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Information on EC 3.4.21.107 - peptidase Do and Organism(s) Xenopus laevis and UniProt Accession A6YFB5

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.107 peptidase Do
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This record set is specific for:
Xenopus laevis
UNIPROT: A6YFB5 not found.
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Word Map
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-/-Val
Synonyms
htra1, htra2, htra3, htra4, serine protease htra1, high-temperature requirement a, htra protease, high temperature requirement a, serine protease htra, degp protease, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
protease do
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
161108-11-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
biglycan + H2O
?
show the reaction diagram
-
-
-
?
glypican-4 + H2O
?
show the reaction diagram
-
-
-
?
syndecan-4 + H2O
?
show the reaction diagram
-
-
-
?
additional information
?
-
HtrA1 promotes posterior development in mRNA-injected Xenopus laevis embryos, e.g. induces secondary tail-like structures, expansion of mesoderm, and formation of ectopic neurons in an FGF-dependent manner, HtrA1 activates FGF/ERK signaling and the transcription of FGF genes by cleaving proteoglycans and releasing cell surface-bound FGF ligands, overview
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
HtrA1 promotes posterior development in mRNA-injected Xenopus laevis embryos, e.g. induces secondary tail-like structures, expansion of mesoderm, and formation of ectopic neurons in an FGF-dependent manner, HtrA1 activates FGF/ERK signaling and the transcription of FGF genes by cleaving proteoglycans and releasing cell surface-bound FGF ligands, overview
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dermatan sulfate
triggers HtrA1-induced peteriorization, overview
heparan sulfate
triggers HtrA1-induced peteriorization, overview
additional information
HtrA1 is expressed in early embryo and activated by FGF signals
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
HtrA1 is expressed in early embryo and activated by FGF signals
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
secretion of embryo HtrA1
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HTRA1_XENLA
459
0
48991
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50000
x * 50000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
HtrA knockdown promotes anterior development and impairs mesoderm and neuronal differentiation, phenotype, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene htrA1, DNA and amino acid sequence determination and analysis, expression in HEK-293T cells and secretion of the recombinant enzyme to the cell culture medium
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hou, S.; Maccarana, M.; Min, T.H.; Strate, I.; Pera, E.M.
The secreted serine protease HtrA1 stimulates long-range FGF signaling in the early Xenopus embryo
Dev. Cell
13
226-241
2007
Xenopus laevis (A6YFB5)
Manually annotated by BRENDA team