Reference on EC 3.4.21.41 - complement subcomponent C1r
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Busby, T.F.; Ingham, K.C.
Calcium-sensitive thermal transitions and domain structure of human complement subcomponent C1r
Biochemistry
26
5564-5571
1987
Homo sapiens
Journet, A.; Tosi, M.
Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r
Biochem. J.
240
783-787
1986
Homo sapiens
Thielens, N.M.; Illy, C.; Bally, I.M.; Arlaud, G.J.
Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q
Biochem. J.
301
509-516
1994
Homo sapiens
Loos, M.; Clas, F.; Heinz, H.P.
C1rbar-esterase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
514-527
1984
Homo sapiens
-
Illy, C.; Thielens, N.M.; Arlaud, G.J.
Chemical characterization and location of ionic interactions involved in the assembly of the C1 complex of human complement
J. Protein Chem.
12
771-781
1993
Homo sapiens
Gal, P.; Zavodzky, P.
Structure and function of the serine-protease subcomponents of C1: protein engineering studies
Immunobiology
199
317-326
1998
Homo sapiens
Andrews, J.M.; Baillie, R.D.
The enzymatic nature of human c1r: a subcomponent of the first component of complement
J. Immunol.
123
1403-1408
1979
Homo sapiens
Sim, R.B.; Porter, R.R.; Reid, K.B.M.; Gigli, I.
The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement
Biochem. J.
163
219-227
1977
Homo sapiens
Sim, R.; Arlaud, G.J.; Colomb, M.G.
Kinetics of reaction of human C1bar-inhibitor with the human complement system proteases C1rbar and C1sbar
Biochim. Biophys. Acta
612
433-449
1980
Homo sapiens
Sim, R.B.
The human complement system serine proteases C1bar and C1sbar and their proenzymes
Methods Enzymol.
80
26-42
1981
Homo sapiens
Nilsson, T.; Wiman, B.
Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s
Eur. J. Biochem.
129
663-667
1983
Homo sapiens
Reboul, A.; Bensa, J.C.; Colomb, M.G.
Characteristics of complement subcomponents C1r and C1s synthesized by Hep G2 cells
Biochem. J.
233
559-564
1986
Homo sapiens
Arlaud, G.J.; Villiers, C.L.; Chesne, S.; Colomb, M.G.
Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage
Biochim. Biophys. Acta
616
116-129
1980
Homo sapiens
Thielens, N.M.; Aude, C.A.; Lacroix, M.B.; Gagnon, J.; Arlaud, G.J.
Ca2+ binding properties and Ca2+-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1rbar and C1sbar
J. Biol. Chem.
265
14469-14475
1990
Homo sapiens
Katz, Y.; Guterman, M.; Lahat, E.
Regulation of synthesis of complement proteins in HEp2 cells
Clin. Immunol. Immunopathol.
67
117-123
1993
Homo sapiens
Zavodszky, P.; Gal, P.; Cseh, S.; Schumaker, V.N.
Protein engineering studies on C1r and C1s
Behring Inst. Mitt.
93
103-114
1993
Homo sapiens
Gulati, P.; Lemercier, C.; Guc, D.; Lappin, D.; Whaley, K.
Regulation of the synthesis of C1 subcomponents and C1-inhibitor
Behring Inst. Mitt.
93
196-203
1993
Homo sapiens
Arlaud, G.J.; Thielens, N.M.
Human complement serine proteases C1r and C1s and their proenzymes
Methods Enzymol.
223
61-82
1993
Homo sapiens
Kam, C.M.; Oglesby, T.J.; Pangburn, M.K.; Volanakis, J.E.; Powers, J.C.
Substituted isocoumarins as inhibitors of complement serine proteases
J. Immunol.
149
163-168
1992
Homo sapiens
Dobo, J.; Gal, P.; Szilagyi, K.; Cseh, S.; Lrincz, Z.; Schumaker, V.N.; Zavodszky, P.
One active C1r subunit is sufficient for the activity of the complement C1 complex: stabilization of C1r in the zymogen form by point mutations
J. Immunol.
162
1108-1112
1999
Homo sapiens
Budayova-Spano, M.; Lacroix, M.; Thielens, N.M.; Arlaud, G.J.; Fontecilla-Camps, J.C.; Gaboriaud, C.
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
EMBO J.
21
231-239
2002
Homo sapiens (P00736), Homo sapiens
Lacroix, M.; Ebel, C.; Kardos, J.; Dobo, J.; Gal, P.; Zavodszky, P.; Arlaud, G.J.; Thielens, N.M.
Assembly and enzymatic properties of the catalytic domain of human complement protease C1r
J. Biol. Chem.
276
36233-36240
2001
Homo sapiens
Kardos, J.; Gal, P.; Szilagyi, L.; Thielens, N.M.; Szilagyi, K.; Lorincz, Z.; Kulcsar, P.; Graf, L.; Arlaud, G.J.; Zavodszky, P.
The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r
J. Immunol.
167
5202-5208
2001
Homo sapiens
Budayova-Spano, M.; Grabarse, W.; Thielens, N.M.; Hillen, H.; Lacroix, M.; Schmidt, M.; Fontecilla-Camps, J.C.; Arlaud, G.J.; Gaboriaud, C.
Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: further insights into the C1 activation mechanism
Structure
10
1509-1519
2002
Homo sapiens (P00736), Homo sapiens
Duncan, R.C.; Wijeyewickrema, L.C.; Pike, R.N.
The initiating proteases of the complement system: controlling the cleavage
Biochimie
90
387-395
2008
Homo sapiens
Biro, A.; Rovo, Z.; Papp, D.; Cervenak, L.; Varga, L.; Fuest, G.; Thielens, N.M.; Arlaud, G.J.; Prohaszka, Z.
Studies on the interactions between C-reactive protein and complement proteins
Immunology
121
40-50
2007
Homo sapiens
Kardos, J.; Harmat, V.; Pallo, A.; Barabas, O.; Szilagyi, K.; Graf, L.; Naray-Szabo, G.; Goto, Y.; Zavodszky, P.; Gal, P.
Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r
Mol. Immunol.
45
1752-1760
2008
Homo sapiens (P00736), Homo sapiens
Gaultier, A.; Arandjelovic, S.; Niessen, S.; Overton, C.D.; Linton, M.F.; Fazio, S.; Campana, W.M.; Cravatt, B.F.; Gonias, S.L.
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
Blood
111
5316-5325
2008
Mus musculus
Goesswein, T.; Kocot, A.; Emmert, G.; Kreuz, W.; Martinez-Saguer, I.; Aygoeren-Puersuen, E.; Rusicke, E.; Bork, K.; Oldenburg, J.; Mueller, C.R.
Mutational spectrum of the C1INH (SERPING1) gene in patients with hereditary angioedema
Cytogenet. Genome Res.
121
181-188
2008
Homo sapiens
Geach, T.J.; Dale, L.
Molecular determinants of Xolloid action in vivo
J. Biol. Chem.
283
27057-27063
2008
Xenopus laevis
Davis, A.E.; Mejia, P.; Lu, F.
Biological activities of C1 inhibitor
Mol. Immunol.
45
4057-4063
2008
Homo sapiens
Lang, A.; Szilagyi, K.; Major, B.; Gal, P.; Zavodszky, P.; Perczel, A.
Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology
FEBS J.
277
3986-3998
2010
Homo sapiens
Lang, A.; Major, B.; Szilagyi, K.; Gaspari, Z.; Gal, P.; Zavodszky, P.; Perczel, A.
Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease
FEBS Lett.
584
4565-4569
2010
Homo sapiens
Major, B.; Kardos, J.; Kekesi, K.A.; Lorincz, Z.; Zavodszky, P.; Gal, P.
Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r
J. Biol. Chem.
285
11863-11869
2010
Homo sapiens
Brier, S.; Pflieger, D.; Le Mignon, M.; Bally, I.; Gaboriaud, C.; Arlaud, G.J.; Daniel, R.
Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex
J. Biol. Chem.
285
32251-32263
2010
Homo sapiens
Valck, C.; Ramirez, G.; Lopez, N.; Ribeiro, C.H.; Maldonado, I.; Sanchez, G.; Ferreira, V.P.; Schwaeble, W.; Ferreira, A.
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin
Mol. Immunol.
47
1516-1521
2010
Homo sapiens
Kaplan, A.P.; Ghebrehiwet, B.
The plasma bradykinin-forming pathways and its interrelationships with complement
Mol. Immunol.
47
2161-2169
2010
Homo sapiens
Wijeyewickrema, L.C.; Yongqing, T.; Tran, T.P.; Thompson, P.E.; Viljoen, J.E.; Coetzer, T.H.; Duncan, R.C.; Kass, I.; Buckle, A.M.; Pike, R.N.
Molecular determinants of the substrate specificity of the complement-initiating protease, C1r
J. Biol. Chem.
288
15571-15580
2013
Homo sapiens (P00736)
Venkatraman Girija, U.; Gingras, A.R.; Marshall, J.E.; Panchal, R.; Sheikh, M.A.; Gal, P.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.; Wallis, R.
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
Proc. Natl. Acad. Sci. USA
110
13916-13920
2013
Homo sapiens (P00736)
Bally, I.; Ancelet, S.; Moriscot, C.; Gonnet, F.; Mantovani, A.; Daniel, R.; Schoehn, G.; Arlaud, G.J.; Thielens, N.M.
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites
Proc. Natl. Acad. Sci. USA
110
8650-8655
2013
Homo sapiens (P00736), Homo sapiens
Beveridge, A.J.; Wallis, R.; Samani, N.J.
A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex
Proteins
80
1987-1997
2012
Homo sapiens (P00736)
Kapferer-Seebacher, I.; Pepin, M.; Werner, R.; Aitman, T.J.; Nordgren, A.; Stoiber, H.; Thielens, N.; Gaboriaud, C.; Amberger, A.; Schossig, A.; Gruber, R.; Giunta, C.; Bamshad, M.; Bjoerck, E.; Chen, C.; Chitayat, D.; Dorschner, M.; Schmitt-Egenolf, M.; Hale, C.J.; Hanna, D.; Hennies, H.C.; Heiss-Kisielewsky, I.
Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement
Am. J. Hum. Genet.
99
1005-1014
2016
Homo sapiens (P00736)
Schaer, C.A.; Owczarek, C.; Deuel, J.W.; Schauer, S.; Baek, J.H.; Yalamanoglu, A.; Hardy, M.P.; Scotney, P.D.; Schmidt, P.M.; Pelzing, M.; Soupourmas, P.; Buehler, P.W.; Schaer, D.J.
Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics
BMC Biotechnol.
18
15
2018
Homo sapiens (Q9NZP8), Homo sapiens
Nilojan, J.; Bathige, S.D.N.K.; Kugapreethan, R.; Yang, H.; Kim, M.J.; Nam, B.H.; Lee, J.
Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii
Dev. Comp. Immunol.
81
279-290
2018
Sebastes schlegelii (A0A2I6BQJ9)
Godahewa, G.I.; Bathige, S.D.; Herath, H.M.; Noh, J.K.; Lee, J.
Characterization of rock bream (Oplegnathus fasciatus) complement components C1r and C1s in terms of molecular aspects, genomic modulation, and immune responsive transcriptional profiles following bacterial and viral pathogen exposure
Fish Shellfish Immunol.
46
656-668
2015
Oplegnathus fasciatus (A0A0K0LFE3)
Almitairi, J.O.M.; Venkatraman Girija, U.; Furze, C.M.; Simpson-Gray, X.; Badakshi, F.; Marshall, J.E.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.E.; Wallis, R.
Structure of the C1r-C1s interaction of the C1 complex of complement activation
Proc. Natl. Acad. Sci. USA
115
768-773
2018
Homo sapiens (P00736)
html completed
