Reference on EC 3.4.21.36 - pancreatic elastase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mallory, P.A.; Travis, J.
Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase
Biochemistry
14
722-730
1975
Homo sapiens
Szilagyi, C.M.; Sarfati, P.; Pradayrol, L.; Morisset, J.
Purification, characterization and substrate specificity of rat pancreatic elastase II
Biochim. Biophys. Acta
1251
55-65
1995
Rattus norvegicus
Powers, J.C.; Gupton, B.F.; Harley, A.D.; Nishino, N.; Whitley, R.J.
Specificity of porcine pancreatic elastase, human leukocyte elastase and cathepsin G. Inhibition with peptide chloromethyl ketones
Biochim. Biophys. Acta
485
156-166
1977
Sus scrofa
Largman, C.
Isolation and characterization of rat pancreatic elastase
Biochemistry
22
3763-3770
1983
Rattus norvegicus
Fujimoto, K.; Ogawa, M.; Saito, N.; Kosaki, G.; Minamiura, N.; Yamamoto, T.
A novel method of isolation and some characteristic properties of human pancreatic elastases
Biochim. Biophys. Acta
612
262-267
1980
Homo sapiens
Katagiri, K.; Takeuchi, T.; Taniguchi, K.; Sasaki, M.
One step purification procedure of elastase from pancreatic powder by affinity chromatography
Anal. Biochem.
86
159-165
1978
Sus scrofa
Ohlsson, K.; Olsson, A.S.
Purification and partial characterization of human pancreatic elastase
Hoppe-Seyler's Z. Physiol. Chem.
357
1153-1161
1976
Homo sapiens
Largman, C.; Brodrick, J.W.; Geokas, M.C.
Purification and characterization of two human pancreatic elastases
Biochemistry
15
2491-2500
1976
Homo sapiens
Ardelt, W.
Partial purification and properties of porcine pancreatic elastase II
Biochim. Biophys. Acta
341
318-326
1974
Sus scrofa
Tsunemi, M.; Matsuura, Y.; Sakakibara, S.; Katsube, Y.
Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution
Biochemistry
35
11570-11576
1996
Sus scrofa (P00772), Sus scrofa
Tsunemi, M.; Matsuura, Y.; Sakakibara, S.; Katsube, Y.
Crystallization of a complex between an elastase-specific inhibitor elafin and porcine pancreatic elastase
J. Mol. Biol.
232
310-311
1993
Sus scrofa
Erlendsson, L.S.; Filippsusson, H.
Purification and characterization of ovine pancreatic elastase
Comp. Biochem. Physiol. B
120
549-557
1998
Ovis aries
Berglund, G.I.; Smalas, A.O.; Outzen, H.; Willassen, N.P.
Purification and characterization of pancreatic elastase from North Atlantic salmon (Salmo salar)
Mol. Mar. Biol. Biotechnol.
7
105-114
1998
Salmo salar
Wendorf, P.; Linder, D.; Sziegoleit, A.; Geyer, R.
Carbohydrate structure of human pancreatic elastase 1
Biochem. J.
278
505-514
1991
Homo sapiens
Smine, A.; Gal, Y.L.
Purification and characterization of two pancreatic elastase isoforms from dogfish (Scyliorhinus canicula)
Mol. Mar. Biol. Biotechnol.
4
295-303
1995
Scyliorhinus canicula
Smine, A.; Guerard, F.; Gal, Y.L.
Purification and characterization of pancreatic elastase from tuna (Thunnus albacora)
J. Mar. Biotechnol.
1
41-46
1993
Thunnus albacora
-
Berglund, G.I.; Willassen, N.P.; Hordvik, A.; Smalas, A.O.
Structure of native pancreatic elastase from north atlantic salmon at 1.6 A resolution
Acta Crystallogr. Sect. D
51
925-937
1995
Salmo salar
Mattos, C.; Gianmmona, D.A.; Petsko, G.A.; Ringe, D.
Structural analysis of the active site of porcine pancreatic elastase based on the X-ray crystal structures of complexes with trifluoroacetyl-dipeptide-anilide inhibitors
Biochemistry
34
3193-3203
1995
Sus scrofa
Bode, W.; Meyer Jr., E.; Powers, J.C.
Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors
Biochemistry
28
1951-1963
1989
Sus scrofa
Wendorf, P.; Geyer, R.; Sziegoleit, A.; Linder, D.
Localization and characterization of the glycosylation site of human pancreatic elastase 1
FEBS Lett.
249
275-278
1989
Homo sapiens
Gildberg, A.; Overbo, K.
Purification and characterization of pancreatic elastase from Atlantic cod (Gadus morhua)
Comp. Biochem. Physiol. B
97
775-782
1990
Gadus morhua
Plaskon, R.R.; Kam, C.M.; Burgess, E.M.; Powers, J.C.; Suddath, F.L.
Michaelis complexes of porcine pancreatic elastase with 7-[(alkylcarbamoyl)amino]-4-chloro-3-ethoxyisocoumarins: translational sampling of inhibitor position and kinetic measurements
Proteins
13
141-151
1992
Sus scrofa
Wurtele, M.; Hahn, M.; Hilpert, K.; Hohne, W.
Atomic resolution structure of native porcine pancreatic elastase at 1.1 A
Acta Crystallogr. Sect. D
56
520-523
2000
Sus scrofa
-
Hilpert, K.; Schneider-Mergener, J.; Ay, J.
Crystallization and preliminary X-ray analysis of the complex of porcine pancreatic elastase and a hybrid squash inhibitor
Acta Crystallogr. Sect. D
58
672-674
2002
Sus scrofa (P00772), Sus scrofa
Ay, J.; Hilpert, K.; Krauss, N.; Schneider-Mergener, J.; Hohne, W.
Structure of a hybrid squash inhibitor in complex with porcine pancreatic elastase at 1.8 A resolution
Acta Crystallogr. Sect. D
59
247-254
2003
Sus scrofa
Jaspard, E.
Role of protein-solvent interactions in refolding. Effects of cosolvent additives on the renaturation of porcine pancreatic elastase at various pHs
Arch. Biochem. Biophys.
375
220-228
2000
Sus scrofa
Wright, P.A.; Wilmouth, R.C.; Clifton, I.J.; Schofield, C.J.
'pH-jump' crystallographic analyses of gamma-lactam-porcine pancreatic elastase complexes
Biochem. J.
351
335-340
2000
Sus scrofa
-
Kinoshita, T.; Nakanishi, I.; Sato, A.; Tada, T.
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor
Bioorg. Med. Chem. Lett.
13
21-24
2003
Sus scrofa (P00772), Sus scrofa
Matern, U.; Schleberger, C.; Jelakovic, S.; Weckesser, J.; Schulz, G.E.
Binding structure of elastase inhibitor scyptolin A
Chem. Biol.
10
997-1001
2003
Sus scrofa (P00772), Sus scrofa
Hilpert, K.; Wessner, H.; Schneider-Mergener, J.; Welfle, K.; Misselwitz, R.; Welfle, H.; Hocke, A.C.; Hippenstiel, S.; Hohne, W.
Design and characterization of a hybrid miniprotein that specifically inhibits porcine pancreatic elastase
J. Biol. Chem.
278
24986-24993
2003
Sus scrofa (P00772), Sus scrofa
Zani, M.L.; Nobar, S.M.; Lacour, S.A.; Lemoine, S.; Boudier, C.; Bieth, J.G.; Moreau, T.
Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris
Eur. J. Biochem.
271
2370-2378
2004
Homo sapiens
Ito, N.; Iwamori, Y.; Hanaoka, K.; Iwamori, M.
Inhibition of pancreatic elastase by sulfated lipids in the intestinal mucosa
J. Biochem.
123
107-114
1998
Sus scrofa
Kinoshita, T.; Yamaguchi, A.; Tada, T.
Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase
Acta Crystallogr. Sect. F
62
623-626
2006
Sus scrofa, Sus scrofa (P00772)
Dementiev, A.; Dobo, J.; Gettins, P.G.
Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase
J. Biol. Chem.
281
3452-3457
2006
Sus scrofa, Sus scrofa (P00772)
Hilpert, K.; Wessner, H.; Scholz, C.; Scheerer, P.; Volkmer-Engert, R.; Kraubeta, N.
Crystallization and preliminary X-ray analysis of complexes of porcine pancreatic elastase with two natural inhibitors
Protein Pept. Lett.
11
393-399
2004
Sus scrofa
Tesch, L.D.; Raghavendra, M.P.; Bedsted-Faarvang, T.; Gettins, P.G.; Olson, S.T.
Specificity and reactive loop length requirements for crmA inhibition of serine proteases
Protein Sci.
14
533-542
2005
Sus scrofa
Kinoshita, T.; Tamada, T.; Imai, K.; Kurihara, K.; Ohhara, T.; Tada, T.; Kuroki, R.
Crystallization of porcine pancreatic elastase and a preliminary neutron diffraction experiment
Acta Crystallogr. Sect. F
63
315-317
2007
Sus scrofa (P00772), Sus scrofa
Walkowiak, J.; Wadolowska, L.; Szaflarska-Poplawska, A.; Lisowska, A.; Bugajewska, A.; Przyslawski, J.
The elimination of meat from the diet selectively decreases pancreatic elastase secretion
Br. J. Nutr.
98
154-158
2007
Homo sapiens
Chen, C.Y.; Tsai, W.L.; Wu, H.C.; Syu, M.J.; Wu, C.C.; Shiesh, S.C.
Diagnostic role of biliary pancreatic elastase for cholangiocarcinoma in patients with cholestasis
Clin. Chim. Acta
390
82-89
2008
Homo sapiens (Q9UNI1), Homo sapiens
Naruse, S.; Ishiguro, H.; Ko, S.B.; Yoshikawa, T.; Yamamoto, T.; Yamamoto, A.; Futakuchi, S.; Goto, H.; Saito, Y.; Takahashi, S.
Fecal pancreatic elastase: a reproducible marker for severe exocrine pancreatic insufficiency
J. Gastroenterol.
41
901-908
2006
Homo sapiens
Oliveira, T.F.; Mulchande, J.; Moreira, R.; Iley, J.; Archer, M.
Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor
Protein Pept. Lett.
14
93-95
2007
Sus scrofa
Benahmed, N.A.; Manene, D.; Barbot, L.; Kapel, N.
Fecal pancreatic elastase in infants under 2 years of age
Ann. Biol. Clin. (Paris)
66
549-552
2008
Homo sapiens
Erickson, J.A.; Aldeen, W.E.; Grenache, D.G.; Ashwood, E.R.
Evaluation of a fecal pancreatic elastase-1 enzyme-linked immunosorbent assay: Assessment versus an established assay and implication in classifying pancreatic function
Clin. Chim. Acta
397
87-91
2008
Homo sapiens
Nadarajah, D.; Atkinson, M.A.; Huebner, P.; Starcher, B.
Enzyme kinetics and characterization of mouse pancreatic elastase
Connect. Tissue Res.
49
409-415
2008
Mus musculus
Suzuki, M.; Betsuyaku, T.; Ito, Y.; Nagai, K.; Odajima, N.; Moriyama, C.; Nasuhara, Y.; Nishimura, M.
Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice
Am. J. Physiol. Lung Cell Mol. Physiol.
296
L614-L623
2009
Sus scrofa
Conlon, J.M.; Raza, H.; Coquet, L.; Jouenne, T.; Leprince, J.; Vaudry, H.; King, J.D.
Purification of peptides with differential cytolytic activities from the skin secretions of the Central American frog, Lithobates vaillanti (Ranidae)
Comp. Biochem. Physiol. C
150
150-154
2009
Sus scrofa
Tamada, T.; Kinoshita, T.; Kurihara, K.; Adachi, M.; Ohhara, T.; Imai, K.; Kuroki, R.; Tada, T.
Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond
J. Am. Chem. Soc.
131
11033-11040
2009
Sus scrofa (P00772), Sus scrofa
Inoue, K.; Koike, E.; Yanagisawa, R.; Takano, H.
Extensive analysis of elastase-induced pulmonary emphysema in rats: ALP in the lung, a new biomarker for disease progression?
J. Clin. Biochem. Nutr.
46
168-176
2010
Sus scrofa
Kwan, J.C.; Taori, K.; Paul, V.J.; Luesch, H.
Lyngbyastatins 8-10, elastase inhibitors with cyclic depsipeptide scaffolds isolated from the marine cyanobacterium Lyngbya semiplena
Mar. Drugs
7
528-538
2009
Sus scrofa
Rietschel, B.; Arrey, T.; Meyer, B.; Bornemann, S.; Schuerken, M.; Karas, M.; Poetsch, A.
Elastase digests: New ammunition for shotgun membrane proteomics
Mol. Cell. Proteomics
8
1029-1043
2009
Sus scrofa (P00772), Sus scrofa
Matthew, S.; Paul, V.J.; Luesch, H.
Tiglicamides A-C, cyclodepsipeptides from the marine cyanobacterium Lyngbya confervoides
Phytochemistry
70
2058-2063
2009
Sus scrofa
Bras, N.F.; Goncalves, R.; Fernandes, P.A.; Mateus, N.; Ramos, M.J.; de Freitas, V.
Understanding the binding of procyanidins to pancreatic elastase by experimental and computational methods
Biochemistry
49
5097-5108
2010
Sus scrofa
Herzig, K.; Purhonen, A.; Rsnen, K.; Idziak, J.; Juvonen, P.; Phillps, R.; Walkowiak, J.
Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus
BMC Geriatr.
11
4-4
2011
Homo sapiens
Bras, N.F.; Goncalves, R.; Mateus, N.; Fernandes, P.A.; Ramos, M.J.; de Freitas, V.
Inhibition of pancreatic elastase by polyphenolic compounds
J. Agric. Food Chem.
58
10668-10676
2010
Sus scrofa
Qamar, A.A.; Burke, S.K.; Lafleur, J.D.; Ding, B.C.; Bland, K.S.; Wong, M.D.; Gustafson, P.N.; Blair, A.T.; Franano, F.N.
The ability of serum from alpha 1-antitrypsin-deficient patients to inhibit PRT-201, a recombinant human type I pancreatic elastase
Biotechnol. Appl. Biochem.
59
22-28
2012
Homo sapiens
Qasim, M.A.; Wang, L.; Qasim, S.; Lu, S.; Lu, W.; Wynn, R.; Yi, Z.P.; Laskowski, M.
Additivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB)
FEBS Lett.
587
3021-3026
2013
Sus scrofa
Burke, S.K.; Macdonald, K.; Moss, E.; Bunton, D.; Starcher, B.; Wong, M.D.; Bland, K.S.; Franano, F.N.
Effects of recombinant human type I pancreatic elastase on human atherosclerotic arteries
J. Cardiovasc. Pharmacol.
64
530-535
2014
Homo sapiens
Hofbauer, S.; Brito, J.A.; Mulchande, J.; Nogly, P.; Pessanha, M.; Moreira, R.; Archer, M.
Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking
Acta Crystallogr. Sect. F
71
1346-1351
2015
Sus scrofa
Sadeghi-Kaji, S.; Shareghi, B.; Saboury, A.A.; Farhadian, S.
Spectroscopic and molecular docking studies on the interaction between spermidine and pancreatic elastase
Int. J. Biol. Macromol.
131
473-483
2019
Sus scrofa
Boros, E.; Szabo, A.; Zboray, K.; Heja, D.; Pal, G.; Sahin-Toth, M.
Overlapping specificity of duplicated human pancreatic elastase 3 isoforms and archetypal porcine elastase 1 provides clues to evolution of digestive enzymes
J. Biol. Chem.
292
2690-2702
2017
Homo sapiens, Sus scrofa
Stergiou, P.Y.; Foukis, A.; Gkini, O.A.; Bieth, J.G.; Papamichael, E.M.
Kinetic and computational analysis of the reversible inhibition of porcine pancreatic elastase a structural and mechanistic approach
J. Enzyme Inhib. Med. Chem.
31
131-139
2016
Sus scrofa
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