hypodermin C protease degrades the guinea pig complement C3, and inhibits the complement pathway in vitro, immunosuppressive effect of hypodermin C on complement component 3 in vitro, the cytotoxicity of C3 is inhibited in cultures of stably transfected COS7 cells expressing the enzyme
the first cleavage probably occurs between residues 764 and 765 at Pro-Ala and Thr-Ala bonds on the alpha1 and alpha2 chains respectively. Two more bonds would then by cleaved on the alpha1 chain, Ile776-Ala777 and Val782-Val783, and one more on the alpha2-chain, Ser800-Val801
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DNA and amino acid sequence determination and analysis, recombinant expression in COS7 cells using the pEF1a-IRES-AcGFP expression vector. COS7 cells stably expressing the enzyme are more resistant to lysis by guinea pig complement C3 than the control cells
dynamics of circulating hypodermin C in previously infested cattle resemble those in previously uninfested cattle. Development of a significant immune response during the primary infestation that is reflected in the rapid and substantial production of antibodies upon re-infestation, thus migrating first instars may induce significant reduction in host immune response