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Information on EC 3.4.19.3 - pyroglutamyl-peptidase I and Organism(s) Mus musculus and UniProt Accession Q9ESW8

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.3 pyroglutamyl-peptidase I
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This record set is specific for:
Mus musculus
UNIPROT: Q9ESW8 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Synonyms
pgp-1, pap-i, pyroglutamate aminopeptidase, pyroglutamyl aminopeptidase, pyroglutamyl peptidase i, pcp-0sh, pyrase, pyrrolidone carboxyl peptidase, pyrrolidonyl arylamidase, pyroglutamyl-peptidase i, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pyroglutamyl aminopeptidase I
-
pyrrolidone carboxypeptidase type I
-
5-oxoprolyl-peptidase
-
-
-
-
aminopeptidase, pyroglutamate
-
-
-
-
L-pyrrolidonecarboxylate peptidase
-
-
-
-
pyroglutamate aminopeptidase
-
-
-
-
pyroglutamidase
-
-
-
-
pyroglutamyl aminopeptidase
pyrrolidone-carboxylate peptidase
-
-
-
-
pyrrolidonecarboxy peptidase
-
-
-
-
pyrrolidonecarboxylyl peptidase
-
-
-
-
pyrrolidonyl peptidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9075-21-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
show the reaction diagram
-
-
-
?
thyrotropin-releasing hormone + H2O
?
show the reaction diagram
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
show the reaction diagram
-
-
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
show the reaction diagram
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
show the reaction diagram
-
-
-
-
?
thyrotrophin releasing hormone
?
show the reaction diagram
-
the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
thyrotrophin releasing hormone
?
show the reaction diagram
-
the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyclosporin
-
increases particulate and soluble PAP activity in the renal cortex. Particulate PAP activity returns to levels similar to controls after 15 days of cyclosporin withdrawal, soluble PAP does not regress. Soluble and particulate aminopeptidases in resident and elicited macrophages are unaffected by cyclosporin
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.038
L-pyroglutamyl-p-nitroanilide
37°C, pH 7.4
0.041
thyrotropin-releasing hormone
37°C, pH 7.4
0.58
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide
-
37°C, pH 7.4
0.37
L-2-oxoimidazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
0.57
L-2-oxooxazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
0.33
L-2-oxothiazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
0.046
L-pyroglutamyl-L-Ala
-
37°C, pH 7.4
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.3
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide
-
37°C, pH 7.4
2.7
L-2-oxoimidazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
6.6
L-2-oxooxazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
2.5
L-2-oxothiazolidine-4-carboxyl-L-Ala
-
37°C, pH 7.4
3.2
L-pyroglutamyl-L-Ala
-
37°C, pH 7.4
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
orchidectomy increases activity of pyrrolidone carboxypeptidase type I, testosterone replacement returns it to control levels
Manually annotated by BRENDA team
orchidectomy increases activity of pyrrolidone carboxypeptidase type I, high dose of testosterone returns activity to control levels
Manually annotated by BRENDA team
no change in pyrrolidone carboxypeptidase type I after orchidectomy, activity increases after administration of testosterone
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PGPI_MOUSE
209
0
22934
Swiss-Prot
other Location (Reliability: 2)
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
profiles of macrophage and renal PAP activities may be considered into the elaboration of new potential strategies for preventing nephrotoxicity during cyclosporin treatment
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cruz, C.; Charli, J.L.; Vargas, M.A.; Joseph-Bravo, P.
Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain
J. Neurochem.
56
1594-1601
1991
Mus musculus
Manually annotated by BRENDA team
Court, J.A.; McDermott, J.R.; Gibson, A.M.; Marshall, E.; Bloxham, C.A.; Perry, R.H.; Edwardson, J.A.
Raised thyrotrophin-releasing hormone, pyroglutamylamino peptidase, and proline endopeptidase are present in the spinal cord of wobber mice but not in human motor neurone disease
J. Neurochem.
49
1084-1090
1987
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Abe, K.; Saito, F.; Yamada, M.; Tokui, T.
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid
Biol. Pharm. Bull.
27
113-116
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Abe, K.; Fukuda, K.; Tokui, T.
Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain
Biol. Pharm. Bull.
27
1197-1201
2004
Homo sapiens (Q9NXJ5), Homo sapiens, Mus musculus (Q9ESW8), Mus musculus, Rattus norvegicus (Q76IC5)
Manually annotated by BRENDA team
Garcia-Lopez, M.J.; Martinez-Martos, J.M.; Mayas, M.D.; Carrera, M.P.; Ramirez-Exposito, M.J.
Effects of orchidectomy and testosterone replacement on mouse pyrrolidone carboxypeptidase activity in the HPA axis
Horm. Metab. Res.
36
131-135
2004
Mus musculus (Q9ESW8), Mus musculus
Manually annotated by BRENDA team
Marinho, C.E.; Olivo, R.d.o.A.; Zambotti-Villela, L.; Ribeiro-de-Andrade, T.N.; Fernandes, C.M.; Silveira, P.F.
Renal and macrophage aminopeptidase activities in cyclosporin-treated mice
Int. Immunopharmacol.
6
415-425
2006
Mus musculus
Manually annotated by BRENDA team