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Information on EC 3.4.21.26 - prolyl oligopeptidase and Organism(s) Homo sapiens and UniProt Accession P48147

for references in articles please use BRENDA:EC3.4.21.26

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IUBMB Comments

Found in vertebrates, plants and Flavobacterium. Generally cytosolic, commonly activated by thiol compounds. Type example of peptidase family S9

The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides

Synonyms
prolyl oligopeptidase, fibroblast activation protein, proline endopeptidase, post-proline cleaving enzyme, prolylendopeptidase, proline-specific endopeptidase, post-proline endopeptidase, glutenase, prolyl endoprotease, pepo2, more

SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
prolyl endopeptidase
-
prolyl oligopeptidase
-
endoprolylpeptidase
-
-
-
-
fibroblast activation protein
-
-
peptidase, postproline endo-
-
-
-
-
post prolyl cleaving enzyme
-
-
post-proline cleaving enzyme
post-proline endopeptidase
postproline endopeptidase
-
-
-
-
postproline-cleaving enzyme
-
-
-
-
PPCE
-
-
proline endopeptidase
-
-
-
-
proline-specific endopeptidase
-
-
-
-
prolyl endopeptidase
prolyl oligopeptidase
-
-
prolylendopeptidase
-
-
additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
72162-84-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
bradykinin + H2O
?
show the reaction diagram
-
-
-
?
Gly-Pro-4-nitrophenyl ester + H2O
Gly-Pro + 4-nitrophenol
show the reaction diagram
-
-
-
?
N-benzyloxycarbonyl-Gly-Pro-4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-Gly-Pro + 4-nitrophenol
show the reaction diagram
-
-
-
?
succinyl-Ala-Pro-4-nitrophenyl ester + H2O
succinyl-Ala-Pro + 4-nitrophenol
show the reaction diagram
-
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
(S)-benzyl 2-(2-(4-hydroxynaphthalen-1-ylcarbamoyl)pyrrolidin-1-yl)-2-oxoethylcarbamate + H2O
?
show the reaction diagram
-
specific substrate, UAMC-00682
-
-
?
2-aminobenzoyl-EGPQGLLGA-3-nitrotyrosyl-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-FFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
2-aminobenzoyl-FP + Q-(N-(2,4-dinitrophenyl)ethylenediamine)
show the reaction diagram
-
-
-
?
2-aminobenzoyl-FSQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-Glu-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro-L-Phe-Gly-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-Gly-L-Phe-Gly-L-Pro + L-Phe-Gly-L-4-nitrophenylalanine-L-Ala
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro-L-4-nitrophenylalanine-L-Arg-L-Ala + H2O
2-aminobenzoyl-Gly-L-Phe-L-Arg-L-Pro + L-4-nitrophenylalanine-L-Arg-L-Ala
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-L-Ser-L-Pro-L-4-nitrophenylalanine-L-Ala + H2O
2-aminobenzoyl-L-Ser-L-Pro + 4-nitrophenylalanine-L-Ala
show the reaction diagram
-
-
-
-
?
2-aminobenzoyl-RPPGFQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
2-aminobenzoyl-RPP + GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
show the reaction diagram
-
-
-
?
2-aminobenzoyl-SPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine) + H2O
?
show the reaction diagram
-
-
-
?
4-((4-(dimethylamino)phenyl)azo)benzoyl-GPQGLLGA-L-glutamyl-gamma-(2-(1-sulfonyl-5-naphthyl)-aminoethylamide)-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Abz-Ala-Ala-Pro-4-nitrophenylalanine + H2O
Abz-Ala-Ala-Pro + 4-nitrophenylalanine
show the reaction diagram
-
about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Ala-4-nitrophenylalanine + H2O
Abz-Ala-Pro + L-Ala-4-nitrophenylalanine
show the reaction diagram
-
about 10% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Ala-Pro-Gly-4-nitrophenylalanine + H2O
Abz-Ala-Pro + Gly-4-nitrophenylalanine
show the reaction diagram
-
about 20% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Gly-Pro + 4-nitrophenylalanine
show the reaction diagram
-
about 2% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Gly-L-Phe-L-Arg-L-Pro-L-Phe(NO2)-L-Arg-L-Ala + H2O
Abz-Gly-L-Phe-L-Arg-L-Pro + L-Phe(NO2)-L-Arg-L-Ala
show the reaction diagram
-
-
-
-
?
Abz-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine + H2O
Abz-Gly-L-Phe-L-Ser-L-Pro + L-Phe-L-Arg-L-Ser-L-Ser-L-Arg-L-Ile-Gly-L-Glu-L-Ile-L-Lys-L-Glu-L-Glu-L-Gln-N-(2,4-dinitrophenyl)-ethylenediamine
show the reaction diagram
-
-
-
-
?
Abz-Gly-Pro-4-nitrophenylalanine + H2O
Abz-Gly-Pro + 4-nitrophenylalanine
show the reaction diagram
-
about 7% activity compared to Abz-Lys-Pro-4-nitrophenylalanine
-
-
?
Abz-Lys-Pro-4-nitrophenylalanine + H2O
Abz-Lys-Pro + 4-nitrophenylalanine
show the reaction diagram
-
100% activity
-
-
?
alpa2-antiplasmin + H2O
?
show the reaction diagram
-
not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-synuclein + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin II + H2O
?
show the reaction diagram
-
-
-
-
?
arginine-vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide + H2O
benzyloxycarbonyl-Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-doxorubicin + H2O
benzyloxycarbonyl-Gly-L-Pro + doxorubicin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-L-Pro-melphalan + H2O
benzyloxycarbonyl-Gly-L-Pro + melphalan
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
beta-amyloid + H2O
?
show the reaction diagram
-
-
-
-
?
beta-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
show the reaction diagram
-
-
-
-
?
collagen + H2O
N-acetyl-Pro-Gly-Pro + ?
show the reaction diagram
-
after enzyme activation with LPS
-
-
?
collagen + H2O
Pro-Gly-Pro + ?
show the reaction diagram
-
after enzyme activation with LPS
-
-
?
GEPGPPGPA + H2O
GEP + GPPGP + L-Ala
show the reaction diagram
-
-
-
-
?
GFSPFRQED + H2O
GFSP + FRQED
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
gonadotropin releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
GTAGPNQEQE + H2O
GTAGP + NQEQE
show the reaction diagram
-
-
-
-
?
GTSGPNQEQE + H2O
GTSGP + NQEQE
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-7-amido-4-methylcoumarin + H2O
L-Lys-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
about 5% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
Luliberin + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
show the reaction diagram
-
as active as potentiator B
-
?
melanotropin + H2O
?
show the reaction diagram
-
-
-
-
?
membrane-associated glycoprotein neural cell adhesion molecule + H2O
?
show the reaction diagram
-
-
-
-
?
Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O
Met-Lys-Arg-Pro-Pro + Gly-Phe-Ser-Pro-Phe-Arg
show the reaction diagram
-
as active as potentiator B
-
?
N-carbobenzoxy-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-carbobenzoxy-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-carbobenzyloxy-Ala-Pro-2-naphthylamide + H2O
N-carbobenzyloxy-Ala-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
N-succinyl-Ala-Ala-Ala-4-nitroanilide
N-succinyl-Ala-Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
N-succinyl-Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-succinyl-Gly-Pro-OH + H2O
?
show the reaction diagram
-
-
-
-
?
N-succinyl-glycyl-proline-4-methylcoumarin-7-amide + H2O
N-succinyl-glycyl-proline + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-succinyl-glycyl-prolyl-7-amido-4-methylcoumarin + H2O
N-succinyl-glycyl-prolyl + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
?
show the reaction diagram
-
-
-
-
?
oxytocin + H2O
?
show the reaction diagram
-
-
-
-
?
oxytoxin + H2O
?
show the reaction diagram
-
-
-
-
?
Peptides + H2O
?
show the reaction diagram
-
metabolism of peptides containing altered aspartyl residues
-
-
?
pGlu-Gly-Leu-Pro-Pro-Arg-Pro + H2O
pGlu-Gly-Leu-Pro-Pro + Arg-Pro
show the reaction diagram
-
i.e. potentiator B
-
?
pGlu-Gly-Leu-Pro-Pro-Gly-Pro + H2O
pGlu-Gly-Leu-Pro-Pro + Gly-Pro
show the reaction diagram
-
i.e. potentiator C, as active as potentiator B
-
?
polysialylated membrane-associated glycoprotein neural cell adhesion molecule + H2O
?
show the reaction diagram
-
-
-
-
?
RPKPQQFFGLM + H2O
L-Arg-L-Pro + L-Lys-L-Pro + QQFFGLM
show the reaction diagram
-
-
-
-
?
RPPGFSPFR + H2O
?
show the reaction diagram
-
i.e. bradykinin, 90% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro
-
?
RPPGFSPFR-amide + H2O
RPP + GFSPFR-amide
show the reaction diagram
-
i.e. bradykinin, 70% of the activity with potentiator B, i.e. pGlu-Gly-Leu-Pro-Pro-Arg-Pro
-
?
SPRY2 + H2O
?
show the reaction diagram
-
not an in vivo substrate of fibroblast activation protein
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Gly-Pro-4-methylcoumarin 7-amide + H2O
?
show the reaction diagram
-
-
-
-
?
succinyl-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-4-methylcoumaryl-7-amide
?
show the reaction diagram
-
-
-
-
?
succinyl-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin + H2O
succinyl-Gly-Pro-Leu-Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
about 58% activity compared to Z-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
?
tau protein + H2O
?
show the reaction diagram
-
-
-
-
?
thymosin beta4 + H2O
acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?
show the reaction diagram
-
-
-
-
?
thyroliberin + H2O
?
show the reaction diagram
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
tuftsin + H2O
?
show the reaction diagram
-
-
-
-
?
Vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Ala-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ala-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 90% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Arg-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Arg-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 87% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asn-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asn-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Asp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Asp-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 5% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gln-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gln-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 38% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Glu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Glu-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 18% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gly-L-Pro-4-nitroanilide + H2O
Z-Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Z-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Z-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Z-Gly-Pro-2-naphthylamide + H2O
Z-Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Z-Gly-Pro-4-nitroanilide + H2O
Z-Gly-Pro + p-nitroaniline
show the reaction diagram
-
assay at 37┬░C
-
-
?
Z-Gly-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Gly-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 22% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin
Z-Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
assay at pH 8.0, 37┬░C, reaction stopped with sodium acetate
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Gly-Pro-7-amido-4-methylcoumarin + H2O
z-Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Z-His-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-His-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 58% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ile-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ile-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 92% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Leu-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Leu-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 70% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Lys-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
100% activity
-
-
?
Z-Met-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Met-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 68% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Phe-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Phe-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 48% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Pro-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Pro-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 3% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Ser-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Ser-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 30% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Thr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Thr-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 75% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Trp-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Trp-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 23% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Tyr-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Tyr-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 60% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
Z-Val-Pro-7-amido-4-carbamoylmethylcoumarin + H2O
Z-Val-Pro + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
-
about 20% activity compared to Z-Lys-Pro-7-amido-4-carbamoylmethylcoumarin
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
bradykinin + H2O
?
show the reaction diagram
-
-
-
?
alpa2-antiplasmin + H2O
?
show the reaction diagram
-
not a robust substrate in vitro, the enzyme cleaves after Pro12 in the T9S10G11P12-N13 Q14E15Q16E17 sequence
-
-
?
alpha-melanocyte-stimulating hormone + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-synuclein + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin II + H2O
?
show the reaction diagram
-
-
-
-
?
arginine-vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-amyloid + H2O
?
show the reaction diagram
-
-
-
-
?
beta-endorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin potentiating peptide + H2O
?
show the reaction diagram
-
-
-
-
?
gonadotropin releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
Luliberin + H2O
?
show the reaction diagram
-
-
-
-
?
melanotropin + H2O
?
show the reaction diagram
-
-
-
-
?
membrane-associated glycoprotein neural cell adhesion molecule + H2O
?
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
?
show the reaction diagram
-
-
-
-
?
oxytocin + H2O
?
show the reaction diagram
-
-
-
-
?
oxytoxin + H2O
?
show the reaction diagram
-
-
-
-
?
Peptides + H2O
?
show the reaction diagram
-
metabolism of peptides containing altered aspartyl residues
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
tau protein + H2O
?
show the reaction diagram
-
-
-
-
?
thymosin beta4 + H2O
acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro + ?
show the reaction diagram
-
-
-
-
?
thyroliberin + H2O
?
show the reaction diagram
-
-
-
-
?
thyrotropin releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
tuftsin + H2O
?
show the reaction diagram
-
-
-
-
?
Vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
i.e. KYP-2047, hyperbolic kinetics of KYP-2047 binding to human PREP with pseudo-firstorder rate constant, Van't Hoff plot for binding of KYP-2047 to human PREP, a covalent bond is formed between the nitrile group of KYP-2047 and the active site serine
Boc-Asn-Phe-Pro-aldehyde
-
Z-Pro-Pro-aldehyde-dimethyl acetal
-
((8'Z)-pentadecenyl)-salicylic acid
-
a noncompetitive inhibitor isolated from Gingko biloba leaves
(1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid
-
81.9% inhibition at 0.5 mM
(1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid
-
88% inhibition at 0.5 mM
(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
-
93.8% inhibition at 0.5 mM
(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
-
29.4% inhibition at 0.5 mM
(2E)-3-(4-methoxyphenyl)prop-2-enoic acid
-
less than 10% inhibition at 0.5 mM
(2E)-3-phenylprop-2-enoic acid
-
16.1% inhibition at 0.5 mM
(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid
-
72.9% inhibition at 0.5 mM
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxo- ethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2- carbonitrile
-
potent and selective inhibitor of FAP, 0.01 mM used in assay conditions
(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indole
-
S-17092
(3S)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(2,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(2,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(3,5-difluorobenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-tert-butylbenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-6-[(4-tert-butylbenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-(2,2,2-trifluoroethoxy)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-(2-phenylethyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,4-dichlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(3-chloro-4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-chlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(1H-pyrazol-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[(4-methoxybenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(3S)-8-acetyl-6-[2-(4-fluorophenyl)ethyl]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one
-
-
(5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
-
88.3% inhibition at 0.5 mM
(6S)-1,3-dichloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(cyclohexylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(naphthalen-2-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-(pyridin-4-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one
-
-
(6S)-1-chloro-3-phenoxy-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one