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Information on EC 3.4.21.77 - semenogelase and Organism(s) Mus musculus and UniProt Accession P00756

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.77 semenogelase
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This record set is specific for:
Mus musculus
UNIPROT: P00756 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Preferential cleavage: -Tyr-/-
Synonyms
prostate-specific antigen, prostate stem cell antigen, gamma-sm, gamma-seminoprotein, steap, gamma-ngf, six-transmembrane epithelial antigen of the prostate, kallikrein-related peptidase 3, kallikrein 3, seminal proteinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7S nerve growth factor gamma chain
-
gamma-NGF
-
tissue kallikrein
-
antigen (human clone lambdaHPSA-1 prostate-specific protein moiety reduced)
-
-
-
-
antigen PSA (human clone 5P1 protein moiety reduced)
-
-
-
-
antigen PSA (human prostate-specific)
-
-
-
-
gamma-seminoglycoprotein (human protein moiety reduced)
-
-
-
-
gamma-SM
-
-
-
-
glandular kallikrein
-
-
-
-
kallikrein 3
-
-
-
-
kallikrein-related peptidase 3
-
-
KLK3
-
-
P-30 antigen
-
-
-
-
prostate-specific antigen
-
-
S01.162
-
-
-
-
seminin
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
110157-83-0
-
95829-41-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
PTHrP + H2O
?
show the reaction diagram
-
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
PSA inhibits fibroblast growth factor mediated angiogenesis in a Matrigel plug assay. It can inactivate PTHrP-stimulated cAMP accumulation in mouse osteoblasts
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
K1KB3_MOUSE
261
0
28998
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P00756), Homo sapiens (P07288), Rattus norvegicus (P15950), Macaca mulatta (P33619)
Manually annotated by BRENDA team
LeBeau, A.M.; Kostova, M.; Craik, C.S.; Denmeade, S.R.
Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer
Biol. Chem.
391
333-343
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team