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(7-methoxycoumarin-4-yl)AIRRVSYSF-(5-amino-2-nitro)benzamide + H2O
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Thr-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Thr + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Val + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoic acid-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoic acid-Ile-Met-Val + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Val + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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?
2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
2-aminobenzoyl-Ile-Met-Val + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
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Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O
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(35S) Met-labeled proteolytically inactive S306 form of full length HtrA2 + H2O
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(7-methoxycoumarin-4-yl)acetyl-IRRVSYSF(Dnp)KK + H2O
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best substrate
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(7-methoxycoumarin-4-yl)acetyl-VTLCAVPS(Dnp)KK + H2O
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cleavage occurs between cysteine and alanine
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35S-beta-casein + H2O
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C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity
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A beta 40
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HtrA2/Omi binds preferentially to the short form of A beta peptides, the enzyme does not perform degradation by direct hydrolysis
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A beta 42
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HtrA2/Omi binds poorly to A beta 42, the enzyme does not perform degradation by direct hydrolysis
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Ala(7-methoxycoumarin-4-acetic acid)-IRRVSYSF-(5-amido-2-nitrobenzamide) + H2O
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alpha-casein + H2O
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alpha-secretase peptide
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HtrA2/Omi does not perform degradation by direct hydrolysis
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amyloid precursor protein + H2O
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amyloid precursor protein-like protein 1 + H2O
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processed into two major fragments of 65 and 67 kDa
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?
amyloid precursor protein-like protein 2 + H2O
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processed into cleaved fragments of 103 and 109 kDa
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beta-casein
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protease activity is activated by the binding of the PDZ domain of the mature form of Omi to the C-terminal region of the reduced form of Pag
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beta-secretase peptide
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HtrA2/Omi does not perform degradation by direct hydrolysis
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c-inhibitor of apoptosis protein1 + H2O
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C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
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c-inhibitor of apoptosis protein2 + H2O
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C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
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Fas-Fas L + H2O
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FLIP + H2O
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Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein
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gamma-secretase peptide
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HtrA2/Omi binds less strongly to gamma-secretase substrate peptide as compared to alpha-secretase substrate peptide and beta-secretase substrate peptide, the enzyme does not perform degradation by direct hydrolysis
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glycoprotein alpha1 + H2O
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HS1-associated protein X1 + H2O
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HAX-1
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hyaluronidase + H2O
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inhibitor of apoptosis + H2O
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IAP
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parkin + H2O
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using cleavage and binding assays, it is demonstrated that HtrA2 specifically binds to and directly cleaves the E3 ubiquitin ligase Parkin
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PDZ-interacting peptides + H2O
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PED-PEA 15 + H2O
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death effector domain-containing protein
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ped/pea-15
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HtrA2 is a specific interactor of the ped/pea-15 death effector domain and leads to its degradation
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reduced bovine serum albumin
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HtrA2-Opt peptides stimulate the delta N-HtrA1 protease activity more than 3fold
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thanatos-associated protein 5 (THAP5) + H2O
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in a yeast two-hybrid assay it is shown that Omi/HtrA2 protease interacts with thanatos-associated protein 5. Degradation assays show that thanatos-associated protein 5 is cleaved by Omi/HtrA2
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?
unidentified substrate + H2O
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its cleavage by Omi/HtrA2 leads to permeabilization of the mitochondria outer membrane and release of chytochrome c followed by enhanced caspase activation
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WARTS kinase + H2O
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WARTS, WTS, large tumor-suppressor 1 mitotic kinase
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Wilms' tumor suppressor 1 + H2O
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Wilms' tumor suppressor protein WT1 + H2O
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X-linked inhibitor of apoptosis protein + H2O
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additional information
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alpha-casein + H2O
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alpha-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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preferred substrate
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amyloid precursor protein + H2O
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amyloid precursor protein + H2O
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APP
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amyloid precursor protein + H2O
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efficient cleavage by HtrA2 in the normal physiological condition. HtrA2-mediated cleavage product is the C161 fragment encompassing amino acids 535695 of amyloid precursor protein 695. Mature HtrA2 and full-length HtrA2 can process amyloid precursor protein into C161
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Apollon + H2O
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HtrA2 cleaves Apollon, a huge inhibitor of apoptosis protein, with its serine protease activity, conversely, Apollon ubiquitylates and facilitates proteasomal degradation of HtrA2, thus both downregulate each other
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Apollon + H2O
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BRUCE-apollon
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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beta-casein + H2O
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main selectivity at position P1 is for non-polar aliphatic amino acids, in particular valine, isoleucine and methionine. At the P2 and P3 positions arginine is selected most strongly with a secondary selection for other hydrophilic residues
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casein + H2O
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casein + H2O
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strong hydrolytic activity
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Wilms' tumor suppressor 1 + H2O
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bona fide substrate for HtrA2-mediated proteolysis, cleavage sites are in the C terminus at Val286 and Leu320, resulting in fragments of 20000 and 35000 Da, respectively, while another cleavage site is in the N terminus at Leu91 adjacent to suppression domain
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Wilms' tumor suppressor 1 + H2O
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HtrA2 cleaves at, at least, two specific sites. Wilms' tumor suppressor 1 degradation by HtrA2 reveals two major proteolytic products of 20000 Da and 15000 Da, but the same samples immunoblotted with N-Ter antibody reveals major fragment sizes of 35000 Da and 30000 Da. The potential cleavage site that produces the 20000 Da fragment is at Val286, and the potential cleavage site producing the 15000 Da fragment is at Leu320
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Wilms' tumor suppressor protein WT1 + H2O
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Wilms' tumor suppressor protein WT1 + H2O
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using a yeat two-hybrid assay WT1 is identified as a binding partner of HtrA2/Omi. HtrA2/Omi cleaves WT1 at multiple binding sites following the treatment of cells with cytotoxic drugs
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X-linked inhibitor of apoptosis protein + H2O
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X-linked inhibitor of apoptosis protein + H2O
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autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death
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X-linked inhibitor of apoptosis protein + H2O
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BIR2
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X-linked inhibitor of apoptosis protein + H2O
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C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity
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X-linked inhibitor of apoptosis protein + H2O
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homotrimeric structure of enzyme is required for executing its activity
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X-linked inhibitor of apoptosis protein + H2O
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Omi/HtrA2 cleaves as well as directly binds and inactivates X-linked inhibitor of apoptosis protein to promote caspase activation
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additional information
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role in apoptosis
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additional information
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role in apoptosis
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additional information
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role in apoptosis, degradation of aberrantly folded proteins during conditions of cellular stress
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additional information
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role in apoptosis, degradation of aberrantly folded proteins during conditions of cellular stress
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additional information
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allostery does regulate HtrA2 activity using a non-canonical selective binding pocket in HtrA2 which initiates signal propagation to the distal active site through a complex allosteric mechanism
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additional information
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Omi can degrade inhibitor of apoptosis proteins
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additional information
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can promote caspase activation and cell death apoptosis
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additional information
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induces atypical cell death. Inhibits the caspase-inhibitory activity of XIAP by direct binding to it. Only mature form but not its precursor binds to IAPs
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additional information
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role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity
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additional information
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role in apoptosis, binds to XIAP-binding protein
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additional information
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role in apoptosis, enzyme can induce apoptosis in a caspase-independent manner through its protease activity and in a caspase-dependent manner via its ability to disrupt caspase-IAP interaction
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additional information
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does not bind the reversed control peptide A beta 41-1 and peptide H2-Opt
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additional information
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beta-synuclein is not cleaved by HtrA2
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additional information
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degradation of inhibitor of apoptosis proteins, IAPs
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additional information
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HtrA2 cleaves p73alpha in the C-terminal portion
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additional information
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co-immunoprecipitation show direct interaction of Omi/HtrA2 with optic atrophy protein 1 (OPA1)
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additional information
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HtrA2 fails to cleave the Wilms' tumor suppressor 1 cofactors Par-4 and BASP1
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Acute Kidney Injury
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
Adenocarcinoma
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
aldehyde dehydrogenase (nad+) deficiency
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Alzheimer Disease
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
Alzheimer Disease
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation.
Alzheimer Disease
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Alzheimer Disease
Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.
Alzheimer Disease
Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease.
Alzheimer Disease
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Amyotrophic Lateral Sclerosis
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis.
Brain Diseases
Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction.
Brain Diseases
Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.
Brain Injuries
Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain.
Brain Injuries
UCF-101, a novel Omi/HtrA2 inhibitor, protects against cerebral ischemia/reperfusion injury in rats.
Brain Ischemia
Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.
Brain Ischemia
The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion.
Carcinogenesis
Activation of apoptosis in hepatocellular carcinoma by the Chinese traditional medicine Hu Qisan.
Carcinogenesis
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Carcinoma
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
Carcinoma
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Carcinoma
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Carcinoma
[The prognostic significance of Omi/HtrA2 expression, and correlation between Omi/HtrA2 and hypoxia-inducible factor-1? in primary hepatocelluar carcinoma cells].
Carcinoma, Hepatocellular
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
Carcinoma, Hepatocellular
Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
Carcinoma, Hepatocellular
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The expression and clinical significance of Omi/Htra2 in hepatocellular carcinoma.
Carcinoma, Renal Cell
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
Cardiomegaly
Response of caspase-independent apoptotic factors to high salt diet-induced heart failure.
Cerebral Hemorrhage
Increased expression of Apo-J and Omi/HtrA2 after Intracerebral Hemorrage in rats.
Colonic Neoplasms
Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria.
Colonic Neoplasms
Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.
Cytomegalovirus Infections
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA).
Deafness
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
Dementia
Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Dementia
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Dementia
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Dystonia
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
endopeptidase la deficiency
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Essential Tremor
Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease.
Essential Tremor
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Heart Failure
Response of caspase-independent apoptotic factors to high salt diet-induced heart failure.
htra2 peptidase deficiency
HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.
htra2 peptidase deficiency
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
htra2 peptidase deficiency
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Huntington Disease
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Huntington Disease
Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.
Infarction, Middle Cerebral Artery
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Infections
Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53-mediated down-regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis.
Infections
Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway.
Infertility, Male
[Expression of Omi/HtrA2 UP-regulated in the spermatozoa of chronic bacterial prostatitis patients]
Leukemia
Can application of serine protease inhibitors TPCK and TLCK provide evidence for possible involvement of serine protease Omi/HtrA2 in imatinib mesylate-induced cell death of BCR-ABL-positive human leukemia cells?
Leukemia
Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK).
Leukemia, Lymphocytic, Chronic, B-Cell
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Liver Cirrhosis
Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells.
Lung Neoplasms
[Inhibitory effect and the mechanism of Astragalus polysaccharide combined with cisplatin on growth of inplanted Lewis lung carcinoma in mice].
Lymphatic Metastasis
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
Lymphatic Metastasis
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Lymphoma
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Expression of AIF and HtrA2/Omi in small lymphocytic lymphoma and diffuse large B-cell lymphoma.
Melanoma
Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase.
Movement Disorders
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.
Multiple Myeloma
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Myocardial Ischemia
Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.
Neoplasm Metastasis
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
Neoplasm Metastasis
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Neoplasms
Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways.
Neoplasms
Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.
Neoplasms
HtrA2, taming the oncogenic activities of WT1.
Neoplasms
Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.
Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
Neoplasms
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.
Neoplasms
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Neoplasms
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.
Neoplasms
Mitochondrial proteases and cancer.
Neoplasms
Omi/HtrA2 pro-apoptotic marker differs in various hepatocellular carcinoma cell lines owing to ped/pea-15 expression level.
Neoplasms
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.
Neoplasms
Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.
Neoplasms
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
Neoplasms
The Expression and Clinical Significance of Omi/Htra2 in Hepatocellular Carcinoma.
Neoplasms
Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization.
Neoplasms
YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways.
Neoplasms
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Neoplasms
[Inhibitory effect and the mechanism of Astragalus polysaccharide combined with cisplatin on growth of inplanted Lewis lung carcinoma in mice].
Neuroblastoma
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Neuroblastoma
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Neurodegenerative Diseases
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Neurodegenerative Diseases
Association of Omi/HtrA2 with ?-secretase in mitochondria.
Neurodegenerative Diseases
Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.
Neurodegenerative Diseases
HtrA2/Omi, a sheep in wolf's clothing.
Neurodegenerative Diseases
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer.
Neurodegenerative Diseases
Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
Neurodegenerative Diseases
Pathogenic Role of Serine Protease HtrA2/Omi in Neurodegenerative Diseases.
Neurodegenerative Diseases
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.
Neurodegenerative Diseases
Temperature-induced changes of HtrA2(Omi) protease activity and structure.
Neurodegenerative Diseases
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
Neurodegenerative Diseases
The mitochondrial serine protease HtrA2/Omi: an overview.
Optic Atrophy
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Ovarian Neoplasms
Regulation of HtrA2/Omi by X-linked inhibitor of apoptosis protein in chemoresistance in human ovarian cancer cells.
Parkinson Disease
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Parkinson Disease
Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.
Parkinson Disease
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Parkinson Disease
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
Parkinson Disease
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.
Parkinson Disease
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.
Parkinson Disease
Genetic variation of Omi/HtrA2 and Parkinson's disease.
Parkinson Disease
Genetic variations of Omi/HTRA2 in Chinese patients with Parkinson's disease.
Parkinson Disease
Genetics of Parkinson disease and essential tremor.
Parkinson Disease
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies.
Parkinson Disease
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Parkinson Disease
Loss of GSK-3? mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype.
Parkinson Disease
Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo.
Parkinson Disease
Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: Relevance to Parkinson's disease.
Parkinson Disease
Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis.
Parkinson Disease
Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease.
Parkinson Disease
Mitochondrial Serine Protease HTRA2 p.G399S in a Female with Di George Syndrome and Parkinson's Disease.
Parkinson Disease
Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Parkinson Disease
Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.
Parkinson Disease
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
Parkinson Disease
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.
Parkinson Disease
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.
Parkinson Disease
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
Parkinson Disease
The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy.
Parkinson Disease
The mitochondrial serine protease HtrA2/Omi: an overview.
Parkinson Disease
The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.
Parkinsonian Disorders
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
Peripheral Nervous System Diseases
Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi.
Progeria
Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver.
Prostatic Hyperplasia
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.
Prostatic Neoplasms
The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
Prostatic Neoplasms
[Effects of Omi/HtrA2 on expression of anti-apoptotic protein PED/PEA-15 and apoptosis of prostate cancer cell line PC-3]
Prostatitis
Reduced semen quality in chronic prostatitis patients that induce the release of apoptotic protein Omi/HtrA2 from spermatozoa.
Prostatitis
Retraction: Reduced semen quality in chronic prostatitis patients that induce the release of apoptotic protein Omi/HtrA2 from spermatozoa.
Prostatitis
[Expression of Omi/HtrA2 UP-regulated in the spermatozoa of chronic bacterial prostatitis patients]
Rectal Neoplasms
YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways.
Renal Insufficiency
Acute renal failure in zebrafish: a novel system to study a complex disease.
Retinal Degeneration
The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi.
Sarcopenia
Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia.
Status Epilepticus
Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain.
Stomach Neoplasms
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
Stomach Neoplasms
[Association of Omi/HtrA2 expression and prognosis in patients with gastric carcinoma.]
Synucleinopathies
Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.
Ureteral Obstruction
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.
Uterine Cervical Neoplasms
Role of Smac, survivin, XIAP, and Omi/HtrA2 proteins in determining the chemotherapeutic response of patients with cervical cancer treated with neoadjuvant chemotherapy.
Warts
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
Wilms Tumor
The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.
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Gray, C.W.; Ward, R.V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; Southan, C.; Barton, A.; Fantom, K.G.; West, A.; Savopoulos, J.; Hassan, N.J.; Clinkenbeard, H.; Hanning, C.; Amegadzie, B.; Davis, J.B.; Dingwall, C.; Livi, G.P.; Creasy, C.L.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
Eur. J. Biochem.
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5699-5710
2000
Homo sapiens (O43464), Mus musculus (Q9JIY5)
brenda
Faccio, L.; Fusco, C.; Chen, A.; Martinotti, S.; Bonventre, J.V.; Zervos, A.S.
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
J. Biol. Chem.
275
2581-2588
2000
Homo sapiens (O43464)
brenda
Hegde, R.; Srinivasula, S.M.; Zhang, Z.; Wassell, R.; Mukattash, R.; Cilenti, L.; DuBois, G.; Lazebnik, Y.; Zervos, A.S.; Fernandes-Alnemri, T.; Alnemri, E.S.
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
J. Biol. Chem.
277
432-438
2002
Homo sapiens
brenda
Martins, L.M.; Iaccarino, I.; Tenev, T.; Gschmeissner, S.; Totty, N.F.; Lemoine, N.R.; Savopoulos, J.; Gray, C.W.; Creasy, C.L.; Dingwall, C.; Downward, J.
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
J. Biol. Chem.
277
439-444
2002
Homo sapiens
brenda
Srinivasula, S.M.; Gupta, S.; Datta, P.; Zhang, Z.; Hegde, R.; Cheong, N.; Fernandes-Alnemri, T.; Alnemri, E.S.
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
J. Biol. Chem.
278
31469-31472
2003
Homo sapiens
brenda
Martins, L.M.; Turk, B.E.; Cowling, V.; Borg, A.; Jarrell, E.T.; Cantley, L.C.; Downward, J.
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
J. Biol. Chem.
278
49417-49427
2003
Homo sapiens
brenda
Suzuki, Y.; Imai, Y.; Nakayama, H.; Takahashi, K.; Takio, K.; Takahashi, R.
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Mol. Cell
8
613-621
2001
Homo sapiens
brenda
Savopoulos, J.W.; Carter, P.S.; Turconi, S.; Pettman, G.R.; Karran, E.H.; Gray, C.W.; Ward, R.V.; Jenkins, O.; Creasy, C.L.
Expression, purification, and functional analysis of the human serine protease HtrA2
Protein Expr. Purif.
19
227-234
2000
Homo sapiens (O43464), Homo sapiens
brenda
Cilenti, L.; Kyrizis, G.A.; Soundarapandian, M.M.; Stratico, V.; Yerkes, A.; Park, K.M.; Sheridan, A.M.; Alnemri, E.S.; Bonventre, J.V.; Zervos, A.S.
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells
Am. J. Physiol. Renal Physiol.
288
F371-F379
2005
Homo sapiens, Mus musculus, Mus musculus C57BL6
brenda
Sekine, K.; Hao, Y.; Suzuki, Y.; Takahashi, R.; Tsuruo, T.; Naito, M.
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
Biochem. Biophys. Res. Commun.
330
279-285
2005
Homo sapiens
brenda
Murwantoko, C.; Yano, M.; Ueta, Y.; Murasaki, A.; Kanda, H.; Oka, C.; Kawaichi, M.
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
Biochem. J.
381
895-904
2004
Homo sapiens
brenda
Zhang, X.; Chang, Z
Temperature dependent protease activity and structural properties of human HtrA2 protease
Biochemistry (Moscow)
69
687-692
2004
Homo sapiens
brenda
Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R.
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
Cell Death Differ.
11
208-216
2004
Homo sapiens
brenda
Blink, E.; Maianski, N.A.; Alnemri, E.S.; Zervos, A.S.; Roos, D.; Kuijpers, T.W.
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
Cell Death Differ.
11
937-939
2004
Homo sapiens
brenda
Nam, M.K.; Seong, Y.M.; Park, H.J.; Choi, J.Y.; Kang, S.; Rhim, H.
The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
Exp. Mol. Med.
38
26-43
2006
Homo sapiens
brenda
Hong, S.K.; Cha, M.K.; Kim, I.H.
Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2
Free Radic. Biol. Med.
40
275-284
2006
Homo sapiens
brenda
Strauss, K.M.; Martins, L.M.; Plun-Favreau, H.; Marx, F.P.; Kautzmann, S.; Berg, D.; Gasser, T.; Wszolek, Z.; Mueller, T.; Bornemann, A.; Wolburg, H.; Downward, J.; Riess, O.; Schulz, J.B.; Krueger, R.
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
Hum. Mol. Genet.
14
2099-2111
2005
Homo sapiens
brenda
Seong, Y.M.; Choi, J.Y.; Park, H.J.; Kim, K.J.; Ahn, S.G.; Seong, G.H.; Kim, I.K.; Kang, S.; Rhim, H.
Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP
J. Biol. Chem.
279
37588-37596
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Gupta, S.; Singh, R.; Datta, P.; Zhang, Z.; Orr, C.; Lu, Z.; Dubois, G.; Zervos, A.S.; Meisler, M.H.; Srinivasula, S.M.; Fernandes-Alnemri, T.; Alnemri, E.S.
The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity
J. Biol. Chem.
279
45844-45854
2004
Homo sapiens
brenda
Trencia, A.; Fiory, F.; Maitan, M.A.; Vito, P.; Barbagallo, A.P.; Perfetti, A.; Miele, C.; Ungaro, P.; Oriente, F.; Cilenti, L.; Zervos, A.S.; Formisano, P.; Beguinot, F.
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
J. Biol. Chem.
279
46566-46572
2004
Homo sapiens
brenda
Liu, M.L.; Liu, M.J.; Kim, J.M.; Kim, H.J.; Kim, J.H.; Hong, S.T.
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation
Mol. Cell
20
83-89
2005
Homo sapiens
brenda
Park, H.J.; Seong, Y.M.; Choi, J.Y.; Kang, S.; Rhim, H.
Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi
Neurosci. Lett.
357
63-67
2004
Homo sapiens (Q92743), Homo sapiens
brenda
Seong, Y.M.; Park, H.J.; Seong, G.H.; Choi, J.Y.; Yoon, S.J.; Min, B.R.; Kang, S.; Rhim, H.
N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi
Protein Expr. Purif.
33
200-208
2004
Homo sapiens (O43464), Homo sapiens, Mus musculus
brenda
Vande Walle, L.; Lamkanfi, M.; Vandenabeele, P.
The mitochondrial serine protease HtrA2/Omi: an overview
Cell Death Differ.
15
453-460
2008
Bacillus sp. (in: Bacteria), Bos taurus, Canis lupus familiaris, Clostridium sp., Drosophila melanogaster, Escherichia coli, Homo sapiens, Macaca mulatta, Mesorhizobium loti, Mus musculus, no activity in Caenorhabditis elegans, no activity in Mycoplasma genitalium, no activity in Mycoplasma pneumoniae, Rattus norvegicus
brenda
Park, H.J.; Kim, S.S.; Seong, Y.M.; Kim, K.H.; Goo, H.G.; Yoon, E.J.; Min, d.o..S.; Kang, S.; Rhim, H.
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria
J. Biol. Chem.
281
34277-34287
2006
Homo sapiens, Mus musculus
brenda
Yang, L.; Sun, M.; Sun, X.M.; Cheng, G.Z.; Nicosia, S.V.; Cheng, J.Q.
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212
J. Biol. Chem.
282
10981-10987
2007
Homo sapiens
brenda
Plun-Favreau, H.; Klupsch, K.; Moisoi, N.; Gandhi, S.; Kjaer, S.; Frith, D.; Harvey, K.; Deas, E.; Harvey, R.J.; McDonald, N.; Wood, N.W.; Martins, L.M.; Downward, J.
The mitochondrial protease HtrA2 is regulated by Parkinsons disease-associated kinase PINK1
Nat. Cell Biol.
9
1243-1252
2007
Homo sapiens, Mus musculus
brenda
Kuninaka, S.; Iida, S.I.; Hara, T.; Nomura, M.; Naoe, H.; Morisaki, T.; Nitta, M.; Arima, Y.; Mimori, T.; Yonehara, S.; Saya, H.
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation
Oncogene
26
2395-2406
2007
Homo sapiens, Mus musculus, synthetic construct
brenda
Ma, X.; Kalakonda, S.; Srinivasula, S.M.; Reddy, S.P.; Platanias, L.C.; Kalvakolanu, D.V.
GRIM-19 associates with the serine protease HtrA2 for promoting cell death
Oncogene
26
4842-4849
2007
Homo sapiens
brenda
Plun-Favreau, H.; Gandhi, S.; Wood-Kaczmar, A.; Deas, E.; Yao, Z.; Wood, N.W.
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinsons disease?
Ann. N. Y. Acad. Sci.
1147
30-36
2008
Homo sapiens
brenda
Bhuiyan, M.S.; Fukunaga, K.
Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury
Cardiovasc. ther.
26
224-232
2008
Homo sapiens
brenda
Marabese, M.; Mazzoletti, M.; Vikhanskaya, F.; Broggini, M.
HtrA2 enhances the apoptotic functions of p73 on bax
Cell Death Differ.
15
849-858
2008
Homo sapiens
brenda
Narkiewicz, J.; Klasa-Mazurkiewicz, D.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer
Clin. Biochem.
41
561-569
2008
Homo sapiens
brenda
Bhuiyan, M.S.; Fukunaga, K.
Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target
Curr. Drug Targets
10
372-383
2009
Homo sapiens
brenda
Inagaki, R.; Tagawa, K.; Qi, M.L.; Enokido, Y.; Ito, H.; Tamura, T.; Shimizu, S.; Oyanagi, K.; Arai, N.; Kanazawa, I.; Wanker, E.E.; Okazawa, H.
Omi /HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntingtons disease
Eur. J. Neurosci.
28
30-40
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Simon-Sanchez, J.; Singleton, A.B.
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
Hum. Mol. Genet.
17
1988-1993
2008
Homo sapiens (O43464)
brenda
Bogaerts, V.; Nuytemans, K.; Reumers, J.; Pals, P.; Engelborghs, S.; Pickut, B.; Corsmit, E.; Peeters, K.; Schymkowitz, J.; De Deyn, P.P.; Cras, P.; Rousseau, F.; Theuns, J.; Van Broeckhoven, C.
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Hum. Mutat.
29
832-840
2008
Homo sapiens (O43464), Homo sapiens
brenda
Han, C.; Nam, M.K.; Park, H.J.; Seong, Y.M.; Kang, S.; Rhim, H.
Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2
J. Microbiol. Biotechnol.
18
1197-1202
2008
Homo sapiens
brenda
Ross, O.A.; Soto, A.I.; Vilarino-Gueell, C.; Heckman, M.G.; Diehl, N.N.; Hulihan, M.M.; Aasly, J.O.; Sando, S.; Gibson, J.M.; Lynch, T.; Krygowska-Wajs, A.; Opala, G.; Barcikowska, M.; Czyzewski, K.; Uitti, R.J.; Wszolek, Z.K.; Farrer, M.J.
Genetic variation of Omi/HtrA2 and Parkinsons disease
Parkinsonism Relat. Disord.
14
539-543
2008
Homo sapiens
brenda
McCormick, A.L.; Roback, L.; Mocarski, E.S.
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)
PLoS Pathog.
4
e1000063
2008
Homo sapiens (O43464)
brenda
Krick, S.; Shi, S.; Ju, W.; Faul, C.; Tsai, S.Y.; Mundel, P.; Boettinger, E.P.
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
Proc. Natl. Acad. Sci. USA
105
14106-14111
2008
Chlorocebus aethiops, Homo sapiens, Mus musculus
brenda
Balakrishnan, M.P.; Cilenti, L.; Mashak, Z.; Popat, P.; Alnemri, E.S.; Zervos, A.S.
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death
Am. J. Physiol. Heart Circ. Physiol.
297
H643-H653
2009
Homo sapiens
brenda
Park, H.M.; Kim, G.Y.; Nam, M.K.; Seong, G.H.; Han, C.; Chung, K.C.; Kang, S.; Rhim, H.
The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity
Biochem. Biophys. Res. Commun.
387
537-542
2009
Homo sapiens, Mus musculus
brenda
Kieper, N.; Holmstroem, K.M.; Ciceri, D.; Fiesel, F.C.; Wolburg, H.; Ziviani, E.; Whitworth, A.J.; Martins, L.M.; Kahle, P.J.; Krueger, R.
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
Exp. Cell Res.
316
1213-1224
2010
Drosophila melanogaster, Homo sapiens, Mus musculus
brenda
Kooistra, J.; Milojevic, J.; Melacini, G.; Ortega, J.
A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor
J. Alzheimers Dis.
17
281-294
2009
Homo sapiens
brenda
Wang, C.Y.; Lin, Y.S.; Su, W.C.; Chen, C.L.; Lin, C.F.
Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis
Mol. Biol. Cell
20
4153-4161
2009
Homo sapiens
brenda
Hartkamp, J.; Carpenter, B.; Roberts, S.G.
The Wilms tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi
Mol. Cell
37
159-171
2010
Homo sapiens, Mus musculus
brenda
Kawamoto, Y.; Ito, H.; Kobayashi, Y.; Suzuki, Y.; Akiguchi, I.; Fujimura, H.; Sakoda, S.; Kusaka, H.; Hirano, A.; Takahashi, R.
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis
Neuropathol. Appl. Neurobiol.
36
331-344
2010
Homo sapiens
brenda
Narkiewicz, J.; Lapinska-Szumczyk, S.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer
Oncol. Rep.
21
1529-1537
2009
Homo sapiens
brenda
Essafi, A.; Hastie, N.D.
WT1 the oncogene: a tale of death and HtrA
Mol. Cell
37
153-155
2010
Homo sapiens
brenda
Liu, Q.B.; Liu, L.L.; Lu, Y.M.; Tao, R.R.; Huang, J.Y.; Shioda, N.; Moriguchi, S.; Fukunaga, K.; Han, F.; Lou, Y.J.
The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells
Toxicol. Appl. Pharmacol.
244
374-384
2010
Homo sapiens
brenda
Chien, J.
WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases
Future Oncol.
6
1233-1235
2010
Homo sapiens
brenda
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
brenda
Zurawa-Janicka, D.; Jarzab, M.; Polit, A.; Skorko-Glonek, J.; Lesner, A.; Gitlin, A.; Gieldon, A.; Ciarkowski, J.; Glaza, P.; Lubomska, A.; Lipinska, B.
Temperature-induced changes of HtrA2(Omi) protease activity and structure
Cell Stress Chaperones
18
35-51
2013
Homo sapiens (O43464)
brenda
Singh, N.; DSouza, A.; Cholleti, A.; Sastry, G.M.; Bose, K.
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
FEBS J.
281
2456-2470
2014
Homo sapiens (O43464)
brenda
Luo, F.; Wei, L.; Sun, C.; Chen, X.; Wang, T.; Li, Y.; Liu, Z.; Chen, Z.; Xu, P.
HtrA2/Omi is involved in 6-OHDA-induced endoplasmic reticulum stress in SH-SY5Y cells
J. Mol. Neurosci.
47
120-127
2012
Homo sapiens (O43464), Homo sapiens
brenda
Bejugam, P.; Kuppili, R.; Singh, N.; Gadewal, N.; Chaganti, L.; Sastry, G.; Bose, K.
Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket
PLoS ONE
8
e55416
2013
Homo sapiens (O43464)
brenda
Winkler, J.; Rand, M.L.; Schmugge, M.; Speer, O.
Omi/HtrA2 and XIAP are components of platelet apoptosis signalling
Thromb. Haemost.
109
532-539
2013
Homo sapiens (O43464)
brenda
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
brenda
Jarzab, M.; Wenta, T.; Zurawa-Janicka, D.; Polit, A.; Gieldon, A.J.; Wysocka, M.; Glaza, P.; Skorko-Glonek, J.; Ciarkowski, J.; Lesner, A.; Lipinska, B.
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
Biochim. Biophys. Acta
1864
283-296
2016
Homo sapiens (O43464)
brenda
Wagh, A.R.; Bose, K.
Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2
Biosci. Rep.
38
BSR20181072
2018
Homo sapiens (O43464), Homo sapiens
brenda
Merski, M.; Moreira, C.; Abreu, R.M.; Ramos, M.J.; Fernandes, P.A.; Martins, L.M.; Pereira, P.J.B.; Macedo-Ribeiro, S.
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
Cell Death Dis.
8
e3119
2017
Homo sapiens (O43464), Homo sapiens
brenda
Hu, Y.; Bi, Y.; Yao, D.; Wang, P.; Li, Y.
Omi/HtrA2 protease associated cell apoptosis participates in blood-brain barrier dysfunction
Front. Mol. Neurosci.
12
48
2019
Homo sapiens (O43464), Homo sapiens
brenda
Sun, M.L.; Sun, L.M.; Wang, Y.Q.
Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
J. Mol. Recognit.
31
e2698
2018
Homo sapiens (O43464)
brenda
Lucotte, B.; Tajhizi, M.; Alkhatib, D.; Samuelsson, E.; Wiehager, B.; Schedin-Weiss, S.; Sundstrom, E.; Winblad, B.; Tjernberg, L.; Behbahani, H.
Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells
Mol. Neurobiol.
52
1077-1092
2015
Homo sapiens (O43464), Homo sapiens
brenda
Glaza, P.; Osipiuk, J.; Wenta, T.; Zurawa-Janicka, D.; Jarzab, M.; Lesner, A.; Banecki, B.; Skorko-Glonek, J.; Joachimiak, A.; Lipinska, B.
Structural and functional analysis of human HtrA3 protease and its subdomains
PLoS ONE
10
e0131142
2015
Homo sapiens (P83110)
brenda
Gieldon, A.; Zurawa-Janicka, D.; Jarzab, M.; Wenta, T.; Golik, P.; Dubin, G.; Lipinska, B.; Ciarkowski, J.
Distinct 3D architecture and dynamics of the human HtrA2(Omi) protease and its mutated variants
PLoS ONE
11
e0161526
2016
Homo sapiens (O43464), Homo sapiens
brenda