's syndrome: immunobiology of exocrine gland dysfunction.
Lymphoma, T-Cell, Cutaneous
Thrombospondin-1 promotes tumor progression in cutaneous T-cell lymphoma via CD47.
Lymphoproliferative Disorders
The clinicopathologic spectrum of cytotoxic lymphomas of the skin.
Macular Degeneration
Effect of Risk Alleles in CFH, C3, and VEGFA on the Response to Intravitreal Bevacizumab in Tunisian Patients with Neovascular Age-related Macular Degeneration.
Medulloblastoma
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.
Melanoma
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.
Human microvascular endothelial cells adhere to thrombospondin-1 via an RGD/CSVTCG domain independent mechanism.
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Interference of macrophage migration inhibitory factor expression in a mouse melanoma inhibits tumor establishment by up-regulating thrombospondin-1.
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.
Novel application of adipose-derived mesenchymal stem cells via producing antiangiogenic factor TSP-1 in lung metastatic melanoma animal model.
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression.
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model.
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment.
Thrombospondin-1 is a putative target gene of Runx2 and Runx3.
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Triamcinolone acetonide and anecortave acetate do not stimulate uveal melanoma cell growth.
Melanoma, Experimental
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Meningioma
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Common Brain Tumors.
Meningitis
Escherichia coli K1 promotes the ligation of CD47 with thrombospondin-1 to prevent the maturation of dendritic cells in the pathogenesis of neonatal meningitis.
Mesothelioma
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Mesothelioma, Malignant
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS.
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Metabolic Diseases
The role of thrombospondin (TSP)-1 in obesity and diabetes.
Thrombospondin 1 Suppresses Insulin Signaling in C2C12 Myotubes.
Microscopic Polyangiitis
Complement profile in microscopic polyangiitis and granulomatosis with polyangiitis: analysis using sera from a nationwide prospective cohort study.
Mucocutaneous Lymph Node Syndrome
[Predicting value of thrombospondin-2 for coronary artery dilatation in patients with Kawasaki disease].
Muscular Diseases
Role of thrombospondin 1 in macrophage inflammation in dysferlin myopathy.
Mycosis Fungoides
Granzyme A mRNA expression in mycosis fungoides progression.
Myocardial Infarction
A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants.
Association of Thrombospondin-1 (N700S) and Thrombospondin-4 (A387P) Gene Polymorphisms with the Incidence of Acute Myocardial Infarction in Egyptians.
Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling.
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population.
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Thrombospondins, potential drug targets for cardiovascular diseases.
Myocardial Ischemia
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Myositis
Immunohistochemical analysis of perforin and granzyme A in inflammatory myopathies.
Neoplasm Metastasis
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance.
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
CD36 tango in cancer: signaling pathways and functions.
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Cyclin D1 functions in cell migration.
Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling.
Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein.
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts.
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGF?-1.
Postoperative administration of ketorolac averts morphine-induced angiogenesis and metastasis in triple-negative breast cancer.
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.
Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2.
The alteration of Id-1 and TSP-1 expression in mucoepidermoid carcinoma associated with its clinical features and prognosis.
The effect of thrombospondin-1 on breast cancer metastasis.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
The role of thrombospondin-1 in tumor progression and angiogenesis.
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer.
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
[The poor prognosis is correlated with the high expression of vascular endothelial growth factor (VEGF) and low expression of thrombospondin 1 (TSP-1) in patients with breast cancer].
Neoplasm Micrometastasis
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Neoplasms
A novel cancer therapeutic using thrombospondin 1 in dendritic cells.
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
AAV-mediated expression of 3TSR inhibits tumor and metastatic lesion development and extends survival in a murine model of epithelial ovarian carcinoma.
Aberrant Expression of Chemokine Receptor CCR4 in Human Gastric Cancer Contributes to Tumor-Induced Immunosuppression.
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates.
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Adhesive proteins and the hematogenous spread of cancer.
All-trans retinoic acid induces Thrombospondin-1 expression in acute promyelocytic leukemia cells though down-regulation of its transcription repressor, c-MYC oncoprotein.
Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1.
Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance.
Angiogenic characteristics of circulating and tumoural thrombospondin-1 in breast cancer.
Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering a thrombospondin-derived peptide.
Anti-angiogenesis effect of 3'-sulfoquinovosyl-1'-monoacylglycerol via upregulation of thrombospondin 1.
Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts.
Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib.
Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts.
Antiangiogenic Variant of TSP-1 Targets Tumor Cells in Glioblastomas.
Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors.
Association of angiogenesis markers with lymph node metastasis in early colorectal cancer.
Association of epigenetic inactivation of RASSF1A with poor outcome in human neuroblastoma.
Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes.
Association of platelet activation markers with cancer-associated venous thromboembolism.
Association of thrombospondin-1 and cardiac allograft vasculopathy in human cardiac allografts.
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1.
c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.
Carrageenan inhibits granzyme A-induced detachment of and interleukin-8 release from alveolar epithelial A549 cells.
Cationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft.
CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix.
CD36 tango in cancer: signaling pathways and functions.
CD36-mediated activation of endothelial cell apoptosis by an N-terminal recombinant fragment of thrombospondin-2 inhibits breast cancer growth and metastasis in vivo.
Cell density regulates thrombospondin-1 production in malignant glioma cells.
Changes in thrombospondin-1 levels in the endothelial cells of the anterior pituitary during estrogen-induced prolactin-secreting pituitary tumors.
Characterization of integrin beta6 and thrombospondin-1 double-null mice.
Circulating pro- and anti-angiogenic factors in multi-stage liver disease and hepatocellular carcinoma progression.
Clinical significance of thrombospondin-1 expression in relation to vascular endothelial growth factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal carcinoma.
Clinicopathologic study of vascular endothelial growth factor, thrombospondin-1, and microvessel density assessed by CD34 in patients with stage III ovarian carcinoma.
Cloning and characterization of angiocidin, a tumor cell binding protein for thrombospondin-1.
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion.
Combination of metronomic administration and target delivery strategies to improve the anti-angiogenic and anti-tumor effects of triptolide.
Context dependent role of the CD36--thrombospondin--histidine-rich glycoprotein axis in tumor angiogenesis and growth.
Contrasting effects of VEGF gene disruption in embryonic stem cell-derived versus oncogene-induced tumors.
Correlation between pathological data and the RNA expression of p53 or p53-targeted genes in primary invasive ductal breast carcinomas: a preliminary study.
Correlation between the expression of thrombospondin-1 and neovascularization in mucoepidermoid carcinoma.
Correlation of thrombospondin-1 and transforming growth factor-beta expression with malignancy of glioma.
Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection.
Cyclin D1 functions in cell migration.
Cytotoxic lymphocyte granzymes trigger a target cell internal disintegration pathway leading to cytolysis and DNA breakdown.
Cytotoxic markers and frequency predict functional capacity of natural killer cells infiltrating renal cell carcinoma.
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A.
Decrease in immune function and the role of mitogen-activated protein kinase (MAPK) overactivation in apoptosis during T lymphocytes activation induced by zearalenone, deoxynivalenol, and their combinations.
Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors.
Development of a Cancer Treatment with the Concomitant Use of Low-Intensity Ultrasound: Entering the Age of Simultaneous Diagnosis and Treatment.
Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment.
Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.
Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein.
EBAG9 modulates host immune defense against tumor formation and metastasis by regulating cytotoxic activity of T lymphocytes.
Effect of oral anticoagulant therapy on thrombospondin-1 and von Willebrand factor in patients with stable heart failure.
Effects of a phytoestrogen-containing soy extract on the growth-inhibitory activity of ICI 182 780 in an experimental model of estrogen-dependent breast cancer.
Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells.
Efficacy of schedule-dependent metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells.
Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status.
Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women.
Enhanced expression of thrombospondin-1 and hypovascularity in human cholangiocarcinoma.
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Estrogen regulation of thrombospondin-1 in human breast cancer cells.
Evidence of a bi-phasic effect of thrombospondin-1 on angiogenesis.
Expression of the type-1 repeats of thrombospondin-1 inhibits tumor growth through activation of transforming growth factor-beta.
Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer.
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Expression of thrombospondin-1 in cancer: a role in tumor progression.
Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1.
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density.
Expression of thrombospondin-1 in prostate-derived cell lines.
Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis.
Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer.
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma.
Expresson of vascular endothelial growth factor, its receptors (FLT-1, KDR) and TSP-1 related to microvessel density and patient outcome in vertical growth phase melanomas.
Extraction of RNA from archival tissues and measurement of thrombospondin-1 mRNA in normal, dysplastic, and malignant oral tissues.
Fascin overexpression correlates with positive thrombospondin-1 and syndecan-1 expressions and a more aggressive clinical course in patients with gallbladder cancer.
Fibroblasts promote breast cancer cell invasion by upregulating tumor matrix metalloproteinase-9 production.
Functional Characterization of BK Virus-Specific CD4(+) T Cells with Cytotoxic Potential in Seropositive Adults.
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.
General Strategy for Direct Cytosolic Protein Delivery via Protein-Nanoparticle Co-engineering.
Genes encoding tumor necrosis factor alpha and granzyme A are expressed during development of autoimmune diabetes.
Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties.
Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity.
Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN.
Halofuginone Inhibits Tumor Growth in the Polyoma Middle T Antigen Mouse via a Thrombospondin-1 Independent Mechanism.
HBV-specific CD4+ cytotoxic T cells in hepatocellular carcinoma are less cytolytic toward tumor cells and suppress CD8+ T cell-mediated antitumor immunity.
Hepatocyte growth factor (HGF) downregulates thrombospondin 1 (TSP-1) expression in thyroid papillary carcinoma cells.
Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation.
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
Histopathology and clinical assessment correlate with the cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) receptor of thrombospondin-1 in breast tumors.
Human breast tumors override the antiangiogenic effect of stromal thrombospondin-1 in vivo.
Human cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53.
Human eosinophils exert TNF-? and granzyme A-mediated tumoricidal activity toward colon carcinoma cells.
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Hyperthermia improves the antitumour effect of metronomic cyclophosphamide in a rat transplantable brain tumour.
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Immunohistochemical expression of thrombospondin-1 in invasive vulvar squamous cell carcinoma.
Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients.
Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell-Derived Thrombospondin-1.
Improved therapeutic responses for liposomal doxorubicin targeted via thrombospondin peptidomimetics versus untargeted doxorubicin.
Independent association of angiogenesis index with outcome in prostate cancer.
Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma.
Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1.
Inhibition of tumor growth by systemic treatment with thrombospondin-1 peptide mimetics.
Interference of macrophage migration inhibitory factor expression in a mouse melanoma inhibits tumor establishment by up-regulating thrombospondin-1.
Interleukin-4 impairs granzyme-mediated cytotoxicity of Simian virus 40 large tumor antigen-specific CTL in BALB/c mice.
Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma.
Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts.
Markers of angiogenesis in high-risk, early-stage cervical cancer: A Gynecologic Oncology Group study.
Matricellular TSP-1 as a target of interest for impeding melanoma spreading: towards a therapeutic use for TAX2 peptide.
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.
Metronomic docetaxel chemotherapy inhibits angiogenesis and tumor growth in a gastric cancer model.
Microencapsulation of low-passage poorly-differentiated human mucoepidermoid carcinoma cells by alginate microcapsules: in vitro profiling of angiogenesis-related molecules.
Microvessel Density and Expression of Thrombospondin-1 in Non-small Cell Lung Cancer and Their Correlation with Clinicopathological Features.
Migration of CX3CR1-positive T cells producing type 1 cytokines and cytotoxic molecules into the synovium of patients with rheumatoid arthritis.
Modulation of macrophage activation state protects tissue from necrosis during critical limb ischemia in thrombospondin-1-deficient mice.
Molecular mediators of angiogenesis in bladder cancer.
Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes.
Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells.
Murine Thy-1+ dendritic epidermal T cell lines express granule-associated perforin and a family of granzyme molecules.
Mutant p53 correlates with reduced expression of thrombospondin-1, increased angiogenesis, and metastatic progression in melanoma.
Net platelet angiogenic activity (NPAA) correlates with progression and prognosis of non-small cell lung cancer.
Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor.
Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector Cells.
Original insights on thrombospondin-1-related antireceptor strategies in cancer.
Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer.
Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis.
Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas.
Overexpression of thrombospondin-1 reduces growth and vascular index but not perfusion in glioblastoma.
p53 accumulation in favorable-histology Wilms tumor is associated with angiogenesis and clinically aggressive disease.
Pericytes Elicit Resistance to Vemurafenib and Sorafenib Therapy in Thyroid Carcinoma via the TSP-1/TGF?1 Axis.
Peripheral T cell activation in long-term renal transplant patients: concordant upregulation of adhesion molecules and cytokine gene transcription.
Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer.
Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.
Platelet TSP-1 controls prostate cancer-induced osteoclast differentiation and bone marrow-derived cell mobilization through TGF?-1.
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: Its implication in motility and invasion.
Production of gastrointestinal tumors in mice by modulating latent TGF-?1 activation.
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression.
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1.
Protein tyrosine phosphatase non-receptor type 2 controls colorectal cancer development.
Purification and analysis of thrombospondin-1.
Quantification of thrombospondin-1 secretion and expression of alphavbeta3 and alpha3beta1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells.
Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.
Recurrent low-dose chemotherapy to inhibit and oxygenate head and neck tumors.
Reduced expression of thrombospondin-1 correlates with a poor prognosis in patients with non-small cell lung cancer.
Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer.
Regional control of tumor growth.
Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells.
Regulation of tumor angiogenesis by thrombospondin-1.
Regulation of tumor dormancy as a function of tumor-mediated paracrine regulation of stromal Tsp-1 and VEGF expression.
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma.
Role of TSP-1 as prognostic marker in various cancers: a systematic review and meta-analysis.
Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: Relationship to platelet a-granule content and primary activation.
Shift in the balance between circulating thrombospondin-1 and vascular endothelial growth factor in cancer patients: relationship to platelet alpha-granule content and primary activation.
Significance of tumour-associated macrophages, vascular endothelial growth factor and thrombospondin-1 expression for tumour angiogenesis and prognosis in endometrial carcinomas.
Silencing of PTGS2 exerts promoting effects on angiogenesis endothelial progenitor cells in mice with ischemic stroke via repression of the NF-?B signaling pathway.
Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma.
Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.
Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch.
Systemic administration of attenuated Salmonella choleraesuis carrying thrombospondin-1 gene leads to tumor-specific transgene expression, delayed tumor growth and prolonged survival in the murine melanoma model.
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
The application of an anti-angiogenic gene (thrombospondin-1) in the treatment of human prostate cancer xenografts.
The cellular basis of cardiac allograft rejection: VIII. Mechanisms underlying delayed allograft rejection in PVG C6-deficient rats.
The effect of thrombospondin-1 and TGF-beta 1 on pancreatic cancer cell invasion.
The effect of thrombospondin-1 on breast cancer metastasis.
The expression levels of thrombospondin-1 in dermatofibroma and dermatofibrosarcoma protuberans.
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment.
The expression of thrombospondin-1 in benign prostatic hyperplasia and prostatic intraepithelial neoplasia is decreased in prostate cancer.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
The N-terminal domain of thrombospondin-1: a key for the dual effect of TSP-1 in angiogenesis and cancer progression?
The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.
The pharmacological bases of the antiangiogenic activity of paclitaxel.
The role of angiocidin in sarcomas.
The role of thrombospondin-1 in tumor progression and angiogenesis.
The role of thrombospondin-1 in tumor progression.
The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma.
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.
Thrombopoietic cells and the bone marrow vascular niche.
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells.
Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2.
Thrombospondin 1 mRNA as a Candidate for a Marker to Detect Thyroid-derived Fibroblasts in Fine Needle Aspiration Biopsy of the Thyroid.
Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast.
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.
Thrombospondin in Tumor Microenvironment.
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Thrombospondin-1 (TSP-1) and Survivin (S) expression in non-Hogkin's lymphomas.
Thrombospondin-1 (TSP-1) promotes the invasive properties of human breast cancer.
Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin alpha6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion.
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Thrombospondin-1 and -2 in node-negative breast cancer: correlation with angiogenic factors, p53, cathepsin D, hormone receptors and prognosis.
Thrombospondin-1 and -2 messenger RNA expression in epithelial ovarian tumor.
Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis.
Thrombospondin-1 and -2 messenger RNA expression in normal and neoplastic endometrial tissues: correlation with angiogenesis and prognosis.
Thrombospondin-1 and its CSVTCG-specific receptor in wound healing and cancer.
Thrombospondin-1 and transforming growth factor-beta l promote breast tumor cell invasion through up-regulation of the plasminogen/plasmin system.
Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth.
Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression.
Thrombospondin-1 enhances human thyroid carcinoma cell invasion through urokinase activity.
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma.
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Thrombospondin-1 expression in breast cancer: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Thrombospondin-1 expression in epithelial ovarian carcinoma: association with p53 status, tumor angiogenesis, and survival in platinum-treated patients.
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
Thrombospondin-1 expression in relation to p53 status and VEGF expression in human breast cancers.
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
Thrombospondin-1 in a Murine Model of Colorectal Carcinogenesis.
Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde.
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Thrombospondin-1 is a putative target gene of Runx2 and Runx3.
Thrombospondin-1 is a transcriptional repression target of PRMT6.
Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis.
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma.
Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro.
Thrombospondin-1 plus irinotecan: a novel antiangiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice.
Thrombospondin-1 promotes tumor progression in cutaneous T-cell lymphoma via CD47.
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation.
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Thrombospondin-1 selectively inhibits early-stage carcinogenesis and angiogenesis but not tumor lymphangiogenesis and lymphatic metastasis in transgenic mice.
Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts.
Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium.
Thrombospondin-1 up-regulates tumor cell invasion through the urokinase plasminogen activator receptor in head and neck cancer cells.
Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate.
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1.
Thrombospondin-1: a unique marker to identify in vitro platelet activation when monitoring in vivo processes.
Thrombospondin-1: multiple paths to inflammation.
Thrombospondin-2 inhibits tumor cell invasion through the modulation of MMP-9 and uPA in pancreatic cancer cells.
Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis.
Thrombospondins as anti-angiogenic therapeutic agents.
Thrombospondins, metallo proteases and thrombospondin receptors messenger RNA and protein expression in different tumour sublines of the Dunning prostate cancer model.
Thrombospondins: from structure to therapeutics : Thrombospondins in cancer.
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.
Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of V?9V?2 T cells in low levels of IL-2.
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients.
Tumor progression: the effects of thrombospondin-1 and -2.
Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.
Tumor-derived interleukin-4 reduces tumor clearance and deviates the cytokine and granzyme profile of tumor-induced CD8+ T cells.
Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma.
Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells.
Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes.
Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells.
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
Vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and thrombospondin-1 (TSP-1) expression in urothelial carcinomas.
[Correlation between the expression of thrombospondin-1 and the angiogenesis in mucoepidermoid carcinoma]
[Inhibition of fibrosarcoma growth in mice by antibody against B cell epitope on mouse Toll-like receptor-2 extracellular domain]
[Mechanism of reversion of myocardial interstitial fibrosis in diabetic cardiomyopathy by valsartan]
[Relationship between changes of serum concentrations of antiangiogenic factors and disease progression in patients of pancreatic carcinoma]
[Relationship between thrombospondin-1 and the occurrence and development of oral and maxillofacial malignancy].
Neoplasms, Glandular and Epithelial
Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
Nephritis
TSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis rats.
Nephrosclerosis
Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model.
[Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]
Neuroblastoma
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma.
Retinoic acid alters the mechanism of attachment of malignant astrocytoma and neuroblastoma cells to thrombospondin-1.
TGF?R1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells.
Thrombospondin-1 protects against A?-induced mitochondrial fragmentation and dysfunction in hippocampal cells.
Neuroinflammatory Diseases
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Obesity
Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids.
Serum levels of TSP-1, NF-?B and TGF-?1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation.
The role of thrombospondin (TSP)-1 in obesity and diabetes.
Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation.
Oligodendroglioma
EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Osteoarthritis
CD56(+)/CD16(-) Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis.
Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis.
Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage.
Intraarticular gene transfer of thrombospondin-1 suppresses the disease progression of experimental osteoarthritis.
Osteosarcoma
Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the alpha 4 beta 1 integrin.
Identification of cell adhesive active sites in the N-terminal domain of thrombospondin-1.
Platelet-osteosarcoma cell interaction is mediated through a specific fibrinogen-binding sequence located within the N-terminal domain of thrombospondin 1.
Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
Otitis Media
[H Factor Deficiency: A Case with an Atypical Presentation].
Ovarian Neoplasms
Alteration of HGF and TSP-1 expression in ovarian carcinoma associated with clinical features.
Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts.
Pancreatic Neoplasms
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: role in matrix metalloproteinase-9 production.
Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo.
The effect of thrombospondin-1 and TGF-beta 1 on pancreatic cancer cell invasion.
Thrombospondin-1 and transforming growth factor beta-1 upregulate plasminogen activator inhibitor type 1 in pancreatic cancer.
Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma.
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
Pancreatitis, Acute Necrotizing
Eomesodermin of atlantic salmon: an important regulator of cytolytic gene and interferon gamma expression in spleen lymphocytes.
Papillomavirus Infections
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Paralysis
Angiotensin II sustains brain inflammation in mice via TGF-beta.
Penile Neoplasms
Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma.
Periodontitis
Targeting TSP-1 decreased periodontitis by attenuating extracellular matrix degradation and alveolar bone destruction.
Thrombospondin-1 production is enhanced by Porphyromonas gingivalis lipopolysaccharide in THP-1 cells.
Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-?B Signaling Pathway.
Peripheral Arterial Disease
Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.
Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.
Peritoneal Fibrosis
Blockade of thrombospondin-1 ameliorates high glucose-induced peritoneal fibrosis through downregulation of TGF-?1/Smad3 signaling pathway.
Persistent Infection
CD8+ T-cell dysfunction due to cytolytic granule deficiency in persistent Friend retrovirus infection.
Pituitary ACTH Hypersecretion
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Pituitary Neoplasms
Regulation of VEGF-A, VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line (HP75) by TGFbeta1, bFGF, and EGF.
TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease.
Pleural Effusion
Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions.
Pneumonia
Granzyme A impairs host defense during Streptococcus pneumoniae pneumonia.
Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.
Pneumovirus Infections
Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
Polycystic Ovary Syndrome
Serum levels of TSP-1, NF-?B and TGF-?1 in polycystic ovarian syndrome (PCOS) patients in northern China suggest PCOS is associated with chronic inflammation.
Polymyositis
Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis.
Pre-Eclampsia
Circulating levels of thrombospondin-1 are decreased in HELLP syndrome.
Maternal serum thrombospondin-1 is significantly altered in cases with established preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Glucocorticoid-induced granzyme A expression can be used as a marker of glucocorticoid sensitivity for acute lymphoblastic leukemia therapy.
Primary Myelofibrosis
Thrombospondin-1 (TSP-1) in primary myelofibrosis (PMF) - a megakaryocyte-derived biomarker which largely discriminates PMF from essential thrombocythemia.
Thrombospondin-1 is not the major activator of TGF-{beta}1 in thrombopoietin-induced myelofibrosis.
Prolactinoma
Thrombospondin-1 (TSP-1) Analogs ABT-510 and ABT-898 Inhibit Prolactinoma Growth and Recover Active Pituitary Transforming Growth Factor-?1 (TGF-?1).
Prostatic Diseases
Antibody array profiling reveals serum TSP-1 as a marker to distinguish benign from malignant prostatic disease.
Prostatic Hyperplasia
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Prostatic Intraepithelial Neoplasia
The expression of thrombospondin-1 in benign prostatic hyperplasia and prostatic intraepithelial neoplasia is decreased in prostate cancer.
Prostatic Neoplasms
Expression of thrombospondin-1 in prostate-derived cell lines.
Quercetin inhibits angiogenesis through thrombospondin-1 upregulation to antagonize human prostate cancer PC-3 cell growth in vitro and in vivo.
The application of an anti-angiogenic gene (thrombospondin-1) in the treatment of human prostate cancer xenografts.
Thrombospondin-1 (TSP-1) up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) production in human tumor cells: Exploring the functional significance in tumor cell invasion.
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Thrombospondin-1 regulates the normal prostate in vivo through angiogenesis and TGF-beta activation.
Thrombospondin-1, vascular endothelial growth factor expression and their relationship with p53 status in prostate cancer and benign prostatic hyperplasia.
Proteinuria
Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.
[Localized expressing tendency of nuclear transcription factor kappa-B, pro-fibrosis genetic factors and fibronectin mRNA in renal tissues in proteinuria overload nephrotic young rats]
Pseudolymphoma
Expression of apoptosis associated proteins Survivin, Livin and Thrombospondin-1 in Burkitt lymphoma.
Psoriasis
Thrombospondin-1/CD47 Interaction Regulates Th17 and Treg Differentiation in Psoriasis.
Pterygium
Thrombospondin 1 polymorphism associated with decreased expression and increased risk of pterygium.
Pulmonary Arterial Hypertension
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril.
Pulmonary Disease, Chronic Obstructive
Increased granzyme A expression in type II pneumocytes of patients with severe chronic obstructive pulmonary disease.
Involvement of type II pneumocytes in the pathogenesis of chronic obstructive pulmonary disease.
Pulmonary Fibrosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Thrombospondin-1 Deficient Mice Are Not Protected from Bleomycin-Induced Pulmonary Fibrosis.
TSP-1 in lung fibrosis.
[The Role of TSP-1-CD47 in ROS-mediated Pulmonary Fibrosis Induced by Paraquat].
[The roles of TSP-1 and its receptor CD47 in pathogenesis of paraquat-induced pulmonary fibrosis in rats].
Purpura, Thrombotic Thrombocytopenic
Postoperative thrombotic thrombocytopenic purpura in an infant: case report and literature review.
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.
Renal Insufficiency
Identification of thrombospondin 1 (TSP-1) as a novel mediator of cell injury in kidney ischemia.
Renal Insufficiency, Chronic
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction.
[Role of thrombospondin-1 in the development of kidney diseases].
Retinal Degeneration
Enhanced functional integration of human photoreceptor precursors into human and rodent retina in an ex vivo retinal explant model system.
Retinal Neovascularization
[Expression and significance of thrombonspondin-1 in oxygen-induced retinopathy in mice.]
Retinoblastoma
Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle.
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Retinopathy of Prematurity
Inhibition of retinal angiogenesis by peptides derived from thrombospondin-1.
Sarcoidosis
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
[Granzymes A and B in pulmonary sarcoidosis (experimental study)]
Sarcoidosis, Pulmonary
High serum levels of thrombospondin-1 in patients with idiopathic interstitial pneumonia.
Sarcoma
Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.
The role of angiocidin in sarcomas.
Seizures
A Purinergic P2 Receptor Family-Mediated Increase in Thrombospondin-1 Bolsters Synaptic Density and Epileptic Seizure Activity in the Amygdala-Kindling Rat Model.
Circulating Levels of Thrombospondin-1 and Thrombospondin-2 in Patients with Temporal Lobe Epilepsy Before and After Surgery.
P2Y4/TSP-1/TGF-?1/pSmad2/3 pathway contributes to acute generalized seizures induced by kainic acid.
Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus.
Sepsis
Adipose-Derived Inflammatory and Coagulant Mediators in Patients with Sepsis.
Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: a single-center cohort study on the intensive care unit.
Curcumin protects against lipopolysaccharide-induced vasoconstriction dysfunction via inhibition of thrombospondin-1 and transforming growth factor-?1.
Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.
Heparin-binding protein as a novel biomarker for sepsis-related acute kidney injury.
LncRNA NEAT1 facilitates the progression of sepsis through up-regulating TSP-1 via sponging miR-370-3p.
Reduction of plasma granzyme A correlates with severity of sepsis in burn patients.
Thrombospondin-1 contributes to mortality in murine sepsis through effects on innate immunity.
Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome.
Severe Combined Immunodeficiency
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Silicosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
[Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis].
Spinal Cord Injuries
Protection of erythropoietin on experimental spinal cord injury by reducing the expression of thrombospondin-1 and transforming growth factor-beta.
The role of thrombospondin-1 and transforming growth factor-beta after spinal cord injury in the rat.
TSP-1 expression changes in diabetic rats with spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation.
The localization of thrombospondin-1 (TSP-1), cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) TSP receptor, and matrix metalloproteinase-9 (MMP-9) in colorectal cancer.
Thrombospondin-1 expression in oral squamous cell carcinomas: correlations with tumor vascularity, clinicopathological features and survival.
ST Elevation Myocardial Infarction
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Increased plasma cathepsin S and trombospondin-1 in patients with acute ST segment elevation myocardial infarction.
Stomach Neoplasms
An armed oncolytic herpes simplex virus expressing thrombospondin-1 has an enhanced in vivo antitumor effect against human gastric cancer.
Effect of geldanamycin on the expression of the matrix molecules and angiogenetic factors in a gastric cancer cell line.
Effects of caffeic acid phenethyl ester on matrix molecules and angiogenetic and anti-angiogenetic factors in gastric cancer cells cultured on different substrates.
Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer.
Expression of thrombospondin-1 is correlated with microvessel density in gastric carcinoma.
IL-18 enhances thrombospondin-1 production in human gastric cancer via JNK pathway.
Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells.
Stimulation of natural killer cells with rhCD137 ligand enhances tumor-targeting antibody efficacy in gastric cancer.
Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer.
Stroke
An evaluation of the ability of thrombospondin-1 to predict stroke outcomes and mortality after ischemic stroke.
Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1).
Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke.
Subarachnoid Hemorrhage
Elevated cerebrospinal fluid levels of thrombospondin-1 correlate with adverse clinical outcome in patients with aneurysmal subarachnoid hemorrhage.
Synovitis
Thrombospondin 1 as an effective gene therapeutic strategy in collagen-induced arthritis.
TDP-43 Proteinopathies
Defective synthesis and release of astrocytic thrombospondin-1 mediates the neuronal TDP-43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies.
Telangiectasia, Hereditary Hemorrhagic
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasis
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Thrombasthenia
Association of thrombospondin-1 with the actin cytoskeleton of human thrombin-activated platelets through an alphaIIbbeta3- or CD36-independent mechanism.
Thrombocytopenia
Decreased serum thrombospondin-1 and elevation of its autoantibody are associated with multiple exacerbated clinical manifestations in systemic lupus erythematosus.
Evaluation of complement regulatory components in patients with atypical hemolytic uremic syndrome.
Thrombosis
Differential expression of SPARC and thrombospondin 1 in wound repair: immunolocalization and in situ hybridization.
Neutrophil-Mediated Proteolysis of Thrombospondin-1 Promotes Platelet Adhesion and String Formation.
Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting (sub)endothelial VWF from cleavage by ADAMTS13.
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Towards the Therapeutic Use of Thrombospondin 1/CD47 Targeting TAX2 Peptide as an Antithrombotic Agent.
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.
Whole-exome sequencing detects mutations in pediatric patients with atypical hemolytic uremic syndrome in Taiwan.
Thymoma
Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties.
Thyroid Cancer, Papillary
Activating transcription factor-1-mediated hepatocyte growth factor-induced down-regulation of thrombospondin-1 expression leads to thyroid cancer cell invasion.
Thyroid Neoplasms
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
Pituitary tumor-transforming gene regulates multiple downstream angiogenic genes in thyroid cancer.
The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells.
Thrombospondin-1 in differentiated thyroid cancer: Dr. Jekyll and Mr. Hyde.
Thrombospondin-1 Silencing Down-Regulates Integrin Expression Levels in Human Anaplastic Thyroid Cancer Cells with BRAF(V600E): New Insights in the Host Tissue Adaptation and Homeostasis of Tumor Microenvironment.
Thyroiditis
[H Factor Deficiency: A Case with an Atypical Presentation].
Trauma, Nervous System
Trauma-induced expression of astrocytic thrombospondin-1 is regulated by P2 receptors coupled to protein kinase cascades.
Tuberculosis
Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease.
Granzyme A Is Expressed in Mouse Lungs during Mycobacterium tuberculosis Infection but Does Not Contribute to Protection In Vivo.
Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis.
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Tuberculosis, Bovine
Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers.
Tuberculosis, Pulmonary
Regulatory role of 1, 25-dihydroxyvitamin D3 and vitamin D receptor gene variants on intracellular granzyme A expression in pulmonary tuberculosis.
Typhoid Fever
Expression of intra- and extracellular granzymes in patients with typhoid fever.
Ureteral Obstruction
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction.
Thrombospondin-1 Short Hairpin RNA Suppresses Tubulointerstitial Fibrosis in the Kidney of Ureteral Obstruction by Ameliorating Peritubular Capillary Injury.
Urinary Bladder Neoplasms
Effects of TSP-1-696 C/T polymorphism on bladder cancer susceptibility and clinicopathologic features.
GP73 promotes invasion and metastasis of bladder cancer by regulating the epithelial-mesenchymal transition through the TGF-?1/Smad2 signalling pathway.
Molecular mediators of angiogenesis in bladder cancer.
Reduced thrombospondin-1 at presentation predicts disease progression in superficial bladder cancer.
Role of angiogenesis in urothelial bladder carcinoma.
The Pathological Significance and Prognostic Roles of Thrombospondin-1, and -2, and 4N1K-peptide in Bladder Cancer.
The role of hypoxia and p53 in the regulation of angiogenesis in bladder cancer.
Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and association with p53 alterations, tumour angiogenesis and extracellular matrix components.
TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population.
Urologic Neoplasms
Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects.
Urticaria
Endostatin and Thrombospondin-1 levels are increased in the sera of patients with chronic spontaneous urticaria.
Uterine Cervical Neoplasms
A novel role of thrombospondin-1 in cervical carcinogenesis: inhibit stroma reaction by inhibiting activated fibroblasts from invading cancer.
Thrombospondin-1 and -2 messenger RNA expression in invasive cervical cancer: correlation with angiogenesis and prognosis.
Uveitis
Environmental conditioning in the control of macrophage thrombospondin-1 production.
Vaccinia
Differential regulation of granzyme and perforin in effector and memory T cells following smallpox immunization.
Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.
Vascular Diseases
Thrombospondin-5 and fluvastatin promote angiogenesis and are protective against endothelial cell apoptosis.
Vascular System Injuries
Thrombospondin-1 promotes haemostasis through modulation of cAMP signalling in blood platelets.
Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets.
Thrombospondins Differentially Regulate Proteins Involved in Arterial Remodeling.
Vascular response to intra-arterial injury in the thrombospondin-1 null mouse.
Vasculitis
Endothelial-derived thrombospondin-1 promotes macrophage recruitment and apoptotic cell clearance.
Ventricular Fibrillation
Decreased TSP-1 following percutaneous coronary intervention is associated with major adverse cardiac events in ST-elevation myocardial infarction.
Virus Diseases
Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection.
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Immunosurveillance by Antiangiogenesis: Tumor Growth Arrest by T Cell-Derived Thrombospondin-1.
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection.
Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice.
Vulvar Neoplasms
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer.
Whooping Cough
Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes.
Oncogenes and Angiogenesis: down-regulation of thrombospondin-1 in normal fibroblasts exposed to factors from cancer cells harboring mutant ras.
The role of G proteins in thromospondin-1-induced vascular smooth muscle cell migration.
Wilms Tumor
Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin.