Reference on EC 3.4.21.41 - complement subcomponent C1r

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Busby, T.F.; Ingham, K.C.
Calcium-sensitive thermal transitions and domain structure of human complement subcomponent C1r
Biochemistry
26
5564-5571
1987
Homo sapiens
Manually annotated by BRENDA team
Journet, A.; Tosi, M.
Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r
Biochem. J.
240
783-787
1986
Homo sapiens
Manually annotated by BRENDA team
Thielens, N.M.; Illy, C.; Bally, I.M.; Arlaud, G.J.
Activation of human complement serine-proteinase C1r is down-regulated by a Ca(2+)-dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q
Biochem. J.
301
509-516
1994
Homo sapiens
Manually annotated by BRENDA team
Loos, M.; Clas, F.; Heinz, H.P.
C1rbar-esterase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
514-527
1984
Homo sapiens
-
Manually annotated by BRENDA team
Illy, C.; Thielens, N.M.; Arlaud, G.J.
Chemical characterization and location of ionic interactions involved in the assembly of the C1 complex of human complement
J. Protein Chem.
12
771-781
1993
Homo sapiens
Manually annotated by BRENDA team
Gal, P.; Zavodzky, P.
Structure and function of the serine-protease subcomponents of C1: protein engineering studies
Immunobiology
199
317-326
1998
Homo sapiens
Manually annotated by BRENDA team
Andrews, J.M.; Baillie, R.D.
The enzymatic nature of human c1r: a subcomponent of the first component of complement
J. Immunol.
123
1403-1408
1979
Homo sapiens
Manually annotated by BRENDA team
Sim, R.B.; Porter, R.R.; Reid, K.B.M.; Gigli, I.
The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement
Biochem. J.
163
219-227
1977
Homo sapiens
Manually annotated by BRENDA team
Sim, R.; Arlaud, G.J.; Colomb, M.G.
Kinetics of reaction of human C1bar-inhibitor with the human complement system proteases C1rbar and C1sbar
Biochim. Biophys. Acta
612
433-449
1980
Homo sapiens
Manually annotated by BRENDA team
Sim, R.B.
The human complement system serine proteases C1bar and C1sbar and their proenzymes
Methods Enzymol.
80
26-42
1981
Homo sapiens
Manually annotated by BRENDA team
Nilsson, T.; Wiman, B.
Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s
Eur. J. Biochem.
129
663-667
1983
Homo sapiens
Manually annotated by BRENDA team
Reboul, A.; Bensa, J.C.; Colomb, M.G.
Characteristics of complement subcomponents C1r and C1s synthesized by Hep G2 cells
Biochem. J.
233
559-564
1986
Homo sapiens
Manually annotated by BRENDA team
Arlaud, G.J.; Villiers, C.L.; Chesne, S.; Colomb, M.G.
Purified proenzyme C1r. Some characteristics of its activation and subsequent proteolytic cleavage
Biochim. Biophys. Acta
616
116-129
1980
Homo sapiens
Manually annotated by BRENDA team
Thielens, N.M.; Aude, C.A.; Lacroix, M.B.; Gagnon, J.; Arlaud, G.J.
Ca2+ binding properties and Ca2+-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1rbar and C1sbar
J. Biol. Chem.
265
14469-14475
1990
Homo sapiens
Manually annotated by BRENDA team
Katz, Y.; Guterman, M.; Lahat, E.
Regulation of synthesis of complement proteins in HEp2 cells
Clin. Immunol. Immunopathol.
67
117-123
1993
Homo sapiens
Manually annotated by BRENDA team
Zavodszky, P.; Gal, P.; Cseh, S.; Schumaker, V.N.
Protein engineering studies on C1r and C1s
Behring Inst. Mitt.
93
103-114
1993
Homo sapiens
Manually annotated by BRENDA team
Gulati, P.; Lemercier, C.; Guc, D.; Lappin, D.; Whaley, K.
Regulation of the synthesis of C1 subcomponents and C1-inhibitor
Behring Inst. Mitt.
93
196-203
1993
Homo sapiens
Manually annotated by BRENDA team
Arlaud, G.J.; Thielens, N.M.
Human complement serine proteases C1r and C1s and their proenzymes
Methods Enzymol.
223
61-82
1993
Homo sapiens
Manually annotated by BRENDA team
Kam, C.M.; Oglesby, T.J.; Pangburn, M.K.; Volanakis, J.E.; Powers, J.C.
Substituted isocoumarins as inhibitors of complement serine proteases
J. Immunol.
149
163-168
1992
Homo sapiens
Manually annotated by BRENDA team
Dobo, J.; Gal, P.; Szilagyi, K.; Cseh, S.; Lörincz, Z.; Schumaker, V.N.; Zavodszky, P.
One active C1r subunit is sufficient for the activity of the complement C1 complex: stabilization of C1r in the zymogen form by point mutations
J. Immunol.
162
1108-1112
1999
Homo sapiens
Manually annotated by BRENDA team
Budayova-Spano, M.; Lacroix, M.; Thielens, N.M.; Arlaud, G.J.; Fontecilla-Camps, J.C.; Gaboriaud, C.
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex
EMBO J.
21
231-239
2002
Homo sapiens, Homo sapiens (P00736)
Manually annotated by BRENDA team
Lacroix, M.; Ebel, C.; Kardos, J.; Dobo, J.; Gal, P.; Zavodszky, P.; Arlaud, G.J.; Thielens, N.M.
Assembly and enzymatic properties of the catalytic domain of human complement protease C1r
J. Biol. Chem.
276
36233-36240
2001
Homo sapiens
Manually annotated by BRENDA team
Kardos, J.; Gal, P.; Szilagyi, L.; Thielens, N.M.; Szilagyi, K.; Lorincz, Z.; Kulcsar, P.; Graf, L.; Arlaud, G.J.; Zavodszky, P.
The role of the individual domains in the structure and function of the catalytic region of a modular serine protease, C1r
J. Immunol.
167
5202-5208
2001
Homo sapiens
Manually annotated by BRENDA team
Budayova-Spano, M.; Grabarse, W.; Thielens, N.M.; Hillen, H.; Lacroix, M.; Schmidt, M.; Fontecilla-Camps, J.C.; Arlaud, G.J.; Gaboriaud, C.
Monomeric structures of the zymogen and active catalytic domain of complement protease C1r: further insights into the C1 activation mechanism
Structure
10
1509-1519
2002
Homo sapiens, Homo sapiens (P00736)
Manually annotated by BRENDA team
Duncan, R.C.; Wijeyewickrema, L.C.; Pike, R.N.
The initiating proteases of the complement system: controlling the cleavage
Biochimie
90
387-395
2008
Homo sapiens
Manually annotated by BRENDA team
Biro, A.; Rovo, Z.; Papp, D.; Cervenak, L.; Varga, L.; Fuest, G.; Thielens, N.M.; Arlaud, G.J.; Prohaszka, Z.
Studies on the interactions between C-reactive protein and complement proteins
Immunology
121
40-50
2007
Homo sapiens
Manually annotated by BRENDA team
Kardos, J.; Harmat, V.; Pallo, A.; Barabas, O.; Szilagyi, K.; Graf, L.; Naray-Szabo, G.; Goto, Y.; Zavodszky, P.; Gal, P.
Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: structure of the active catalytic region of C1r
Mol. Immunol.
45
1752-1760
2008
Homo sapiens, Homo sapiens (P00736)
Manually annotated by BRENDA team
Gaultier, A.; Arandjelovic, S.; Niessen, S.; Overton, C.D.; Linton, M.F.; Fazio, S.; Campana, W.M.; Cravatt, B.F.; Gonias, S.L.
Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
Blood
111
5316-5325
2008
Mus musculus
Manually annotated by BRENDA team
Goesswein, T.; Kocot, A.; Emmert, G.; Kreuz, W.; Martinez-Saguer, I.; Aygoeren-Puersuen, E.; Rusicke, E.; Bork, K.; Oldenburg, J.; Mueller, C.R.
Mutational spectrum of the C1INH (SERPING1) gene in patients with hereditary angioedema
Cytogenet. Genome Res.
121
181-188
2008
Homo sapiens
Manually annotated by BRENDA team
Geach, T.J.; Dale, L.
Molecular determinants of Xolloid action in vivo
J. Biol. Chem.
283
27057-27063
2008
Xenopus laevis
Manually annotated by BRENDA team
Davis, A.E.; Mejia, P.; Lu, F.
Biological activities of C1 inhibitor
Mol. Immunol.
45
4057-4063
2008
Homo sapiens
Manually annotated by BRENDA team
Lang, A.; Szilagyi, K.; Major, B.; Gal, P.; Zavodszky, P.; Perczel, A.
Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r: structural biology
FEBS J.
277
3986-3998
2010
Homo sapiens
Manually annotated by BRENDA team
Lang, A.; Major, B.; Szilagyi, K.; Gaspari, Z.; Gal, P.; Zavodszky, P.; Perczel, A.
Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease
FEBS Lett.
584
4565-4569
2010
Homo sapiens
Manually annotated by BRENDA team
Major, B.; Kardos, J.; Kekesi, K.A.; Lorincz, Z.; Zavodszky, P.; Gal, P.
Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r
J. Biol. Chem.
285
11863-11869
2010
Homo sapiens
Manually annotated by BRENDA team
Brier, S.; Pflieger, D.; Le Mignon, M.; Bally, I.; Gaboriaud, C.; Arlaud, G.J.; Daniel, R.
Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex
J. Biol. Chem.
285
32251-32263
2010
Homo sapiens
Manually annotated by BRENDA team
Valck, C.; Ramirez, G.; Lopez, N.; Ribeiro, C.H.; Maldonado, I.; Sanchez, G.; Ferreira, V.P.; Schwaeble, W.; Ferreira, A.
Molecular mechanisms involved in the inactivation of the first component of human complement by Trypanosoma cruzi calreticulin
Mol. Immunol.
47
1516-1521
2010
Homo sapiens
Manually annotated by BRENDA team
Kaplan, A.P.; Ghebrehiwet, B.
The plasma bradykinin-forming pathways and its interrelationships with complement
Mol. Immunol.
47
2161-2169
2010
Homo sapiens
Manually annotated by BRENDA team
Wijeyewickrema, L.C.; Yongqing, T.; Tran, T.P.; Thompson, P.E.; Viljoen, J.E.; Coetzer, T.H.; Duncan, R.C.; Kass, I.; Buckle, A.M.; Pike, R.N.
Molecular determinants of the substrate specificity of the complement-initiating protease, C1r
J. Biol. Chem.
288
15571-15580
2013
Homo sapiens (P00736)
Manually annotated by BRENDA team
Venkatraman Girija, U.; Gingras, A.R.; Marshall, J.E.; Panchal, R.; Sheikh, M.A.; Gal, P.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.; Wallis, R.
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
Proc. Natl. Acad. Sci. USA
110
13916-13920
2013
Homo sapiens (P00736)
Manually annotated by BRENDA team
Bally, I.; Ancelet, S.; Moriscot, C.; Gonnet, F.; Mantovani, A.; Daniel, R.; Schoehn, G.; Arlaud, G.J.; Thielens, N.M.
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites
Proc. Natl. Acad. Sci. USA
110
8650-8655
2013
Homo sapiens, Homo sapiens (P00736)
Manually annotated by BRENDA team
Beveridge, A.J.; Wallis, R.; Samani, N.J.
A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex
Proteins
80
1987-1997
2012
Homo sapiens (P00736)
Manually annotated by BRENDA team