Reference on EC 3.4.21.72 - IgA-specific serine endopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bachovchin, W.W.; Plaut, A.G.; Flentke, G.R.; Lynch, M.; Kettner, C.A.
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids
J. Biol. Chem.
265
3738-3743
1990
Haemophilus influenzae, Neisseria gonorrhoeae
Plaut, A.G.
The IgA1 proteases of pathogenic bacteria
Annu. Rev. Microbiol.
37
603-622
1983
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Streptococcus sanguinis
Plaut, A.G.; Bachovchin, W.W.
IgA-specific prolyl endopeptidases: serine type
Methods Enzymol.
244
137-151
1994
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Ureaplasma urealyticum
Grundy, F.J.; Plaut, A.; Wright, A.
Haemophilus influenzae immunoglobulin A1 protease genes: cloning by plasmid integration-excision, comparative analyses, and localization of secretion determinants
J. Bacteriol.
169
4442-4450
1987
Haemophilus influenzae
Pohlner, J.; Halter, R.; Beyreuther, K.; Meyer, T.F.
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease
Nature
325
458-462
1987
Neisseria gonorrhoeae
Klauser, T.; Krmer, J.; Otzelberger, K.; Pohlner, J.; Meyer, T.F.
Characterization of the Neisseria Iga beta-core. The essential unit for outer membrane targeting and extracellular protein secretion
J. Mol. Biol.
234
579-593
1993
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis
Bleeg, H.S.; Reinholdt, J.; Kilian, M.
Bacterial immunoglobulin A proteases monitored by continuous spectrophotometry
FEBS Lett.
188
357-362
1985
Haemophilus influenzae, Haemophilus influenzae HK 393
Lindler, L.E.; Stutzenberger, F.J.
Nephelometric assay for the immunoglobulin A1-protease produced by the oral bacterium Streptococcus sanguis
Arch. Oral Biol.
27
853-859
1982
Streptococcus sanguinis
Mortensen, S.B.; Kilian, M.
Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus
Infect. Immun.
45
550-557
1984
Prevotella melaninogenica
Hauck, C.R.; Meyer, T.F.
The lysosomal/phagosomal membrane protein h-lamp-1 is a target of the IgA1 protease of Neisseria gonorrhoeae
FEBS Lett.
405
86-90
1997
Neisseria gonorrhoeae, no activity in Neisseria gonorrhoeae, no activity in Neisseria gonorrhoeae MS11, Neisseria gonorrhoeae MS11-N139
Parsons, H.K.; Vitovski, S.; Sayers, J.R.
Immunoglobulin A1 proteases: a structure-function update
Biochem. Soc. Trans.
32
1130-1132
2004
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis
McGillivary, G.; Smoot, L.M.; Actis, L.A.
Characterization of the IgA1 protease from the Brazilian purpuric fever strain F3031 of Haemophilus influenzae biogroup aegyptius
FEMS Microbiol. Lett.
250
229-236
2005
Haemophilus influenzae (Q93T34), Haemophilus influenzae
Senior, B.W.; Woof, J.M.
Effect of mutations in the human immunoglobulin A1 (IgA1) hinge on its susceptibility to cleavage by diverse bacterial IgA1 proteases
Infect. Immun.
73
1515-1522
2005
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis (Q9K0B4), Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis, Streptococcus mitis SK599, Streptococcus mitis SK597, Streptococcus oralis SK10, Streptococcus sanguinis SK4, Streptococcus pneumoniae SK690, Streptococcus sanguinis SK1, Streptococcus sanguinis SK49, Streptococcus mitis SK564
Vidarsson, G.; Overbeeke, N.; Stemerding, A.M.; van den Dobbelsteen, G.; van Ulsen, P.; van der Ley, P.; Kilian, M.; van de Winkel, J.G.
Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease
Infect. Immun.
73
6721-6726
2005
Neisseria meningitidis (Q9K0B4), Neisseria meningitidis
Mistry, D.; Stockley, R.A.
IgA1 protease
Int. J. Biochem. Cell Biol.
38
1244-1248
2006
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis
Bender, M.H.; Weiser, J.N.
The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function
Mol. Microbiol.
61
526-543
2006
Streptococcus pneumoniae
Romanello, V.; Marcacci, M.; Dal Molin, F.; Moschioni, M.; Censini, S.; Covacci, A.; Baritussio, A.G.; Montecucco, C.; Tonello, F.
Cloning, expression, purification, and characterization of Streptococcus pneumoniae IgA1 protease
Protein Expr. Purif.
45
142-149
2006
Streptococcus pneumoniae
Fernaays, M.M.; Lesse, A.J.; Cai, X.; Murphy, T.F.
Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae
Infect. Immun.
74
5860-5870
2006
Haemophilus influenzae
Vitovski, S.; Sayers, J.R.
Relaxed cleavage specificity of an immunoglobulin A1 protease from Neisseria meningitidis
Infect. Immun.
75
2875-2885
2007
Neisseria meningitidis (Q51169), Neisseria meningitidis
Lamm, M.E.; Emancipator, S.N.; Robinson, J.K.; Yamashita, M.; Fujioka, H.; Qiu, J.; Plaut, A.G.
Microbial IgA protease removes IgA immune complexes from mouse glomeruli in vivo: potential therapy for IgA nephropathy
Am. J. Pathol.
172
31-36
2008
Haemophilus influenzae
Hotomi, M.; Kono, M.; Togawa, A.; Arai, J.; Takei, S.; Ikeda, Y.; Ogami, M.; Murphy, T.F.; Yamanaka, N.
Haemophilus influenzae and Haemophilus haemolyticus in tonsillar cultures of adults with acute pharyngotonsillitis
Auris Nasus Larynx
37
594-600
2010
Haemophilus influenzae, no activity in Haemophilus haemolyticus
Abuknesha, R.A.; Jeganathan, F.; Wildeboer, D.; Price, R.G.
Optimisation of the detection of bacterial proteases using adsorbed immunoglobulins as universal substrates
Talanta
81
1237-1244
2010
Bacillus licheniformis, Streptomyces griseus
Pyo, H.M.; Kim, I.J.; Kim, S.H.; Kim, H.S.; Cho, S.D.; Cho, I.S.; Hyun, B.H.
Escherichia coli expressing single-chain Fv on the cell surface as a potential prophylactic of porcine epidemic diarrhea virus
Vaccine
27
2030-2036
2009
Neisseria gonorrhoeae
Zhang, A.; Mu, X.; Chen, B.; Liu, C.; Han, L.; Chen, H.; Jin, M.
Identification and characterization of IgA1 protease from Streptococcus suis
Vet. Microbiol.
140
171-175
2010
Streptococcus suis
Johnson, T.A.; Qiu, J.; Plaut, A.G.; Holyoak, T.
Active-site gating regulates substrate selectivity in a chymotrypsin-like serine protease the structure of Haemophilus influenzae IgA1 protease
J. Mol. Biol.
389
559-574
2009
Haemophilus influenzae (P44969), Haemophilus influenzae
He, S.; Su, Y.; Lin, Y.; Kuo, H.
The surface domain of neisserial IgA1 protease plays a role in induction of bacterial adherence to human epithelial cells
Asian Biomed.
4
231-241
2010
Neisseria meningitidis (Q0PVD3)
-
Iagudaeva, E.; Zhigis, L.; Razguliaeva, O.; Zueva, V.; Melnikov, E.; Zubov, V.; Kozlov, L.; Bichucher, A.; Kotelnikova, O.; Alliluev, A.; Avakov, A.; Rumsh, L.
Isolation and determination of activity of IgA1 protease from Neisseria meningitidis
Bioorg. Khim.
36
89-97
2010
Neisseria meningitidis
Long, S.; Phan, E.; Vellard, M.C.
The expression of soluble and active recombinant Haemophilus influenzae IgA1 protease in E. coli
J. Biomed. Biotechnol.
2010
253983
2010
Haemophilus influenzae (P44969), Haemophilus influenzae
Xie, L.S.; Huang, J.; Qin, W.; Fan, J.M.
Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy
Nephrology
15
584-586
2010
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis
Murphy, T.; Lesse, A.; Kirkham, C.; Zhong, H.; Sethi, S.; Munson Jr., R.
A clonal group of nontypeable Haemophilus influenzae with two IgA proteases is adapted to infection in chronic obstructive pulmonary disease
PLoS ONE
6
e25923
2011
Haemophilus influenzae
Yagudaeva, E.; Zhigis, L.; Razgulyaeva, O.; Zueva, V.; Melnikov, E.; Zubov, V.; Kozlov, L.; Bichucher, A.; Kotelnikova, O.; Alliluev, A.; Avakov, A.; Rumsh, L.
Isolation and determination of the activity of IgA1 protease from Neisseria meningitidis
Russ. J. Bioorg. Chem.
36
81-89
2010
Neisseria meningitidis
Zhang, A.; Mu, X.; Chen, B.; Han, L.; Chen, H.; Jin, M.
IgA1 protease contributes to the virulence of Streptococcus suis
Vet. Microbiol.
148
436-439
2011
Streptococcus suis, Streptococcus suis 05ZYS
Mullins, M.A.; Register, K.B.; Bayles, D.O.; Butler, J.E.
Haemophilus parasuis exhibits IgA protease activity but lacks homologs of the IgA protease genes of Haemophilus influenzae
Vet. Microbiol.
153
407-412
2011
Haemophilus influenzae (P44969), Haemophilus influenzae
Mistry, D.V.; Stockley, R.A.
The cleavage specificity of an IgA1 protease from Haemophilus influenzae
Virulence
2
103-110
2011
Haemophilus influenzae (P44969), Haemophilus influenzae
Choudary, S.K.; Qiu, J.; Plaut, A.G.; Kritzer, J.A.
Versatile substrates and probes for IgA1 protease activity
ChemBioChem
14
2007-2012
2013
Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria gonorrhoeae MKB, Neisseria meningitidis 1C
Murphy, T.F.; Kirkham, C.; Jones, M.M.; Sethi, S.; Kong, Y.; Pettigrew, M.M.
Expression of IgA proteases by Haemophilus influenzae in the respiratory tract of adults with chronic obstructive pulmonary disease
J. Infect. Dis.
212
1798-1805
2015
Haemophilus influenzae (N0BM78), Haemophilus influenzae (Q19V48), Haemophilus influenzae, Haemophilus influenzae 124P3H1 (Q19V48), Haemophilus influenzae RD (N0BM78)
Bek-Thomsen, M.; Poulsen, K.; Kilian, M.
Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
mBio
3
e00303-12
2012
no activity in Streptococcus suis
Bek-Thomsen, M.; Poulsen, K.; Kilian, M.
Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
mBio
3
e00303
2012
no activity in Streptococcus parasanguinis, no activity in Streptococcus cristatus, no activity in Streptococcus oligofermentans, no activity in Streptococcus australis, no activity in Streptococcus peroris, Streptococcus sanguinis (A0A859EML3), Streptococcus sanguinis (F0FDI1), Streptococcus sanguinis (F0FRC4), Streptococcus sanguinis (F0IMK7), Streptococcus sanguinis, Streptococcus mitis (F9MKY1), Streptococcus mitis, Streptococcus sanguinis SK150 (F0IMK7), Streptococcus sanguinis VMC66 (A0A859EML3), Streptococcus sanguinis SK678 (F0FRC4), Streptococcus sanguinis SK353 (F0FDI1), Streptococcus mitis SK569 (F9MKY1)
Roussel-Jazede, V.; Arenas, J.; Langereis, J.D.; Tommassen, J.; van Ulsen, P.
Variable processing of the IgA protease autotransporter at the cell surface of Neisseria meningitidis
Microbiology
160
2421-2431
2014
Neisseria meningitidis, Neisseria meningitidis H44/76
Shehaj, L.; Choudary, S.K.; Makwana, K.M.; Gallo, M.C.; Murphy, T.F.; Kritzer, J.A.
Small-molecule inhibitors of Haemophilus influenzae IgA1 protease
ACS Infect. Dis.
5
1129-1138
2019
Haemophilus influenzae NTHI
Zhigis, L.S.; Kotelnikova, O.V.; Vikhrov, A.A.; Zinchenko, A.A.; Serova, O.V.; Zueva, V.S.; Razgulyaeva, O.A.; Gordeeva, E.A.; Melikhova, T.D.; Nokel, E.A.; Alliluev, A.P.; Drozhzhina, E.Y.; Rumsh, L.D.
A new methodological approach to estimation of IgA1 and IgA2 content in human serum using recombinant IgA1 protease from Neisseria meningitidis
Biotechnol. Lett.
37
2289-2293
2015
Neisseria meningitidis serogroup B, Neisseria meningitidis serogroup B H44/76
Kotelnikova, O.V.; Zinchenko, A.A.; Vikhrov, A.A.; Alliluev, A.P.; Serova, O.V.; Gordeeva, E.A.; Zhigis, L.S.; Zueva, V.S.; Razgulyaeva, O.A.; Melikhova, T.D.; Nokel, E.A.; Drozhzhina, E.Y.; Rumsh, L.D.
Serological analysis of immunogenic properties of recombinant meningococcus IgA1 protease-based proteins
Bull. Exp. Biol. Med.
161
391-394
2016
Neisseria meningitidis serogroup B, Neisseria meningitidis serogroup B B44/76
Gallo, M.C.; Kirkham, C.; Eng, S.; Bebawee, R.S.; Kong, Y.; Pettigrew, M.M.; Tettelin, H.; Murphy, T.F.
Changes in IgA protease expression are conferred by changes in genomes during persistent infection by nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease
Infect. Immun.
86
e00313-18
2018
Haemophilus influenzae NTHI
Lechner, S.M.; Abbad, L.; Boedec, E.; Papista, C.; Le Stang, M.B.; Moal, C.; Maillard, J.; Jamin, A.; Bex-Coudrat, J.; Wang, Y.; Li, A.; Martini, P.G.; Monteiro, R.C.; Berthelot, L.
IgA1 protease treatment reverses mesangial deposits and hematuria in a model of IgA nephropathy
J. Am. Soc. Nephrol.
27
2622-2629
2016
Haemophilus influenzae
Kotelnikova, O.; Alliluev, A.; Zinchenko, A.; Zhigis, L.; Prokopenko, Y.; Nokel, E.; Razgulyaeva, O.; Zueva, V.; Tokarskaya, M.; Yastrebova, N.; Gordeeva, E.; Melikhova, T.; Kaliberda, E.; Rumsh, L.
Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections
Microbes Infect.
21
336-340
2019
Neisseria meningitidis serogroup B, Neisseria meningitidis serogroup B B44/76
Wang, H.; Zhong, X.; Li, J.; Zhu, M.; Wang, L.; Ji, X.; Fan, J.; Wang, L.
Cloning and expression of H. influenzae 49247 IgA protease in E. coli
Mol. Biotechnol.
60
134-140
2018
Haemophilus influenzae, Haemophilus influenzae ATCC 49247
Besbes, A.; Le Goff, S.; Antunes, A.; Terrade, A.; Hong, E.; Giorgini, D.; Taha, M.K.; Deghmane, A.E.
Hyperinvasive meningococci induce intra-nuclear cleavage of the NF-kappaB protein p65/RelA by meningococcal IgA protease
PLoS Pathog.
11
e1005078
2015
Neisseria meningitidis serogroup C
Wang, L.; Li, X.; Shen, H.; Mao, N.; Wang, H.; Cui, L.; Cheng, Y.; Fan, J.
Bacterial IgA protease-mediated degradation of agIgA1 and agIgA1 immune complexes as a potential therapy for IgA nephropathy
Sci. Rep.
6
30964
2016
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria gonorrhoeae ATCC 49226, Haemophilus influenzae ATCC 10211, Haemophilus influenzae ATCC 49247, Neisseria meningitidis ATCC 13090
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