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Disease on EC 3.4.21.117 - stratum corneum chymotryptic enzyme

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression of human kallikrein 7 (hK7/SCCE) and its inhibitor antileukoprotease (ALP/SLPI) in uterine endocervical glands and in cervical adenocarcinomas.
Expression of kallikrein-related peptidase 7 predicts poor prognosis in patients with unresectable pancreatic ductal adenocarcinoma.
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin.
The extracellular matrix protein fibronectin is a substrate for kallikrein 7.
Alzheimer Disease
Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Breast Neoplasms
Evaluation of Kallikrein-related Peptidase 5 Expression and its Significance for Breast Cancer Patients: Association with Kallikrein-related Peptidase 7 Expression.
Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma.
Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer.
Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer.
Carcinogenesis
Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia.
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
The Role of Kallikrein 7 in Tumorigenesis.
Carcinoma
Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors.
Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression.
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression.
Immunohistochemical expression of kallikrein 7 in oral squamous cell carcinoma.
Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.
The Co-Expression of Kallikrein 5 and Kallikrein 7 Associates with Poor Survival in Non-HPV Oral Squamous-Cell Carcinoma.
Carcinoma, Ovarian Epithelial
Kallikrein-related peptidase 7 promotes multicellular aggregation via the alpha(5)beta(1) integrin pathway and paclitaxel chemoresistance in serous epithelial ovarian carcinoma.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
Colonic Neoplasms
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
Colorectal Neoplasms
Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer.
Dermatitis
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Dermatitis, Atopic
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Evaluation of kallikrein 7 as a disease-causing gene for canine atopic dermatitis using microsatellite-based association mapping.
Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease.
Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis.
The 3'-UTR AACCins5874 in the stratum corneum chymotryptic enzyme gene (SCCE/KLK7), associated with atopic dermatitis; causes an increased mRNA expression without altering its stability.
Eczema
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
Transcriptional gene silencing of kallikrein 5 and kallikrein 7 using siRNA prevents epithelial cell detachment induced by alkaline shock in an in vitro model of eczema.
Frontotemporal Dementia
Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia.
Ichthyosis
Expression of stratum corneum chymotryptic enzyme in ichthyoses and squamoproliferative processes.
Skin Barrier Function Is Not Impaired and Kallikrein 7 Gene Polymorphism Is Frequently Observed in Korean X-linked Ichthyosis Patients Diagnosed by Fluorescence in Situ Hybridization and Array Comparative Genomic Hybridization.
Insulin Resistance
Role of Kallikrein 7 in Body Weight and Fat Mass Regulation.
Melanoma
Aberrant expression of kallikrein-related peptidase 7 is correlated with human melanoma aggressiveness by stimulating cell migration and invasion.
Cell adhesion and communication proteins are differentially expressed in melanoma progression model.
Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype.
Neoplasm Metastasis
Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia.
Neoplasms
3D-quantitative structure-activity relationship and docking studies of coumarin derivatives as tissue kallikrein 7 inhibitors.
An unexpected switch in peptide binding mode: from simulation to substrate specificity.
Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia.
Definition of an immunogenic region within the ovarian tumor antigen stratum corneum chymotryptic enzyme.
Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium.
Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer.
Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding.
Expression of kallikrein-related peptidase 7 is decreased in prostate cancer.
Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors.
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
Isomannide derivatives as new class of inhibitors for human kallikrein 7.
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin.
Kallikrein-related peptidase 7 (KLK7) is a proliferative factor that is aberrantly expressed in human colon cancer.
Parallel underexpression of kallikrein 5 and kallikrein 7 mRNA in breast malignancies.
The extracellular matrix protein fibronectin is a substrate for kallikrein 7.
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells.
The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease.
SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7.
Nevus
Cell adhesion and communication proteins are differentially expressed in melanoma progression model.
Obesity
Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.
Ovarian Neoplasms
Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer.
Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family.
Expression of the protease inhibitor antileukoprotease and the serine protease stratum corneum chymotryptic enzyme (SCCE) is coordinated in ovarian tumors.
Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression.
Integration of two in-depth quantitative proteomics approaches determines the kallikrein-related peptidase 7 (KLK7) degradome in ovarian cancer cell secretome.
Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer.
Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols.
Pancreatic Neoplasms
Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer.
Expression of kallikrein 7 diminishes pancreatic cancer cell adhesion to vitronectin and enhances urokinase-type plasminogen activator receptor shedding.
Kallikrein 7 enhances pancreatic cancer cell invasion by shedding E-cadherin.
Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Prostatic Neoplasms
Expression of kallikrein-related peptidase 7 is decreased in prostate cancer.
Expression of the serine protease kallikrein 7 and its inhibitor antileukoprotease is decreased in prostate cancer.
Human kallikrein 7 induces epithelial-mesenchymal transition-like changes in prostate carcinoma cells: a role in prostate cancer invasion and progression.
Immunohistochemical localization and analysis of kallikrein-related peptidase 7 and 11 expression in paired cancer and benign foci in prostate cancer patients.
Pruritus
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Psoriasis
Crystallization and preliminary crystallographic studies of human kallikrein 7, a serine protease of the multigene kallikrein family.
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Stratum corneum chymotryptic enzyme in psoriasis.
Skin Diseases
A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7.
A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases.
An unexpected switch in peptide binding mode: from simulation to substrate specificity.
Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis.
Generation of a quenched phosphonate activity-based probe for labelling the active KLK7 protease.
Generation of recombinant antibodies against human tissue kallikrein 7 to treat skin diseases.
Pyrido-imidazodiazepinones as a new class of reversible inhibitors of human kallikrein 7.
Sleep Deprivation
Sleep loss and cytokines levels in an experimental model of psoriasis.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical expression of kallikrein 7 in oral squamous cell carcinoma.
Stomach Neoplasms
Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer.
Uterine Cervical Neoplasms
Serum human kallikrein 7 represents a new marker for cervical cancer.
The serine protease stratum corneum chymotryptic enzyme (kallikrein 7) is highly overexpressed in squamous cervical cancer cells.