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Information on EC 3.4.21.62 - Subtilisin
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3.4.21.62 SubtilisinSpecify your search results
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- 3.4.21.62
- hydrolysates
- chymotrypsin
- prion
- elastase
- papain
- sds
- aeruginosa
- prpsc
- proteinases
- casein
- staphylococcus
- proprotein
- pronase
-
convertase
- alpha-chymotrypsin
- scrapie
- dnase
-
ultrafiltration
-
proteinaceous
-
spongiform
- thermolysin
- pmsf
-
bacteriocins
- licheniformis
- propeptide
-
paraffin-embedded
- gelatin
-
protease-resistant
-
formalin-fixed
- pcsk9
- alpha-amylase
-
cytotoxin
-
boil
- creutzfeldt-jakob
-
phenylmethylsulfonyl
- amyloliquefaciens
- pumilus
- bromelain
-
alkaliphilic
-
shiga
-
i-converting
-
transesterification
- furin
- album
-
defatted
- prodomain
- pancreatin
- p-nitroanilide
-
kazal
- detergent
- industry
- biotechnology
- food industry
- medicine
- synthesis
- degradation
- analysis
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyses peptide amides
Synonyms
proteinase k, subtilisin, alkaline protease, alcalase, subtilisin carlsberg, subtilase, subtilisin-like protease, savinase, alkaline serine protease, subtilisin a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Alcalase
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-
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Alcalase 0.6L
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-
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Alcalase 2.5L
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-
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ALK-enzyme
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-
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Alkaline mesentericopeptidase
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-
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Alkaline protease
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Bacillopeptidase A
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-
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Bacillopeptidase B
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-
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Bacillus subtilis alkaline proteinase Bioprase
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-
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Bioprase AL 15
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Bioprase APL 30
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Colistinase
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-
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Esperase
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-
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Genenase I
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-
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Kazusase
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-
-
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Maxatase
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-
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Nagarse
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-
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Opticlean
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-
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Orientase 10B
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Peptidase, subtilo-, A
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-
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Protease S
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Protease VIII
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-
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Protease XXVII
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-
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Proteinase, Bacillus subtilis alkaline
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-
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Protin A 3L
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-
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Savinase
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Savinase 16.0L
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Savinase 32.0 L EX
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Savinase 4.0T
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Savinase 8.0L
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SP 266
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Subtilisin E
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Subtilisin GX
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Subtilisin Novo
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Subtilisin S41
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Subtilisin Sendai
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Subtilopeptidase
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Superase
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Thermoase
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Thermoase PC 10
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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-
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ester bond hydrolysis
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-
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transpeptidation
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transesterification
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-
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-
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CAS REGISTRY NUMBER
COMMENTARY
9014-01-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
N-methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide + H2O
N-methoxysuccinyl-Ala-Ala-Pro-Val + p-nitroaniline
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-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abetalipoproteinemia
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Acute Coronary Syndrome
Comparative effects of high-dose atorvastatin versus rosuvastatin on lipid parameters, oxidized low-density lipoprotein, and proprotein convertase subtilisin kexin 9 in acute coronary syndrome.
Adenocarcinoma
A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas.
Adenocarcinoma
Actin-resistant DNAse I Expression From Oncolytic Adenovirus Enadenotucirev Enhances Its Intratumoral Spread and Reduces Tumor Growth.
Adenocarcinoma
Effect of non-tumor cell contamination on detection of p53 gene mutations in human gastric cancer cells by polymerase chain reaction single-strand conformation polymorphism analysis.
Adenocarcinoma
Protein Hydrolysates from Fenugreek (Trigonella foenum graecum) as Nutraceutical Molecules in Colon Cancer Treatment.
Adenocarcinoma
Serine protease modulation of Dependence Receptors and EMT protein expression.
Adenoma
Proteinase K Combining Two-Step Liquid-Liquid Extraction for Plasma Untargeted Liquid Chromatography-Mass Spectrometry-Based Metabolomics To Discover the Potential Mechanism of Colorectal Adenoma.
Alzheimer Disease
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Amyotrophic Lateral Sclerosis
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Anaphylaxis
Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary reactions.
Anaphylaxis
Scanning electron microscopic studies of the nasal mucosa in normal rabbit and rabbit exposed to alcalase.
Anaphylaxis
The release of four mediators of immediate hypersensitivity from human leukemic basophils.
Anthrax
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Arenaviridae Infections
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.
Arthritis, Experimental
Selective Abrogation of BiP/GRP78 Blunts Activation of NF-{kappa}B through the ATF6 Branch of the UPR: Involvement of C/EBP{beta} and mTOR-Dependent Dephosphorylation of Akt.
Arthritis, Rheumatoid
[The expression and clinical significance of proprotein convertase subtilisin kexin 9 in rheumatoid arthritis].
Aspergillosis
Inhibition of Aspergillus serine proteinase by Streptomyces subtilisin inhibitor and high-level expression of this inhibitor in Pichia pastoris.
Asthma
Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.
Asthma
Aspergillus fumigatus Protease Alkaline Protease 1 (Alp1): A New Therapeutic Target for Fungal Asthma.
Asthma
Aspergillus fumigatus-Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma.
Asthma, Occupational
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Asthma, Occupational
Occupational Asthma in Female Factory Worker Resulting from Exposure to Savinase in Dishwashing Tablets-A Case Study.
Bacterial Infections
Real Time Monitoring of Layer-by-Layer Polyelectrolyte Deposition and Bacterial Enzyme Detection in Nanoporous Anodized Aluminum Oxide.
Bacterial Infections
Shrimp single WAP domain (SWD)-containing protein exhibits proteinase inhibitory and antimicrobial activities.
Bacterial Infections
The adjacent flanking region plays a critical role in facilitating the presentation of the Listeria monocytogenes product lemA to H2 M3wt-restricted, peptide-specific murine CD8 cells.
Blister
A quantitative method to detect human exposure to sulfur and nitrogen mustards via protein adducts.
Brain Diseases
A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies.
Brain Diseases
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Brain Diseases
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Brain Diseases
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Brain Diseases
Detergents modify proteinase K resistance of PrP(Sc) in different transmissible spongiform encephalopathies (TSEs).
Brain Diseases
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Brain Diseases
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
Brain Diseases
Identification and characterization of proteinase K-resistant proteins in members of the class Mollicutes.
Brain Diseases
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy.
Brain Diseases
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.
Brain Diseases
Localization of disease-related PrP in Danish patients with different subtypes of prion disease.
Brain Diseases
Measurement of altered aspartyl residues in the scrapie associated form of prion protein.
Brain Diseases
Molecular profiling and comparison of field transmissible spongiform encephalopathy cases diagnosed in Catalunya.
Brain Diseases
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site.
Brain Diseases
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Brain Diseases
Transmissible spongiform encephalopathy strain-associated diversity of N-terminal proteinase K cleavage sites of PrP(Sc) from scrapie-infected and bovine spongiform encephalopathy-infected mice.
Brain Neoplasms
Temperature dependence of radiation-induced DNA-protein crosslinks formed under hypoxic conditions.
Breast Neoplasms
Proteinase K added to the extraction procedure markedly increases RNA yield from primary breast tumors for use in microarray studies.
Carcinoma
Improved method for release of cell nuclei from paraffin-embedded cell material of squamous cell carcinomas.
Carcinoma
Sensitivity of in situ detection with biotinylated probes of human papilloma virus type 16 DNA in frozen tissue sections of squamous cell carcinomas of the cervix.
Carcinoma
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Carcinoma, Ehrlich Tumor
Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.
Carcinoma, Hepatocellular
Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.
Carcinoma, Hepatocellular
Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro.
Carcinoma, Hepatocellular
Isolation of mitochondria from ascites tumor cells permeabilized with digitonin.
Carcinoma, Squamous Cell
Improved method for release of cell nuclei from paraffin-embedded cell material of squamous cell carcinomas.
Carcinoma, Squamous Cell
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Carcinosarcoma
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
Cardiovascular Diseases
Post-transcriptional Regulation of PCSK9 by miR-191, miR-222, and miR-224.
Cardiovascular Diseases
Quantitative pharmacokinetic evaluation of Subtilisin QK-2 after a bolus IV injection in a rat model using a novel sandwich enzyme-linked immunosorbent assay.
Charcot-Marie-Tooth Disease
Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases.
Cholera
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Chondrosarcoma
Adaptation of FACE methodology for microanalysis of total hyaluronan and chondroitin sulfate composition from cartilage.
Clostridium Infections
The protease CspB is essential for initiation of cortex hydrolysis and dipicolinic acid (DPA) release during germination of spores of Clostridium perfringens type A food poisoning isolates.
Coinfection
Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.
Colonic Neoplasms
A sulfated polysaccharide of Ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis.
Colonic Neoplasms
[Extraction of RNA from paraffin embedded tissues and analysis of p53 gene expression in colonic cancer]
Colorectal Neoplasms
Dependence receptor involvement in subtilisin-induced long-term depression and in long-term potentiation.
Colorectal Neoplasms
Serine protease modulation of Dependence Receptors and EMT protein expression.
Communicable Diseases
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Confusion
Is the presence of abnormal prion protein in the renal glomeruli of feline species presenting with FSE authentic?
Conjunctivitis
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Corneal Injuries
Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model.
Coronary Artery Disease
The relationship between protein convertase subtilisin kexin type-9 levels and extent of coronary artery disease in patients with non-ST-elevation myocardial infarction.
Coronary Disease
Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.
Coronary Disease
Protective lipid-lowering variants in healthy older individuals without coronary heart disease.
Coronary Disease
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
Corticobasal Degeneration
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
COVID-19
Comparison Between a Standard and SalivaDirect RNA Extraction Protocol for Molecular Diagnosis of SARS-CoV-2 Using Nasopharyngeal Swab and Saliva Clinical Samples.
COVID-19
Direct Clinical Evidence Recommending the Use of Proteinase K or Dithiothreitol to Pretreat Sputum for Detection of SARS-CoV-2.
Creutzfeldt-Jakob Syndrome
A chicken monoclonal antibody with specificity for the N-terminal of human prion protein.
Creutzfeldt-Jakob Syndrome
A comparative study of abnormal prion protein isoforms between Gerstmann-Sträussler-Scheinker syndrome and Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Creutzfeldt-Jakob Syndrome
Beyond PrP res type 1/type 2 dichotomy in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Biochemical and conformational variability of human prion strains in sporadic Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Creutzfeldt-Jakob Syndrome
Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy.
Creutzfeldt-Jakob Syndrome
Oligomeric forms of peptide fragment PrP(214-226) in solution are preferentially recognized by PrP(Sc)-specific antibody.
Creutzfeldt-Jakob Syndrome
Prion protein oligomers in Creutzfeldt-Jakob disease detected by gel-filtration centrifuge columns.
Creutzfeldt-Jakob Syndrome
THE RELATIVE ABUNDANCE OF APOE AND A?1-42 ASSOCIATED WITH ABNORMAL PRION PROTEIN DIFFERS BETWEEN CREUTZFELDT-JAKOB DISEASE SUBTYPES.
Creutzfeldt-Jakob Syndrome
Two-dimensional mapping of three phenotype-associated isoforms of the prion protein in sporadic Creutzfeldt-Jakob disease.
Cystic Fibrosis
Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa.
Cystic Fibrosis
Gallium induces the production of virulence factors in Pseudomonas aeruginosa.
Cystic Fibrosis
Immunoenzymometric assays for alkaline protease and exotoxin A from Pseudomonas aeruginosa: development and use in detecting exoproteins in clinical isolates from patients with cystic fibrosis.
Cystic Fibrosis
Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis.
Cystic Fibrosis
Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa.
Cystic Fibrosis
Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis.
Cystic Fibrosis
Quantitation and enzymatic activity of the alkaline protease from Pseudomonas aeruginosa in culture supernatants from clinical strains.
Cystic Fibrosis
Relation between antibody response to Pseudomonas aeruginosa exoproteins and colonization/infection in patients with cystic fibrosis.
Cystic Fibrosis
[Alginate, elastase and alkaline protease production of Pseudomonas aeruginosa strains isolated from various body sites]
Cystic Fibrosis
[Production of elastase, exotoxin A and alkaline protease during bronchopulmonary exacerbations in patients with mucoviscidosis chronically infected by Pseudomonas aeruginosa]
Cysts
Analysis of Giardia lamblia Interactions with Polymer Surfaces Using a Microarray Approach.
Cysts
First Report of Soybean Cyst Nematode (Heterodera glycines) on Tobacco in Henan, Central China.
Cysts
Resistance of Acanthamoeba to classic DNA extraction methods used for the diagnosis of corneal infections.
Cysts
Sensitivity of Vermamoeba (Hartmannella) vermiformis cysts to conventional disinfectants and protease.
Deglutition Disorders
A novel soft surimi gel with functionality prepared using alcalase for people suffering from dysphagia.
Dehydration
Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents?
Dehydration
High salt- and SDS-stable DNA binding protein complexes with ATPase and protein kinase activity retained in chromatin-depleted nuclei.
Dementia
Rapidly progressive dementia with thalamic degeneration and peculiar cortical prion protein immunoreactivity, but absence of proteinase K resistant PrP: a new disease entity?
Demyelinating Diseases
Viral-based rodent and nonhuman primate models of multiple system atrophy: Fidelity to the human disease.
Dengue
Cellular proteins bind to the 3' and 5' untranslated regions of dengue 2 virus genome.
Dermatitis, Atopic
Mutations in the SASPase Gene (ASPRV1) Are Not Associated with Atopic Eczema or Clinically Dry Skin.
Diabetes Mellitus
Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.
Dyslipidemias
Expression of LDLRs (Low-Density Lipoprotein Receptors), Dyslipidemia Severity, and Response to PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Homozygous Familial Hypercholesterolemia: Connecting the Dots.
Dyslipidemias
New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people?
Dyslipidemias
Proprotein convertase subtilisin / kexin 9 (PCSK9) inhibitors and the future of dyslipidemia therapy: an updated patent review (2011-2015).
Dyslipidemias
[PCSK9 inhibitors in hypercholesterolemia : New hope for patients with diabetes mellitus?]
Encephalopathy, Bovine Spongiform
A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies.
Encephalopathy, Bovine Spongiform
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Encephalopathy, Bovine Spongiform
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Encephalopathy, Bovine Spongiform
Four independent molecular prion protein parameters for discriminating new cases of C, L, and h bovine spongiform encephalopathy in cattle.
Encephalopathy, Bovine Spongiform
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Endemic Diseases
Systemic effects of Subtilase cytotoxin produced by Escherichia coli O113:H21.
Eosinophilia
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Epidermal Cyst
Molecular evidence supporting the neoplastic nature of some epidermoid cysts of the testis.
Eye Burns
[Necrolytic properties of alkaline protease in the treatment of severe eye burns]
Fibrosarcoma
Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro.
Foodborne Diseases
The protease CspB is essential for initiation of cortex hydrolysis and dipicolinic acid (DPA) release during germination of spores of Clostridium perfringens type A food poisoning isolates.
Frontotemporal Dementia
Enhancement of native and phosphorylated TDP-43 immunoreactivity by proteinase K treatment following autoclave heating.
Gastrointestinal Diseases
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.
Genetic Diseases, Inborn
[Homozygous hypercholesterolemia - new therapeutic options in cases with complete lack of LDL- receptor].
Glomerulonephritis
Nutritionally induced necrotizing glomerulonephritis and polyarteritis nodosa in pigs.
Hemolytic-Uremic Syndrome
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli.
Hemolytic-Uremic Syndrome
Combined Action of Shiga Toxin Type 2 and Subtilase Cytotoxin in the Pathogenesis of Hemolytic Uremic Syndrome.
Hemolytic-Uremic Syndrome
Escherichia coli subtilase cytotoxin induces apoptosis regulated by host Bcl-2 family proteins Bax/Bak.
Hemorrhagic Fever, Crimean
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.
Hepatitis
HIV and Hepatitis C-Coinfected Patients Have Lower Low-Density Lipoprotein Cholesterol Despite Higher Proprotein Convertase Subtilisin Kexin 9 (PCSK9): An Apparent "PCSK9-Lipid Paradox".
Hepatitis
The spectrum of complement-fixing antinuclear antibodies in patients with hepatocellular carcinoma.
Hepatitis C
Detection of hepatitis "C" virus in formalin-fixed liver tissue by nested polymerase chain reaction.
Hepatitis C
Hepatitis C: description of a highly sensitive method for clinical detection of viral RNA.
Hepatitis C
Localization of hepatitis C virus RNA in human liver biopsies by in situ hybridization using thymine-thymine dimerized oligo DNA probes: improved method.
Hepatitis C
Measuring Hepatitis C Virus Envelopment by Using a Proteinase K Protection Assay.
Herpes Zoster
Evidence for a role of the major glycoprotein in the structural maintenance of the pig zona pellucida.
Homozygous Familial Hypercholesterolemia
Expression of LDLRs (Low-Density Lipoprotein Receptors), Dyslipidemia Severity, and Response to PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Homozygous Familial Hypercholesterolemia: Connecting the Dots.
Hypercholesterolemia
Dyslipidemia in rat fed with high-fat diet is not associated with PCSK9-LDL-receptor pathway but ageing.
Hypercholesterolemia
Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.
Hypercholesterolemia
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
Hypercholesterolemia
Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia.
Hypercholesterolemia
Endothelial function improvement in patients with familial hypercholesterolemia receiving PCSK-9 inhibitors on top of maximally tolerated lipid lowering therapy.
Hypercholesterolemia
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.
Hypercholesterolemia
OSLER and ODYSSEY LONG TERM: PCSK9 inhibitors on the right track of reducing cardiovascular events.
Hypercholesterolemia
Proprotein Convertase Subtilisin Kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies.
Hypercholesterolemia
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: Effect on stroke risk.
Hypercholesterolemia
Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia.
Hypercholesterolemia
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
Hypercholesterolemia
The therapeutic potential of PCSK9 inhibition in primary dyslipidemia, the example from SAR236553/REGN727 McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase Subtilisin/Kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012. [Epub ahead of print].
Hypercholesterolemia
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.
Hypercholesterolemia
[Homozygous hypercholesterolemia - new therapeutic options in cases with complete lack of LDL- receptor].
Hyperglycemia
Polysaccharides of a fermented food, natto, suppress sucrose-induced hyperglycemia in an in vivo evaluation system and inhibit glucose uptake by human intestinal cells.
Hyperlipidemias
Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice.
Hyperlipidemias
Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential.
Hyperlipoproteinemia Type II
Consensus statement of professional associations on prescribing of PCSK9-inhibitors.
Hyperlipoproteinemia Type II
Correction to: Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Hyperlipoproteinemia Type II
Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.
Hyperlipoproteinemia Type II
Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia.
Hyperlipoproteinemia Type II
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.
Hyperlipoproteinemia Type II
Novel PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Variants in Patients With Familial Hypercholesterolemia From Cape Town.
Hyperlipoproteinemia Type II
Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia.
Hyperlipoproteinemia Type II
Strategies for proprotein convertase subtilisin kexin 9 modulation: a perspective on recent patents.
Hyperlipoproteinemia Type II
Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.
Hypersensitivity
Antigenic and allergenic characterization of the enzymes alcalase and savinase by crossed immunoelectrophoresis and crossed radioimmunoelectrophoresis.
Hypersensitivity
Distinct human T cell repertoires mediate immediate and delayed-type hypersensitivity to the Trichophyton antigen, Tri r 2.
Hypersensitivity
Experimental sensitization to subtilisin. I. Production of immediate- and late-onset pulmonary reactions.
Hypersensitivity
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN'-induced hypersensitivity.
Hypersensitivity
Phosphorylation and Enzymatic Hydrolysis with Alcalase and Papain Effectively Reduce Allergic Reactions to Gliadins in Normal Mice.
Hypersensitivity
Scanning electron microscopic studies of the nasal mucosa in normal rabbit and rabbit exposed to alcalase.
Hypersensitivity, Delayed
An alkaline protease in the delayed hypersensitivity skin lesions in the guinea-pigs.
Hypertension
ACE inhibitory activity of pangasius catfish (Pangasius sutchi) skin and bone gelatin hydrolysate.
Hypertension
Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates.
Hypertension
In vitro Angiotesin-1-converting enzyme, ?-amylase and ?-glucosidase inhibitory and antioxidant activities of Luffa cylindrical (L.) M. Roem seed protein hydrolysate.
Hypertension
Purification and characterisation of a novel angiotensin-I converting enzyme (ACE)-inhibitory peptide derived from the enzymatic hydrolysate of Enteromorpha clathrata protein.
Hypobetalipoproteinemias
Hypobetalipoproteinemia and abetalipoproteinemia: liver disease and cardiovascular disease.
Infections
A genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays.
Infections
A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease.
Infections
A neutral protease from Bacillus nematocida, another potential virulence factor in the infection against nematodes.
Infections
A smooth-type, phage-resistant Klebsiella pneumoniae mutant strain reveals OmpC is indispensable for GH-K3 infection.
Infections
Aaprb1, a subtilsin-like protease, required for autophagy and virulence of the tangerine pathotype of Alternaria alternata.
Infections
Alkaline protease-deficient mutants of Pseudomonas aeruginosa are virulent in the eye.
Infections
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6.
Infections
Application of in situ hybridization to tissue sections for identification of molds causing invasive fungal infection.
Infections
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Infections
Characterization of subtilase protease in Cryptosporidium parvum and C. hominis.
Infections
Cloning of and genetic variation in protease VCP1 from the nematophagous fungus Pochonia chlamydosporia.
Infections
Cloning, expression and deletion of the cuticle-degrading protease BLG4 from nematophagous bacterium Brevibacillus laterosporus G4.
Infections
Comparative proteomic analysis of the sweetpotato provides insights into response mechanisms to Fusarium oxysporum f. sp. batatas.
Infections
Conditioned Medium from Enterohemorrhagic Escherichia coli-Infected T84 Cells Inhibits Signal Transducer and Activator of Transcription 1 Activation by Gamma Interferon.
Infections
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.
Infections
Development of a high-efficiency gene knockout system for Pochonia chlamydosporia.
Infections
Differential gene expression in the pathogenic dermatophyte Arthroderma benhamiae in vitro versus during infection.
Infections
Diverse effects of Galleria mellonella infection with entomopathogenic and clinical strains of Pseudomonas aeruginosa.
Infections
Effect of hydrophobic mutations in the H2-H3 subdomain of prion protein on stability and conversion in vitro and in vivo.
Infections
Entry of mouse hepatitis virus into cells by endosomal and nonendosomal pathways.
Infections
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Infections
Expression of Exogenous Human Hepatic Nuclear Factor-1? by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2.
Infections
Expression of pathogenesis-related genes in Metarhizium anisopliae when infecting Spodoptera exigua
Infections
Failure to induce formation of proteinase K resistant fibrils in pigeons through experimental infection with paramyxovirus type 1.
Infections
Functional identification of the gene bace16 from nematophagous bacterium Bacillus nematocida.
Infections
Fusion of Semliki Forest virus infected Aedes albopictus cells at low pH is a fusion from within.
Infections
Identification of a Highly Antigenic Region of Subtilisin-Like Serine Protease 1 for Serodiagnosis of Neospora caninum Infection.
Infections
In situ cleavage of the baculovirus occlusion derived virus receptor binding protein P74 in the peroral infectivity complex.
Infections
In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection.
Infections
In vivo characterization of host and bacterial protease expression during Pseudomonas aeruginosa corneal infections in naive and immunized mice.
Infections
Influence of Leishmania infection on blood-meal digestion in the sandflies Phlebotomus papatasi and P. langeroni.
Infections
Isolation and characterization of alkaline protease-deficient mutants of Pseudomonas aeruginosa in vitro and in a mouse eye model.
Infections
Lipopolysaccharide from nonvirulent Ara+ Burkholderia pseudomallei isolates is immunologically indistinguishable from lipopolysaccharide from virulent Ara- clinical isolates.
Infections
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Infections
Optimization of DNA Extraction from Field-Collected Mammalian Whole Blood on Filter Paper for Trypanosoma cruzi (Chagas Disease) Detection.
Infections
Plasmodium berghei PIMMS2 promotes ookinete invasion of the Anopheles gambiae mosquito midgut.
Infections
Plasmodium falciparum subtilisin-like ookinete protein SOPT plays an important and conserved role during ookinete infection of the Anopheles stephensi midgut.
Infections
Recent Findings in Onychomycosis and Their Application for Appropriate Treatment.
Infections
Role of CpSUB1, a subtilisin-like protease, in Cryptosporidium parvum infection in vitro.
Infections
Role of elastase as a virulence factor in experimental Pseudomonas aeruginosa infection in mice.
Infections
Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein.
Infections
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
Infections
Strain-dependent differences in beta-sheet conformations of abnormal prion protein.
Infections
Subtilisin-like proteases in plant-pathogen recognition and immune priming: a perspective.
Infections
Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition.
Infections
Testing plasma subtilisin inhibitory activity as a selective marker for dermo resistance in eastern oysters.
Infections
The Pochonia chlamydosporia serine protease gene vcp1 is subject to regulation by carbon, nitrogen and pH: implications for nematode biocontrol.
Infections
Toll-Like Receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus.
Infections
Transcriptome of an entomophthoralean fungus (Pandora formicae) shows molecular machinery adjusted for successful host exploitation and transmission.
Infections
[Significance of Pseudomonas aeruginosa virulence factors for acute and chronic Pseudomonas aeruginosa infections]
Infections
[Significance of Pseudomonas aeruginosa virulence factors in acute and chronic Pseudomonas aeruginosa infections]
Influenza, Human
Comparative Evaluation of Three Preprocessing Methods for Extraction and Detection of Influenza A Virus Nucleic Acids from Sputum.
Influenza, Human
Expression of influenza B virus hemagglutinin containing multibasic residue cleavage sites.
Influenza, Human
Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools.
Influenza, Human
Linker and/or transmembrane regions of influenza A/Group-1, A/Group-2, and type B virus hemagglutinins are packed differently within trimers.
Insomnia, Fatal Familial
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Insomnia, Fatal Familial
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Invasive Pulmonary Aspergillosis
The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis.
Invasive Pulmonary Aspergillosis
Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis.
Ischemic Stroke
PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Hyperglycemic Mice Increases the Risk of Hemorrhagic Transformation of Ischemic Stroke.
Keratitis
Corneal virulence of Pseudomonas aeruginosa elastase B and alkaline protease produced by Pseudomonas putida.
Keratitis
Degradation of uniquely glycosylated secretory immunoglobulin a in tears from patients with Pseudomonas aeruginosa keratitis.
Keratitis
Detection of virulence factors in Serratia strains isolated from contact lens-associated corneal ulcers.
Keratitis
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Keratitis
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Keratitis
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Kuru
Wernicke encephalopathy-like symptoms as an early manifestation of Creutzfeldt-Jakob disease in a chronic alcoholic.
Leukemia-Lymphoma, Adult T-Cell
Development of ultra-super sensitive immunohistochemistry and its application to the etiological study of adult T-cell leukemia/lymphoma.
Lewy Body Disease
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Liver Cirrhosis
Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis.
Lung Diseases
Equinins in equine neutrophils: quantification in tracheobronchial secretions as an aid in the diagnosis of chronic pulmonary disease.
Lupus Erythematosus, Systemic
Proprotein convertase subtilisin kexin 9 is associated with disease activity and is implicated in immune activation in systemic lupus erythematosus.
Lymphocytic Choriomeningitis
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P.
Lymphoma
Binding of BiP to the processing enzyme lymphoma proprotein convertase prevents aggregation, but slows down maturation.
Lymphoma
[Effect of microwave pretreatment on the detection of Epstein-Barr virus EBER RNA's using in situ hybridization]
Malaria
A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1.
Malaria
A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase.
Malaria
Expression of Exogenous Human Hepatic Nuclear Factor-1? by a Lentiviral Vector and Its Interactions with Plasmodium falciparum Subtilisin-Like Protease 2.
Malaria
Maturation and specificity of Plasmodium falciparum subtilisin-like protease-1, a malaria merozoite subtilisin-like serine protease.
Malaria
Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum.
Malaria
The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.
Mastitis
Identification of pathogens in mastitis milk samples with fluorescent in situ hybridization.
Melanoma
Invasion of melanoma cells by Mycoplasma hyorhinis: enhancement by protease treatment.
Melanoma
Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein.
Memory Disorders
Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase.
Metabolic Syndrome
Pilot-scale produced fermented lentil protects against t-BHP-triggered oxidative stress by activation of Nrf2 dependent on SAPK/JNK phosphorylation.
Metrorrhagia
Detection of Plasmodium falciparum using a cloned DNA probe: a simple procedure suitable for field application.
Metrorrhagia
Radioactive and enzymatic cloned cDNA probes for bovine enteric coronavirus detection by molecular hybridization.
Multiple System Atrophy
Biochemical characterization of the core structure of alpha-synuclein filaments.
Muscular Atrophy
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Muscular Dystrophies
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Neoplasms
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Neoplasms
Carcinosarcoma of the breast: molecular-biological study for analysis of histogenesis.
Neoplasms
Clinicopathological Characterization of TSH-Producing Adenomas: Special Reference to TSH-immunoreactive but Clinically Non-functioning Adenomas.
Neoplasms
Dense distribution of nuclear alkaline protease to nucleoli with increase in rapidly growing cells in rats.
Neoplasms
Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells.
Neoplasms
Effect of Different Proteinase K Digest Protocols and Deparaffinization Methods on Yield and Integrity of DNA Extracted From Formalin-fixed, Paraffin-embedded Tissue.
Neoplasms
Evaluation of a novel subtilisin inhibitor gene and mutant derivatives for the expression and secretion of mouse tumor necrosis factor alpha by Streptomyces lividans.
Neoplasms
Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells.
Neoplasms
GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy.
Neoplasms
Immunomodulatory properties of the milk whey products obtained by enzymatic and microbial hydrolysis
Neoplasms
Improved DNA content histograms from formalin-fixed, paraffin-embedded liver tissue by proteinase K digestion.
Neoplasms
Inhibition of tumor necrosis factor-alpha-induced RANTES secretion by alkaline protease in A549 cells.
Neoplasms
Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor ?B pathway.
Neoplasms
Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro.
Neoplasms
Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of beta catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy.
Neoplasms
Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications.
Neoplasms
Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis.
Neoplasms
Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population.
Neoplasms
Primary tumor tissue lysates are enriched in heat shock proteins and induce the maturation of human dendritic cells.
Neoplasms
pspA overexpression in Streptomyces lividans improves both Sec- and Tat-dependent protein secretion.
Neoplasms
Radiation-induced DNA damage in tumors and normal tissues. I. Feasibility of estimating the hypoxic fraction.
Neoplasms
Radiation-induced DNA damage in tumors and normal tissues: IV. Influence of proliferation status and cell type on the formation of oxygen-dependent DNA damage in cultured cells.
Neoplasms
Secretagogue activities in cod (Gadus morhua) and shrimp (Penaeus aztecus) extracts and alcalase hydrolysates determined in AR4-2J pancreatic tumour cells.
Neoplasms
Squid gelatin hydrolysates with antihypertensive, anticancer and antioxidant activity
Neoplasms
Thymidylate synthase polymorphism in Mexican patients with colon cancer treated with 5-fluorouracil.
Neoplasms
Tumor-induced sensitivity to apoptosis in T cells from patients with renal cell carcinoma: role of nuclear factor-kappaB suppression.
Neoplasms
[Apoptosis of HL-60 cells induced by crystal proteins from Bacillus thuringiensis Bt9875]
Nephrotic Syndrome
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
Neuritis, Autoimmune, Experimental
Proteinase induced demyelination. An electrophysiological and histological study.
Neuroblastoma
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Neuroblastoma
Assessing proteinase K resistance of fish prion proteins in a scrapie-infected mouse neuroblastoma cell line.
Neuroblastoma
Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis.
Neuroblastoma
Quantitation and characterisation of poly(A)-containing messenger RNAs from mouse neuroblastoma cells.
Neurodegenerative Diseases
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Neurodegenerative Diseases
Detection of proteinase K resistant proteins in the urine of patients with Creutzfeldt-Jakob and other neurodegenerative diseases.
Neuromuscular Diseases
Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.
Non-alcoholic Fatty Liver Disease
Interrogation of selected genes influencing serum LDL-Cholesterol levels in patients with well characterized NAFLD.
Non-alcoholic Fatty Liver Disease
The Role of PCSK9 in the Pathogenesis of Non-alcoholic Fatty Liver Disease and the Effect of PCSK9 Inhibitors.
Non-ST Elevated Myocardial Infarction
The relationship between protein convertase subtilisin kexin type-9 levels and extent of coronary artery disease in patients with non-ST-elevation myocardial infarction.
Onychomycosis
Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2).
Onychomycosis
Determination of terbinafine in nail samples during systemic treatment for onychomycoses.
Osteosarcoma
Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na+-Taurocholate Cotransporting Polypeptide.
Paralysis
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Parkinson Disease
Distinct ?-synuclein strains differentially promote tau inclusions in neurons.
Parkinsonian Disorders
The aggregation state of ?-synuclein deposits in dermal nerve fibers of patients with Parkinson's disease resembles that in the brain.
Periodontal Pocket
Inhibitory effect of serum globulins on the adhesion of Prevotella nigrescens to hydroxyapatite.
Photosensitivity Disorders
Hematoporphyrin photosensitization of serum albumin and subtilisin BPN'.
Pick Disease of the Brain
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Pneumonia
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Pneumonia
[Changes of the activity of blood serum alkaline protease in young children with acute pneumonia]
Polycystic Kidney Diseases
Molecular analysis of the gene encoding a novel chitin-binding protease from Alteromonas sp. strain O-7 and its role in the chitinolytic system.
Polyneuropathies
Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases.
Prion Diseases
A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine. Contamination with bacterial outer membrane proteins.
Prion Diseases
Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions.
Prion Diseases
Cellular phenotyping of secretory and nuclear prion proteins associated with inherited prion diseases.
Prion Diseases
Cerebrospinal Fluid and Plasma Small Extracellular Vesicles and miRNAs as Biomarkers for Prion Diseases.
Prion Diseases
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Prion Diseases
Detergents modify proteinase K resistance of PrP(Sc) in different transmissible spongiform encephalopathies (TSEs).
Prion Diseases
Development of oligomeric prion-protein aggregates in a mouse model of prion disease.
Prion Diseases
Endogenous proteolytic cleavage of normal and disease-associated isoforms of the human prion protein in neural and non-neural tissues.
Prion Diseases
Further Characterization of Glycoform-Selective Prions of Variably Protease-Sensitive Prionopathy.
Prion Diseases
Genetic influence on the structural variations of the abnormal prion protein.
Prion Diseases
Genetic prion disease: no role for the immune system in disease pathogenesis?
Prion Diseases
Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA.
Prion Diseases
Identification and characterization of proteinase K-resistant proteins in members of the class Mollicutes.
Prion Diseases
Identification and Structural Characterization of the Precursor Conformation of the Prion Protein which Directly Initiates Misfolding and Oligomerization.
Prion Diseases
Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.
Prion Diseases
Increased expression of the normal cellular isoform of prion protein in inclusion-body myositis, inflammatory myopathies and denervation atrophy.
Prion Diseases
Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains.
Prion Diseases
Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid.
Prion Diseases
Localization of disease-related PrP in Danish patients with different subtypes of prion disease.
Prion Diseases
Measurement of altered aspartyl residues in the scrapie associated form of prion protein.
Prion Diseases
Molecular profiling and comparison of field transmissible spongiform encephalopathy cases diagnosed in Catalunya.
Prion Diseases
Overexpression of nonconvertible PrPc delta114-121 in scrapie-infected mouse neuroblastoma cells leads to trans-dominant inhibition of wild-type PrP(Sc) accumulation.
Prion Diseases
Pressure-assisted dissociation and degradation of "proteinase K-resistant" fibrils prepared by seeding with scrapie-infected hamster prion protein.
Prion Diseases
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
Prion Diseases
Proteinase K enhanced immunoreactivity of the prion protein-specific monoclonal antibody 2A11.
Prion Diseases
Proteomic analysis of prion diseases: creating clarity or causing confusion?
Prion Diseases
PrPSc level and incubation time in a transgenic mouse model expressing Borna disease virus phosphoprotein after intracerebral prion infection.
Prion Diseases
Transmissible spongiform encephalopathy strain-associated diversity of N-terminal proteinase K cleavage sites of PrP(Sc) from scrapie-infected and bovine spongiform encephalopathy-infected mice.
Prion Diseases
Use of a new immunoassay to measure PrP Sc levels in scrapie-infected sheep brains reveals PrP genotype-specific differences.
Prostatic Neoplasms
Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells.
Proteinuria
Mass spectrometry-based proteomic exploration of the small urinary extracellular vesicles in ANCA-associated vasculitis in comparison with total urine.
Pseudomonas Infections
Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa.
Pulmonary Aspergillosis
Polymerase chain reaction amplification of Asp f I and alkaline protease genes from fungus balls: clinical application in pulmonary aspergillosis.
Rabies
A simple method for detection of rabies viral sequences in 16-year old archival brain specimens with one-week fixation in formalin.
Renal Insufficiency, Chronic
Preparation, characterization and physicochemical properties of novel low-phosphorus egg yolk protein.
Respiratory Hypersensitivity
A fungal protease allergen provokes airway hyper-responsiveness in asthma.
Retinoblastoma
Identification of discrete structural domains in the retinoblastoma protein. Amino-terminal domain is required for its oligomerization.
Scabies
Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state.
Scrapie
A Distinct Proteinase K Resistant Prion Protein Fragment in Goats with No Signs of Disease in a Classical Scrapie Outbreak.
Scrapie
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Scrapie
Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones.
Scrapie
Biochemical differences among scrapie-associated fibrils support the biological diversity of scrapie agents.
Scrapie
Biochemical properties of protease resistant prion protein PrPsc in natural sheep scrapie.
Scrapie
Cancer isoform of a tumor-associated cell surface NADH oxidase (tNOX) has properties of a prion.
Scrapie
Characterization of proteinase K-resistant N- and C-terminally truncated PrP in Nor98 atypical scrapie.
Scrapie
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
Scrapie
Conformational change in hamster scrapie prion protein (PrP27-30) associated with proteinase K resistance and prion infectivity.
Scrapie
Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion.
Scrapie
Detection of scrapie-associated fibril (SAF) proteins using anti-SAF antibody in non-purified tissue preparations.
Scrapie
Detection of ultra-low levels of pathologic prion protein in scrapie infected hamster brain homogenates using real-time immuno-PCR.
Scrapie
Differences in proteinase K resistance and neuronal deposition of abnormal prion proteins characterize bovine spongiform encephalopathy (BSE) and scrapie strains.
Scrapie
Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein.
Scrapie
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity.
Scrapie
Evaluation of a combinatorial approach to prion inactivation using an oxidizing agent, SDS, and proteinase K.
Scrapie
Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE).
Scrapie
Immunological characterization of abnormal prion protein from atypical scrapie cases in sheep using a panel of monoclonal antibodies.
Scrapie
Influence of guanidine on proteinase K resistance in vitro and infectivity of scrapie prion protein PrP(Sc).
Scrapie
Infrared microspectroscopy detects protein misfolding cyclic amplification (PMCA)-induced conformational alterations in hamster scrapie progeny seeds.
Scrapie
Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins.
Scrapie
Molecular analysis of the abnormal prion protein during coinfection of mice by bovine spongiform encephalopathy and a scrapie agent.
Scrapie
Molecular mass, biochemical composition, and physicochemical behavior of the infectious form of the scrapie precursor protein monomer.
Scrapie
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells.
Scrapie
Overexpression of active Syrian golden hamster prion protein PrPc as a glutathione S-transferase fusion in heterologous systems.
Scrapie
Protease-resistant and detergent-insoluble prion protein is not necessarily associated with prion infectivity.
Scrapie
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions.
Scrapie
Purification and partial characterization of the normal cellular homologue of the scrapie agent protein.
Scrapie
Rapid expression of polymorphic ovine prion proteins and studies on their protease sensitivity.
Scrapie
Rapid typing of transmissible spongiform encephalopathy strains with differential ELISA.
Scrapie
Recombinant human prion protein mutants huPrP D178N/M129 (FFI) and huPrP+9OR (fCJD) reveal proteinase K resistance.
Scrapie
Recombinant prion protein rPrP27-30 from Syrian golden hamster reveals proteinase K sensitivity.
Scrapie
Reduction of prion infectivity and levels of scrapie prion protein by lithium aluminum hydride: implications for RNA in prion diseases.
Scrapie
Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein.
Scrapie
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.
Scrapie
Scrapie-infected cells, isolated prions, and recombinant prion protein: a comparative study.
Scrapie
Strain-specific proteolytic processing of the prion protein in prion diseases of ruminants transmitted in ovine transgenic mice.
Scrapie
The effects of prion protein proteolysis and disaggregation on the strain properties of hamster scrapie.
Scrapie
The N-terminal cleavage site of PrPSc from BSE differs from that of PrPSc from scrapie.
Scrapie
Use of a new immunoassay to measure PrP Sc levels in scrapie-infected sheep brains reveals PrP genotype-specific differences.
Scrapie
Using small molecule reagents to selectively modify epitopes based on their conformation.
Scrub Typhus
Toll-Like Receptor 2 recognizes Orientia tsutsugamushi and increases susceptibility to murine experimental scrub typhus.
Sepsis
Effect of passive immunotherapy on murine gut-derived sepsis caused by Pseudomonas aeruginosa.
Sepsis
Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in mice.
Skin Diseases
Low-molecular-weight fractions of Alcalase hydrolyzed egg ovomucin extract exert anti-inflammatory activity in human dermal fibroblasts through the inhibition of tumor necrosis factor-mediated nuclear factor ?B pathway.
Skin Diseases
T cell stimulating stratum corneum antigens: characterization by chromatography and electrophoresis indicates limited diversity.
Sleep Initiation and Maintenance Disorders
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Sleep Initiation and Maintenance Disorders
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
Spinal Dysraphism
Allergic and latex-specific sensitization: route, frequency, and amount of exposure that are required to initiate IgE production.
Squamous Cell Carcinoma of Head and Neck
Fusobacteria modulate oral carcinogenesis and promote cancer progression.
Squamous Cell Carcinoma of Head and Neck
[DNA extraction using Chelex resin for oncogenic amplification analysis in head and neck tumours]
Starvation
Functional analysis of a subtilisin-like serine protease gene from biocontrol fungus Trichoderma harzianum.
Starvation
Selective inhibition of calcium-stimulated cation-induced pinocytosis by starvation and inhibitors of protein synthesis in Amoeba proteus.
Stroke
Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: Effect on stroke risk.
subtilisin deficiency
Alkaline protease deficiency in the cr-1 (crisp) mutant of Neurospora crassa.
Supranuclear Palsy, Progressive
C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders.
Tetanus
X-ray absorption spectroscopy study of zinc coordination in tetanus neurotoxin, astacin, alkaline protease and thermolysin.
Thrombosis
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli.
Thrombosis
High-level extracellular production of recombinant nattokinase in Bacillus subtilis WB800 by multiple tandem promoters.
Thrombosis
Improvement of the acid resistance, catalytic efficiency, and thermostability of nattokinase by multisite-directed mutagenesis.
Thrombosis
Molecular analysis of a fibrin-degrading enzyme from Bacillus subtilis K2 isolated from the Indonesian soybean-based fermented food moromi.
Thrombosis
Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis.
Thrombosis
Protective immunization of mice with an active-site mutant of subtilase cytotoxin of Shiga toxin-producing Escherichia coli.
Thrombosis
Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles.
Thrombosis
Thrombolytic effect of Subtilisin QK on carrageenan induced thrombosis model in mice.
Thrombosis
Tissue factordependent procoagulant activity of subtilase cytotoxin, a potent AB5 toxin produced by shiga toxigenic Escherichia coli.
Thrombosis
[Evaluating thrombolytic efficacy and thrombus targetability of RGDS-liposomes encapsulating subtilisin FS33 in vivo]
Tinea
Assessment of the subtilisin gene profile in Trichophyton verrucosum isolated from human and animal dermatophytoses in two-stage multiplex PCR.
Tinea
Detection of subtilisin 3 and 6 in skin biopsies of cattle with clinically manifested bovine ringworm.
Tuberculosis
Development of antigen detection assay for diagnosis of tuberculosis using sputum samples.
Tuberculosis
Human CD4-CD8- alpha beta + T-cell receptor T cells recognize different mycobacteria strains in the context of CD1b.
Tuberculosis
Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis.
Tuberculosis
Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.
Tuberculosis, Pleural
Modified TB rapid test by proteinase K for rapid diagnosis of pleural tuberculosis.
Urinary Tract Infections
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Uterine Cervical Neoplasms
Characterization of the anti-cancer-cell parasporal proteins of a Bacillus thuringiensis isolate.
Uterine Cervical Neoplasms
Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum.
Vascular Diseases
Efficacy and Safety of PCSK9 Inhibitors in Hypercholesterolemia Associated With Refractory Nephrotic Syndrome.
Vesicular Stomatitis
Endocytosis in Saccharomyces cerevisiae: internalization of enveloped viruses into spheroplasts.
Vibrio Infections
Cloning and expression of the gene encoding an extracellular alkaline serine protease from Vibrio alginolyticus strain HY9901, the causative agent of vibriosis in Lutjanus erythopterus (Bloch).
Vibrio Infections
Role of alkaline serine protease, asp, in vibrio alginolyticus virulence and regulation of its expression by luxO-luxR regulatory system.
Warts
Human papillomavirus DNA from warts for typing by endonuclease restriction patterns: purification by alkaline plasmid methods.
Wasting Disease, Chronic
A simple in vitro assay for assessing the efficacy, mechanisms and kinetics of anti-prion fibril compounds.
Wasting Disease, Chronic
Generation of a Persistently Infected MDBK Cell Line with Natural Bovine Spongiform Encephalopathy (BSE).
Wasting Syndrome
Myofibrillar protease activity in muscle tissue from patients in catabolic conditions.
Whooping Cough
AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.
Whooping Cough
Bacterial type AB? enterotoxins--structure, function and mechanism of action.
Whooping Cough
Dissociation of catalytic and invasive activities of Bordetella pertussis adenylate cyclase.
Whooping Cough
Dynamic Duo-The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin.
Whooping Cough
Major outbreak of pertussis in northern Alberta, Canada: analysis of discrepant direct fluorescent-antibody and culture results by using polymerase chain reaction methodology.
Whooping Cough
Surface anchoring of bacterial subtilisin important for maturation function.
Whooping Cough
The Major Leukocyte Chemotactic and Activating Factors in the Mouse Gut Lumen Are Not N-Formylpeptide Receptor 1 Agonists.
Wilms Tumor
Microsatellite analysis of the DCC gene in nephroblastomas: pathologic correlations and prognostic implications.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
strains causing virulent footrot secrete the subtilisin-like protease BprV
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A5EVD0_DICNV
Dichelobacter nodosus (strain VCS1703A)
603
0
63843
TrEMBL
-
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
by the hanging-drop vapour-diffusion method. Crystals of BprV diffract to 2.0 A resolution. The crystals belong to space group P21, with unit-cell parameters a = 38.5, b = 89.6, c = 47.7 A , beta = 113.6. The crystals contain one molecule in the asymmetric unit, with a solvent content of 40%
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
vector pET22b-BprV encoded residues 1-476 of BprV with a C-terminal His6 tag and transformed into Escherichia coli strain Rosetta-Gami(DE3)pLysS
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wong, W.; Kennan, R.M.; Rosado, C.J.; Rood, J.I.; Whisstock, J.C.; Porter, C.J.
Crystallization of the virulent and benign subtilisin-like proteases from the ovine footrot pathogen Dichelobacter nodosus
Acta Crystallogr. Sect. F
66
289-293
2010
Dichelobacter nodosus, Dichelobacter nodosus (A5EVD0), Dichelobacter nodosus (A5EXI3), Dichelobacter nodosus (Q46547), Dichelobacter nodosus C305 (Q46547), Dichelobacter nodosus VCS1703A (A5EVD0), Dichelobacter nodosus VCS1703A (A5EXI3)
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Release 2023.1 (January 2023)
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