Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.21.45 - complement factor I and Organism(s) Mus musculus and UniProt Accession Q61129

for references in articles please use BRENDA:EC3.4.21.45
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.45 complement factor I
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
UNIPROT: Q61129 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage
Synonyms
complement factor i, c3b inactivator, c3bina, serine protease factor i, c3b/c4b inactivator, factor i-like activity, complement inhibitor factor i, gcif-1, gcif-2, gcif-3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C3b inactivator
-
-
-
-
C3bINA
-
-
-
-
complement C3b inactivator
-
-
-
-
complement C3b/C4b inactivator
-
-
-
-
complement C4b inactivator
-
-
-
-
complement C4bi
-
-
-
-
complement compoment C3b inactivator
-
-
-
-
conglutinogen-activating factor C
-
-
-
-
factor I
CAS REGISTRY NUMBER
COMMENTARY hide
80295-66-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
complement component C3b + H2O
complement component C3c + ?
show the reaction diagram
complement component C3b + H2O
?
show the reaction diagram
-
-
-
-
?
complement component C3b + H2O
inactivated C3b + ?
show the reaction diagram
-
-
-
-
?
complement component C4b + H2O
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
complement component C3b + H2O
complement component C3c + ?
show the reaction diagram
-
-
-
?
complement component C3b + H2O
?
show the reaction diagram
-
-
-
-
?
complement component C4b + H2O
?
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
factor H
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
amyloid beta
-
production of inactivated C3b is significantly decreased when C3b and factor H are incubated with eyes from neprilysin gene-disrupted mice, which leads to an increased deposition of amyloid beta, compared with when C3b and factor H are incubated with eyes from wild-type mice
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
complement component C3 level measured in plasma, glomerular complement component C3 staining and complement profile in mice with deficiency of complement factor I indicated
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
renal transplantation studies of mice included
Manually annotated by BRENDA team
-
RPE-Bruch's membrane-choriocapillaris complex from eyes of 12-month-old neprilysin gene-disrupted mice and age-matched wild-type mice
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CFAI_MOUSE
603
0
67261
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
88000
SDS-PAGE, nonreducing conditions, detection of murine complement factor I by using a crossreactive polyclonal goat antibody against human complement factor I
27000
-
1 * 27000 + 1 * 37500, calculation from nucleotide sequence
37500
-
1 * 27000 + 1 * 37500, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterodimer
-
dimer
-
1 * 27000 + 1 * 37500, calculation from nucleotide sequence
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
side-chain modification
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli, generation of mice strains deficient of complement factor I
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
studies on inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2)
medicine
-
amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Minta, J.O.; Wong, M.J.; Kozak, C.A.; Kunnath-Muglia, L.M.; Goldberger, G.
cDNA Cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): Identification of a species specific divergent segment in factor I
Mol. Immunol.
33
101-112
1996
Mus musculus
Manually annotated by BRENDA team
Rose, K.L.; Paixao-Cavalcante, D.; Fish, J.; Manderson, A.P.; Malik, T.H.; Bygrave, A.E.; Lin, T.; Sacks, S.H.; Walport, M.J.; Cook, H.T.; Botto, M.; Pickering, M.C.
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
J. Clin. Invest.
118
608-618
2008
Mus musculus (Q61129)
Manually annotated by BRENDA team
Wang, J.; Ohno-Matsui, K.; Yoshida, T.; Kojima, A.; Shimada, N.; Nakahama, K.; Safranova, O.; Iwata, N.; Saido, T.C.; Mochizuki, M.; Morita, I.
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen
J. Immunol.
181
712-720
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team