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Information on EC 3.4.21.105 - rhomboid protease

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.105 rhomboid protease
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This record set is specific for:
UNIPROT: Q9BUN8 not found.
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Word Map
  • 3.4.21.105
  • flap
  • drosophila
  • medial
  • dorsal
  • posterior
  • ventral
  • glossitis
  • midline
  • trapezius
  • shoulder
  • thalamic
  • scapula
  • fossa
  • pilonidal
  • reuniens
  • serratus
  • paraventricular
  • levator
  • er-associated
  • intercostal
  • ventromedial
  • ventrolateral
  • mediodorsal
  • intralaminar
  • parafascicular
  • sacrococcygeal
  • abduct
  • electromyographic
  • paracentral
  • retrotranslocation
  • aesthetic
  • latissimus
  • cheilitis
  • birefringent
  • erector
  • anteroventral
  • nicastrin
  • anteromedial
  • supraspinatus
  • incerta
  • clavicle
  • myofascial
  • site-2
  • argos
  • extradural
  • seromas
  • petrous
  • infraspinatus
  • gurken
  • glenohumeral
  • analysis
  • medicine
  • molecular biology
The enzyme appears in viruses and cellular organisms
Reaction Schemes
cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains
Synonyms
rhomboid, derlin-1, rhbdd1, rhomboid protease, intramembrane protease, rhbdl2, rhbdl4, rhomboid protein, ehrom1, rho-4, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
rhomboid pseudoprotease
-
CAS REGISTRY NUMBER
COMMENTARY hide
713145-02-9
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
rhomboid pseudoprotease Derlin-1 is required for the dislocation of mutant alpha-1 antitrypsin from the endoplasmic reticulum
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DERL1_HUMAN
251
0
28801
Swiss-Prot
other Location (Reliability: 5)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Greenblatt, E.J.; Olzmann, J.A.; Kopito, R.R.
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant alpha-1 antitrypsin from the endoplasmic reticulum
Nat. Struct. Mol. Biol.
18
1147-1152
2011
Homo sapiens (Q9BUN8), Homo sapiens
Manually annotated by BRENDA team