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Reference on EC 3.4.21.106 - hepsin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Leytus, S.P.; Loeb, K.R.; Hagen, F.S.; Kurachi, K.; Davie, E.W.
A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells
Biochemistry
27
1067-1074
1988
Homo sapiens
Manually annotated by BRENDA team
Zhukov, A.; Hellman, U.; Ingelman-Sundberg, M.
Purification and characterization of hepsin from rat liver microsomes
Biochim. Biophys. Acta
1337
85-95
1997
Rattus norvegicus
Manually annotated by BRENDA team
Tsuji, A.; Torres-Rosado, A.; Arai, T.; Chou, S.H.; Kurachi, K.
Characterization of hepsin, a membrane bound protease
Biomed. Biochim. Acta
50
791-793
1991
Homo sapiens, Papio ursinus
Manually annotated by BRENDA team
Srikantan, V.; Valladares, M.; Rhim, J.S.; Moul, J.W.; Srivastava, S.
Hepsin inhibits cell growth/invasion in prostate cancer cells
Cancer Res.
62
6812-6816
2002
Homo sapiens
Manually annotated by BRENDA team
Tsuji, A.; Torres-Rosado, A.; Arai, T.; Le Beau, M.M.; Lemons, R.S.; Chou, S.H.; Kurachi, K.
Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization
J. Biol. Chem.
266
16948-16953
1991
Homo sapiens, Papio ursinus
Manually annotated by BRENDA team
Kazama, Y.; Hamamoto, T.; Foster, D.C.; Kisiel, W.
Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation
J. Biol. Chem.
270
66-72
1995
Homo sapiens
Manually annotated by BRENDA team
Kurachi, K.; Torres-Rosado, A.; Tsuji, A.
Hepsin
Methods Enzymol.
244
100-114
1994
Cricetulus griseus, Homo sapiens, Papio ursinus
Manually annotated by BRENDA team
Torres-Rosado, A.; O'Shea, K.S.; Tsuji, A.; Chou, S.H.; Kurachi, K.
Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth
Proc. Natl. Acad. Sci. USA
90
7181-7185
1993
Homo sapiens
Manually annotated by BRENDA team
Somoza, J.R.; Ho, J.D.; Luong, C.; Ghate, M.; Sprengeler, P.A.; Mortara, K.; Shrader, W.D.; Sperandio, D.; Chan, H.; McGrath, M.E.; Katz, B.A.
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain
Structure
11
1123-1131
2003
Homo sapiens
Manually annotated by BRENDA team
Zhang, J.L.; Zhao, W.G.; Wu, K.L.; Wang, K.; Zhang, X.; Gu, C.F.; Li, Y.; Zhu, Y.; Wu, J.G.
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease hepsin
Arch. Virol.
150
721-741
2005
Homo sapiens (P05981), Homo sapiens
Manually annotated by BRENDA team
Herter, S.; Piper, D.E.; Aaron, W.; Gabriele, T.; Cutler, G.; Cao, P.; Bhatt, A.S.; Choe, Y.; Craik, C.S.; Walker, N.; Meininger, D.; Hoey, T.; Austin, R.J.
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Biochem. J.
390
125-136
2005
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Yu, Z.; Zhao, X.; Shen, S.
Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform
Biochim. Biophys. Acta
1681
157-165
2005
Homo sapiens
Manually annotated by BRENDA team
Klezovitch, O.; Chevillet, J.; Mirosevich, J.; Roberts, R.L.; Matusik, R.J.; Vasioukhin, V.
Hepsin promotes prostate cancer progression and metastasis
Cancer Cell
6
185-195
2004
Mus musculus
Manually annotated by BRENDA team
Kirchhofer, D.; Peek, M.; Lipari, M.T.; Billeci, K.; Fan, B.; Moran, P.
Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2
FEBS Lett.
579
1945-1950
2005
Homo sapiens (P05981)
Manually annotated by BRENDA team
Nakamura, K.; Nasu, Y.; Hongo, A.; Matsuo, T.; Kodama, J.; Ebara, S.; Nagai, A.; Abrzua, F.; Kumon, H.; Hiramatsu, Y.
Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines
Int. J. Oncol.
28
393-398
2006
Homo sapiens
Manually annotated by BRENDA team
Roemer, A.; Schwettmann, L.; Jung, M.; Stephan, C.; Roigas, J.; Kristiansen, G.; Loening, S.A.; Lichtinghagen, R.; Jung, K.
The membrane proteases adams and hepsin are differentially expressed in renal cell carcinoma. Are they potential tumor markers?
J. Urol.
172
2162-2166
2004
Homo sapiens (P05981), Homo sapiens
Manually annotated by BRENDA team
Guipponi, M.; Tan, J.; Cannon, P.Z.; Donley, L.; Crewther, P.; Clarke, M.; Wu, Q.; Shepherd, R.K.; Scott, H.S.
Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss
Am. J. Pathol.
171
608-616
2007
Mus musculus
Manually annotated by BRENDA team
Matsuo, T.; Nakamura, K.; Takamoto, N.; Kodama, J.; Hongo, A.; Abrzua, F.; Nasu, Y.; Kumon, H.; Hiramatsu, Y.
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer
Anticancer Res.
28
159-164
2008
Homo sapiens
Manually annotated by BRENDA team
Kunii, D.; Shimoji, M.; Nakama, S.; Ikebe, M.; Hachiman, T.; Sato, I.; Tamaki, A.; Yamazaki, K.; Aniya, Y.
Purification of liver serine protease which activates microsomal glutathione S-transferase: possible involvement of hepsin
Biol. Pharm. Bull.
29
868-874
2006
Rattus norvegicus
Manually annotated by BRENDA team
Wu, Q.; Parry, G.
Hepsin and prostate cancer
Front. Biosci.
12
5052-5059
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Pal, P.; Xi, H.; Kaushal, R.; Sun, G.; Jin, C.H.; Jin, L.; Suarez, B.K.; Catalona, W.J.; Deka, R.
Variants in the HEPSIN gene are associated with prostate cancer in men of European origin
Hum. Genet.
120
187-192
2006
Homo sapiens
Manually annotated by BRENDA team
Moran, P.; Li, W.; Fan, B.; Vij, R.; Eigenbrot, C.; Kirchhofer, D.
Pro-urokinase-type plasminogen activator is a substrate for hepsin
J. Biol. Chem.
281
30439-30446
2006
Homo sapiens
Manually annotated by BRENDA team
Beliveau, F.; Desilets, A.; Leduc, R.
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides
FEBS J.
276
2213-2226
2009
Homo sapiens
Manually annotated by BRENDA team
Miao, J.; Mu, D.; Ergel, B.; Singavarapu, R.; Duan, Z.; Powers, S.; Oliva, E.; Orsulic, S.
Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model
Int. J. Cancer
123
2041-2047
2008
Homo sapiens (P05981)
Manually annotated by BRENDA team
Nakamura, K.; Takamoto, N.; Abarzua, F.; Hongo, A.; Kodama, J.; Nasu, Y.; Kumon, H.; Hiramatsu, Y.
Hepsin inhibits the cell growth of endometrial cancer
Int. J. Mol. Med.
22
389-397
2008
Homo sapiens
Manually annotated by BRENDA team
Tripathi, M.; Nandana, S.; Yamashita, H.; Ganesan, R.; Kirchhofer, D.; Quaranta, V.
Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression
J. Biol. Chem.
283
30576-30584
2008
Homo sapiens
Manually annotated by BRENDA team
Halabian, R.; Roudkenar, M.H.; Esmaeili, N.S.; Masroori, N.; Roushandeh, A.M.; Najafabadi, A.J.
Establishment of a cell line expressing recombinant factor VII and its subsequent conversion to active form FVIIa through hepsin by genetic engineering method
Vox Sang.
96
309-315
2009
Homo sapiens
Manually annotated by BRENDA team
Owen, K.A.; Qiu, D.; Alves, J.; Schumacher, A.M.; Kilpatrick, L.M.; Li, J.; Harris, J.L.; Ellis, V.
Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
Biochem. J.
426
219-228
2010
Homo sapiens
Manually annotated by BRENDA team
Nakama, S.; Oshiro, N.; Aniya, Y.
Activation of rat liver microsomal glutathione transferase by hepsin
Biol. Pharm. Bull.
33
561-567
2010
Rattus norvegicus
Manually annotated by BRENDA team
Li, W.; Wang, B.E.; Moran, P.; Lipari, T.; Ganesan, R.; Corpuz, R.; Ludlam, M.J.; Gogineni, A.; Koeppen, H.; Bunting, S.; Gao, W.Q.; Kirchhofer, D.
Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis
Cancer Res.
69
8395-8402
2009
Mus musculus
Manually annotated by BRENDA team
Chen, M.; Chen, L.M.; Lin, C.Y.; Chai, K.X.
Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor
Mol. Cell. Biochem.
337
259-266
2010
Homo sapiens
Manually annotated by BRENDA team
Holt, S.K.; Kwon, E.M.; Lin, D.W.; Ostrander, E.A.; Stanford, J.L.
Association of hepsin gene variants with prostate cancer risk and prognosis
Prostate
70
1012-1019
2010
Homo sapiens
Manually annotated by BRENDA team
Nandana, S.; Ellwood-Yen, K.; Sawyers, C.; Wills, M.; Weidow, B.; Case, T.; Vasioukhin, V.; Matusik, R.
Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model
Prostate
70
591-600
2010
Mus musculus
Manually annotated by BRENDA team
Koschubs, T.; Dengl, S.; Duerr, H.; Kaluza, K.; Georges, G.; Hartl, C.; Jennewein, S.; Lanzendoerfer, M.; Auer, J.; Stern, A.; Huang, K.S.; Packman, K.; Gubler, U.; Kostrewa, D.; Ries, S.; Hansen, S.; Kohnert, U.; Cramer, P.; Mundigl, O.
Allosteric antibody inhibition of human Hepsin protease
Biochem. J.
442
483-494
2012
Homo sapiens (P05981), Homo sapiens
Manually annotated by BRENDA team
Raevskaya, A.A.; Kuznetsova, E.M.; Savvateeva, M.V.; Severin, S.E.
Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli
Biochemistry
75
866-872
2010
Homo sapiens
Manually annotated by BRENDA team
Ganesan, R.; Kolumam, G.A.; Lin, S.J.; Xie, M.H.; Santell, L.; Wu, T.D.; Lazarus, R.A.; Chaudhuri, A.; Kirchhofer, D.
Proteolytic activation of pro-macrophage-stimulating protein by hepsin
Mol. Cancer Res.
9
1175-1186
2011
Homo sapiens
Manually annotated by BRENDA team
Khandekar, G.; Jagadeeswaran, P.
Role of hepsin in factor VII activation in zebrafish
Blood Cells Mol. Dis.
52
76-81
2014
Danio rerio
Manually annotated by BRENDA team
Zhang, C.; Zhang, M.; Wu, Q.; Peng, J.; Ruan, Y.; Gu, J.
Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2alpha phosphorylation in prostate cancer
Cell. Signal.
27
789-797
2015
Homo sapiens (P05981)
Manually annotated by BRENDA team
Hsu, Y.C.; Huang, H.P.; Yu, I.S.; Su, K.Y.; Lin, S.R.; Lin, W.C.; Wu, H.L.; Shi, G.Y.; Tao, M.H.; Kao, C.H.; Wu, Y.M.; Martin, P.E.; Lin, S.Y.; Yang, P.C.; Lin, S.W.
Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice
Hepatology
56
1913-1923
2012
Mus musculus (O35453), Mus musculus
Manually annotated by BRENDA team
Niehaus, J.Z.; Miedel, M.T.; Good, M.; Wyatt, A.N.; Pak, S.C.; Silverman, G.A.; Luke, C.J.
SERPINB12 is a slow-binding inhibitor of granzyme A and hepsin
Biochemistry
54
6756-6759
2015
Homo sapiens (P05981)
Manually annotated by BRENDA team
Kim, K.; Kwon, H.; Choi, D.; Lim, T.; Minn, I.; Son, S.H.; Byun, Y.
Design and synthesis of dye-conjugated hepsin inhibitors
Bioorg. Chem.
89
102990
2019
Homo sapiens (P05981)
Manually annotated by BRENDA team
Franco, F.M.; Jones, D.E.; Harris, P.K.; Han, Z.; Wildman, S.A.; Jarvis, C.M.; Janetka, J.W.
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors Evaluation of potency and selectivity derived from distinct binding pockets
Bioorg. Med. Chem.
23
2328-2343
2015
Homo sapiens (P05981)
Manually annotated by BRENDA team
Goswami, R.; Wohlfahrt, G.; Toermaekangas, O.; Moilanen, A.; Lakshminarasimhan, A.; Nagaraj, J.; Arumugam, K.N.; Mukherjee, S.; Chacko, A.R.; Krishnamurthy, N.R.; Jaleel, M.; Palakurthy, R.K.; Samiulla, D.S.; Ramachandra, M.
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors
Bioorg. Med. Chem. Lett.
25
5309-5314
2015
Homo sapiens (P05981)
Manually annotated by BRENDA team
Kwon, H.; Kim, Y.; Park, K.; Choi, S.A.; Son, S.H.; Byun, Y.
Structure-based design, synthesis, and biological evaluation of Leu-Arg dipeptide analogs as novel hepsin inhibitors
Bioorg. Med. Chem. Lett.
26
310-314
2016
Homo sapiens (P05981)
Manually annotated by BRENDA team
Brunati, M.; Perucca, S.; Han, L.; Cattaneo, A.; Consolato, F.; Andolfo, A.; Schaeffer, C.; Olinger, E.; Peng, J.; Santambrogio, S.; Perrier, R.; Li, S.; Bokhove, M.; Bachi, A.; Hummler, E.; Devuyst, O.; Wu, Q.; Jovine, L.; Rampoldi, L.
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
eLife
4
e08887
2015
Mus musculus (O35453)
Manually annotated by BRENDA team
Subedi, M.; Minn, I.; Chen, J.; Kim, Y.; Ok, K.; Jung, Y.W.; Pomper, M.G.; Byun, Y.
Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands
Eur. J. Med. Chem.
118
208-218
2016
Homo sapiens (P05981)
Manually annotated by BRENDA team
Sroka, W.D.; Adamowski, M.; Slupski, P.; Siodmiak, J.; Jarzemski, P.; Odrowaz-Sypniewska, G.; Marszall, M.P.
Alpha-methylacyl-CoA racemase and hepsin as urinary prostate cancer markers
Int. J. Biol. Markers
30
e401-e406
2015
Homo sapiens (P05981)
Manually annotated by BRENDA team
Damalanka, V.C.; Han, Z.; Karmakar, P.; ODonoghue, A.J.; La Greca, F.; Kim, T.; Pant, S.M.; Helander, J.; Klefstroem, J.; Craik, C.S.; Janetka, J.W.
Discovery of selective matriptase and hepsin serine protease inhibitors useful chemical tools for cancer cell biology
J. Med. Chem.
62
480-490
2019
Homo sapiens (P05981)
Manually annotated by BRENDA team
Wilkinson, D.J.; Desilets, A.; Lin, H.; Charlton, S.; Del Carmen Arques, M.; Falconer, A.; Bullock, C.; Hsu, Y.C.; Birchall, K.; Hawkins, A.; Thompson, P.; Ferrell, W.R.; Lockhart, J.; Plevin, R.; Zhang, Y.; Blain, E.; Lin, S.W.; Leduc, R.; Milner, J.M.; Rowan, A.D.
The serine proteinase hepsin is an activator of pro-matrix metalloproteinases molecular mechanisms and implications for extracellular matrix turnover
Sci. Rep.
7
16693
2017
Homo sapiens (P05981)
Manually annotated by BRENDA team