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Information on EC 3.4.21.38 - coagulation factor XIIa and Organism(s) Homo sapiens

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     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.38 coagulation factor XIIa
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Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Synonyms
factor xii, hageman factor, fxiia, factor xiia, coagulation factor xii, activated factor xii, prekallikrein activator, beta-factor xiia, blood coagulation factor xii, beta-fxiia, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
activated coagulation factor XII
-
-
activated factor XII
-
-
alpha-FXIIa
-
-
alphaFXIIa
-
-
beta-factor XIIa
-
beta-FXIIa
blood coagulation factor XII
-
-
blood-coagulation factor XII, activated beta
-
-
-
0
blood-coagulation factor XIIabeta
-
-
-
0
blood-coagulation factor XIIf
-
-
-
0
coagulation beta-factor XIIa
-
-
coagulation factor XII
coagulation factor XIIa
-
factor XII
factor XII Osaka
-
abnormal factor XII with partially defective prekallikrein cleavage activity
FXIIa
HAF
-
-
-
0
Hageman factor
Hageman factor beta-fragment
-
-
-
0
Hageman factor fragment HFf
-
-
-
0
Hagemann factor
-
-
-
0
kallikreinogen, activator
-
-
-
0
prealbumin activator
-
-
-
0
prekallikrein activator
-
-
-
0
single-chain FXII
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
75216-42-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
benzyloxycarbonyl-Ala-Arg-SCH2C6H5 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ala-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Glu-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
best substrate
-
0
?
benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Phe-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Pro-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ser-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
Biophen CS11-22 + H2O
?
show the reaction diagram
-
-
-
0
?
Boc-Gln-Gly-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
fluorogenic substrate
-
0
?
C1 esterase + H2O
activated C1 esterase
show the reaction diagram
-
-
-
0
?
D-Pro-Phe-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
factor VII + H2O
factor VIIa
show the reaction diagram
-
-
-
?
factor XI + H2O
factor XIa
show the reaction diagram
-
-
-
0
?
factor XI + H2O
factor XIa + ?
show the reaction diagram
factor XII + H2O
factor XIIa + ?
show the reaction diagram
-
the enzyme undergoes autoactivation to alpha-fXIIa in the presence of polyphosphate
-
0
?
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
0
?
Nalpha-benzoyl-Ile-Glu-OCH-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
Nalpha-benzoyl-Ile-Glu-OH-Gly-Arg-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
0
?
Pefachrome + H2O
?
show the reaction diagram
-
-
-
0
?
plasma prekallikrein + H2O
plasma kallikrein + ?
show the reaction diagram
-
-
-
0
?
plasminogen + H2O
plasmin + ?
show the reaction diagram
-
-
-
0
?
prekallikrein + H2O
?
show the reaction diagram
-
-
-
?
prekallikrein + H2O
activated prekallikrein
show the reaction diagram
-
-
-
0
?
prekallikrein + H2O
activated prekallikrein + ?
show the reaction diagram
-
-
-
0
?
prekallikrein + H2O
kallikrein + ?
show the reaction diagram
-
-
-
0
?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
show the reaction diagram
prekallikrein + H2O
kallikrein + kallikrein propeptide
show the reaction diagram
-
-
-
0
?
Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
0
?
S-2251 + H2O
?
show the reaction diagram
-
-
-
0
?
S-2302 + H2O
?
show the reaction diagram
-
-
-
0
?
tert-butyloxycarbonyl-Arg-SCH2C6H5 + H2O
?
show the reaction diagram
-
-
-
0
?
tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2 + H2O
?
show the reaction diagram
-
-
-
0
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
factor XI + H2O
factor XIa + ?
show the reaction diagram
plasma prekallikrein + H2O
plasma kallikrein + ?
show the reaction diagram
-
-
-
-
?
plasminogen + H2O
plasmin + ?
show the reaction diagram
-
-
-
-
?
prekallikrein + H2O
kallikrein + ?
show the reaction diagram
-
-
-
-
?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
show the reaction diagram
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-((1-aminoisoquinolin-6-yl)phenyl)boronic acid
-
Ala-Phe-Arg-chloromethylketone
-
-
alpha2-Macroglobulin
-
-
-
antithrombin
minor inhibitory activity
-
antithrombin III
-
-
-
benzamidine
-
C1 esterase inhibitor
-
-
-
C1 inhibitor
-
-
-
C1INH
-
-
-
corn trypsin inhibitor
-
D-Pro-Phe-Arg-chloromethyl ketone
-
-
dansyl-Glu-Gly-Arg-chloromethylketone
-
-
histidine-rich glycoprotein
-
inhibitor of autoactivation, inhibitor of activation of factor XI
-
Ir-CPI
-
the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz type protein expressed by the salivary glands of the tick Ixodes ricinus, specifically interacts with activated human contact phase factors FXIIa, FXIa, and kallikrein. Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview
-
Phe-Phe-Arg-chloromethylketone
-
-
Phe-Pro-Arg-chloromethylketone
-
-
plasminogen activator inhibitor 1
minor inhibitory activity
Pro-Phe-Arg chloromethylketone
Pumpkin seed inhibitor
-
the inhibitor is isolated from Cucurbita maxima, minimum MW is 3268 Da
-
serpin C1 esterase inhibitor
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-kallikrein
-
-
-
Dextran
-
dextran-mediated activation and autoactivation
ellagic acid
-
activation of factor XII by negatively charged agents, e.g. ellagic acid, is not necessarily accompanied by molecular scission
High molecular weight kininogen
-
-
Kallikrein
-
mediates activation of the zymogen FXII
-
kaolin
-
-
-
long-chain polyphosphate
-
-
plasma kallikrein
-
-
-
plasma prekallikrein
-
-
Polyphosphate
-
-
streptokinase SK
-
enzyme activity in plasma increases 2fold over 60 min in patients treated with fibrinolytic agents, tissue plasminogen activator t-PA or with streptokinase SK
-
TGFbeta
-
treatment of human lung fibroblasts with TGF-beta1 results in a time-dependent increase in FXII production, activation of p44/42, p38, JNK, and Akt, and phosphorylation and translocation into the nucleus of Smad3
-
tissue plasminogen activator t-PA
-
enzyme activity in plasma increases 2fold over 60 min in patients treated with fibrinolytic agents, tissue plasminogen activator t-PA or with streptokinase SK
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.012
benzyloxycarbonyl-Ala-Arg-SCH2C6H5
-
-
0.034
benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2
-
-
3.9
benzyloxycarbonyl-Ala-Gly-Arg-4-nitroanilide
-
-
1.5
benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide
-
-
0.103
benzyloxycarbonyl-Arg-SCH2CH(CH3)2
-
-
2.7
benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide
-
-
0.66
benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide
-
-
0.15
benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2
-
-
0.036
benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2
-
-
0.054
benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2
-
-
0.7
benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide
-
-
0.16
benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide
-
-
0.019
benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2
-
-
0.006
benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2
-
-
8.2
benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide
-
-
0.036
benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2
-
-
6.7
benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide
-
-
0.056
benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2
-
-
0.96
benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide
-
-
0.054
benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2
-
-
0.046
benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2
-
-
0.021 - 0.19
D-Pro-Phe-Arg-4-nitroanilide
0.018
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide
-
-
0.0008 - 0.0017
prekallikrein
-
0.054
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
0.1 - 2.7
S-2302
0.18
tert-butyloxycarbonyl-Arg-SCH2C6H5
-
-
0.095
tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
15
benzyloxycarbonyl-Ala-Arg-SCH2C6H5
-
-
14
benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2
-
-
34.6
benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide
-
-
22
benzyloxycarbonyl-Arg-SCH2CH(CH3)2
-
-
18 - 23
benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide
23
benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide
-
-
9.2
benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2
-
-
43
benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2
-
-
15
benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2
-
-
25
benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide
-
-
23
benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide
-
-
2.5
benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2
-
-
8.3
benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2
-
-
14
benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide
-
-
8.3
benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2
-
-
9.2
benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide
-
-
13
benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2
-
-
28
benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide
-
-
11
benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2
-
-
17
benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2
-
-
14 - 15
D-Pro-Phe-Arg-4-nitroanilide
23
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide
-
-
0.000062 - 0.73
prekallikrein
-
1.9
Pro-Phe-Arg-4-methylcoumarin 7-amide
-
-
0.108 - 11.7
S-2302
2.9
tert-butyloxycarbonyl-Arg-SCH2C6H5
-
-
9.2
tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2
-
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.077 - 4333
prekallikrein
-
0.4 - 116.7
S-2302
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000115 - 0.000287
histidine-rich glycoprotein
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
temperature not specified in the publication
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE