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Information on EC 3.4.19.12 - ubiquitinyl hydrolase 1 and Organism(s) Mus musculus and UniProt Accession Q9R0P9

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.12 ubiquitinyl hydrolase 1
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This record set is specific for:
Mus musculus
UNIPROT: Q9R0P9 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
uch-l1, uchl1, ataxin-3, deubiquitinating enzyme, pgp 9.5, usp22, pgp9.5, plpro, otub1, isopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ubiquitin C-terminal hydrolase L1
-
ubiquitin carboxy terminal hydrolase-L1
-
ubiquitin carboxy-terminal hydrolase 1
-
ubiquitin carboxy-terminal hydrolase L1
-
ubiquitin carboxyl-terminal hydrolase 1
-
ubiquitin carboxyl-terminal hydrolase L-1
-
ubiquitin carboxyl-terminal hydrolase L1
-
ubiquitin carboxyl-terminal hydrolase-L1
-
ubiquitin hydrolase Uch-L1
-
AD-019
-
-
-
-
CGI-70
-
-
-
-
esterase, ubiquitin thiol-
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal
-
-
-
-
hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch)
-
-
-
-
isopeptidase
-
-
-
-
isopeptidase T
-
-
-
-
Neuron cytoplasmic protein 9.5
-
-
-
-
PGP 9.5
PGP9.5
ubiquitin C-terminal hydrolase
ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch)
-
-
-
-
ubiquitin C-terminal hydrolase isoform L3
-
-
ubiquitin C-terminal hydrolase L-1
-
-
ubiquitin C-terminal hydrolase L1
-
-
ubiquitin C-terminal hydrolase L3
-
Ubiquitin C-terminal hydrolase UCH37
-
-
-
-
ubiquitin C-terminal hydrolase-L1
-
-
ubiquitin C-terminal hydrolase-L5
-
-
ubiquitin carboxy terminal hydrolase-L1
-
-
ubiquitin carboxy terminal hydrolase-L3
-
ubiquitin carboxy-terminal hydrolase
-
-
-
-
ubiquitin carboxy-terminal hydrolase L1
-
-
ubiquitin carboxy-terminal hydrolase-L1
-
-
ubiquitin carboxyl-terminal hydrolase
-
-
-
-
ubiquitin carboxyl-terminal hydrolase L1
-
-
ubiquitin carboxyl-terminal hydrolase l3
-
-
ubiquitin carboxyterminal hydrolase-L1
-
-
Ubiquitin thiolesterase
Ubiquitin thiolesterase L1
-
-
-
-
Ubiquitin thiolesterase L3
-
-
-
-
Ubiquitin thiolesterase L4
-
-
-
-
Ubiquitin thiolesterase L5
-
-
-
-
ubiquitin-carboxyl-terminal hydrolase PGP-9.5
-
-
-
-
UCH-1
-
-
-
-
UCH-L1
UCH-L2
-
-
-
-
UCH-L3
UCH-L4
-
-
-
-
UCH-L5
-
-
-
-
UCH37
-
-
UCHL1/PGP 9.5
-
-
Uchl3
UCHL5
-
-
yeast ubiquitin hydrolase
-
-
-
-
YUH1
-
-
-
-
additional information
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
189642-63-5
-
86480-67-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
polyubiquitin + H2O
ubiquitin
show the reaction diagram
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
ubiquitinyl-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Nedd-8 + H2O
?
show the reaction diagram
-
-
-
-
?
polyubiquitin + H2O
ubiquitin
show the reaction diagram
ubiquitin + H2O
?
show the reaction diagram
-
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polyubiquitin + H2O
ubiquitin
show the reaction diagram
-
UCHL1/PGP 9.5, overview
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ubiquitin
-
3-amino-2-(cyclohexylcarbonyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-keto-7Hthieno[2,3-b]pyridin-6-one derivative
-
-
3-amino-2-[(2-methoxyphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-[(4-chlorophenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-[(4-methylphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-[(4-tert-butylphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-[(naphthalen-1-yloxy)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-2-[(naphthalen-2-yloxy)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
3-amino-6-oxo-2-[[4-(trifluoromethyl)phenyl]carbonyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
4,5,6,7-tetrachloroindan-1,3-dione
-
UCH-L3 inhibition reduces epithelial sodium channel currents, decreases apical membrane epithelial sodium channel expression and increases epithelial sodium channel ubiquitination at the apical surface
amyloid beta
30% inhibition
-
LDN-57444
reversible, competitive, active site-directed isatin oxime, 70% inhibition with 0.005 mM
oligomeric Abeta
-
treatment of hippocampal slices produces a deficit in long term potentiation. Effect can be reversed by coadministering a recombinant UCH-L1 protein
-
siRNA
-
knockdown of UCH-L3 leads to a decrease of epithelial sodium channel currents
-
tosyl-L-phenylalanine chloromethyl ketone
inhibits fragmentation of AT-3 carrying six consecutive glutamines
ubiquitin
isozyme L1
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
DTT
-
required, hydrolase activity of UCH-L1 in vitro is decreased when reducing dithiothreitol is omitted from the reaction buffer
additional information
-
UCH-L1 is easily affected by redox status
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00016
ubiquitinyl-7-amido-4-methylcoumarin
25°C
0.00016
ubiquitin-7-amido-4-methylcoumarin
recombinant wild-type isozyme L1, pH 7.5, 25°C
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
ubiquitinyl-7-amido-4-methylcoumarin
25°C
0.02
ubiquitin-7-amido-4-methylcoumarin
recombinant wild-type isozyme L1, pH 7.5, 25°C
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0033
ubiquitin
25°C
0.002
3-amino-2-(cyclohexylcarbonyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0028
3-amino-2-keto-7Hthieno[2,3-b]pyridin-6-one derivative
-
-
0.0053
3-amino-2-[(2-methoxyphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0012
3-amino-2-[(4-chlorophenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.00091
3-amino-2-[(4-methylphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0014
3-amino-2-[(4-tert-butylphenyl)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0015
3-amino-2-[(naphthalen-1-yloxy)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.00074
3-amino-2-[(naphthalen-2-yloxy)carbonyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0036
3-amino-6-oxo-2-[[4-(trifluoromethyl)phenyl]carbonyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
-
-
0.0033
ubiquitin
pH 7.5, 25°C, recombinant wild-type isozyme L1
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.12
-
UCH-L1, isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
high expression level of UCH-L1 in caput epididymis
Manually annotated by BRENDA team
high expression level of UCH-L3 in caudate epididymis
Manually annotated by BRENDA team
the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes. Constitutive UCH-L1 expression in tubulointerstitial and glomerular cells
Manually annotated by BRENDA team
in cultured proliferating NPCs, UCH-L1 is coexpressed with nestin. In differentiating cells, UCH-L1 is highly co-expressed with the early neuronal marker TuJ1
Manually annotated by BRENDA team
at 6.5 day of gestation of PGP9.5 is detected at various levels in decidual and primary trophoblast giant cells in the placenta. At 10.5 and 14 day of gestation PGP9.5 is expressed at moderate to strong levels in neurons. At 10.5 and 14 day of gestation PGP9.5 is expressed rarely
Manually annotated by BRENDA team
the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes
Manually annotated by BRENDA team
cholinergic neuronal cell line
Manually annotated by BRENDA team
UCHL1 is expressed in defective spermatozoa but not in normal spermatozoa
Manually annotated by BRENDA team
specific carbonyl level of UCH-L1 is significantly increased in spinal cord of G93A-SOD1 transgenic mice compared to that of nontransgenic mice
Manually annotated by BRENDA team
strong expression of UCHL1, no expression of UCHL3
Manually annotated by BRENDA team
-
UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells
Manually annotated by BRENDA team
high expression of UCH-L1
Manually annotated by BRENDA team
-
of mouse hind-paw
Manually annotated by BRENDA team
-
UCH-L3 is the predominant deubiquitinating enzyme in endosomal compartments of collecting duct epithelial cells
Manually annotated by BRENDA team
-
level of UCH-L3 decreases with age, while the level of UCH-L1 increases with age in wild-type mice
Manually annotated by BRENDA team
-
embryonic
Manually annotated by BRENDA team
-
lateral
Manually annotated by BRENDA team
expression level of CYLD is extremely low
Manually annotated by BRENDA team
-
MES13 cell line
Manually annotated by BRENDA team
at least two populations exist in the embryonic brain, cell culture
Manually annotated by BRENDA team
-
high content of UCHL1
Manually annotated by BRENDA team
-
distribution in cellular compartments, overview
Manually annotated by BRENDA team
-
including sensory and motor nerves
Manually annotated by BRENDA team
-
UCHL1 is expressed in podocytes of K256E-ACTN4pod+/UCHL1+/+ mice
Manually annotated by BRENDA team
CYLD is drastically upregulated during RANKL-induced differentiation of preosteoclasts
Manually annotated by BRENDA team
UCH-L1 protein
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
only localization
Manually annotated by BRENDA team
-
membrane associated form UCH-L1M, C-terminal farnesylation promotes the association of UCH-L1 with the membrane
Manually annotated by BRENDA team
additional information
-
UCH-L1 exists in a membrane-associated form, UCH-L1M, in addition to the commonly studied soluble form
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
the enzyme is required for regulated protein degradation through the ubiquitin proteasome system in kidney
physiological function
malfunction
metabolism
-
UCH-L1 in cell signaling, detailed overview
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
UCHL1_MOUSE
223
0
24838
Swiss-Prot
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25100
-
x * 25100, UCH-L1, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 25100, UCH-L1, SDS-PAGE
dimer
-
UCH-L1 can form dimers, whose form seems to act as another enzymatic activity in UCH-L1, ubiquitin ligase activity
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lipoprotein
-
C-terminal farnesylation promotes the association of UCH-L1 with membranes. Inhibition of UCH-L1 farnesylation by farnesyltransferase inhibitor FTI-277
additional information
-
cysteine residues of UCH-L1 are readily carbonylated by 4-hydroxy-2-nonenal or other unsaturated aldehydes, and the carbonylated UCH-L1 exhibits altered properties in hydrolase activity and protein-protein interactions
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C95S
retains the affinity to interact with ubiquitin dimers
D33A
loses the affinity to interact with ubiquitin dimers. D33A mutant expressing cells do not show any signs of free ubiquitin dimers accumulation
C14A
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
C14A/H119L
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
C95S
retains the affinity to interact with ubiquitin dimers
D30K
site-directed mutagenesis, isozyme L1, inactive
D33A
loses the affinity to interact with ubiquitin dimers. D33A mutant expressing cells do not show any signs of free ubiquitin dimers accumulation
H119L
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
S18Y
mutant of the Uch-L1 protein fused to the transduction domain of HIV-transactivator protein, has similar hydrolase activity than the unmutated fusion protein
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
fusion proteins purified by ProBond purification system
recombinant His-tagged wild-type and mutants of isozyme L1 expressed in Escherichia coli
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
ataxin-3 carrying six consecutive glutamines cloned into plasmid pGEX6P-1 and expressed as a GST fusion protein in the Escherichia coli Codon Plus-RIL strain
expressed in KR-4 cells
-
expression of wild-type and hydrolase-deficient mutant UCH-L3 in mouse embryonic finbroblasts
-
isozyme L1: expression of wild-type and mutants in Escherichia coli as His-tagged proteins
overexpression of isozyme L1 in mouse embryonic fibroblasts via adenovirus transfection
recombinant fusion proteins expressed in Escherichia Coli BL21(DE3)pLysS cells
UCH-L1 expression analysis by microarray, quantitative real time-PCR
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
germ cell apoptosis after testicular torsion treatment triggers downregulation of UCH-L1 in testis at both mRNA and protein levels
UCHL1 is significantly upregulated in denervated skeletal muscle
UCHL1 protein level is continuously declined during cell differentiation
camptothecin induces enzyme expression, also in RNAi silenced 293T and KR4 cells
-
enzyme downregulation by RNAi in C33A cells. UCH L1 suppression inhibits cell proliferation and migration and induces G0/G1 arrest and apoptosis
-
high glucose increases UCHL5 protein expression
-
increased UCH-L1 protein, together with the corresponding changes of Jab1, is detected in morphologically abnormal oocytes of prepubertal ovaries
-
treatment with LiCl induces UCH L1 expression in 3T3 cells, no induction by TCF-4, but synergistic effects of TCF-4 and LiCl, TCF4 binds to the endogenous uchl1 promoter
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
degradation
protein L-isoaspartate O-methyltransferase initiates the repair of isoaspartyl residues in aged or stress-damaged proteins in vivo, e.g. UCHL1 is a substrate for the L-isoaspartate methyltransferase in vivo
medicine
analysis
-
UCH-L1 is a neuronal marker
medicine
additional information
-
dynamic regulation of apically located epithelial sodium channel by recycling, which is facilitated by UCH-L3
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Osaka, H.; Wang, Y.L.; Takada, K.; Takizawa, S.; Setsuie, R.; Li, H.; Sato, Y.; Nishikawa, K.; Sun, Y.J.; Sakurai, M.; Harada, T.; Hara, Y.; Kimura, I.; Chiba, S.; Namikawa, K.; Kiyama, H.; Noda, M.; Aoki, S.; Wada, K.
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
Hum. Mol. Genet.
12
1945-1958
2003
Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Harada, T.; Harada, C.; Wang, Y.L.; Osaka, H.; Amanai, K.; Tanaka, K.; Takizawa, S.; Setsuie, R.; Sakurai, M.; Sato, Y.; Noda, M.; Wada, K.
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo
Am. J. Pathol.
164
59-64
2004
Mus musculus
Manually annotated by BRENDA team
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sato, Y.; Sakurai, M.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
Am. J. Pathol.
165
1367-1374
2004
Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sakurai, M.; Sato, Y.; Lee, W.W.; Ishii, Y.; Kyuwa, S.; Noda, M.; Wada, K.; Yoshikawa, Y.
Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
Biol. Reprod.
71
515-521
2004
Mus musculus, Mus musculus (P15347), Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Kwon, J.; Mochida, K.; Wang, Y.L.; Sekiguchi, S.; Sankai, T.; Aoki, S.; Ogura, A.; Yoshikawa, Y.; Wada, K.
Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
Biol. Reprod.
73
29-35
2005
Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Kwon, J.; Sekiguchi, S.; Wang, Y.L.; Setsuie, R.; Yoshikawa, Y.; Wada, K.
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis
Exp. Anim.
55
35-43
2006
Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Wood, M.A.; Kaplan, M.P.; Brensinger, C.M.; Guo, W.; Abel, T.
Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
Hippocampus
15
610-621
2005
Mus musculus, Mus musculus (Q9JKB1)
Manually annotated by BRENDA team
Sakurai, M.; Ayukawa, K.; Setsuie, R.; Nishikawa, K.; Hara, Y.; Ohashi, H.; Nishimoto, M.; Abe, T.; Kudo, Y.; Sekiguchi, M.; Sato, Y.; Aoki, S.; Noda, M.; Wada, K.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
J. Cell Sci.
119
162-171
2006
Homo sapiens, Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Dong, X.; Yagita, K.; Zhang, J.; Okamura, H.
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1
Biomed. Res.
26
43-49
2005
Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Gong, B.; Cao, Z.; Zheng, P.; Vitolo, O.V.; Liu, S.; Staniszewski, A.; Moolman, D.; Zhang, H.; Shelanski, M.; Arancio, O.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
Cell
126
775-788
2006
Mus musculus, Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Sekiguchi, S.; Yoshikawa, Y.; Tanaka, S.; Kwon, J.; Ishii, Y.; Kyuwa, S.; Wada, K.; Nakamura, S.; Takahashi, K.
Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse
Exp. Anim.
52
365-369
2003
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Poon, H.F.; Hensley, K.; Thongboonkerd, V.; Merchant, M.L.; Lynn, B.C.; Pierce, W.M.; Klein, J.B.; Calabrese, V.; Butterfield, D.A.
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
Free Radic. Biol. Med.
39
453-462
2005
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Castegna, A.; Thongboonkerd, V.; Klein, J.; Lynn, B.C.; Wang, Y.L.; Osaka, H.; Wada, K.; Butterfield, D.A.
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
J. Neurochem.
88
1540-1546
2004
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Wang, Y.L.; Liu, W.; Sun, Y.J.; Kwon, J.; Setsuie, R.; Osaka, H.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice
Mol. Reprod. Dev.
73
40-49
2006
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Sano, Y.; Furuta, A.; Setsuie, R.; Kikuchi, H.; Wang, Y.L.; Sakurai, M.; Kwon, J.; Noda, M.; Wada, K.
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice
Am. J. Pathol.
169
132-141
2006
Mus musculus
Manually annotated by BRENDA team
Sekiguchi, S.; Kwon, J.; Yoshida, E.; Hamasaki, H.; Ichinose, S.; Hideshima, M.; Kuraoka, M.; Takahashi, A.; Ishii, Y.; Kyuwa, S.; Wada, K.; Yoshikawa, Y.
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy
Am. J. Pathol.
169
1722-1729
2006
Mus musculus
Manually annotated by BRENDA team
Mermerian, A.H.; Case, A.; Stein, R.L.; Cuny, G.D.
Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors
Bioorg. Med. Chem. Lett.
17
3729-3732
2007
Mus musculus
Manually annotated by BRENDA team
Lansbury, P.T.
Improving synaptic function in a mouse model of AD
Cell
126
655-657
2006
Aplysia sp., Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bifsha, P.; Landry, K.; Ashmarina, L.; Durand, S.; Seyrantepe, V.; Trudel, S.; Quiniou, C.; Chemtob, S.; Xu, Y.; Gravel, R.A.; Sladek, R.; Pshezhetsky, A.V.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway
Cell Death Differ.
14
511-523
2007
Mus musculus, Homo sapiens (P09936), Homo sapiens
Manually annotated by BRENDA team
Sakurai, M.; Sekiguchi, M.; Zushida, K.; Yamada, K.; Nagamine, S.; Kabuta, T.; Wada, K.
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
Eur. J. Neurosci.
27
691-701
2008
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Mauri, P.L.; Riva, M.; Ambu, D.; De Palma, A.; Secundo, F.; Benazzi, L.; Valtorta, M.; Tortora, P.; Fusi, P.
Ataxin-3 is subject to autolytic cleavage
FEBS J.
273
4277-4286
2006
Mus musculus (Q9CVD2)
Manually annotated by BRENDA team
Vigneswara, V.; Lowenson, J.D.; Powell, C.D.; Thakur, M.; Bailey, K.; Clarke, S.; Ray, D.E.; Carter, W.G.
Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
J. Biol. Chem.
281
32619-32629
2006
Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Burg, D.; Johnson, J.P.; Frizzell, R.A.
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
J. Biol. Chem.
282
37885-37893
2007
Mus musculus
Manually annotated by BRENDA team
Fujino, R.S.; Ishikawa, Y.; Tanaka, K.; Kanatsu-Shinohara, M.; Tamura, K.; Kogo, H.; Shinohara, T.; Hara, T.
Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells
Mol. Reprod. Dev.
73
955-966
2006
Mus musculus, Mus musculus DBA/2
Manually annotated by BRENDA team
Sun, J.; Ying, M.; Li, H.; Shang, X.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury
Biochem. Biophys. Res. Commun.
366
539-544
2008
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Vasu, V.T.; Ott, S.; Hobson, B.; Rashidi, V.; Oommen, S.; Cross, C.E.; Gohil, K.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice
Free Radic. Res.
43
106-116
2009
Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Jin, W.; Chang, M.; Paul, E.M.; Babu, G.; Lee, A.J.; Reiley, W.; Wright, A.; Zhang, M.; You, J.; Sun, S.C.
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
J. Clin. Invest.
118
1858-1866
2008
Mus musculus (Q80TQ2)
Manually annotated by BRENDA team
Lu, Y.; Adegoke, O.A.; Nepveu, A.; Nakayama, K.I.; Bedard, N.; Cheng, D.; Peng, J.; Wing, S.S.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Mol. Cell. Biol.
29
547-558
2009
Mus musculus (Q3UJD6), Rattus norvegicus (Q6J1Y9)
Manually annotated by BRENDA team
Setsuie, R.; Sakurai, M.; Sakaguchi, Y.; Wada, K.
Ubiquitin dimers control the hydrolase activity of UCH-L3
Neurochem. Int.
54
314-321
2009
Homo sapiens (P09936), Homo sapiens (P15374), Mus musculus (Q9JKB1), Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Fang, Y.; Fu, D.; Shen, X.Z.
The potential role of ubiquitin C-terminal hydrolases in oncogenesis
Biochim. Biophys. Acta
1806
1-6
2010
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Suzuki, M.; Setsuie, R.; Wada, K.
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis
Endocrinology
150
5230-5239
2009
Mus musculus
Manually annotated by BRENDA team
Pfeffer, M.; Plenzig, S.; Gispert, S.; Wada, K.; Korf, H.W.; Von Gall, C.
Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene
Neurobiol. Aging
33
393-403
2012
Mus musculus
Manually annotated by BRENDA team
Goto, A.; Wang, Y.L.; Kabuta, T.; Setsuie, R.; Osaka, H.; Sawa, A.; Ishiura, S.; Wada, K.
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse
Neurochem. Int.
54
330-338
2009
Mus musculus
Manually annotated by BRENDA team
Setsuie, R.; Suzuki, M.; Tsuchiya, Y.; Wada, K.
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
Neurochem. Int.
56
911-918
2010
Mus musculus
Manually annotated by BRENDA team
Nagamine, S.; Kabuta, T.; Furuta, A.; Yamamoto, K.; Takahashi, A.; Wada, K.
Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
Neurochem. Int.
57
102-110
2010
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
PLoS ONE
4
e5955
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bheda, A.; Shackelford, J.; Pagano, J.S.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes
PLoS ONE
4
e6764
2009
Mus musculus
Manually annotated by BRENDA team
Liu, Z.; Meray, R.K.; Grammatopoulos, T.N.; Fredenburg, R.A.; Cookson, M.R.; Liu, Y.; Logan, T.; Lansbury, P.T.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease
Proc. Natl. Acad. Sci. USA
106
4635-4640
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chen, F.; Sugiura, Y.; Myers, K.G.; Liu, Y.; Lin, W.
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
Proc. Natl. Acad. Sci. USA
107
1636-1641
2010
Mus musculus
Manually annotated by BRENDA team
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Gu, Y.Q.; Chen, Q.J.; Gu, Z.; Shi, Y.; Yao, Y.W.; Wang, J.; Sun, Z.G.; Tso, J.K.
Ubiquitin carboxyl-terminal hydrolase L1 contributes to the oocyte selective elimination in prepubertal mouse ovaries
Sheng Li Xue Bao
61
175-184
2009
Mus musculus, Mus musculus ICR
Manually annotated by BRENDA team
Ko, Y.M.; Chang, C.Y.; Chiou, S.J.; Hsu, F.J.; Huang, J.S.; Yang, Y.L.; Guh, J.Y.; Chuang, L.Y.
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells
Arch. Biochem. Biophys.
535
177-186
2013
Mus musculus
Manually annotated by BRENDA team
Read, N.C.; Gutsol, A.; Holterman, C.E.; Carter, A.; Coulombe, J.; Gray, D.A.; Kennedy, C.R.
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis
Biochim. Biophys. Acta
1842
1028-1040
2014
Mus musculus
Manually annotated by BRENDA team
Hartnett, S.; Zhang, F.; Abitz, A.; Li, Y.
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells
Neurosci. Lett.
564
115-119
2014
Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Gao, H.; Hartnett, S.; Li, Y.
Ubiquitin C-terminal hydrolase L1 regulates myoblast proliferation and differentiation
Biochem. Biophys. Res. Commun.
492
96-102
2017
Mus musculus (Q9R0P9), Mus musculus
Manually annotated by BRENDA team
Bishop, P.; Rocca, D.; Henley, J.M.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) structure, distribution and roles in brain function and dysfunction
Biochem. J.
473
2453-2462
2016
Homo sapiens (P09936), Mus musculus (Q9R0P9)
Manually annotated by BRENDA team
Radon, V.; Czesla, M.; Reichelt, J.; Fehlert, J.; Hammel, A.; Rosendahl, A.; Knop, J.H.; Wiech, T.; Wenzel, U.O.; Sachs, M.; Reinicke, A.T.; Stahl, R.A.K.; Meyer-Schwesinger, C.
Ubiquitin C-terminal hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Kidney Int.
93
110-127
2018
Mus musculus (Q9R0P9)
Manually annotated by BRENDA team