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polyubiquitin + H2O
ubiquitin
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
-
-
-
?
ubiquitinyl-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
-
-
-
?
polyubiquitin + H2O
ubiquitin
ubiquitin + H2O
?
-
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
additional information
?
-
polyubiquitin + H2O
ubiquitin
-
-
-
-
?
polyubiquitin + H2O
ubiquitin
-
UCHL1/PGP 9.5, overview
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
-
-
-
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
ubiquitin + 7-amino-4-methylcoumarin
recombinant wild-type isozyme L1
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-
?
additional information
?
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-
affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
-
-
?
additional information
?
-
affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
-
-
?
additional information
?
-
gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
-
-
?
additional information
?
-
-
gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
-
-
?
additional information
?
-
mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
-
-
?
additional information
?
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-
mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
-
-
?
additional information
?
-
the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
-
-
?
additional information
?
-
-
the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
-
-
?
additional information
?
-
-
ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
-
-
?
additional information
?
-
ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
-
-
?
additional information
?
-
UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
-
-
?
additional information
?
-
-
UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
-
-
?
additional information
?
-
-
UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
-
-
?
additional information
?
-
UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
-
-
?
additional information
?
-
is overexpressed in alpha-tocopherol deficient mice
-
-
?
additional information
?
-
UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
-
-
?
additional information
?
-
-
UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
-
-
?
additional information
?
-
-
isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
-
-
?
additional information
?
-
isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
-
-
?
additional information
?
-
-
the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
-
-
?
additional information
?
-
the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
-
-
?
additional information
?
-
-
the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
-
-
?
additional information
?
-
the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
-
-
?
additional information
?
-
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in neural cell apoptosis induced by ischemic retinal injury, e.g. in mice with gracile axonal dystrophy, overview
-
-
?
additional information
?
-
-
UCH-L1 functions in sperm quality control during epididymal maturation
-
-
?
additional information
?
-
UCH-L1 functions in sperm quality control during epididymal maturation
-
-
?
additional information
?
-
-
UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
-
UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
-
-
Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
-
-
?
additional information
?
-
Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
-
-
?
additional information
?
-
-
the enzyme shows de-ubiquinating activity
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-
?
additional information
?
-
the enzyme shows de-ubiquinating activity
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-
?
additional information
?
-
-
ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
-
-
?
additional information
?
-
ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
-
-
?
additional information
?
-
AT-3 carrying six consecutive glutamines undergoes fragmentation upon incubation at room temperature. Cys14 and His119 are involved in the autolytic activity
-
-
?
additional information
?
-
CYLD negatively regulates RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. CYLD interacts physically with the signaling adaptor p62 and thereby is recruited to TRAF6. CYLD is a crucial negative regulator of osteoclastogenesis and may be involved in the p62/TRAF6 signaling axis
-
-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
-
-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
-
-
?
additional information
?
-
UCH-L3 does not function to hydrolyze free ubiquitin dimers
-
-
?
additional information
?
-
UCH-L3 does not function to hydrolyze free ubiquitin dimers
-
-
?
additional information
?
-
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons
-
-
?
additional information
?
-
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons
-
-
?
additional information
?
-
-
UCH-L3 is capable of cleaving Ub from the Ub chains in vitro, and UCH-L3 directly hydrolyses polyubiquitinated proteins. Wild-type, but not its hydrolase activity or ubiquitin binding activity deficient, UCH-L3 shows the ability to cleave ubiquitin from polyubiquitinated lysozyme in vitro, which is no substrate of UCH-L1
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
polyubiquitin + H2O
ubiquitin
-
UCHL1/PGP 9.5, overview
-
-
?
additional information
?
-
additional information
?
-
-
affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
-
-
?
additional information
?
-
affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
-
-
?
additional information
?
-
gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
-
-
?
additional information
?
-
-
gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
-
-
?
additional information
?
-
mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
-
-
?
additional information
?
-
-
mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
-
-
?
additional information
?
-
the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
-
-
?
additional information
?
-
-
the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
-
-
?
additional information
?
-
-
ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
-
-
?
additional information
?
-
ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
-
-
?
additional information
?
-
UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
-
-
?
additional information
?
-
-
UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
-
-
?
additional information
?
-
-
UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
-
-
?
additional information
?
-
UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
-
-
?
additional information
?
-
is overexpressed in alpha-tocopherol deficient mice
-
-
?
additional information
?
-
UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
-
-
?
additional information
?
-
-
UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
-
-
?
additional information
?
-
-
isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
-
-
?
additional information
?
-
isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
-
-
?
additional information
?
-
-
the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
-
-
?
additional information
?
-
the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
-
-
?
additional information
?
-
-
the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
-
-
?
additional information
?
-
the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
-
-
?
additional information
?
-
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
the enzyme is involved in spermatogenesis
-
-
?
additional information
?
-
-
the enzyme plays a role in neural cell apoptosis induced by ischemic retinal injury, e.g. in mice with gracile axonal dystrophy, overview
-
-
?
additional information
?
-
-
UCH-L1 functions in sperm quality control during epididymal maturation
-
-
?
additional information
?
-
UCH-L1 functions in sperm quality control during epididymal maturation
-
-
?
additional information
?
-
-
UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
-
UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
-
-
Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
-
-
?
additional information
?
-
Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
-
-
?
additional information
?
-
-
ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
-
-
?
additional information
?
-
ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
-
-
?
additional information
?
-
CYLD negatively regulates RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. CYLD interacts physically with the signaling adaptor p62 and thereby is recruited to TRAF6. CYLD is a crucial negative regulator of osteoclastogenesis and may be involved in the p62/TRAF6 signaling axis
-
-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
-
-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
-
-
?
additional information
?
-
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons
-
-
?
additional information
?
-
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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brenda
high expression level of UCH-L1 in caput epididymis
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high expression level of UCH-L3 in caudate epididymis
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the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes. Constitutive UCH-L1 expression in tubulointerstitial and glomerular cells
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in cultured proliferating NPCs, UCH-L1 is coexpressed with nestin. In differentiating cells, UCH-L1 is highly co-expressed with the early neuronal marker TuJ1
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at 6.5 day of gestation of PGP9.5 is detected at various levels in decidual and primary trophoblast giant cells in the placenta. At 10.5 and 14 day of gestation PGP9.5 is expressed at moderate to strong levels in neurons. At 10.5 and 14 day of gestation PGP9.5 is expressed rarely
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the enzyme is found in tubular and parietal cells of the kidney and is expressed de novo in injured podocytes
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cholinergic neuronal cell line
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UCHL1 is expressed in defective spermatozoa but not in normal spermatozoa
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specific carbonyl level of UCH-L1 is significantly increased in spinal cord of G93A-SOD1 transgenic mice compared to that of nontransgenic mice
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strong expression of UCHL1, no expression of UCHL3
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UCH-L1 present in the outer layer cells of the trophectoderm. UCH-L3 present in the inner cells
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high expression of UCH-L1
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area 1
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MEFs
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of mouse hind-paw
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UCH-L3 is the predominant deubiquitinating enzyme in endosomal compartments of collecting duct epithelial cells
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level of UCH-L3 decreases with age, while the level of UCH-L1 increases with age in wild-type mice
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embryonic
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lateral
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expression level of CYLD is extremely low
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MES13 cell line
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-
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at least two populations exist in the embryonic brain, cell culture
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high content of UCHL1
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-
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-
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distribution in cellular compartments, overview
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including sensory and motor nerves
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UCHL1 is expressed in podocytes of K256E-ACTN4pod+/UCHL1+/+ mice
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CYLD is drastically upregulated during RANKL-induced differentiation of preosteoclasts
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UCH-L1 protein
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embryo, expression pattern in the ventricular zone changes between embryonic day 14 and 16, which corresponds to the transition from neurogenesis to gliogenesis. At embryonic day 14, UCH-L1 is highly expressed in the ventricular zone, where neurogenesis actively occurs, whereas its expression is prominent in the cortical plate at embroynic day 16. UCH-L1 is very weakly detected in the ventricular zone at embryonic day 16, which corresponds to the start of gliogenesis. UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology
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gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
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ubiquitin C-terminal hydrolase L1 is an extremely abundant protein in the brain. It is estimated to make up 1-5% of total neuronal protein
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at 6.5 day of gestation of PGP9.5 is detected at various levels in embryonic ectoderm cells. At 10.5 and 14 day of gestation PGP9.5 is expressed at moderate to strong levels in neurons
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brain, expression pattern in the ventricular zone changes between embryonic day 14 and 16, which corresponds to the transition from neurogenesis to gliogenesis. At embryonic day 14, UCH-L1 is highly expressed in the ventricular zone, where neurogenesis actively occurs, whereas its expression is prominent in the cortical plate at embroynic day 16. UCH-L1 is very weakly detected in the ventricular zone at embryonic day 16, which corresponds to the start of gliogenesis. UCH-L1 spatially mediates and enhances neurogenesis in the embryonic brain by regulating progenitor cell morphology
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the enzyme insures ubiquitin stability within neurons
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beyond its expression in neurons UCH-L1 has only very limited expression in other healthy tissues but it is highly expressed in several forms of cancer
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UCH-L1 may act during mitotic proliferation of spermatogonial stem cells
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upregulated in skeletal muscles in disease conditions
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UCH-L1 may act during mitotic proliferation of spermatogonial stem cells
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absence of UCH-L1 causes resistance to cryptorchid-induced testicular germ cell apoptosis. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism
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absence of UCH-L3 promotes germ cell apoptosis after cryptorchid injury. UCH-L1 and UXH-L3 have reciprocal functions, with respect to mediating injury after experimental cryptorchidism
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mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
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-
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isozymes L1, specific for neuronal cells, testis and ovary, and L3
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embryonic, UCH-L1 expression in the ventricular zone changes during neurogenesis and gliogenesis, high expression level in cortical plate and ventricular zone, overview
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reduced levels of UCH-L1 mRNA (30%) and protein in a mouse model of Sandhoff disease as compared with their wild-type siblings
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in mouse brain regions, e.g. cortex, hippocampus, striatum, and midbrain, both UCH-L1M and UCH-L1S occur in varying relative amounts
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neuron-specific expression of UCH-L1
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UCH-L1 is one of the most abundant proteins in the mammalian brain
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high expression of UCH-L3
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UCH-L1 and UCH-L3 present during all of the embryonic stages. UCH-L1 is essentially constant in all cases, but the level of UCH-L3 is lower in the blastocyst stage. Developing embryos of gad and Uchl3 knockout mice are negative for UCH-L1 and UCH-L3
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regiospecific expression of uchl1 and uchl3 in cauda, corpus, and caput, overview
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testicular
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-
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high expression of UCH-L1
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neuron-specific isozyme UCH-L1
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high content of UCHL1, distribution in neuron types and cellular compartments, overview
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primary dopaminergic neurons
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UCH-L1 is localized on the inside of the plasma membrane of dorsal root ganglion neurons
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UCH-L1 and UCH-L3 present in mature oocytes. Oocytes of gad and Uchl3 knockout mice ovaries are negative for UCH-L1 and UCH-L3, respectively
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expression of UCH-L1 in oocytes in prepubertal mouse ovaries, immunohistochemic analysis. Significant decrease in the follicular pool during the period of day 21 to day 28 after birth
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UCHL1 and UCHL3 are present in the oocyte throughout the oestrous cycle in wild-type mice, but appropriately immunoreactivity for UCHL1 is absent from the gad mouse and UCHL3 immunoreactivity is absent from the UCHL3 knock-out mouse, overview
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isozyme L1, specific for neuronal cells, testis and ovary
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high expression of UCH-L1
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UCH-L1 and UCH-L3 are expressed in ovaries during proestrus, estrus, metestrus, and diestrus. Both proteins are present at all estrous cycle stages in wild-type mice. UCH-L1 is absent from gad ovaries and UCH-L3 from Uchl3 knockout ovaries
brenda
-
analysis of the ovarian UCH-L1 expression, overview
brenda
-
-
brenda
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localization of UCH-L3 in the wild-type retina is altered with age. UCH-L3 is enriched in the photoreceptor inner segment that contains abundant mitochondria. UCH-L1 is expressed in both genotypes in the inner retina, which consists of the inner nuclear layer, inner plexiform layer, and ganglion cell layer
brenda
UCH-L3 protein
brenda
UCH-L3 may function in the meiotic differentiation of spermatocytes into spermatids
brenda
UCH-L3 protein
brenda
UCH-L3 may function in the meiotic differentiation of spermatocytes into spermatids
brenda
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-
brenda
UCH-L1 protein
brenda
-
brenda
-
brenda
-
-
brenda
-
brenda
-
brenda
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-
brenda
-
brenda
isozyme L1, specific for neuronal cells, testis and ovary
brenda
cryptorchid and healthy
brenda
-
high expression of UCH-L1
brenda
additional information
3T3 cell
brenda
additional information
3T3 cell
brenda
additional information
-
no isozyme L1 expression in embryonic fibroblasts
brenda
additional information
no isozyme L1 expression in embryonic fibroblasts
brenda
additional information
-
isozyme L3 is universally expressed in all tissues
brenda
additional information
isozyme L3 is universally expressed in all tissues
brenda
additional information
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expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
brenda
additional information
expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
brenda
additional information
expression pattern of UCH isozymes in Sertoli cells, spermatids, spermatocytes, and spermatogonia, overview
brenda
additional information
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quantitative testicular expression analysis of UCHL1
brenda
additional information
quantitative testicular expression analysis of UCHL1
brenda
additional information
3T3 cell
brenda
additional information
3T3 cell
brenda
additional information
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absence of UCHL1 in the gracile axonal dystrophy mouse, which results in neurodegeneration
brenda
additional information
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UCH-L1 is upregulated and more abundantly expressed in germ line stem cells than in embryonic stem cells
brenda
additional information
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increased expression and activity of UCH L1 in EBV-immortalized cell lines
brenda
additional information
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tissue distribution and immunohistochemic analysis, overview
brenda
additional information
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UCH-L1 is exclusively expressed in brain and testis
brenda
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metabolism
the enzyme is required for regulated protein degradation through the ubiquitin proteasome system in kidney
metabolism
-
UCH-L1 in cell signaling, detailed overview
malfunction
ubiquitination by UCH-L1 is involved in ischemia-reperfusion stress
malfunction
gene knockdown of UCHL1 by siRNA results in a significant decrease in cell proliferation but marked acceleration of cell differentiation and myotube formation. UCHL1 gene knockdown upregulates myogenic factors myoD and Myogenin (MyoG)
malfunction
UCH-L1 dysfunction is implicated in neurodegenerative disease
malfunction
UCH-L1-deficient mice develop proteinuria, without gross changes in glomerular morphology. Tubular cells, endothelial cells, and podocytes show signs of stress with an accumulation of oxidative modified and polyubiquitinated proteins. Mechanistically, abnormal protein accumulation results from an altered proteasome abundance leading to decreased proteasomal activity. UCH-L1-deficient mice exhibit an exacerbated course of disease with increased tubulointerstitial and glomerular damage, acute renal failure, and death, the latter most likely a result of general neurologic impairment
physiological function
UCH-L1 plays an important role in maintaining the intracellular levels of the ubiquitin
physiological function
isoform UCHL1 physically interacts with high affinity choline transporter CHT, which is a key protein regulating Ach re-synthesis. Reduction of UCHL1 by siRNA gene knockdown significantly increases polyubiquitinated CHT and decreased native CHT protein level, but does not affect CHT mRNA expression. Gene knockdown of UCHL1 significantly reduces cytosolic CHT but has no significant effect on membrane CHT level
physiological function
major deubiquitinating enzyme of the nervous system and associated with the development of neurodegenerative diseases
physiological function
the enzyme is required for regulated protein degradation in the kidney by controlling proteasome abundance
physiological function
UCH-L1 is required for the maintenance of axonal integrity
physiological function
UCHL1 may play a role in myogenesis by promoting myoblast proliferation and inhibiting differentiation
malfunction
-
deficiency of UCH-L1 leads to vulnerability to lipid peroxidation both in vivo and in vitro
malfunction
-
in the absence of UCH-L1, synaptic transmission at the neuromuscular junctions is markedly impaired. Loss of normal UCH-L1 activity may result in neurodegeneration in the peripheral nervous system
malfunction
-
increased UCH-L1 protein, together with the corresponding changes of Jab1, is detected in morphologically abnormal oocytes of prepubertal ovaries
malfunction
-
UCH L1 is expressed in a number of malignancies, it might be involved in oncogenic processes. UCH L1 suppression induces G0/G1 arrest and apoptosis
malfunction
-
10-week-old K256E-ACTN4pod+/UCHL1-/- mice exhibit reduced albuminuria, glomerulosclerosis, foot process effacement, glomerular basement membrane thickening, glomerular and tubular cell apoptosis, and ameliorated renal pathology. Observations coincide with decreased polyubiquitinated protein levels and increased K256E-alpha-actinin-4 levels in K256E-ACTN4pod+/UCHL1-/-mice kidneys, suggesting impaired proteolysis of K256E-alpha-actinin-4
physiological function
-
role of UCH-L1 in synaptic function in the brain, overview
physiological function
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons
physiological function
-
UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons
physiological function
-
UCH-L1 is responsible for hydrolyzing carboxyl terminal esters and amides of ubiquitin. Additionally, it possesses ubiquitin ligase activity and functions as a mono-ubiquitin stabilizer, which is independent of enzymatic activity, and is also involved in the co-translational processing of pro-ubiquitin and ribosomal proteins translated as ubiquitin fusions. UCH-L3 is a kind of ubiquitin-protein hydrolase involved in the processing of both ubiquitin precursors and ubiquitinated substrates, generating free monomeric ubiquitin. UCH37, different from other UCH members, is responsible for the Ub isopeptidase activity in the 19S proteasome regulatory complex, overview. UCH-L3 shows deneddylating activity, the only target proteins for neddylation are cullins, which are involved in cell-cycle control, therefore UCH-L3 might function as a cell-cycle regulator
physiological function
-
UCH-L1 mediates maintenance of the temporal integrity and persistence of cyclic AMP response element binding protein, CREB, phosphorylation in the brain
physiological function
-
UCH-L3 functions as a de-ubiquitinating enzyme in vivo. The polyubiquitinated protein accumulation in Uchl3-/- embryonic fibroblasts is attenuated by the exogenous expression of wild-type, but not hydrolase activity deficient UCH-L3
physiological function
-
UCH-L3 promotes insulin signaling and adipogenesis
physiological function
-
UCHL1 is a component of the ubiquitin system, and the UCH-L1-dependent apoptosis is important for spermatogenesis. UCH-L1 plays an important role, possibly in association with Jab1 and p27Kip1, in selective elimination of abnormal oocytes during mouse prepubertal development
physiological function
-
UCHL1/PGP 9.5 is important in the ubiquitin system, detailed overview. UCHL1/PGP 9.5 might be involved in blocking polyspermy, particularly at the plasma membrane
physiological function
-
high glucose increases the TGF-betaR1 protein expression via the PI3K-UCHL5 pathway in mesangial cells
physiological function
-
UCHL5 is required for high glucose-induced reduction of TGFbetaR1 protein ubiquitination, p21WAF1 protein expression, cell hypertrophy and fibronectin protein expression
additional information
-
ectopic expression of UCH-L3 promotes the phosphorylation of insulin/IGF-I receptor and adipocyte differentiation in fibroblasts, overview
additional information
-
membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity, mechanism, overview
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C95S
retains the affinity to interact with ubiquitin dimers
D33A
loses the affinity to interact with ubiquitin dimers. D33A mutant expressing cells do not show any signs of free ubiquitin dimers accumulation
C14A
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
C14A/H119L
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
C95S
retains the affinity to interact with ubiquitin dimers
D30K
site-directed mutagenesis, isozyme L1, inactive
D33A
loses the affinity to interact with ubiquitin dimers. D33A mutant expressing cells do not show any signs of free ubiquitin dimers accumulation
H119L
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature
S18Y
mutant of the Uch-L1 protein fused to the transduction domain of HIV-transactivator protein, has similar hydrolase activity than the unmutated fusion protein
C90S
site-directed mutagenesis, isozyme L1, inactive
C90S
exchange of the active site cysteine
C90S
-
inhibits the protective action of endogenous UCH-L1. C90S-fusion protein does not rescue the deficit in long term potentiation induced by Abeta, acts as a dominant negative mutant, causes a deficit in long term potentiation in the absence of oligomeric Abeta
C90S
mutant of the Uch-L1 protein fused to the transduction domain of HIV-transactivator protein, has little activity
additional information
-
gad mouse null mutants of isozyme L1 show reduced monoubiquitin level in neurons, overexpression of the isozyme L1 leads to an increased monoubiquitin level
additional information
gad mouse null mutants of isozyme L1 show reduced monoubiquitin level in neurons, overexpression of the isozyme L1 leads to an increased monoubiquitin level
additional information
-
gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1
additional information
gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1
additional information
-
gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1 and are resistant to cryptorchid stress-related injury, the show reduced ubiquitin levels, uchl3 knockout mice show profound testicular atrophy and apoptotic germ cell loss after cryptorchid injury, but unaltered ubiquitin levels compared to wild-type mice, testicular phenotype of mutant mice, overview
additional information
gad, i.e. gracile axonal dystrophy, mice testis lack isozyme UCH-L1 and are resistant to cryptorchid stress-related injury, the show reduced ubiquitin levels, uchl3 knockout mice show profound testicular atrophy and apoptotic germ cell loss after cryptorchid injury, but unaltered ubiquitin levels compared to wild-type mice, testicular phenotype of mutant mice, overview
additional information
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UCH-L1-deficient gad mice show progressively decreasing spermatogonial stem cell proliferation
additional information
UCH-L1-deficient gad mice show progressively decreasing spermatogonial stem cell proliferation
additional information
UCH-L1-deficient gad mice show progressively decreasing spermatogonial stem cell proliferation
additional information
-
in gracile axonal dystrophy mice with a spontaneous deletion in the Uch-l1 gene, memory in passive avoidance learning, exploratory behaviour and hippocampal CA1 long-term potentiation are reduced, whereas cyclic AMP response element binding protein phosphorylation is altered
additional information
-
mutant of the Uch-L1 protein fused to the transduction domain of HIV-transactivator protein with a 57 amino acid deletion (130-186) including the H161 site, is inactive
additional information
mutant of the Uch-L1 protein fused to the transduction domain of HIV-transactivator protein with a 57 amino acid deletion (130-186) including the H161 site, is inactive
additional information
-
UCH-L1-deficient ova of gad female mice have a significantly increased rate of polyspermy in in vitro fertilization assays, although the rate of fertilization does not differ significantly from wild-type mice. Litter size of gad female mice is significantly reduced compared with wild-type mice
additional information
-
Uchl3 deletion mutant displays retinal degeneration, muscular degeneration, and mild growth retardation. No significant morphological abnormalities during retinal development, prominent retinal degeneration becomes manifested after 3 weeks of age associated with photoreceptor cell apoptosis. Decreased area of mitochondrial cristae and vacuolar changes in the degenerated inner segment. Loss of UCH-L3 leads to mitochondrial oxidative stress-related photoreceptor cell apoptosis in a caspase-independent manner
additional information
mice with a genetic deficiency of CYLD have aberrant osteoclast differentiation and develop severe osteoporosis. Cultured osteoclast precursors derived from CYLD-deficient mice are hyperresponsive to RANKL-induced differentiation and produce more and larger osteoclasts than do controls upon stimulation
additional information
-
construction of UCH-L1 knockout mice by targeted deletion of the UCH-L1 gene, in the absence of UCH-L1, synaptic transmission at the neuromuscular junctions is markedly impaired and it leads to ultrastructural defects of presynaptic nerve terminals at the neuromuscular junctions. UCH-L1 null mutation leads to progressive paralysis and premature death in mice, external phenotype and survival rate, overview
additional information
-
deficiency of UCH-L1 of gad mice, i.e. UCH-L1-deficient mutant gracile axonal dystrophy mice, leads to vulnerability to lipid peroxidation both in vivo and in vitro. When neurons from dorsal root ganglions are cultured in the vitamin E-free medium, cell death is increased in the neurons of gad mice. Oxidative stress, especially lipid peroxidation, augments the neuronal cell death of gad mice
additional information
-
embryonic fibroblasts from Uchl3-/- mice show an accumulation of polyubiquitinated proteins, the polyubiquitinated protein accumulation in Uchl3-/- embryonic fibroblasts is attenuated by the exogenous expression of wild-type, but not hydrolase activity deficient UCH-L3, overview
additional information
-
enzyme downregulation by RNAi. UCH L1 suppression inhibits cell proliferation and migration and induces G0/G1 arrest and apoptosis
additional information
-
gad, i.e. gracile axonal dystrophy, mice are analogous to a null mutants of UCH-L1, they display the dying-back-type of axonal degeneration in sensory neurons. The level of mono-ubiquitin is decreased in neurons, especially in axons of the sciatic nerve, in gad mice
additional information
-
in UCH-L3 knockout mice, the levels of both Nedd8 and the apoptotic protein p53 and Bax are elevated upon cryptorchid injury, the accumulation of Nedd8-conjugated proteins in UCH-L3 knockout mice contributed to profound germ cell loss via apoptosis
additional information
-
isolated loss of UCHL1/PGP 9.5 function, seen in the gracile axonal dystrophy, GAD, mouse due to a deletion in its gene results in a failure of axonal transport and a dying-back axonopathy beginning distally in long axons, the characteristic lesion in the GAD mouse is axonal dystrophy, gad mouse neuronal function phenotype, detailed overview
additional information
-
melanopsin-Ir is significantly reduced in the retina of gracile axonal dystrophy, i.e. gad, mice with a spontaneous deletion in the Uch-l1 gene, resulting in impairment of circadian light perception in gad mice, overview. In constant darkness, gad mice show circadian rhythms in locomotor activity, indicating the integrity of the endogenous circadian rhythm generator. In addition, gad mice show increased locomotor activity in the light period when kept in a standard photoperiod and entrainment to phase shifts is significantly slower than in wild-type mice
additional information
-
UCHL1-deficient gracile axonal dystrophy, i.e. gad, mice are spontaneous mutants with an in-frame deletion in exons 7 and 8 of Uch-l1. Deletion of the gene encoding UCH-L1 leads to a reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice, overview
additional information
-
Uchl3-deficient mice show reduced content of white adipose tissue and reduced adipogenesis due to attenuated insulin responses, ectopic expression of wild-type UCH-L3 restores the phosphorylation of insulin/IGF-I receptor and adipocyte differentiation in UCH-L3-/- mouse embyronic fibroblasts, overview. Hydrolase-deficient UCH-L3 does not enhance insulin signalling and expression of gluta4, fabp4, and adiponectin, resulting in impaired formation of large lipid droplets
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Osaka, H.; Wang, Y.L.; Takada, K.; Takizawa, S.; Setsuie, R.; Li, H.; Sato, Y.; Nishikawa, K.; Sun, Y.J.; Sakurai, M.; Harada, T.; Hara, Y.; Kimura, I.; Chiba, S.; Namikawa, K.; Kiyama, H.; Noda, M.; Aoki, S.; Wada, K.
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
Hum. Mol. Genet.
12
1945-1958
2003
Mus musculus, Mus musculus (Q9R0P9)
brenda
Harada, T.; Harada, C.; Wang, Y.L.; Osaka, H.; Amanai, K.; Tanaka, K.; Takizawa, S.; Setsuie, R.; Sakurai, M.; Sato, Y.; Noda, M.; Wada, K.
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo
Am. J. Pathol.
164
59-64
2004
Mus musculus
brenda
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sato, Y.; Sakurai, M.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
Am. J. Pathol.
165
1367-1374
2004
Mus musculus, Mus musculus (Q9R0P9)
brenda
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sakurai, M.; Sato, Y.; Lee, W.W.; Ishii, Y.; Kyuwa, S.; Noda, M.; Wada, K.; Yoshikawa, Y.
Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
Biol. Reprod.
71
515-521
2004
Mus musculus, Mus musculus (P15347), Mus musculus (Q9R0P9)
brenda
Kwon, J.; Mochida, K.; Wang, Y.L.; Sekiguchi, S.; Sankai, T.; Aoki, S.; Ogura, A.; Yoshikawa, Y.; Wada, K.
Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
Biol. Reprod.
73
29-35
2005
Mus musculus, Mus musculus (Q9R0P9)
brenda
Kwon, J.; Sekiguchi, S.; Wang, Y.L.; Setsuie, R.; Yoshikawa, Y.; Wada, K.
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis
Exp. Anim.
55
35-43
2006
Mus musculus, Mus musculus (Q9R0P9)
brenda
Wood, M.A.; Kaplan, M.P.; Brensinger, C.M.; Guo, W.; Abel, T.
Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
Hippocampus
15
610-621
2005
Mus musculus, Mus musculus (Q9JKB1)
brenda
Sakurai, M.; Ayukawa, K.; Setsuie, R.; Nishikawa, K.; Hara, Y.; Ohashi, H.; Nishimoto, M.; Abe, T.; Kudo, Y.; Sekiguchi, M.; Sato, Y.; Aoki, S.; Noda, M.; Wada, K.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
J. Cell Sci.
119
162-171
2006
Homo sapiens, Mus musculus, Mus musculus (Q9R0P9)
brenda
Dong, X.; Yagita, K.; Zhang, J.; Okamura, H.
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1
Biomed. Res.
26
43-49
2005
Mus musculus (Q9R0P9)
brenda
Gong, B.; Cao, Z.; Zheng, P.; Vitolo, O.V.; Liu, S.; Staniszewski, A.; Moolman, D.; Zhang, H.; Shelanski, M.; Arancio, O.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
Cell
126
775-788
2006
Mus musculus, Mus musculus (Q9R0P9)
brenda
Sekiguchi, S.; Yoshikawa, Y.; Tanaka, S.; Kwon, J.; Ishii, Y.; Kyuwa, S.; Wada, K.; Nakamura, S.; Takahashi, K.
Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse
Exp. Anim.
52
365-369
2003
Mus musculus (Q9R0P9), Mus musculus
brenda
Poon, H.F.; Hensley, K.; Thongboonkerd, V.; Merchant, M.L.; Lynn, B.C.; Pierce, W.M.; Klein, J.B.; Calabrese, V.; Butterfield, D.A.
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
Free Radic. Biol. Med.
39
453-462
2005
Mus musculus (Q9R0P9), Mus musculus
brenda
Castegna, A.; Thongboonkerd, V.; Klein, J.; Lynn, B.C.; Wang, Y.L.; Osaka, H.; Wada, K.; Butterfield, D.A.
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
J. Neurochem.
88
1540-1546
2004
Mus musculus (Q9R0P9), Mus musculus
brenda
Wang, Y.L.; Liu, W.; Sun, Y.J.; Kwon, J.; Setsuie, R.; Osaka, H.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice
Mol. Reprod. Dev.
73
40-49
2006
Mus musculus (Q9R0P9), Mus musculus
brenda
Sano, Y.; Furuta, A.; Setsuie, R.; Kikuchi, H.; Wang, Y.L.; Sakurai, M.; Kwon, J.; Noda, M.; Wada, K.
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice
Am. J. Pathol.
169
132-141
2006
Mus musculus
brenda
Sekiguchi, S.; Kwon, J.; Yoshida, E.; Hamasaki, H.; Ichinose, S.; Hideshima, M.; Kuraoka, M.; Takahashi, A.; Ishii, Y.; Kyuwa, S.; Wada, K.; Yoshikawa, Y.
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy
Am. J. Pathol.
169
1722-1729
2006
Mus musculus
brenda
Mermerian, A.H.; Case, A.; Stein, R.L.; Cuny, G.D.
Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors
Bioorg. Med. Chem. Lett.
17
3729-3732
2007
Mus musculus
brenda
Lansbury, P.T.
Improving synaptic function in a mouse model of AD
Cell
126
655-657
2006
Aplysia sp., Homo sapiens, Mus musculus
brenda
Bifsha, P.; Landry, K.; Ashmarina, L.; Durand, S.; Seyrantepe, V.; Trudel, S.; Quiniou, C.; Chemtob, S.; Xu, Y.; Gravel, R.A.; Sladek, R.; Pshezhetsky, A.V.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway
Cell Death Differ.
14
511-523
2007
Mus musculus, Homo sapiens (P09936), Homo sapiens
brenda
Sakurai, M.; Sekiguchi, M.; Zushida, K.; Yamada, K.; Nagamine, S.; Kabuta, T.; Wada, K.
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
Eur. J. Neurosci.
27
691-701
2008
Mus musculus, Mus musculus C57/BL6J
brenda
Mauri, P.L.; Riva, M.; Ambu, D.; De Palma, A.; Secundo, F.; Benazzi, L.; Valtorta, M.; Tortora, P.; Fusi, P.
Ataxin-3 is subject to autolytic cleavage
FEBS J.
273
4277-4286
2006
Mus musculus (Q9CVD2)
brenda
Vigneswara, V.; Lowenson, J.D.; Powell, C.D.; Thakur, M.; Bailey, K.; Clarke, S.; Ray, D.E.; Carter, W.G.
Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
J. Biol. Chem.
281
32619-32629
2006
Mus musculus (Q9R0P9)
brenda
Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Burg, D.; Johnson, J.P.; Frizzell, R.A.
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
J. Biol. Chem.
282
37885-37893
2007
Mus musculus
brenda
Fujino, R.S.; Ishikawa, Y.; Tanaka, K.; Kanatsu-Shinohara, M.; Tamura, K.; Kogo, H.; Shinohara, T.; Hara, T.
Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells
Mol. Reprod. Dev.
73
955-966
2006
Mus musculus, Mus musculus DBA/2
brenda
Sun, J.; Ying, M.; Li, H.; Shang, X.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury
Biochem. Biophys. Res. Commun.
366
539-544
2008
Mus musculus (Q9R0P9), Mus musculus
brenda
Vasu, V.T.; Ott, S.; Hobson, B.; Rashidi, V.; Oommen, S.; Cross, C.E.; Gohil, K.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice
Free Radic. Res.
43
106-116
2009
Mus musculus (Q9R0P9)
brenda
Jin, W.; Chang, M.; Paul, E.M.; Babu, G.; Lee, A.J.; Reiley, W.; Wright, A.; Zhang, M.; You, J.; Sun, S.C.
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
J. Clin. Invest.
118
1858-1866
2008
Mus musculus (Q80TQ2)
brenda
Lu, Y.; Adegoke, O.A.; Nepveu, A.; Nakayama, K.I.; Bedard, N.; Cheng, D.; Peng, J.; Wing, S.S.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Mol. Cell. Biol.
29
547-558
2009
Mus musculus (Q3UJD6), Rattus norvegicus (Q6J1Y9)
brenda
Setsuie, R.; Sakurai, M.; Sakaguchi, Y.; Wada, K.
Ubiquitin dimers control the hydrolase activity of UCH-L3
Neurochem. Int.
54
314-321
2009
Homo sapiens (P09936), Homo sapiens (P15374), Mus musculus (Q9JKB1), Mus musculus (Q9R0P9)
brenda
Fang, Y.; Fu, D.; Shen, X.Z.
The potential role of ubiquitin C-terminal hydrolases in oncogenesis
Biochim. Biophys. Acta
1806
1-6
2010
Homo sapiens, Mus musculus
brenda
Suzuki, M.; Setsuie, R.; Wada, K.
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis
Endocrinology
150
5230-5239
2009
Mus musculus
brenda
Pfeffer, M.; Plenzig, S.; Gispert, S.; Wada, K.; Korf, H.W.; Von Gall, C.
Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene
Neurobiol. Aging
33
393-403
2012
Mus musculus
brenda
Goto, A.; Wang, Y.L.; Kabuta, T.; Setsuie, R.; Osaka, H.; Sawa, A.; Ishiura, S.; Wada, K.
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse
Neurochem. Int.
54
330-338
2009
Mus musculus
brenda
Setsuie, R.; Suzuki, M.; Tsuchiya, Y.; Wada, K.
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
Neurochem. Int.
56
911-918
2010
Mus musculus
brenda
Nagamine, S.; Kabuta, T.; Furuta, A.; Yamamoto, K.; Takahashi, A.; Wada, K.
Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
Neurochem. Int.
57
102-110
2010
Mus musculus, Mus musculus C57/BL6J
brenda
Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
PLoS ONE
4
e5955
2009
Homo sapiens, Mus musculus
brenda
Bheda, A.; Shackelford, J.; Pagano, J.S.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes
PLoS ONE
4
e6764
2009
Mus musculus
brenda
Liu, Z.; Meray, R.K.; Grammatopoulos, T.N.; Fredenburg, R.A.; Cookson, M.R.; Liu, Y.; Logan, T.; Lansbury, P.T.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease
Proc. Natl. Acad. Sci. USA
106
4635-4640
2009
Homo sapiens, Mus musculus
brenda
Chen, F.; Sugiura, Y.; Myers, K.G.; Liu, Y.; Lin, W.
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
Proc. Natl. Acad. Sci. USA
107
1636-1641
2010
Mus musculus
brenda
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
brenda
Gu, Y.Q.; Chen, Q.J.; Gu, Z.; Shi, Y.; Yao, Y.W.; Wang, J.; Sun, Z.G.; Tso, J.K.
Ubiquitin carboxyl-terminal hydrolase L1 contributes to the oocyte selective elimination in prepubertal mouse ovaries
Sheng Li Xue Bao
61
175-184
2009
Mus musculus, Mus musculus ICR
brenda
Ko, Y.M.; Chang, C.Y.; Chiou, S.J.; Hsu, F.J.; Huang, J.S.; Yang, Y.L.; Guh, J.Y.; Chuang, L.Y.
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells
Arch. Biochem. Biophys.
535
177-186
2013
Mus musculus
brenda
Read, N.C.; Gutsol, A.; Holterman, C.E.; Carter, A.; Coulombe, J.; Gray, D.A.; Kennedy, C.R.
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis
Biochim. Biophys. Acta
1842
1028-1040
2014
Mus musculus
brenda
Hartnett, S.; Zhang, F.; Abitz, A.; Li, Y.
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells
Neurosci. Lett.
564
115-119
2014
Mus musculus (Q9R0P9)
brenda
Gao, H.; Hartnett, S.; Li, Y.
Ubiquitin C-terminal hydrolase L1 regulates myoblast proliferation and differentiation
Biochem. Biophys. Res. Commun.
492
96-102
2017
Mus musculus (Q9R0P9), Mus musculus
brenda
Bishop, P.; Rocca, D.; Henley, J.M.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) structure, distribution and roles in brain function and dysfunction
Biochem. J.
473
2453-2462
2016
Homo sapiens (P09936), Mus musculus (Q9R0P9)
brenda
Radon, V.; Czesla, M.; Reichelt, J.; Fehlert, J.; Hammel, A.; Rosendahl, A.; Knop, J.H.; Wiech, T.; Wenzel, U.O.; Sachs, M.; Reinicke, A.T.; Stahl, R.A.K.; Meyer-Schwesinger, C.
Ubiquitin C-terminal hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Kidney Int.
93
110-127
2018
Mus musculus (Q9R0P9)
brenda