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Acquired Immunodeficiency Syndrome
Finding effective biomarkers for pediatric traumatic brain injury.
Acquired Immunodeficiency Syndrome
Immunocytochemical identification of T-cells in HIV-1 encephalitis: implications for pathogenesis of CNS disease.
Acute Lung Injury
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Acute Lung Injury
Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury.
Acute Lung Injury
UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo.
Adenocarcinoma
Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Adenocarcinoma
Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A.
Adenocarcinoma
Localization of nerve fibers in colonic polyps, adenomas, and adenocarcinomas by immunocytochemical staining for PGP 9.5.
Adenocarcinoma
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
Adenocarcinoma
Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma.
Adenocarcinoma
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
Adenocarcinoma
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Adenocarcinoma
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
Adenocarcinoma
The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma.
Adenocarcinoma
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ?-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Adenocarcinoma
USP2a alters chemotherapeutic response by modulating redox.
Adenocarcinoma
[Corrigendum] USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ??catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Adenocarcinoma of Lung
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis.
Adenocarcinoma of Lung
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Adenocarcinoma of Lung
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of ?-Catenin.
Adenocarcinoma of Lung
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Adenocarcinoma of Lung
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Adenocarcinoma of Lung
Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma.
Adenocarcinoma of Lung
Targeting USP22 with miR?30?5p to inhibit the hypoxia?induced expression of PD?L1 in lung adenocarcinoma cells.
Adenocarcinoma of Lung
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Adenocarcinoma of Lung
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
Adenocarcinoma of Lung
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating ?H2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
Adenocarcinoma of Lung
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Adenocarcinoma of Lung
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
Adenocarcinoma of Lung
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
Adenocarcinoma of Lung
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
Adenoma
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Adenoma
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Adenoma
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Adenoma
Innervation of human adrenal gland and adrenal cortical lesions.
Adenoma
Localization of nerve fibers in colonic polyps, adenomas, and adenocarcinomas by immunocytochemical staining for PGP 9.5.
Adenoma
Molecular Characteristics of Large Parathyroid Adenomas.
Adenoma
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
Adenoma
Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas.
Adenoma, Oxyphilic
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Adenoma, Pleomorphic
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
Adenomyosis
Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis.
Adenomyosis
Neurotrophin expression is not affected in uteri of women with adenomyosis.
Adenomyosis
[Distribution of nerve fibers in endometrium and its clinical significance in adenomyosis]
Alzheimer Disease
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
Alzheimer Disease
Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.
Alzheimer Disease
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Alzheimer Disease
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Alzheimer Disease
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening.
Alzheimer Disease
Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease.
Alzheimer Disease
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.
Alzheimer Disease
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Alzheimer Disease
MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease.
Alzheimer Disease
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Alzheimer Disease
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.
Alzheimer Disease
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.
Alzheimer Disease
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Alzheimer Disease
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins.
Alzheimer Disease
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Alzheimer Disease
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
Alzheimer Disease
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Alzheimer Disease
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Alzheimer Disease
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.
Alzheimer Disease
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
Alzheimer Disease
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Alzheimer Disease
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Alzheimer Disease
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
Alzheimer Disease
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein.
Amyloidosis
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Amyotrophic Lateral Sclerosis
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Amyotrophic Lateral Sclerosis
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Amyotrophic Lateral Sclerosis
Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis.
Anthrax
Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Aortic Aneurysm
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Appendicitis
Changes of protein gene product 9.5 (PGP 9.5) immunoreactive nerves in inflamed appendix.
Appendicitis
Concentration of UHCL1 in the Serum of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP and Prealbumin.
Appendicitis
Immunoproteasome in the of children with acute appendicitis, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors.
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
Arteritis
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Asthenozoospermia
Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization.
Asthma
Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma.
Astrocytoma
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.
Ataxia
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Ataxia
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Ataxia
Application of protein knockdown strategy targeting ?-sheet structure to multiple disease-associated polyglutamine proteins.
Ataxia
Ataxin-3 and its e3 partners: implications for machado-joseph disease.
Ataxia
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Ataxia
Casein kinase 2 interacts with and phosphorylates ataxin-3.
Ataxia
Clinical and molecular events in patients with Machado-Joseph disease under lamotrigine therapy.
Ataxia
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Ataxia
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Ataxia
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Ataxia
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Ataxia
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Ataxia
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Ataxia
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Ataxia
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Ataxia
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Ataxia
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.
Ataxia
Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
Ataxia
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study.
Ataxia
Prenatal diagnosis of Machado-Joseph disease/Spinocerebellar Ataxia Type 3 in Taiwan: early detection of expanded ataxin-3.
Ataxia
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Ataxia
Structural and functional alterations in the androgen receptor in spinal bulbar muscular atrophy.
Ataxia
Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry.
Ataxia
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Ataxia
Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).
Ataxia
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
Ataxia
The double dealing of cyclin D1.
Ataxia
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
Ataxia
The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.
Ataxia
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Ataxia
Ubiquitin homeostasis is critical for synaptic development and function.
Ataxia
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Ataxia
Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes.
Atherosclerosis
Cezanne is a critical regulator of pathological arterial remodelling by targeting ?-catenin signalling.
Atherosclerosis
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Atherosclerosis
Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells.
Atrial Fibrillation
Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice.
Autoimmune Diseases
A20 functions as a negative regulator in macrophage for DSS-induced colitis.
Autoimmune Diseases
USP19 Suppresses Th17-Driven Pathogenesis in Autoimmunity.
Blindness
Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.
Bone Marrow Diseases
Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.
Bone Resorption
Effect of experimental tooth movement on nerve fibres immunoreactive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats.
Brain Concussion
Accuracy of a rapid glial fibrillary acidic protein/ubiquitin carboxyl-terminal hydrolase L1 test for the prediction of intracranial injuries on head computed tomography after mild traumatic brain injury.
Brain Concussion
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Brain Concussion
Neuronal Biomarker Ubiquitin C-Terminal Hydrolase (UCH-L1) Detects Traumatic Intracranial Lesions on CT in Children and Youth with Mild Traumatic Brain Injury.
Brain Concussion
Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.
Brain Concussion
Study protocol for investigating the performance of an automated blood test measuring GFAP and UCH-L1 in a prospective observational cohort of patients with mild traumatic brain injury: European BRAINI study.
Brain Concussion
Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.
Brain Concussion
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Brain Diseases
Placental clearance/synthesis of neurobiomarkers GFAP and UCH-L1 in healthy term neonates and those with moderate-severe neonatal encephalopathy.
Brain Diseases
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Brain Injuries
Assessing a Blast-Related Biomarker in an Operational Community: Glial Fibrillary Acidic Protein in Experienced Breachers.
Brain Injuries
BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma.
Brain Injuries
Biomarkers May Predict Unfavorable Neurological Outcome after Mild Traumatic Brain Injury.
Brain Injuries
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Brain Injuries
Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury.
Brain Injuries
Damaged: Elevated GFAP and UCH-L1 as the Black Flag of Brain Injury.
Brain Injuries
Development of prognostic models for patients with traumatic brain injury: a systematic review.
Brain Injuries
Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury.
Brain Injuries
Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study.
Brain Injuries
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
Brain Injuries
In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury.
Brain Injuries
Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury.
Brain Injuries
Morphologic and Biochemical Characterization of Brain Injury in a Model of Controlled Blast Overpressure Exposure.
Brain Injuries
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Brain Injuries
Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest.
Brain Injuries
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.
Brain Injuries
Ubiquitin C-Terminal Hydrolase 1 and Phosphorylated Axonal Neurofilament Heavy Chain in Infants Undergoing Cardiac Surgery: Preliminary Assessment as Potential Biomarkers of Brain Injury.
Brain Injuries
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Brain Injuries
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Brain Injuries, Traumatic
176?The Levels of GFAP and UCH-L1 During the First Week After a Traumatic Brain Injury-Correlations With Clinical and Imaging Findings and Outcome.
Brain Injuries, Traumatic
A Panel of Neuron-Enriched Proteins as Markers for Traumatic Brain Injury in Humans.
Brain Injuries, Traumatic
A Pilot Study of Novel biomarkers in neonates with Hypoxic-Ischemic Encephalopathy.
Brain Injuries, Traumatic
Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.
Brain Injuries, Traumatic
Acute biomarkers of traumatic brain injury: Relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP).
Brain Injuries, Traumatic
Acute Temporal Profiles of serum levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology Following Traumatic Brain Injury in Rats.
Brain Injuries, Traumatic
Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids.
Brain Injuries, Traumatic
Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients.
Brain Injuries, Traumatic
Blood Biomarkers Relate to Cognitive Performance Years after Traumatic Brain Injury in Service Members and Veterans.
Brain Injuries, Traumatic
Cerebral Expression of Glial Fibrillary Acidic Protein, Ubiquitin Carboxy-Terminal Hydrolase-L1, and Matrix Metalloproteinase 9 After Traumatic Brain Injury and Secondary Brain Insults in Rats.
Brain Injuries, Traumatic
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Brain Injuries, Traumatic
Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 as a Biomarker of Human Acute Traumatic Spinal Cord Injury.
Brain Injuries, Traumatic
Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury.
Brain Injuries, Traumatic
Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.
Brain Injuries, Traumatic
Comparison of the performances of copeptin and multiple biomarkers in long-term prognosis of severe traumatic brain injury.
Brain Injuries, Traumatic
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Brain Injuries, Traumatic
Elevated Serum Ubiquitin Carboxy-terminal Hydrolase L1 is Associated with Abnormal Blood Brain Barrier Function after Traumatic Brain Injury.
Brain Injuries, Traumatic
Erythropoietin Does Not Alter Serum Profiles of Neuronal and Axonal Biomarkers After Traumatic Brain Injury: Findings From the Australian EPO-TBI Clinical Trial.
Brain Injuries, Traumatic
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Brain Injuries, Traumatic
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
Brain Injuries, Traumatic
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study.
Brain Injuries, Traumatic
Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury.
Brain Injuries, Traumatic
Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury.
Brain Injuries, Traumatic
Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant Traumatic Brain Injury Biomarkers.
Brain Injuries, Traumatic
Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury.
Brain Injuries, Traumatic
Progesterone Treatment Does Not Decrease Serum Levels of Biomarkers of Glial and Neuronal Cell Injury in Moderate and Severe Traumatic Brain Injury Subjects: A Secondary Analysis of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III Trial.
Brain Injuries, Traumatic
Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.
Brain Injuries, Traumatic
Routine Blood Tests for Severe Traumatic Brain Injury: Can They Predict Outcomes?
Brain Injuries, Traumatic
Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review.
Brain Injuries, Traumatic
Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
Brain Injuries, Traumatic
Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.
Brain Injuries, Traumatic
Serum ubiquitin C-terminal hydrolase L1 as a biomarker for traumatic brain injury: a systematic review and meta-analysis.
Brain Injuries, Traumatic
Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.
Brain Injuries, Traumatic
Temporal response profiles of serum ubiquitin C-terminal hydrolase-L1 and the 145-kDa alpha II-spectrin breakdown product after severe traumatic brain injury in children.
Brain Injuries, Traumatic
The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.
Brain Injuries, Traumatic
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings.
Brain Injuries, Traumatic
Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury.
Brain Injuries, Traumatic
Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.
Brain Injuries, Traumatic
Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI.
Brain Injuries, Traumatic
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*
Brain Injuries, Traumatic
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Brain Injuries, Traumatic
Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Prediction of Computed Tomography Findings in Traumatic Brain Injury; a Meta-Analysis.
Brain Injuries, Traumatic
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Brain Injuries, Traumatic
UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma.
Brain Injuries, Traumatic
Valproic Acid Treatment Decreases Serum GFAP and UCH-L1 Level in Swine Subjected to Traumatic Brain Injury.
Brain Injuries, Traumatic
Variation in Candidate Traumatic Brain Injury Biomarker Genes Are Associated with Gross Neurological Outcomes after Severe Traumatic Brain Injury.
Brain Ischemia
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Brain Ischemia
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Brain Neoplasms
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
Breast Neoplasms
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Breast Neoplasms
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.
Breast Neoplasms
Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).
Breast Neoplasms
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
Breast Neoplasms
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
Breast Neoplasms
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
Breast Neoplasms
COPS5 amplification and overexpression confers tamoxifen-resistance in ER?-positive breast cancer by degradation of NCoR.
Breast Neoplasms
Correlation of apoptosis with the distribution and composition of lymphocytic infiltrate in human breast carcinomas.
Breast Neoplasms
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
Breast Neoplasms
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Breast Neoplasms
Deubiquitinase ubiquitin-specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells.
Breast Neoplasms
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1.
Breast Neoplasms
Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells.
Breast Neoplasms
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Breast Neoplasms
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
Breast Neoplasms
Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.
Breast Neoplasms
Erratum: The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
Breast Neoplasms
Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
Breast Neoplasms
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Breast Neoplasms
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
Breast Neoplasms
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer.
Breast Neoplasms
Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells.
Breast Neoplasms
Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro.
Breast Neoplasms
MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.
Breast Neoplasms
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance.
Breast Neoplasms
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.
Breast Neoplasms
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.
Breast Neoplasms
Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients.
Breast Neoplasms
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.
Breast Neoplasms
The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
Breast Neoplasms
The deubiquitinating enzyme USP1 modulates ER? and modulates breast cancer progression.
Breast Neoplasms
The deubiquitinating enzyme USP15 stabilizes ER? and promotes breast cancer progression.
Breast Neoplasms
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
Breast Neoplasms
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
Breast Neoplasms
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
Breast Neoplasms
UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.
Breast Neoplasms
UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer.
Breast Neoplasms
UCH-L1-mediated Down-regulation of Estrogen Receptor ? Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.
Breast Neoplasms
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
Breast Neoplasms
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
Breast Neoplasms
Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast.
Breast Neoplasms
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer.
Breast Neoplasms
USP22 positively modulates ER? action via its deubiquitinase activity in breast cancer.
Breast Neoplasms
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Breast Neoplasms
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Breast Neoplasms
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
Breast Neoplasms
USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Breast Neoplasms
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
Bronchiectasis
[Changes in neuroendocrine cells and immunocompetent cells in bronchiectasis]
Bronchitis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Bronchitis
Coronavirus interactions with the cellular autophagy machinery.
Bronchitis
Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.
Bronchitis
The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity.
Burkitt Lymphoma
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Burkitt Lymphoma
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Bursitis
Enhanced expression of neuronal proteins in idiopathic frozen shoulder.
CADASIL
Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL.
Carcinogenesis
'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state.
Carcinogenesis
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
Carcinogenesis
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Carcinogenesis
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Carcinogenesis
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Carcinogenesis
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Carcinogenesis
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Carcinogenesis
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Carcinogenesis
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Carcinogenesis
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Carcinogenesis
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Carcinogenesis
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Carcinogenesis
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
Carcinogenesis
Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
Carcinogenesis
Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
Carcinogenesis
Friend or Foe: UCHL3 Mediated Carcinogenesis and Current Approaches in Small Molecule Inhibitors' Development.
Carcinogenesis
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Carcinogenesis
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
Carcinogenesis
MiR-101 targets USP22 to inhibit the tumorigenesis of papillary thyroid carcinoma.
Carcinogenesis
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Carcinogenesis
Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.
Carcinogenesis
Novel protein and immune response markers of human serous tubal intraepithelial carcinoma of the ovary.
Carcinogenesis
Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
Carcinogenesis
Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
Carcinogenesis
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Carcinogenesis
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Carcinogenesis
OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma.
Carcinogenesis
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Carcinogenesis
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Carcinogenesis
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Carcinogenesis
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Carcinogenesis
Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy.
Carcinogenesis
Proteasomal deubiquitinase UCH37 inhibits degradation of ?-catenin and promotes cell proliferation and motility.
Carcinogenesis
Proteomics of DF-1 cells infected with avian leukosis virus subgroup J.
Carcinogenesis
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
Carcinogenesis
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Carcinogenesis
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Carcinogenesis
Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.
Carcinogenesis
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
Carcinogenesis
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
Carcinogenesis
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Carcinogenesis
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
Carcinogenesis
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Carcinogenesis
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Carcinogenesis
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
Carcinogenesis
The potential role of TNFAIP3 in malignant transformation of gastric carcinoma.
Carcinogenesis
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Carcinogenesis
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Carcinogenesis
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Carcinogenesis
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Carcinogenesis
Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells.
Carcinogenesis
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Carcinogenesis
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Carcinogenesis
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells.
Carcinogenesis
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
Carcinogenesis
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
Carcinogenesis
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
Carcinogenesis
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
Carcinogenesis
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-?B pathway.
Carcinogenesis
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.
Carcinogenesis
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
Carcinogenesis
Usp22 and its evolving role in systemic carcinogenesis.
Carcinogenesis
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Carcinogenesis
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Carcinogenesis
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Carcinogenesis
Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.
Carcinogenesis
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization.
Carcinogenesis
USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.
Carcinogenesis
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ?-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Carcinogenesis
USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.
Carcinogenesis
USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.
Carcinogenesis
USP4 promotes invasion of breast cancer cells via Relaxin/TGF-?1/Smad2/MMP-9 signal.
Carcinogenesis
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Carcinogenesis
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
Carcinogenesis
USP7 manipulation by viral proteins.
Carcinogenesis
[Research advances on ubiquitin C-terminal hydrolase in oncogenesis and progression].
Carcinoid Tumor
Carcinoid tumour of stomach and primary hyperparathyroidism: a new association.
Carcinoid Tumor
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma
'Neuroendocrine' differentiation in primary neoplasms of the liver.
Carcinoma
?-Chymotrypsin regulates free fatty acids and UCHL-1 to ameliorate N-methyl nitrosourea induced mammary gland carcinoma in albino wistar rats.
Carcinoma
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Carcinoma
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.
Carcinoma
An emerging model for BAP1's role in regulating cell cycle progression.
Carcinoma
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Carcinoma
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Carcinoma
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Carcinoma
CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.
Carcinoma
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Carcinoma
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Carcinoma
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico.
Carcinoma
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Carcinoma
Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.
Carcinoma
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Carcinoma
Cytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomas.
Carcinoma
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Carcinoma
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Carcinoma
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Carcinoma
Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma.
Carcinoma
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Carcinoma
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
Carcinoma
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones.
Carcinoma
Early phase TGF? receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
Carcinoma
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Carcinoma
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Carcinoma
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Carcinoma
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Carcinoma
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Carcinoma
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Carcinoma
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Carcinoma
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
Carcinoma
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Carcinoma
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Carcinoma
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Carcinoma
Increased expression of USP22 is associated with disease progression and patient prognosis of salivary duct carcinoma.
Carcinoma
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Carcinoma
Innervation of human adrenal gland and adrenal cortical lesions.
Carcinoma
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Carcinoma
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Carcinoma
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
Carcinoma
Molecular Characteristics of Large Parathyroid Adenomas.
Carcinoma
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.
Carcinoma
Neuroendocrine differentiation and nerves in human adrenal cortex and cortical lesions.
Carcinoma
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
Carcinoma
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Carcinoma
p38 mitogen-activated protein kinase inhibits USP22 transcription in HeLa cells.
Carcinoma
Parathyroid Carcinoma Encountered After Minimally Invasive Focused Parathyroidectomy may not Require Further Radical Surgery.
Carcinoma
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
Carcinoma
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Carcinoma
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Carcinoma
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Carcinoma
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Carcinoma
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Carcinoma
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Carcinoma
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Carcinoma
Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.
Carcinoma
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
Carcinoma
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Carcinoma
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Carcinoma
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Carcinoma
Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.
Carcinoma
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Carcinoma
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
Carcinoma
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
Carcinoma
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
Carcinoma
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Carcinoma
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Carcinoma
Tumoral infiltrate after local treatment with interferon in squamous cell carcinoma.
Carcinoma
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Carcinoma
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Carcinoma
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Carcinoma
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Carcinoma
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Carcinoma
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Carcinoma
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Carcinoma
USP19 and RPL23 as Candidate Prognostic Markers for Advanced-Stage High-Grade Serous Ovarian Carcinoma.
Carcinoma
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Carcinoma
USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma.
Carcinoma
USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma.
Carcinoma
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Carcinoma
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
Carcinoma
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
Carcinoma
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Carcinoma
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
Carcinoma in Situ
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Carcinoma in Situ
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
Carcinoma, Adenoid Cystic
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Carcinoma, Basal Cell
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Carcinoma, Basal Cell
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Carcinoma, Ductal
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
Carcinoma, Ductal
PGP9.5 as a prognostic factor in pancreatic cancer.
Carcinoma, Embryonal
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Carcinoma, Hepatocellular
'Neuroendocrine' differentiation in primary neoplasms of the liver.
Carcinoma, Hepatocellular
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein.
Carcinoma, Hepatocellular
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Carcinoma, Hepatocellular
Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Carcinoma, Hepatocellular
Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion.
Carcinoma, Hepatocellular
Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
Carcinoma, Hepatocellular
High USP22 expression indicates poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation.
Carcinoma, Hepatocellular
Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest.
Carcinoma, Hepatocellular
Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Self-Activated Cascade-Responsive Sorafenib and USP22 shRNA Co-Delivery System for Synergetic Hepatocellular Carcinoma Therapy.
Carcinoma, Hepatocellular
The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis.
Carcinoma, Hepatocellular
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Carcinoma, Hepatocellular
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Carcinoma, Hepatocellular
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.
Carcinoma, Hepatocellular
USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.
Carcinoma, Hepatocellular
USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1?/USP22 positive feedback loop upon TP53 inactivation.
Carcinoma, Large Cell
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Carcinoma, Lobular
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes.
Carcinoma, Medullary
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
Carcinoma, Neuroendocrine
Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.
Carcinoma, Non-Small-Cell Lung
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Carcinoma, Non-Small-Cell Lung
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Carcinoma, Non-Small-Cell Lung
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-103a Curtails the Stemness of Non-Small Cell Lung Cancer Cells by Binding OTUB1 via the Hippo Signaling Pathway.
Carcinoma, Non-Small-Cell Lung
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Carcinoma, Non-Small-Cell Lung
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth.
Carcinoma, Non-Small-Cell Lung
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Carcinoma, Non-Small-Cell Lung
Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair.
Carcinoma, Non-Small-Cell Lung
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Carcinoma, Non-Small-Cell Lung
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
Carcinoma, Non-Small-Cell Lung
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
Carcinoma, Non-Small-Cell Lung
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
Carcinoma, Non-Small-Cell Lung
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
Carcinoma, Ovarian Epithelial
High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Carcinoma, Ovarian Epithelial
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Carcinoma, Renal Cell
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Carcinoma, Renal Cell
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico.
Carcinoma, Renal Cell
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Carcinoma, Renal Cell
Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.
Carcinoma, Renal Cell
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Carcinoma, Renal Cell
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones.
Carcinoma, Renal Cell
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Carcinoma, Renal Cell
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Carcinoma, Renal Cell
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Carcinoma, Renal Cell
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
Carcinoma, Renal Cell
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Carcinoma, Renal Cell
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
Carcinoma, Small Cell
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Carcinoma, Small Cell
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma, Squamous Cell
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Carcinoma, Squamous Cell
Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Carcinoma, Squamous Cell
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma, Squamous Cell
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Carcinoma, Squamous Cell
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
Carcinoma, Squamous Cell
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Carcinoma, Squamous Cell
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Carcinoma, Squamous Cell
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Carcinoma, Squamous Cell
Tumoral infiltrate after local treatment with interferon in squamous cell carcinoma.
Cardiomegaly
De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
Cardiomegaly
The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor.
Cardiomegaly
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Cardiomegaly
Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy.
Cardiomyopathies
Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry.
Cardiomyopathy, Hypertrophic
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion.
Cataract
Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts.
Cerebellar Ataxia
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
Cerebellar Diseases
Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
Cerebral Hemorrhage
Diagnostic Accuracy of Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase-L1 Serum Concentrations for Differentiating Acute Intracerebral Hemorrhage from Ischemic Stroke.
Cerebral Hemorrhage
Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
Cerebral Hemorrhage
OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage.
Cerebral Hemorrhage
USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Cerebral Infarction
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Chagas Disease
GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection.
Chediak-Higashi Syndrome
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Chickenpox
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Cholangiocarcinoma
Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma.
Cholangiocarcinoma
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Chondrosarcoma
Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.
Chordoma
Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.
Chordoma
Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.
Chordoma
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas.
Chordoma
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.
Chorea
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
Chorioamnionitis
Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses.
Chronic Traumatic Encephalopathy
The anatomy of concussion and chronic traumatic encephalopathy: A comprehensive review.
Cleft Lip
Characteristics of Neuropeptide-Containing Innervation, Tissue Remodeling, Growth, and Vascularity in Noses of Patients With Cleft Lip and Palate.
Cleft Lip
Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-?3 Signaling Pathway.
Cleft Palate
Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-?3 Signaling Pathway.
Colitis
A20 functions as a negative regulator in macrophage for DSS-induced colitis.
Colitis
Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway.
Colitis
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
Colitis
USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer.
Colonic Neoplasms
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
Colonic Neoplasms
Colon cancer bears overexpression of OTUB1.
Colonic Neoplasms
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Colonic Neoplasms
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Colonic Neoplasms
Establishment of a high-throughput detection system for DNA demethylating agents.
Colonic Neoplasms
Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
Colonic Neoplasms
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.
Colonic Neoplasms
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
Colonic Neoplasms
PGP9.5 methylation as a marker for metastatic colorectal cancer.
Colonic Neoplasms
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.
Colonic Neoplasms
Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway.
Colonic Neoplasms
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Colonic Neoplasms
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.
Colorectal Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Colorectal Neoplasms
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Colorectal Neoplasms
Ataxin-3 expression correlates with the clinicopathologic stage and prognosis of colorectal cancer.
Colorectal Neoplasms
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Colorectal Neoplasms
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Colorectal Neoplasms
Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1.
Colorectal Neoplasms
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Colorectal Neoplasms
ERR? Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration.
Colorectal Neoplasms
Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
Colorectal Neoplasms
Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas.
Colorectal Neoplasms
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Colorectal Neoplasms
Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth.
Colorectal Neoplasms
Long Non-Coding RNA SNHG16 Activates USP22 Expression to Promote Colorectal Cancer Progression by Sponging miR-132-3p.
Colorectal Neoplasms
miR-542-3p inhibits colorectal cancer cell proliferation, migration and invasion by targeting OTUB1.
Colorectal Neoplasms
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.
Colorectal Neoplasms
PGP9.5 as a marker for invasive colorectal cancer.
Colorectal Neoplasms
PGP9.5 methylation as a marker for metastatic colorectal cancer.
Colorectal Neoplasms
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Colorectal Neoplasms
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Colorectal Neoplasms
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.
Colorectal Neoplasms
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
Colorectal Neoplasms
TGF-?1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
Colorectal Neoplasms
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
Colorectal Neoplasms
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Colorectal Neoplasms
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
Colorectal Neoplasms
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
Colorectal Neoplasms
UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.
Colorectal Neoplasms
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
Colorectal Neoplasms
USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway.
Colorectal Neoplasms
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
Colorectal Neoplasms
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Colorectal Neoplasms
USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer.
Colorectal Neoplasms
USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/?-catenin pathway via Axin1 deubiquitination.
Coma
Biomarkers May Predict Unfavorable Neurological Outcome after Mild Traumatic Brain Injury.
Coma
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
Coma
Glial Neuronal Ratio (GNR): a Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury.
Coma
Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study.
Coma
Serum concentrations of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI.
Coma
Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
Coma
Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients.
Coma
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings.
Common Variable Immunodeficiency
Abnormal CD45R expression in patients with common variable immunodeficiency and X-linked agammaglobulinaemia.
Communicable Diseases
Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach.
Communicable Diseases
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Communicable Diseases
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Coronavirus Infections
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Coronavirus Infections
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
Coronavirus Infections
Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.
Coronavirus Infections
Coronavirus interactions with the cellular autophagy machinery.
Coronavirus Infections
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Coronavirus Infections
Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches.
Coronavirus Infections
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
Coronavirus Infections
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
Coronavirus Infections
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Coronavirus Infections
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Coronavirus Infections
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.
Coronavirus Infections
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.
Coronavirus Infections
Structurally guided removal of deISGylase biochemical activity from papain-Like protease originating from the Middle East Respiratory Syndrome Virus.
Coronavirus Infections
The emerging SARS-CoV-2 papain-like protease: Its relationship with recent coronavirus epidemics.
Coronavirus Infections
Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus.
COVID-19
"Identification of Nafamostat and VR23 as COVID-19 drug candidates by targeting 3CLpro and PLpro."
COVID-19
3CLpro and PLpro affinity, a docking study to fight COVID19 based on 900 compounds from PubChem and literature. Are there new drugs to be found?
COVID-19
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
COVID-19
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
COVID-19
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
COVID-19
Chemical-informatics approach to COVID-19 drug discovery: Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules as papain-like protease (PLpro) inhibitors.
COVID-19
Computational Evidences of Phytochemical Mediated Disruption of PLpro Driven Replication of SARS-CoV-2: A Therapeutic Approach Against COVID-19.
COVID-19
Coronavirus interactions with the cellular autophagy machinery.
COVID-19
Discovery of small molecule PLpro inhibitor against COVID-19 using structure-based virtual screening, molecular dynamics simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) calculation.
COVID-19
Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach.
COVID-19
Drug repurposing using computational methods to identify therapeutic options for COVID-19.
COVID-19
Dual targeting of 3CLpro and PLpro of SARS-CoV-2: A novel structure-based design approach to treat COVID-19.
COVID-19
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients.
COVID-19
Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease.
COVID-19
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
COVID-19
Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19.
COVID-19
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
COVID-19
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
COVID-19
Losartan Inhibits SARS-CoV-2 Replication in Vitro.
COVID-19
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
COVID-19
Molecular docking of potential SARS-CoV-2 papain-like protease inhibitors.
COVID-19
Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2.
COVID-19
Natural Products with tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 effects: A Drug Discovery Perspective against SARS-CoV-2.
COVID-19
Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs.
COVID-19
Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines.
COVID-19
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.
COVID-19
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
COVID-19
Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease.
COVID-19
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease.
COVID-19
Spatial and temporal roles of SARS-CoV PLpro -A snapshot.
COVID-19
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study.
COVID-19
Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19.
COVID-19
The Promising Enzymes for Inhibitors Development against COVID-19.
COVID-19
Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases.
COVID-19
Virtual screening of phytoconstituents from miracle herb nigella sativa targeting nucleocapsid protein and papain-like protease of SARS-CoV-2 for COVID-19 treatment.
Craniocerebral Trauma
BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma.
Craniocerebral Trauma
Biofluid biomarkers of traumatic brain injury.
Craniocerebral Trauma
Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury.
Craniocerebral Trauma
Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study.
Craniocerebral Trauma
Neuronal Biomarker Ubiquitin C-Terminal Hydrolase (UCH-L1) Detects Traumatic Intracranial Lesions on CT in Children and Youth with Mild Traumatic Brain Injury.
Craniocerebral Trauma
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.
Craniocerebral Trauma
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Cryptorchidism
Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation.
Cryptorchidism
Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism.
Cryptorchidism
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis.
Cryptorchidism
Uchl1 and its associated proteins were involved in spermatocyte apoptosis in mouse experimental cryptorchidism.
Cystic Fibrosis
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.
Cystic Fibrosis
Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.
Cystitis
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Cysts
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Cysts
Innervation of ectopic endometrium in a rat model of endometriosis.
Deglutition Disorders
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Delirium
Association of neuronal repair biomarkers with delirium among survivors of critical illness.
Delirium
Association of Plasma Neurofilament Light with Postoperative Delirium.
Delirium
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Delirium
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
Dementia
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Dementia
Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.
Dementia
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
Demyelinating Diseases
OTUB1 inhibits CNS autoimmunity by preventing IFN-?-induced hyperactivation of astrocytes.
Demyelinating Diseases
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Dengue
A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication.
Dermatitis, Atopic
Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.
Dermatitis, Atopic
PGP 9.5 distribution patterns in biopsies from early lesions of atopic dermatitis.
Dermatitis, Atopic
[Role of the skin expression of neuropeptides, neurotrophins and their receptors in the pathogenesis of dermatoses].
Dermatofibrosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Diabetes Mellitus
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Diabetes Mellitus
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Diabetes Mellitus, Type 1
Adrenal medullitis in type I diabetes.
Diabetes Mellitus, Type 1
Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.
Diabetes Mellitus, Type 2
BETA-CELL DYSFUNCTIONAL ERAD/UBIQUITIN/PROTEASOME SYSTEM IN TYPE 2 DIABETES MEDIATED BY IAPP-INDUCED UCH-L1 DEFICIENCY.
Diabetes Mellitus, Type 2
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Diabetes Mellitus, Type 2
Patterns of cutaneous nerve fibre loss and regeneration in type 2 diabetes with painful and painless polyneuropathy.
Diabetes Mellitus, Type 2
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Diabetic Nephropathies
AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells.
Diabetic Nephropathies
BMSCs-derived exosomal microRNA-let-7a plays a protective role in diabetic nephropathy via inhibition of USP22 expression.
Diabetic Neuropathies
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.
Diabetic Neuropathies
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Diastema
Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers.
Diverticular Diseases
Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.
DNA Virus Infections
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.
Down Syndrome
A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury.
Down Syndrome
Placenta proteome analysis from Down syndrome pregnancies for biomarker discovery.
Down Syndrome
Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.
Dysgerminoma
Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas.
Dyslipidemias
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Dystonia
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
Encephalitis
Immunocytochemical identification of T-cells in HIV-1 encephalitis: implications for pathogenesis of CNS disease.
Encephalitis
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Encephalitis, Tick-Borne
High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses.
Endometrial Neoplasms
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
Endometrial Neoplasms
OTU-domain containing ubiquitin aldehyde binding protein 1 (OTUB1) deubiquitinates estrogen receptor - alpha (ERalpha ) and affects ERalpha transcriptional activity.
Endometrial Neoplasms
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Endometrial Neoplasms
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Endometrial Neoplasms
Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression.
Endometriosis
Calcium-binding protein expression in peritoneal endometriosis-associated nerve fibres.
Endometriosis
Combination of the non-invasive tests for the diagnosis of endometriosis.
Endometriosis
Decreased nerve fibers in the oviduct isthmus of women with endometriosis.
Endometriosis
Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis.
Endometriosis
Detection of the pan neuronal marker PGP9.5 by immuno-histochemistry and quantitative PCR in eutopic endometrium from women with and without endometriosis.
Endometriosis
Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis.
Endometriosis
Endometrial biopsy and density of nerve fibers in eutopic endometrium. Looking for easier ways to diagnose endometriosis.
Endometriosis
Identification of biomarkers for endometriosis in eutopic endometrial cells from patients with endometriosis using a proteomics approach.
Endometriosis
The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis.
Endometriosis
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Ependymoma
Paraganglioma of the cauda equina. A case report and review of the literature.
Epilepsy
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Epilepsy
Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Epilepsy
Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy.
Epilepsy
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
Epstein-Barr Virus Infections
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Epstein-Barr Virus Infections
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Esophageal Neoplasms
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Esophageal Neoplasms
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
Esophageal Neoplasms
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
Esophageal Neoplasms
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Esophageal Neoplasms
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Esophageal Neoplasms
Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer.
Esophageal Neoplasms
USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.
Esophageal Neoplasms
[The role of hypermethylation in promoter region of ubiquitin carboxyl-terminal hydrolase L1 in human esophageal cancer].
Esophageal Squamous Cell Carcinoma
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
Esophageal Squamous Cell Carcinoma
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
Esophageal Squamous Cell Carcinoma
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
Esophageal Squamous Cell Carcinoma
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Esophageal Squamous Cell Carcinoma
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Esophageal Squamous Cell Carcinoma
USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma.
Exanthema
Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy.
Fanconi Anemia
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.
Fanconi Anemia
Inactivation of Uaf1 causes Defective Homologous Recombination and Early Embryonic Lethality in Mice.
Fanconi Anemia
Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes.
Fanconi Anemia
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Fanconi Anemia
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination.
Fanconi Anemia
UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
Fetal Growth Retardation
USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction.
Fibroadenoma
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Fibrosarcoma
Multiple Polymerase Chain Reaction Markers for the Differentiation of Canine Cutaneous Peripheral Nerve Sheath Tumours versus Canine Fibrosarcomas.
Gallbladder Neoplasms
PGP9.5 methylation as a marker for metastatic colorectal cancer.
Gallstones
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Ganglioneuroblastoma
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Ganglioneuroma
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Gastrinoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Gastritis, Atrophic
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Gastroenteritis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Gastroenteritis
Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates.
Gastroenteritis
Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-
Gastrointestinal Neoplasms
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Gastrointestinal Neoplasms
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Gastrointestinal Stromal Tumors
The significance of PGP 9.5 in tumours--an immunohistochemical study of gastrointestinal stromal tumours.
Gaucher Disease
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Genetic Diseases, Inborn
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Giant Cell Tumors
Silencing of the UCHL1 gene in giant cell tumors of bone.
Gingival Diseases
Expression of immunoreactivities to 75 kDa nerve growth factor receptor, trk gene product and phosphotyrosine in granular cell tumors.
Gingivitis
Comparison of NK-cell (Leu-7+ and Leu-11b+) populations in clinically healthy gingiva, chronic gingivitis and chronic adult periodontitis.
Glioblastoma
Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity.
Glioblastoma
Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
Glioblastoma
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
Glioblastoma
Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.
Glioma
'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state.
Glioma
Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor.
Glioma
ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1.
Glioma
Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells.
Glioma
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
Glioma
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
Glioma
RNA interference-mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest.
Glioma
Silencing of OTUB1 inhibits migration of human glioma cells in vitro.
Glioma
Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma.
Glioma
Ubiquitin carboxyl-terminal hydrolase isozyme L5 inhibits human glioma cell migration and invasion via downregulating SNRPF.
Glioma
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Glioma
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells.
Glioma
Ubiquitin-specific protease 22: a novel molecular biomarker in glioma prognosis and therapeutics.
Glioma
UCHL1 enhances the malignant development of glioma via targeting GAS2.
Glioma
Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade.
Glomerulonephritis
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Glomerulonephritis
Detection of UCH-L1 expression by pre-embedding immunoelectron microscopy with colloidal gold labeling in diseased glomeruli.
Glomerulonephritis
Macrophages in human immunodeficiency virus-associated kidney diseases.
Glomerulonephritis
Neonatal Fc receptor stimulation induces ubiquitin c-terminal hydrolase-1 overexpression in podocytes through activation of p38 mitogen-activated protein kinase.
Glomerulonephritis
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Glomerulonephritis
OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level.
Glomerulonephritis
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
Glomerulonephritis
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glomerulonephritis
[Immunohistochemical analysis of protein gene product 9.5, a new marker for parietal epithelial cells of Bowman's capsules, in anti-glomerular basement membrane(GBM) antibody induced glomerulonephritis of WKY rats]
Glomerulonephritis, IGA
An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy.
Glomerulonephritis, IGA
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Glomerulonephritis, IGA
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glomerulonephritis, Membranous
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Glomerulonephritis, Membranous
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Glomerulonephritis, Membranous
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glomerulonephritis, Membranous
UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
Glomerulosclerosis, Focal Segmental
Macrophages in human immunodeficiency virus-associated kidney diseases.
Glomerulosclerosis, Focal Segmental
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.
Glomerulosclerosis, Focal Segmental
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glucagonoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Glucose Intolerance
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
Granular Cell Tumor
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Granular Cell Tumor
Immunohistochemical analysis of equine pulmonary granular cell tumours.
Granular Cell Tumor
PGP 9.5, a new marker for human neuroendocrine tumours.
Graves Disease
Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease.
Hearing Loss
Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.
Hearing Loss
Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss.
Heart Arrest
Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.
Heart Arrest
Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients.
Heart Arrest
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Heart Diseases
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Heart Diseases
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Heart Diseases
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Hematologic Neoplasms
Immunophenotyping of hematopoietic malignancies in paraffin sections.
Hemorrhagic Stroke
Different expression of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.
Hepatic Encephalopathy
Preferential recruitment of ataxin-3 independent of expanded polyglutamine: an immunohistochemical study on Marinesco bodies.
Hepatitis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Hepatitis
Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis.
Hepatitis
Coronavirus interactions with the cellular autophagy machinery.
Hepatitis
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Hepatitis
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Hepatitis
The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond.
Hepatitis B
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Hepatitis C
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Hepatitis C, Chronic
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Hepatitis C, Chronic
Clinical and histopathologic analysis of the relationship between lichen planus and chronic hepatitis C.
Hepatitis E
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Herpes Simplex
Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions.
Herpes Simplex
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Herpes Simplex
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding.
Herpes Zoster
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
Herpes Zoster
Natural history of cutaneous innervation following herpes zoster.
Herpes Zoster
The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles.
Herpes Zoster
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Hidradenitis Suppurativa
Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.
Hirschsprung Disease
Evaluation of PGP9.5 in the diagnosis of Hirschsprung's disease.
Hirschsprung Disease
Morphometric evaluation of PGP9.5 and NCAM expressing nerve fibers in colonic muscle of patients with Hirschsprung's disease.
Hirschsprung Disease
The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.
Histiocytic Sarcoma
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Histiocytoma, Malignant Fibrous
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Histiocytosis
Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis.
Histiocytosis, Langerhans-Cell
Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis.
Hodgkin Disease
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Hodgkin Disease
Hodgkin disease with subsequent transformation to CD30 positive non-hodgkin lymphoma in six patients.
Hodgkin Disease
Hodgkin-like lymphoma, simulating anaplastic large cell lymphoma in the patient after renal transplantation--unusual case report and literature review.
Hodgkin Disease
Immunohistochemical characteristics of Hodgkin and Reed-Sternberg cells in relation to age and clinical outcome.
Hodgkin Disease
Lymphocyte predominance Hodgkin's disease--an immunohistochemical study.
Hodgkin Disease
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Hodgkin Disease
[The immunological characterization of 63 cases of Hodgkin's disease with a panel of 8 antibodies]
Huntington Disease
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.
Huntington Disease
Broadening the therapeutic scope for rapamycin treatment.
Huntington Disease
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Huntington Disease
Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease.
Huntington Disease
Polymorphism of HD and UCHL-1 genes in Huntington's disease.
Huntington Disease
Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.
Huntington Disease
The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.
Huntington Disease
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
Huntington Disease
The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington's disease.
Hyperalgesia
A pain in the skin. Regenerating nerve sprouts are distinctly associated with ongoing burning pain in patients with diabetes.
Hyperalgesia
The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholds.
Hyperalgesia
The reduction of intraepidermal P2X3 nerve fiber density correlates with behavioral hyperalgesia in a rat model of nerve injury-induced pain.
Hyperglycemia
Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.
Hyperglycemia
Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination.
Hyperglycemia
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14.
Hyperlipidemias
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Hyperlipoproteinemia Type I
Lipoprotein lipase deficiency leads to ?-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction.
Hyperphosphatemia
Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary ?-klotho deficiency and perturbed phosphate homeostasis.
Hypersensitivity
Voltage-gated ion channel Na(v)1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
Hypertension
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Hypertension
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Hypertension
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Hypertensive Retinopathy
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Hypophosphatemia, Familial
Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary ?-klotho deficiency and perturbed phosphate homeostasis.
Hypotension
De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme l1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication.
Hypoxia-Ischemia, Brain
Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
Hypoxia-Ischemia, Brain
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Hypoxia-Ischemia, Brain
UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A Single Center Pilot Study.
Hypoxia-Ischemia, Brain
Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy.
Hypoxia-Ischemia, Brain
[Effect of hypothermia therapy on serum GFAP and UCH-L1 levels in neonates with hypoxic-ischemic encephalopathy].
Idiopathic Pulmonary Fibrosis
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Immune System Diseases
Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.
Infarction, Middle Cerebral Artery
Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1.
Infarction, Middle Cerebral Artery
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Infarction, Middle Cerebral Artery
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Infections
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Infections
A Scoping Insight on Potential Prophylactics, Vaccines and Therapeutic Weaponry for the Ongoing Novel Coronavirus (COVID-19) Pandemic- A Comprehensive Review.
Infections
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Infections
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Infections
Epstein-Barr Virus Deubiquitinase Downregulates TRAF6-Mediated NF-?B Signaling during Productive Replication.
Infections
GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection.
Infections
Gut-derived cholecystokinin contributes to visceral hypersensitivity via nerve growth factor-dependent neurite outgrowth.
Infections
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Infections
Interplay of the ubiquitin proteasome system and the innate immune response is essential for the replication of infectious bronchitis virus.
Infections
Iridoviral infection can be reduced by UCHL1-loaded exosomes from the testis of Chinese giant salamanders (Andrias davidianus).
Infections
Kaposi's Sarcoma Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells.
Infections
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Infections
Leader protein of encephalomyocarditis virus binds zinc, is phosphorylated during viral infection, and affects the efficiency of genome translation.
Infections
Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.
Infections
Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis.
Infections
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Infections
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Infections
Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1.
Infections
Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures.
Infections
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice.
Infections
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.
Infections
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus.
Infections
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.
Infections
Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1.
Infections
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Infections
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
Infections
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Infections
The deubiquitinating enzyme AMSH1 is required for rhizobial infection and nodule organogenesis in Lotus japonicus.
Infections
The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.
Infections
The Epstein-Barr virus deubiquitinase BPLF1 targets SQSTM1/p62 to inhibit selective autophagy.
Infections
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.
Infections
The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.
Infections
The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase.
Infections
The Translesion Polymerase Pol ? Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.
Infections
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Infections
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Infections
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Infections
Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases.
Infectious Mononucleosis
The Translesion Polymerase Pol ? Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.
Infertility
Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen.
Infertility, Male
Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility.
Infertility, Male
Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization.
Inflammatory Bowel Diseases
The deubiquitinating enzyme OTUD5 sustains inflammatory cytokine response in inflammatory bowel disease.
Influenza, Human
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
Influenza, Human
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Influenza, Human
Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.
Insulinoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Intellectual Disability
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Intellectual Disability
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
Intellectual Disability
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Intellectual Disability
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.
Intestinal Diseases
Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.
Intestinal Diseases
Expression of PGP 9.5 by Enteric Neurons in Horses and Donkeys with and without Intestinal Disease.
Intracranial Hemorrhage, Traumatic
Microwave scan and brain biomarkers to rule out intracranial hemorrhage: study protocol of a planned prospective study (MBI01).
Intracranial Hemorrhages
Investigation of UCH-L1 levels in ischemic stroke, intracranial hemorrhage and metabolic disorder induced impaired consciousness.
Ischemic Stroke
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Ischemic Stroke
cPKC?-mediated down-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway.
Ischemic Stroke
Diagnostic Accuracy of Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase-L1 Serum Concentrations for Differentiating Acute Intracerebral Hemorrhage from Ischemic Stroke.
Ischemic Stroke
Different expression of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.
Ischemic Stroke
Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1.
Ischemic Stroke
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Ischemic Stroke
Investigation of UCH-L1 levels in ischemic stroke, intracranial hemorrhage and metabolic disorder induced impaired consciousness.
Joint Diseases
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Keratoacanthoma
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Kidney Diseases
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Kidney Diseases
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
Kidney Neoplasms
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Klatskin Tumor
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Leber Congenital Amaurosis
Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.
Leiomyoma
Comparison of Nerve Fiber Density between Patients with Uterine Leiomyoma with and without Pain: a Prospective Clinical Study.
Leiomyoma
Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.
Leiomyoma
NT, NPY and PGP 9.5 presence in myomeytrium and in fibroid pseudocapsule and their possible impact on muscular physiology.
Leiomyoma
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
Leiomyoma
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Leiomyoma
[Distribution of nerve fibers in endometrium and its clinical significance in adenomyosis]
Leiomyoma, Epithelioid
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Leiomyosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Leiomyosarcoma
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Leishmaniasis, Visceral
IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
Leprosy
A comparison of the expression of NGFr, PGP 9.5 and NSE in cutaneous lesions of patients with early leprosy using immunohistochemistry.
Leprosy
The expression of NGFr and PGP 9.5 in leprosy reactional cutaneous lesions: an assessment of the nerve fiber status using immunostaining.
Leprosy, Multibacillary
Leprosy patients: neurotrophic factors and axonal markers in skin lesions.
Leukemia
Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions.
Leukemia
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Leukemia
Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
Leukemia
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Leukemia
Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.
Leukemia
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Leukemia
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Leukemia
Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
Leukemia
Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys.
Leukemia
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
Leukemia
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Leukemia
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Leukemia
[Autophagy and Expression of UCH-L3 Induced by Rapamycin in HL-60 Cells].
Leukemia, Lymphocytic, Chronic, B-Cell
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Leukemia, Myeloid
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Leukemia, Myeloid, Acute
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.
Leukemia, Myeloid, Acute
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Leukemia, T-Cell
Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia.
Leukemia-Lymphoma, Adult T-Cell
The distribution of CD45R, CD29 and CD45RO (UCHL1) antigens in mature CD4 positive T-cell leukaemias.
Leukoencephalopathies
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Lewy Body Disease
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Lichen Planus, Oral
Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions.
lipoprotein lipase deficiency
Lipoprotein lipase deficiency leads to ?-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction.
Liposarcoma
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Lissencephaly
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Listeriosis
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.
Listeriosis
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
Liver Cirrhosis
Genetic polymorphisms in ataxin-3 and liver cirrhosis risk related to aflatoxin B1.
Liver Diseases
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Liver Diseases, Alcoholic
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Liver Diseases, Alcoholic
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Liver Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Liver Neoplasms
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Liver Neoplasms
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Liver Neoplasms
Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest.
Liver Neoplasms
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
Liver Neoplasms
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling.
Liver Neoplasms
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
Lung Neoplasms
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Lung Neoplasms
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Lung Neoplasms
BAP1 suppresses lung cancer progression and is inhibited by miR-31.
Lung Neoplasms
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Lung Neoplasms
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
Lung Neoplasms
circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22.
Lung Neoplasms
Clinical value of seven autoantibodies combined detection in the diagnosis of lung cancer.
Lung Neoplasms
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Lung Neoplasms
Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration.
Lung Neoplasms
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Lung Neoplasms
Early detection of lung cancer by using an autoantibody panel in Chinese population.
Lung Neoplasms
Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
Lung Neoplasms
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Lung Neoplasms
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Lung Neoplasms
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.
Lung Neoplasms
Finding Genes Discriminating Smokers from Non-smokers by Applying a Growing Self-organizing Clustering Method to Large Airway Epithelium Cell Microarray Data.
Lung Neoplasms
Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model.
Lung Neoplasms
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Lung Neoplasms
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Lung Neoplasms
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues.
Lung Neoplasms
MicroRNA-103a Curtails the Stemness of Non-Small Cell Lung Cancer Cells by Binding OTUB1 via the Hippo Signaling Pathway.
Lung Neoplasms
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
Lung Neoplasms
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
Lung Neoplasms
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Lung Neoplasms
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Lung Neoplasms
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
Lung Neoplasms
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Lung Neoplasms
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of ?-Catenin.
Lung Neoplasms
Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth.
Lung Neoplasms
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Lung Neoplasms
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Lung Neoplasms
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Lung Neoplasms
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Lung Neoplasms
Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry.
Lung Neoplasms
Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP-specific RT-PCR.
Lung Neoplasms
Serial analysis of gene expression in non-small cell lung cancer.
Lung Neoplasms
Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair.
Lung Neoplasms
Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.
Lung Neoplasms
SP1-mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non-small-cell lung cancer progression via regulating OTUB1.
Lung Neoplasms
Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor.
Lung Neoplasms
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Lung Neoplasms
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
Lung Neoplasms
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
Lung Neoplasms
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.
Lung Neoplasms
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
Lung Neoplasms
The role of seven autoantibodies in lung cancer diagnosis.
Lung Neoplasms
Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells.
Lung Neoplasms
Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers.
Lung Neoplasms
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Lung Neoplasms
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
Lung Neoplasms
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
Lung Neoplasms
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
Lung Neoplasms
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Lung Neoplasms
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Lung Neoplasms
USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
Lung Neoplasms
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
Lung Neoplasms
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
Lung Neoplasms
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
Lung Neoplasms
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
Lupus Nephritis
A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1.
Lupus Nephritis
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Lupus Nephritis
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
Lupus Nephritis
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
Lupus Nephritis
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Lymphatic Metastasis
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Lymphatic Metastasis
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Lymphatic Metastasis
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Lymphatic Metastasis
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Lymphatic Metastasis
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
Lymphatic Metastasis
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Lymphatic Metastasis
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Lymphatic Metastasis
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Lymphatic Metastasis
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Lymphatic Metastasis
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Lymphatic Metastasis
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Lymphatic Metastasis
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Lymphatic Metastasis
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
Lymphatic Metastasis
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Lymphatic Metastasis
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Lymphatic Metastasis
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Lymphatic Metastasis
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Lymphatic Metastasis
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Lymphatic Metastasis
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
Lymphatic Metastasis
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Lymphatic Metastasis
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
Lymphatic Metastasis
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
Lymphatic Metastasis
UCHL1 enhances the malignant development of glioma via targeting GAS2.
Lymphatic Metastasis
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Lymphocytosis
Investigation of bone marrow lymphocyte subsets in normal, reactive, and neoplastic states using paraffin-embedded biopsy specimens.
Lymphoma
A case of primary T-cell lymphoma of the duodenum.
Lymphoma
Aberrant phenotypes in peripheral T cell lymphomas.
Lymphoma
Analysis of DnaK Expression from a Strain of Mycoplasma fermentans in Infected HCT116 Human Colon Carcinoma Cells.
Lymphoma
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
Lymphoma
Application of the cell block method, utilizing mount quick mounting medium.
Lymphoma
Case of plasmablastic lymphoma of the sigmoid colon and literature review.
Lymphoma
CD20 Positive T Cell Lymphoma Involvement of Skin.
Lymphoma
Demonstration of lymphoid antigens in decalcified bone marrow trephines.
Lymphoma
Diagnosis of gastrointestinal T-cell lymphomas in routinely processed tissues.
Lymphoma
Epithelial changes following bone marrow transplantation: cytological atypia and epithelial endocrine cells.
Lymphoma
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Lymphoma
Fine needle aspiration (FNA) biopsy of orbital masses: a critical review of 51 cases.
Lymphoma
Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.
Lymphoma
Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature.
Lymphoma
Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections.
Lymphoma
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Lymphoma
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Lymphoma
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Lymphoma
Immunophenotypic analysis of sinonasal non-Hodgkin's lymphomas.
Lymphoma
Immunophenotypic diagnosis of non-Hodgkin's lymphoma in paraffin sections. Co-expression of L60 (Leu-22) and L26 antigens correlates with malignant histologic findings.
Lymphoma
Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.
Lymphoma
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
Lymphoma
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Lymphoma
Large cell anaplastic lymphoma: evaluation of immunophenotype on paraffin and frozen sections in comparison with ultrastructural features.
Lymphoma
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Lymphoma
Merkel cell carcinoma: Is this a true carcinoma?
Lymphoma
Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues.
Lymphoma
Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.
Lymphoma
Nasopharyngeal carcinomas and malignant lymphomas: an immunohistochemical analysis of 74 cases.
Lymphoma
NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.
Lymphoma
Paraffin-immunohistochemical analysis of 226 non-Hodgkin's malignant lymphomas in the endemic area of human T-cell leukemia virus type 1.
Lymphoma
Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas.
Lymphoma
Pattern of malignant lymphomas in Rwanda.
Lymphoma
Phenotypic analysis of malignant lymphoma in simian immunodeficiency virus infection using anti-human antibodies.
Lymphoma
Primary esophageal non-Hodgkin's lymphoma.
Lymphoma
Primary pulmonary collision tumor including squamous cell carcinoma and T-cell lymphoma.
Lymphoma
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.
Lymphoma
Sarcomatoid variant of anaplastic large cell lymphoma mimicking a primary breast cancer: a challenging diagnosis.
Lymphoma
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Lymphoma
Stereotactic biopsy diagnosis of primary non-Hodgkin's lymphoma of the central nervous system. A histological and immunohistochemical study.
Lymphoma
T-cell intravascular lymphomatosis (angiotropic large cell lymphoma): association with Epstein-Barr viral infection.
Lymphoma
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
Lymphoma
The double dealing of cyclin D1.
Lymphoma
The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: lineage confirmed by JH rearrangement.
Lymphoma
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Lymphoma
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
Lymphoma
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Lymphoma
UCHL1 (anti-T-cell) staining pattern in small intestinal lymphoma of coeliac disease.
Lymphoma
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Lymphoma
Use of monoclonal antibodies for the typing of malignant lymphomas in routinely processed biopsy samples.
Lymphoma
[A case of sellar T cell type malignant lymphoma]
Lymphoma
[Epstein-Barr virus associated Richter's syndrome accompanied by interstitial pneumonia]
Lymphoma
[MALT-type lymphoma of lacrimal gland: case report]
Lymphoma
[Midline malignant reticulosis: a histopathological, ultrastructural and immunohistochemical study of 11 cases]
Lymphoma
[Primary malignant lymphoma of the rib; report of a case]
Lymphoma
[Primary malignant T-cell-rich B-cell lymphoma of the central nervous system: a case report]
Lymphoma, B-Cell
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
Lymphoma, B-Cell
B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature.
Lymphoma, B-Cell
How to differentiate between T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease. Evidence for the value of MB1 and 4KB5 immunostaining.
Lymphoma, B-Cell
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Lymphoma, B-Cell
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Lymphoma, B-Cell
Investigation of bone marrow lymphocyte subsets in normal, reactive, and neoplastic states using paraffin-embedded biopsy specimens.
Lymphoma, B-Cell
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Lymphoma, B-Cell
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Lymphoma, B-Cell
Paraffin section immunophenotyping of non-Hodgkin's lymphoma, using a panel of monoclonal antibodies.
Lymphoma, B-Cell
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Lymphoma, B-Cell
Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case.
Lymphoma, B-Cell
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Lymphoma, B-Cell
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
Lymphoma, Large B-Cell, Diffuse
Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case.
Lymphoma, Large B-Cell, Diffuse
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Immunophenotypic analysis of non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Lymphoma, Non-Hodgkin
Non-Hodgkin's lymphoma: a histopathologic and immunohistochemical study of 79 cases.
Lymphoma, Non-Hodgkin
Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?
Lymphoma, Non-Hodgkin
The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: lineage confirmed by JH rearrangement.
Lymphoma, Non-Hodgkin
[Pathological and clinical study of the primary B and T cell lymphomas of intestines]
Lymphoma, Primary Effusion
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Lymphoma, T-Cell
An immunocytochemical study of T-cell lymphomas using monoclonal and polyclonal antibodies effective in routinely fixed wax embedded tissues.
Lymphoma, T-Cell
CD20 Positive T Cell Lymphoma Involvement of Skin.
Lymphoma, T-Cell
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Lymphoma, T-Cell
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Lymphoma, T-Cell
Immunohistochemical profile of cutaneous B-cell lymphoma on cryostat and paraffin sections.
Lymphoma, T-Cell
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Lymphoma, T-Cell
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Lymphoma, T-Cell
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Lymphoma, T-Cell
Long-term survival in Ki-1 lymphoma.
Lymphoma, T-Cell
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Lymphoma, T-Cell
Paraffin section immunophenotyping of non-Hodgkin's lymphoma, using a panel of monoclonal antibodies.
Lymphoma, T-Cell
Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?
Lymphoma, T-Cell
Primary esophageal non-Hodgkin's lymphoma.
Lymphoma, T-Cell
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Lymphoma, T-Cell, Peripheral
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Machado-Joseph Disease
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.
Machado-Joseph Disease
A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic josephin domain in monomeric form, while leaving the oligomers unaffected.
Machado-Joseph Disease
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
Machado-Joseph Disease
A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.
Machado-Joseph Disease
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Machado-Joseph Disease
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Machado-Joseph Disease
A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins.
Machado-Joseph Disease
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.
Machado-Joseph Disease
A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats.
Machado-Joseph Disease
Absence of ataxin-3 leads to enhanced stress response in C. elegans.
Machado-Joseph Disease
Accurate prediction of protein beta-aggregation with generalized statistical potentials.
Machado-Joseph Disease
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Machado-Joseph Disease
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.
Machado-Joseph Disease
Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.
Machado-Joseph Disease
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.
Machado-Joseph Disease
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Machado-Joseph Disease
Association between Machado-Joseph disease and oxidative stress biomarkers.
Machado-Joseph Disease
Ataxin-3 and its e3 partners: implications for machado-joseph disease.
Machado-Joseph Disease
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Machado-Joseph Disease
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis.
Machado-Joseph Disease
Ataxin-3 is subject to autolytic cleavage.
Machado-Joseph Disease
Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains.
Machado-Joseph Disease
Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
Machado-Joseph Disease
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Machado-Joseph Disease
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Machado-Joseph Disease
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Machado-Joseph Disease
Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon.
Machado-Joseph Disease
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation.
Machado-Joseph Disease
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Machado-Joseph Disease
Attenuated nuclear shrinkage in neurons with nuclear aggregates--a morphometric study on pontine neurons of Machado-Joseph disease brains.
Machado-Joseph Disease
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Machado-Joseph Disease
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Machado-Joseph Disease
Axonal inclusions in spinocerebellar ataxia type 3.
Machado-Joseph Disease
Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients.
Machado-Joseph Disease
Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.
Machado-Joseph Disease
Broadening the therapeutic scope for rapamycin treatment.
Machado-Joseph Disease
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Machado-Joseph Disease
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Machado-Joseph Disease
Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
Machado-Joseph Disease
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Machado-Joseph Disease
Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
Machado-Joseph Disease
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
Machado-Joseph Disease
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
Machado-Joseph Disease
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Machado-Joseph Disease
Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3.
Machado-Joseph Disease
Casein kinase 2 interacts with and phosphorylates ataxin-3.
Machado-Joseph Disease
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Machado-Joseph Disease
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Machado-Joseph Disease
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Machado-Joseph Disease
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Machado-Joseph Disease
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Machado-Joseph Disease
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Machado-Joseph Disease
Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3.
Machado-Joseph Disease
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Machado-Joseph Disease
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Machado-Joseph Disease
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Machado-Joseph Disease
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Machado-Joseph Disease
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Machado-Joseph Disease
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Machado-Joseph Disease
Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.
Machado-Joseph Disease
Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.
Machado-Joseph Disease
Differential susceptibility of cultured cell lines to aggregate formation and cell death produced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Machado-Joseph Disease
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Machado-Joseph Disease
Distribution of amyloid-like and oligomeric species from protein aggregation kinetics.
Machado-Joseph Disease
Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3.
Machado-Joseph Disease
Divalproex sodium regulates ataxin-3 translocation likely by an importin ?1-dependent pathway.
Machado-Joseph Disease
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Machado-Joseph Disease
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Machado-Joseph Disease
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Machado-Joseph Disease
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
Machado-Joseph Disease
Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.
Machado-Joseph Disease
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Machado-Joseph Disease
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Machado-Joseph Disease
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
Machado-Joseph Disease
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3.
Machado-Joseph Disease
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Machado-Joseph Disease
Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3.
Machado-Joseph Disease
Functional interactions as a survival strategy against abnormal aggregation.
Machado-Joseph Disease
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Machado-Joseph Disease
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Machado-Joseph Disease
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
Machado-Joseph Disease
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Machado-Joseph Disease
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
Machado-Joseph Disease
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Machado-Joseph Disease
Heterogeneous intracellular localization and expression of ataxin-3.
Machado-Joseph Disease
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Machado-Joseph Disease
Identification and functional dissection of localization signals within ataxin-3.
Machado-Joseph Disease
Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1.
Machado-Joseph Disease
Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3.
Machado-Joseph Disease
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.
Machado-Joseph Disease
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Machado-Joseph Disease
Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains.
Machado-Joseph Disease
Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.
Machado-Joseph Disease
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
Machado-Joseph Disease
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Machado-Joseph Disease
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
Machado-Joseph Disease
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Machado-Joseph Disease
Karyopherin ?-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Machado-Joseph Disease
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Machado-Joseph Disease
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Machado-Joseph Disease
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Machado-Joseph Disease
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Machado-Joseph Disease
Magnetic resonance imaging demonstrates differential atrophy of pontine base and tegmentum in Machado-Joseph disease.
Machado-Joseph Disease
Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay.
Machado-Joseph Disease
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Machado-Joseph Disease
Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.
Machado-Joseph Disease
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Machado-Joseph Disease
Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.
Machado-Joseph Disease
Mouse models of Machado-Joseph disease and other polyglutamine spinocerebellar ataxias.
Machado-Joseph Disease
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Machado-Joseph Disease
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
Machado-Joseph Disease
Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.
Machado-Joseph Disease
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Machado-Joseph Disease
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Machado-Joseph Disease
N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.
Machado-Joseph Disease
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Machado-Joseph Disease
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Machado-Joseph Disease
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Machado-Joseph Disease
Novel polyglutamine model uncouples proteotoxicity from aging.
Machado-Joseph Disease
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
Machado-Joseph Disease
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Machado-Joseph Disease
Observation of liquid-liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy.
Machado-Joseph Disease
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Machado-Joseph Disease
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Machado-Joseph Disease
p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.
Machado-Joseph Disease
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Machado-Joseph Disease
p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine.
Machado-Joseph Disease
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Machado-Joseph Disease
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Machado-Joseph Disease
Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.
Machado-Joseph Disease
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Machado-Joseph Disease
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Machado-Joseph Disease
Polyglutamine expansion diseases: More than simple repeats.
Machado-Joseph Disease
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Machado-Joseph Disease
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Machado-Joseph Disease
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
Machado-Joseph Disease
Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease.
Machado-Joseph Disease
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Machado-Joseph Disease
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Machado-Joseph Disease
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA-3.
Machado-Joseph Disease
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Machado-Joseph Disease
Proteotoxic stress increases nuclear localization of ataxin-3.
Machado-Joseph Disease
Purification of polyglutamine proteins.
Machado-Joseph Disease
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Machado-Joseph Disease
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Machado-Joseph Disease
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Machado-Joseph Disease
Research on screening and identification of proteins interacting with ataxin-3.
Machado-Joseph Disease
Reversibility of symptoms in a conditional mouse model of Spinocerebellar Ataxia Type 3.
Machado-Joseph Disease
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
Machado-Joseph Disease
RNA toxicity is a component of ataxin-3 degeneration in Drosophila.
Machado-Joseph Disease
RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3.
Machado-Joseph Disease
Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.
Machado-Joseph Disease
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
Machado-Joseph Disease
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
Machado-Joseph Disease
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Machado-Joseph Disease
Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions.
Machado-Joseph Disease
Spinocerebellar ataxia type 3 in Israel: phenotype and genotype of a Jew Yemenite subpopulation.
Machado-Joseph Disease
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.
Machado-Joseph Disease
Structural modeling of ataxin-3 reveals distant homology to adaptins.
Machado-Joseph Disease
Study of subcellular localization and proteolysis of ataxin-3.
Machado-Joseph Disease
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Machado-Joseph Disease
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.
Machado-Joseph Disease
T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.
Machado-Joseph Disease
Temperature profoundly affects ataxin-3 fibrillogenesis.
Machado-Joseph Disease
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
Machado-Joseph Disease
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
Machado-Joseph Disease
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
Machado-Joseph Disease
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
Machado-Joseph Disease
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Machado-Joseph Disease
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.
Machado-Joseph Disease
The Machado-Joseph disease-associated form of ataxin-3 impacts dynamics of clathrin-coated pits.
Machado-Joseph Disease
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
Machado-Joseph Disease
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
Machado-Joseph Disease
The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.
Machado-Joseph Disease
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis.
Machado-Joseph Disease
The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.
Machado-Joseph Disease
The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3.
Machado-Joseph Disease
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
Machado-Joseph Disease
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Machado-Joseph Disease
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.
Machado-Joseph Disease
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Machado-Joseph Disease
Transcript Diversity of Machado-Joseph Disease Gene (ATXN3) Is Not Directly Determined by SNPs in Exonic or Flanking Intronic Regions.
Machado-Joseph Disease
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Machado-Joseph Disease
Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
Machado-Joseph Disease
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Machado-Joseph Disease
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Machado-Joseph Disease
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Machado-Joseph Disease
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Machado-Joseph Disease
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Machado-Joseph Disease
Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients.
Machado-Joseph Disease
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Machado-Joseph Disease
Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
Machado-Joseph Disease
Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3.
Machado-Joseph Disease
Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.
Machado-Joseph Disease
[Screening for proteins interacting with ataxin-3, the gene product of SCA3/MJD]
Malaria
Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor ?-chain suggests involvement of endocytosis and membrane protein trafficking.
Malaria
Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei.
Malaria
Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.
Malaria
Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action.
Malaria, Cerebral
The Deubiquitinating Enzyme Cylindromatosis Dampens CD8(+) T Cell Responses and Is a Critical Factor for Experimental Cerebral Malaria and Blood-Brain Barrier Damage.
Malocclusion
Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite: a light and electron microscopic observation using immunohistochemistry for PGP 9.5.
Measles
Microwave antigen retrieval for immunocytochemistry on formalin-fixed, paraffin-embedded post-mortem CNS tissue.
Medulloblastoma
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Megacolon
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.
Melanoma
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
Melanoma
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Melanoma
BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma.
Melanoma
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Melanoma
Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.
Melanoma
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma.
Melanoma
Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature.
Melanoma
Interplay of the ubiquitin proteasome system and the innate immune response is essential for the replication of infectious bronchitis virus.
Melanoma
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Melanoma
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Melanoma
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Melanoma
OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
Melanoma
Overview of BAP1 cancer predisposition syndrome and the relationship to uveal melanoma.
Melanoma
PGP 9.5, a new marker for human neuroendocrine tumours.
Melanoma
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS.
Melanoma
Targeting the Proteasome-Associated Deubiquitinating Enzyme USP14 Impairs Melanoma Cell Survival and Overcomes Resistance to MAPK-Targeting Therapies.
Melanoma
The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
Melanoma
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
Melanoma
UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes.
Melanoma
UCHL3 plays an important role in the occurrence and development of melanoma.
Melanoma
Update in molecular diagnostics in melanocytic neoplasms.
Melanoma
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
Melanoma
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization.
Melanoma
Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma.
Melanoma
Uveal Melanoma Nuclear BRCA1-Associated Protein-1 Immunoreactivity Is an Indicator of Metastasis.
Memory Disorders
Improving synaptic function in a mouse model of AD.
Memory Disorders
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Memory Disorders
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
Meningioma
Genetic Alterations Associated With Progression and Recurrence in Meningiomas.
Meningioma
Immunohistochemical Detection of CD34, E-cadherin, Claudin-1, Glucose Transporter 1, Laminin, and Protein Gene Product 9.5 in 28 Canine and 8 Feline Meningiomas.
Mesothelioma
A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair.
Mesothelioma
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Mesothelioma
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Mesothelioma
Cytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomas.
Mesothelioma
Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
Mesothelioma
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Mesothelioma
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Mesothelioma
Malignant Mesothelioma and Its Non-Asbestos Causes.
Mesothelioma
Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young females.
Mesothelioma
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
Mesothelioma
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Mesothelioma
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Mesothelioma, Malignant
Diagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions.
Mesothelioma, Malignant
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Mesothelioma, Malignant
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Mesothelioma, Malignant
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
Microphthalmos
Cutaneous melanocytoneuroma: the first case of a distinctive intraneural tumor with dual nerve sheath and melanocytic differentiation.
Microphthalmos
Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus.
Microphthalmos
Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information.
Movement Disorders
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Movement Disorders
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Multiple Myeloma
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Multiple Myeloma
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.
Multiple Myeloma
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Multiple Myeloma
Characterization of PMI-5011 on the Regulation of Deubiquitinating Enzyme Activity in Multiple Myeloma Cell Extracts.
Multiple Myeloma
Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.
Multiple Myeloma
Targeting UCHL1 Induces Cell Cycle Arrest in High-Risk Multiple Myeloma with t(4;14).
Multiple Myeloma
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells.
Multiple Myeloma
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
Multiple Myeloma
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Multiple Myeloma
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression.
Multiple Sclerosis
A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.
Multiple System Atrophy
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Multiple System Atrophy
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
Muscle Spasticity
Novel splice-site variant of UCHL1 in an Indian family with autosomal recessive spastic paraplegia-79.
Muscular Atrophy
Muscular atrophy, impaired epithelial autophagy and UCHL1 in androgen-deficient cauda epididymis.
Muscular Atrophy
The biology of A20-like molecules.
Muscular Atrophy
The preventive effect of ?-carotene on denervation-induced soleus muscle atrophy in mice.
Muscular Atrophy
UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle.
Muscular Atrophy, Spinal
Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target.
Muscular Atrophy, Spinal
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts.
Muscular Diseases
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Mycosis Fungoides
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Mycosis Fungoides
Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.
Myocardial Infarction
Cardiac sympathetic innervation and PGP9.5 expression by cardiomyocytes after myocardial infarction: effects of central MR blockade.
Myocardial Infarction
Induction of apoptosis and ubiquitin hydrolase gene expression by human serum factors in the early phase of acute myocardial infarction.
Myoclonic Epilepsies, Progressive
Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation.
Myoclonic Epilepsies, Progressive
Application of protein knockdown strategy targeting ?-sheet structure to multiple disease-associated polyglutamine proteins.
Myoclonic Epilepsies, Progressive
Non-expanded polyglutamine proteins in intranuclear inclusions of hereditary ataxias--triple-labeling immunofluorescence study.
Myoclonic Epilepsies, Progressive
Targeting several CAG expansion diseases by a single antisense oligonucleotide.
Myositis
Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: A potential therapeutic target.
Myxoma
Atrial myxoma: a tumour in search of its origins.
Nasopharyngeal Carcinoma
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Nasopharyngeal Carcinoma
MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22.
Nasopharyngeal Carcinoma
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma.
Neoplasm Metastasis
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Neoplasm Metastasis
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
Neoplasm Metastasis
BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma.
Neoplasm Metastasis
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Neoplasm Metastasis
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Neoplasm Metastasis
COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.
Neoplasm Metastasis
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Neoplasm Metastasis
Crosstalk in cancer resistance and metastasis.
Neoplasm Metastasis
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Neoplasm Metastasis
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Neoplasm Metastasis
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Neoplasm Metastasis
Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein.
Neoplasm Metastasis
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Neoplasm Metastasis
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
Neoplasm Metastasis
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Neoplasm Metastasis
Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.
Neoplasm Metastasis
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Neoplasm Metastasis
ERR? Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration.
Neoplasm Metastasis
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Neoplasm Metastasis
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
Neoplasm Metastasis
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
Neoplasm Metastasis
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis.
Neoplasm Metastasis
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Neoplasm Metastasis
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
Neoplasm Metastasis
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
Neoplasm Metastasis
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
Neoplasm Metastasis
MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22.
Neoplasm Metastasis
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
Neoplasm Metastasis
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Neoplasm Metastasis
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
Neoplasm Metastasis
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.
Neoplasm Metastasis
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Neoplasm Metastasis
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Neoplasm Metastasis
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
Neoplasm Metastasis
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Neoplasm Metastasis
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Neoplasm Metastasis
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Neoplasm Metastasis
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Neoplasm Metastasis
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Neoplasm Metastasis
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Neoplasm Metastasis
Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into ?-arrestin-dependent ERK signaling.
Neoplasm Metastasis
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Neoplasm Metastasis
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Neoplasm Metastasis
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
Neoplasm Metastasis
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Neoplasm Metastasis
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
Neoplasm Metastasis
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
Neoplasm Metastasis
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
Neoplasm Metastasis
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
Neoplasm Metastasis
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Neoplasm Metastasis
The genetics of uveal melanoma: an emerging framework for targeted therapy.
Neoplasm Metastasis
The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer.
Neoplasm Metastasis
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Neoplasm Metastasis
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Neoplasm Metastasis
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Neoplasm Metastasis
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Neoplasm Metastasis
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Neoplasm Metastasis
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Neoplasm Metastasis
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Neoplasm Metastasis
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration.
Neoplasm Metastasis
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Neoplasm Metastasis
Ubiquitin-specific peptidase 22 in cancer.
Neoplasm Metastasis
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Neoplasm Metastasis
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Neoplasm Metastasis
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Neoplasm Metastasis
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
Neoplasm Metastasis
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Neoplasm Metastasis
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
Neoplasm Metastasis
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
Neoplasm Metastasis
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
Neoplasm Metastasis
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
Neoplasm Metastasis
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
Neoplasm Metastasis
UCHL1 enhances the malignant development of glioma via targeting GAS2.
Neoplasm Metastasis
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neoplasm Metastasis
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
Neoplasm Metastasis
UCHL3 stimulates metastasis of gastric cancer through upregulating IGF2.
Neoplasm Metastasis
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
Neoplasm Metastasis
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
Neoplasm Metastasis
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Neoplasm Metastasis
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
Neoplasm Metastasis
USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.
Neoplasm Metastasis
USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.
Neoplasm Metastasis
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
Neoplasm Metastasis
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Neoplasm Metastasis
Uveal Melanoma Nuclear BRCA1-Associated Protein-1 Immunoreactivity Is an Indicator of Metastasis.
Neoplasm Metastasis
Uveal Melanoma Treatment and Prognostication.
Neoplasm Metastasis
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Neoplasm Metastasis
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Neoplasm, Residual
Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia.
Neoplasm, Residual
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Neoplasms
A case of cutaneous Ki-1 positive anaplastic large cell lymphoma in a hemodialysed patient.
Neoplasms
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Neoplasms
A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.
Neoplasms
A fluorescence polarization-based competition assay for measuring interactions between unlabeled ubiquitin chains and UCH37RPN13.
Neoplasms
A neuroendocrine cause of oncogenic osteomalacia.
Neoplasms
A new xenograft model of primary central nervous system lymphoma.
Neoplasms
A Novel Link between Inflammation and Cancer.
Neoplasms
A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.
Neoplasms
A novel type of deubiquitinating enzyme.
Neoplasms
A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair.
Neoplasms
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Neoplasms
A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.
Neoplasms
A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma.
Neoplasms
A substrate for deubiquitinating enzymes based on time-resolved fluorescence resonance energy transfer between terbium and yellow fluorescent protein.
Neoplasms
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Neoplasms
Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer.
Neoplasms
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
Neoplasms
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases.
Neoplasms
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.
Neoplasms
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
Neoplasms
Adult-onset neuroblastoma: Report of seven cases with molecular genetic characterization.
Neoplasms
Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics.
Neoplasms
Amphicrine differentiation in bronchioloalveolar cell carcinoma.
Neoplasms
An autopsy case of so-called midline malignant reticulosis followed by extensive dissemination with immunohistochemical evidence for its T cell malignancy.
Neoplasms
An emerging model for BAP1's role in regulating cell cycle progression.
Neoplasms
An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases.
Neoplasms
An upregulation of SENP3 after spinal cord injury: implications for neuronal apoptosis.
Neoplasms
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
Neoplasms
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Neoplasms
Application of the cell block method, utilizing mount quick mounting medium.
Neoplasms
Argyrophilic nucleolar organiser region counts and prognosis in pharyngeal carcinoma.
Neoplasms
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Neoplasms
Atrial myxoma: a tumour in search of its origins.
Neoplasms
ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Neoplasms
BaBao Dan Suppresses Tumor Growth of Pancreatic Cancer Through Modulating Transcriptional Reprogramming of Cancer-Related Genes.
Neoplasms
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Neoplasms
BAP1 hereditary cancer predisposition syndrome: a case report and review of literature.
Neoplasms
BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response.
Neoplasms
Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
Neoplasms
BAP1 is phosphorylated at serine 592 in S-phase following DNA damage.
Neoplasms
BAP1 links metabolic regulation of ferroptosis to tumour suppression.
Neoplasms
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
Neoplasms
BAP1 suppresses lung cancer progression and is inhibited by miR-31.
Neoplasms
BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
Neoplasms
BAP1: Not just a BRCA1-associated protein.
Neoplasms
Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases.
Neoplasms
Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor.
Neoplasms
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Neoplasms
Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget.
Neoplasms
BRCA1-associated protein 1 deficiency in lung adenocarcinoma predicts poor outcome and increased tumor invasion.
Neoplasms
BRCA1-associated protein 1 expression and prognostic role in prostate adenocarcinoma.
Neoplasms
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Neoplasms
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Neoplasms
Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer.
Neoplasms
CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.
Neoplasms
Cerebellar cortical degeneration in association with small-cell carcinoma of the oesophagus.
Neoplasms
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
Neoplasms
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Neoplasms
Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.
Neoplasms
Characterization of PMI-5011 on the Regulation of Deubiquitinating Enzyme Activity in Multiple Myeloma Cell Extracts.
Neoplasms
CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication.
Neoplasms
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Neoplasms
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.
Neoplasms
Clinicopathological characteristics and molecular abnormalities of primary grade 2 neuroendocrine tumors of the cervix.
Neoplasms
Cloning and characterization of the human USP22 gene promoter.
Neoplasms
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
Neoplasms
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Neoplasms
Comparative study of seven neuroendocrine markers in pancreatic endocrine tumours.
Neoplasms
Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma.
Neoplasms
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases.
Neoplasms
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Neoplasms
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer.
Neoplasms
Construction of hu-PBL/SCID chimeras and development of EBV-related lymphomas.
Neoplasms
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Neoplasms
COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.
Neoplasms
Correction: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Neoplasms
Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1.
Neoplasms
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Neoplasms
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Neoplasms
CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Neoplasms
Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress.
Neoplasms
Crosstalk in cancer resistance and metastasis.
Neoplasms
Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae.
Neoplasms
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
Neoplasms
CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction.
Neoplasms
CYLD in ubiquitin signaling and tumor pathogenesis.
Neoplasms
CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.
Neoplasms
CYLD: a DUB with many talents.
Neoplasms
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma.
Neoplasms
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Neoplasms
Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors.
Neoplasms
Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.
Neoplasms
Demonstration of lymphoid antigens in decalcified bone marrow trephines.
Neoplasms
Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.
Neoplasms
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Neoplasms
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Neoplasms
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Neoplasms
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Neoplasms
Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2.
Neoplasms
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Neoplasms
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Neoplasms
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Neoplasms
Deubiquitinating enzyme inhibitors and their potential in cancer therapy.
Neoplasms
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1.
Neoplasms
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Neoplasms
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.
Neoplasms
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Neoplasms
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Neoplasms
Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.
Neoplasms
Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity.
Neoplasms
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Neoplasms
Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma.
Neoplasms
Development of prognostic models for patients with traumatic brain injury: a systematic review.
Neoplasms
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.
Neoplasms
Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.
Neoplasms
Diagnostic immunohistochemistry of neuroblastic tumors.
Neoplasms
Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3.
Neoplasms
Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1.
Neoplasms
Differentiation of reactive from neoplastic small-cell lymphoid aggregates in paraffin-embedded marrow particle preparations using L-26 (CD20) and UCHL-1 (CD45RO) monoclonal antibodies.
Neoplasms
Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition.
Neoplasms
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Neoplasms
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Neoplasms
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme.
Neoplasms
Disseminated retinoblastoma successfully treated with myeloablative chemotherapy--implication for molecular detection of minimal residual disease.
Neoplasms
Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.
Neoplasms
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Neoplasms
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
Neoplasms
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Neoplasms
Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.
Neoplasms
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Neoplasms
DUBA: a deubiquitinase that regulates type I interferon production.
Neoplasms
DUBbing Ferroptosis in Cancer Cells.
Neoplasms
Early phase TGF? receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
Neoplasms
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Neoplasms
Enzymatic Characterisation of USP7 Deubiquitinating activity and Inhibition.
Neoplasms
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Neoplasms
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Neoplasms
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Neoplasms
Establishment of cell lines with porcine spermatogonial stem cell properties.
Neoplasms
Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
Neoplasms
Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.
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Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Neoplasms
Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells.
Neoplasms
Expression and functional implications of USP17 in glioma.
Neoplasms
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
Neoplasms
Expression of CYLD and NF-kappaB in human cholesteatoma epithelium.
Neoplasms
Expression of HAUSP in gliomas correlates with disease progression and survival of patients.
Neoplasms
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Neoplasms
Expression of nse and pgp-9.5 in nonsmall-cell lung-cancers.
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Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion.
Neoplasms
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Neoplasms
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Neoplasms
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Neoplasms
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
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Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
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Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
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Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
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Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.
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Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.
Neoplasms
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
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Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
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Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma.
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Frequent mutation of BAP1 in metastasizing uveal melanomas.
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Friend or Foe: UCHL3 Mediated Carcinogenesis and Current Approaches in Small Molecule Inhibitors' Development.
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Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer.
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Functions of SAGA in development and disease.
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Gastrointestinal stromal tumors--a recently defined entity. Literature data and personal case report.
Neoplasms
Gene of the month: BAP1.
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Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.
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Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
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Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
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Genomic, prognostic, and cell-signaling advances in uveal melanoma.
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Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus).
Neoplasms
Granular cell tumor (Abrikossoff tumor) of the thyroid gland.
Neoplasms
Granular cell tumors of the tongue: fibroma or schwannoma.
Neoplasms
HAUSP as a therapeutic target for hematopoietic tumors (review).
Neoplasms
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
Neoplasms
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma.
Neoplasms
High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells.
Neoplasms
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
Neoplasms
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer.
Neoplasms
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Neoplasms
High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.
Neoplasms
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis.
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High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
Neoplasms
High USP22 expression indicates poor prognosis in hepatocellular carcinoma.
Neoplasms
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Neoplasms
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog.
Neoplasms
Histologically Diverse BAP1-Deficient Melanocytic Tumors in a Patient With BAP1 Tumor Predisposition Syndrome.
Neoplasms
HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Neoplasms
Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.
Neoplasms
Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity.
Neoplasms
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Neoplasms
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Neoplasms
Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.
Neoplasms
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
Neoplasms
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Neoplasms
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.
Neoplasms
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening.
Neoplasms
Identification of methylation-silenced genes in colorectal cancer cell lines: Genomic screening using oligonucleotide arrays.
Neoplasms
Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation.
Neoplasms
Ileal mucosa-associated lymphoid tissue lymphoma showing several ulcer scars detected using double-balloon endoscopy.
Neoplasms
Immunohistochemical analysis of diethylstilbestrol-induced renal tumors in adult male Syrian hamsters: evidence for relationship to peripheral nerve sheath tumors.
Neoplasms
Immunohistochemical analysis of equine pulmonary granular cell tumours.
Neoplasms
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Neoplasms
Immunohistochemical Expression of Melanocytic Antigen PNL2, Melan A, S100, and PGP 9.5 in Equine Melanocytic Neoplasms.
Neoplasms
Immunophenotypic diagnosis of non-Hodgkin's lymphoma in paraffin sections. Co-expression of L60 (Leu-22) and L26 antigens correlates with malignant histologic findings.
Neoplasms
Immunophenotyping of hematopoietic malignancies in paraffin sections.
Neoplasms
Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.
Neoplasms
Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas.
Neoplasms
Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne.
Neoplasms
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Neoplasms
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Neoplasms
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
Neoplasms
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
Neoplasms
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Neoplasms
Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
Neoplasms
Inhibitory Effect of the HPV-16mE6Delta/mE7/TBhsp70Delta Vaccine on Oral Squamous Cell Carcinoma.
Neoplasms
Insights into the Porcine Reproductive and Respiratory Syndrome Virus Viral Ovarian Tumor Domain Protease Specificity for Ubiquitin and Interferon Stimulated Gene Product 15.
Neoplasms
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Neoplasms
Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors.
Neoplasms
Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach.
Neoplasms
Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth.
Neoplasms
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
Neoplasms
Knockdown of ubiquitin?specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc?finger E?box binding homeobox 1.
Neoplasms
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
Neoplasms
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Neoplasms
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Neoplasms
Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous.
Neoplasms
Large cell lymphoma of the mediastinum with marked tropism for germinal centers.
Neoplasms
Large-cell neuroendocrine carcinoma of the ampulla of Vater.
Neoplasms
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Neoplasms
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Neoplasms
Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma.
Neoplasms
Loss of CYLD might be associated with development of salivary gland tumors.
Neoplasms
Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma.
Neoplasms
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Neoplasms
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Neoplasms
Loss of Tumor Suppressor CYLD Expression Triggers Cisplatin Resistance in Oral Squamous Cell Carcinoma.
Neoplasms
Malignant Mesothelioma and Its Non-Asbestos Causes.
Neoplasms
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Neoplasms
Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.
Neoplasms
Mechanism of pain and cytoskeletal properties in angioleiomyomas: an immunohistochemical study.
Neoplasms
Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11.
Neoplasms
Medulloblastoma. An immunohistological study of 50 cases.
Neoplasms
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
Neoplasms
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues.
Neoplasms
Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
Neoplasms
MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling.
Neoplasms
miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22.
Neoplasms
MiR-4782-3p inhibited non-small cell lung cancer growth via USP14.
Neoplasms
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.
Neoplasms
Molecular Characteristics of Large Parathyroid Adenomas.
Neoplasms
Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis.
Neoplasms
Molecular pathogenesis of malignant mesothelioma.
Neoplasms
Monoclonal antibody Leu-22 (L60) permits the demonstration of some neoplastic T cells in routinely fixed and paraffin-embedded tissue sections.
Neoplasms
Monoclonal antibody OPD4 detects neoplastic T cells but does not distinguish between CD4 and CD8 neoplastic T cells in paraffin tissue sections.
Neoplasms
Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma.
Neoplasms
Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland.
Neoplasms
Negative Parafibromin Staining Predicts Malignant Behavior in Atypical Parathyroid Adenomas.
Neoplasms
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.
Neoplasms
Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma.
Neoplasms
Neuroendocrine Carcinomas of the Canine Mammary Gland: Histopathological and Immunohistochemical Characteristics.
Neoplasms
Neurofibromatosis type I with malignant peripheral nerve sheath tumors in the upper arm: A case report.
Neoplasms
New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients.
Neoplasms
Novel cell lines established from pediatric brain tumors.
Neoplasms
Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma.
Neoplasms
Olfactory neuroblastoma: clinical and pathological aspects.
Neoplasms
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
Neoplasms
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Neoplasms
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Neoplasms
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Neoplasms
OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
Neoplasms
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
Neoplasms
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
Neoplasms
OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers.
Neoplasms
OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination.
Neoplasms
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.
Neoplasms
OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma.
Neoplasms
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
Neoplasms
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Neoplasms
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Neoplasms
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
Neoplasms
OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation.
Neoplasms
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.
Neoplasms
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.
Neoplasms
Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.
Neoplasms
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
Neoplasms
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Neoplasms
Overexpression of USP5 contributes to tumorigenesis in non-small cell lung cancer via the stabilization of ?-catenin protein.
Neoplasms
Overview of BAP1 cancer predisposition syndrome and the relationship to uveal melanoma.
Neoplasms
Paraganglioma of the urinary bladder: a challenging diagnosis in transurethral resection specimens: a case report.
Neoplasms
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Neoplasms
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.
Neoplasms
Pediatric sex cord-stromal tumor with composite morphology: a case report.
Neoplasms
Performance Evaluation of an Enzyme-Linked Immunosorbent Assay for Seven Autoantibodies in Lung Cancer.
Neoplasms
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
Neoplasms
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Neoplasms
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Neoplasms
PGP 9.5, a new marker for human neuroendocrine tumours.
Neoplasms
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Neoplasms
PGP9.5 as a marker for invasive colorectal cancer.
Neoplasms
PGP9.5 as a prognostic factor in pancreatic cancer.
Neoplasms
PGP9.5 methylation as a marker for metastatic colorectal cancer.
Neoplasms
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
Neoplasms
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Neoplasms
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Neoplasms
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Neoplasms
Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13.
Neoplasms
PKA/CREB regulates the constitutive promoter activity of the USP22 gene.
Neoplasms
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Neoplasms
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Neoplasms
Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma.
Neoplasms
Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition.
Neoplasms
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Neoplasms
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Neoplasms
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.
Neoplasms
Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
Neoplasms
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Neoplasms
Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy.
Neoplasms
Premature aging and cancer development in transgenic mice lacking functional CYLD.
Neoplasms
Primary central nervous system involvement of the so called 'peripheral T-cell lymphoma'. Report of a case and review of the literature.
Neoplasms
Primary central nervous system lymphoma following transfer of human peripheral blood lymphocytes into SCID mice.
Neoplasms
Primary cutaneous malignant perivascular epithelioid cell tumor: Case of a rare tumor with review of the literature.
Neoplasms
Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm.
Neoplasms
Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature.
Neoplasms
Primary esophageal non-Hodgkin's lymphoma.
Neoplasms
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Neoplasms
Primary hepatic anaplastic large-cell lymphoma of T-cell phenotype in acquired immunodeficiency syndrome: a report of an autopsy case and review of the literature.
Neoplasms
Primary pulmonary lymphoma diagnosed by gene rearrangement: report of a case.
Neoplasms
Primary T-cell lymphoma of the central nervous system.
Neoplasms
Primitive nonneural granular cell tumor (so-called atypical polypoid granular cell tumor). Report of 2 cases with immunohistochemical and ultrastructural correlation.
Neoplasms
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Neoplasms
Production of polyclonal anti-dUCH (Drosophila Ubiquitin Carboxyl-terminal Hydrolase) antibodies.
Neoplasms
Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma.
Neoplasms
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Neoplasms
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Neoplasms
Prognostic relevance of UCH-L1 and ?-internexin in pancreatic neuroendocrine tumors.
Neoplasms
Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.
Neoplasms
Prognostic significance of BRCA1-associated protein 1 in colorectal cancer.
Neoplasms
Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma.
Neoplasms
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Neoplasms
Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma.
Neoplasms
Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.
Neoplasms
Proteasome Ubiquitin Receptor hRpn13 and its Interacting Deubiquitinating Enzyme Uch37 are Required for Proper Cell Cycle Progression.
Neoplasms
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Neoplasms
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Neoplasms
Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma.
Neoplasms
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
Neoplasms
Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP.
Neoplasms
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways.
Neoplasms
Proteomic analysis of ?-asarone induced cytotoxicity in human glioblastoma U251 cells.
Neoplasms
Proteomic analysis of secreted proteins of non-small cell lung cancer.
Neoplasms
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Neoplasms
PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development.
Neoplasms
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.
Neoplasms
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Neoplasms
Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma.
Neoplasms
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Neoplasms
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
Neoplasms
Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
Neoplasms
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Neoplasms
Regulation of post-translational modification in breast cancer treatment.
Neoplasms
Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
Neoplasms
Regulation of USP28 deubiquitinating activity by SUMO conjugation.
Neoplasms
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.
Neoplasms
Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice.
Neoplasms
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Neoplasms
Role of urokinase plasminogen activator and its receptor in metastasis and invasion of neuroblastoma.
Neoplasms
Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma.
Neoplasms
Sebaceous carcinoma of the breast: case report and review of the literature.
Neoplasms
Selection of tumor?resistant variants following sustained natural killer cell?mediated immune stress.
Neoplasms
Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals.
Neoplasms
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).
Neoplasms
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Neoplasms
Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP-specific RT-PCR.
Neoplasms
Serial analysis of gene expression in non-small cell lung cancer.
Neoplasms
Serum response factor controls CYLD expression via MAPK signaling pathway.
Neoplasms
Serum ST2 as a potential prognostic biomarker for traumatic brain injury.
Neoplasms
Silencing of OTUB1 inhibits migration of human glioma cells in vitro.
Neoplasms
Silencing of the UCHL1 gene in giant cell tumors of bone.
Neoplasms
Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors.
Neoplasms
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Neoplasms
Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.
Neoplasms
Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis.
Neoplasms
Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma.
Neoplasms
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
Neoplasms
Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor.
Neoplasms
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Neoplasms
Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX.
Neoplasms
Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Neoplasms
Substrate recognition and catalysis by UCH-L1.
Neoplasms
Sulawesins A-C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a Psammocinia sp. Marine Sponge.
Neoplasms
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Neoplasms
Survey of differentially methylated promoters in prostate cancer cell lines.
Neoplasms
Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors.
Neoplasms
T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops).
Neoplasms
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Neoplasms
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Neoplasms
Targeting homologous recombination (HR) repair mechanism for cancer treatment: discovery of new potential UCHL-3 inhibitors via virtual screening, molecular dynamics and binding mode analysis.
Neoplasms
Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.
Neoplasms
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
Neoplasms
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Neoplasms
TGF-?1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
Neoplasms
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.
Neoplasms
The Akt DUBbed InAktive.
Neoplasms
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
Neoplasms
The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.
Neoplasms
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
Neoplasms
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
Neoplasms
The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.
Neoplasms
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
Neoplasms
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
Neoplasms
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
Neoplasms
The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth.
Neoplasms
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Neoplasms
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.
Neoplasms
The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
Neoplasms
The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
Neoplasms
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Neoplasms
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
Neoplasms
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
Neoplasms
The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B.
Neoplasms
The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
Neoplasms
The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11.
Neoplasms
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
Neoplasms
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Neoplasms
The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
Neoplasms
The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines.
Neoplasms
The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon.
Neoplasms
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
Neoplasms
The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
Neoplasms
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
Neoplasms
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-?B pathway.
Neoplasms
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
Neoplasms
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
Neoplasms
The potential role of TNFAIP3 in malignant transformation of gastric carcinoma.
Neoplasms
The potential role of ubiquitin c-terminal hydrolases in oncogenesis.
Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Neoplasms
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.
Neoplasms
The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis.
Neoplasms
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Neoplasms
The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review.
Neoplasms
The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death.
Neoplasms
The significance of PGP 9.5 in tumours--an immunohistochemical study of gastrointestinal stromal tumours.
Neoplasms
The solution structure of the ZnF UBP domain of USP33/VDU1.
Neoplasms
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
Neoplasms
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Neoplasms
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Neoplasms
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma.
Neoplasms
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
Neoplasms
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Neoplasms
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Neoplasms
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.
Neoplasms
The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes.
Neoplasms
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Neoplasms
The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma.
Neoplasms
The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference.
Neoplasms
Thymic B-cell non-Hodgkin's lymphoma in a child.
Neoplasms
Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.
Neoplasms
Transgenic mouse model: a new approach for the investigation of endocrine pancreatic B-cell growth.
Neoplasms
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Neoplasms
Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.
Neoplasms
Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.
Neoplasms
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Neoplasms
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Neoplasms
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Neoplasms
Tumor Suppressor Function of PGP9.5 Is Associated with Epigenetic Regulation in Prostate Cancer--Novel Predictor of Biochemical Recurrence after Radical Surgery.
Neoplasms
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Neoplasms
Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation, Independent of its Hydrolase Activity.
Neoplasms
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Neoplasms
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Neoplasms
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Neoplasms
Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers.
Neoplasms
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Neoplasms
Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.
Neoplasms
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Neoplasms
Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4.
Neoplasms
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
Neoplasms
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Neoplasms
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Neoplasms
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Neoplasms
Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases.
Neoplasms
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation.
Neoplasms
Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma.
Neoplasms
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation.
Neoplasms
Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression.
Neoplasms
Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models.
Neoplasms
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Neoplasms
Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
Neoplasms
Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.
Neoplasms
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration.
Neoplasms
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Neoplasms
Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.
Neoplasms
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Neoplasms
Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal Carcinoma.
Neoplasms
Ubiquitin-specific peptidase 22 in cancer.
Neoplasms
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Neoplasms
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Neoplasms
Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1.
Neoplasms
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner.
Neoplasms
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Neoplasms
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Neoplasms
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.
Neoplasms
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Neoplasms
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
Neoplasms
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Neoplasms
Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression via cyclophilin A stabilization and deubiquitination.
Neoplasms
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
Neoplasms
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.
Neoplasms
Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma.
Neoplasms
Ubiquitin?specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial?mesenchymal transition.
Neoplasms
Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.
Neoplasms
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
Neoplasms
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
Neoplasms
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Neoplasms
UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
Neoplasms
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
Neoplasms
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Neoplasms
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
Neoplasms
UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.
Neoplasms
UCH-L1-mediated Down-regulation of Estrogen Receptor ? Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.
Neoplasms
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
Neoplasms
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
Neoplasms
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
Neoplasms
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression.
Neoplasms
UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance.
Neoplasms
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neoplasms
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
Neoplasms
UCHL1 regulates inflammation via MAPK and NF-?B pathways in LPS-activated macrophages.
Neoplasms
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
Neoplasms
UCHL3 plays an important role in the occurrence and development of melanoma.
Neoplasms
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
Neoplasms
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
Neoplasms
UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.
Neoplasms
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
Neoplasms
Unsuspected gastric granulocytic sarcoma in a patient with myelodysplastic syndrome.
Neoplasms
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Neoplasms
Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis.
Neoplasms
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
Neoplasms
Upregulation of USP11 promotes epithelial?to?mesenchymal transition by deubiquitinating Snail in ovarian cancer.
Neoplasms
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Neoplasms
Use of monoclonal antibodies for the typing of malignant lymphomas in routinely processed biopsy samples.
Neoplasms
Usefulness of serum interleukin-33 as a prognostic marker of severe traumatic brain injury.
Neoplasms
USP10 Expression in Normal Adrenal Gland and Various Adrenal Tumors.
Neoplasms
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.
Neoplasms
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
Neoplasms
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states.
Neoplasms
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer.
Neoplasms
USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination.
Neoplasms
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
Neoplasms
USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway.
Neoplasms
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.
Neoplasms
USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination.
Neoplasms
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
Neoplasms
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Neoplasms
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
Neoplasms
USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway.
Neoplasms
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
Neoplasms
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Neoplasms
USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
Neoplasms
USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.
Neoplasms
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Neoplasms
Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.
Neoplasms
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
Neoplasms
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
Neoplasms
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
Neoplasms
USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.
Neoplasms
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
Neoplasms
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
Neoplasms
USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.
Neoplasms
USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A.
Neoplasms
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Neoplasms
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Neoplasms
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
Neoplasms
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Neoplasms
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
Neoplasms
USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors.
Neoplasms
USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1.
Neoplasms
USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/?-catenin pathway via Axin1 deubiquitination.
Neoplasms
USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/?-Catenin Pathway.
Neoplasms
USP7 manipulation by viral proteins.
Neoplasms
USP7: Structure, substrate specificity, and inhibition.
Neoplasms
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Neoplasms
Uveal Melanoma Treatment and Prognostication.
Neoplasms
Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.
Neoplasms
[A case of amelanotic melanoma of the nasal cavity]
Neoplasms
[A case of sellar T cell type malignant lymphoma]
Neoplasms
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
Neoplasms
[B precursor lymphoblastic leukemia/lymphoma manifested at onset as hemophagocytic syndrome]
Neoplasms
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Neoplasms
[Early diagnosis of subtype in early clinical stage lung adenocarcinoma by using an autoantibody panel and computed tomography].
Neoplasms
[Effects of LAK cells activated by IL-2 on MCF-7 human breast cancer cell line maintained in organotypic culture]
Neoplasms
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
Neoplasms
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Neoplasms
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Neoplasms
[Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in Silico Fragment-mapping Method].
Neoplasms
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
Neoplasms
[Primary malignant lymphoma of the rib; report of a case]
Neoplasms
[Primary primitive neuroectodermal tumor of the kidney in an adult. Clinico-pathologic and immunohistochemical case report]
Neoplasms
[The histopathology and immunohistochemistry of granular cell tumour. A study of 12 cases with a brief historical note].
Neoplasms
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Neoplasms, Germ Cell and Embryonal
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Neoplastic Processes
Immunohistochemical evaluation of neoplasms in bone marrow biopsies using monoclonal antibodies reactive in paraffin-embedded tissue.
Neoplastic Syndromes, Hereditary
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases.
Neoplastic Syndromes, Hereditary
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Neoplastic Syndromes, Hereditary
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Neoplastic Syndromes, Hereditary
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
Neoplastic Syndromes, Hereditary
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Nephritis
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Nephritis
Wnt/?-Catenin Signaling Mediated-UCH-L1 Expression in Podocytes of Diabetic Nephropathy.
Nephrosis, Lipoid
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Nephrosis, Lipoid
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Nephrotic Syndrome
Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice.
Nerve Sheath Neoplasms
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Nerve Sheath Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Nerve Sheath Neoplasms
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Nervous System Diseases
A survey of trinucleotide/tandem repeat-containing transcripts (TNRTs) isolated from human spinal cord to identify genes containing unstable DNA regions as candidates for disorders of motor function.
Nervous System Diseases
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Nervous System Diseases
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Nervous System Diseases
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Nervous System Diseases
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Nervous System Diseases
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Nervous System Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Nervous System Neoplasms
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Neuralgia
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Neurilemmoma
Mast cell and lymphoreticular infiltrates in neurofibromas. Comparison with nerve sheath tumors.
Neurilemmoma
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
Neurobehavioral Manifestations
Plasma Biomarker for Post-concussive Syndrome: A Pilot Study Using an Alternating Current Electro-Kinetic Platform.
Neuroblastoma
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Neuroblastoma
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Neuroblastoma
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Neuroblastoma
A?1-42-mediated down-regulation of Uch-L1 is dependent on NF-?B activation and impaired BACE1 lysosomal degradation.
Neuroblastoma
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
Neuroblastoma
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
Neuroblastoma
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
Neuroblastoma
Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma.
Neuroblastoma
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Neuroblastoma
Detection of neuroblastoma cells in bone marrow and peripheral blood by different techniques: accuracy and relationship with clinical features of patients.
Neuroblastoma
Detection of the PGP9.5 and tyrosine hydroxylase mRNAs for minimal residual neuroblastoma cells in bone marrow and peripheral blood.
Neuroblastoma
Dynamic expression of Hsp27 in the presence of mutant ataxin-3.
Neuroblastoma
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Neuroblastoma
Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma.
Neuroblastoma
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
Neuroblastoma
Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4.
Neuroblastoma
Identification of evolutionary conserved regulatory sequences in the 5' untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene.
Neuroblastoma
Improving Detection of Metastatic Neuroblastoma in Bone Marrow Core Biopsies: A Proposed Immunohistochemical Approach.
Neuroblastoma
Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
Neuroblastoma
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
Neuroblastoma
Oxidative stress regulated expression of ubiquitin Carboxyl-terminal Hydrolase-L1: role in cell survival.
Neuroblastoma
Prognostic value of stage IV neuroblastoma metastatic immunophenotype in the bone marrow: preliminary report.
Neuroblastoma
Protective roles of carbonic anhydrase 8 in Machado-Joseph Disease.
Neuroblastoma
S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells.
Neuroblastoma
Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.
Neuroblastoma
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Neuroblastoma
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells.
Neuroblastoma
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.
Neuroblastoma
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Neuroblastoma
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein.
Neuroblastoma
UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM.
Neuroblastoma
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Neurodegenerative Diseases
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.
Neurodegenerative Diseases
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
Neurodegenerative Diseases
A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.
Neurodegenerative Diseases
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Neurodegenerative Diseases
A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.
Neurodegenerative Diseases
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Neurodegenerative Diseases
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Neurodegenerative Diseases
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.
Neurodegenerative Diseases
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
Neurodegenerative Diseases
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Neurodegenerative Diseases
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Neurodegenerative Diseases
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
Neurodegenerative Diseases
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Neurodegenerative Diseases
Ataxin-3 is subject to autolytic cleavage.
Neurodegenerative Diseases
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Neurodegenerative Diseases
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Neurodegenerative Diseases
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Neurodegenerative Diseases
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Neurodegenerative Diseases
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Neurodegenerative Diseases
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion.
Neurodegenerative Diseases
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Neurodegenerative Diseases
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Neurodegenerative Diseases
Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
Neurodegenerative Diseases
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Neurodegenerative Diseases
Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
Neurodegenerative Diseases
Casein kinase 2 interacts with and phosphorylates ataxin-3.
Neurodegenerative Diseases
cDNA cloning and tissue distribution of a rat ubiquitin carboxyl-terminal hydrolase PGP9.5.
Neurodegenerative Diseases
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Neurodegenerative Diseases
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Neurodegenerative Diseases
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Neurodegenerative Diseases
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Neurodegenerative Diseases
Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Neurodegenerative Diseases
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Neurodegenerative Diseases
Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress.
Neurodegenerative Diseases
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Neurodegenerative Diseases
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Neurodegenerative Diseases
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Neurodegenerative Diseases
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Neurodegenerative Diseases
Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.
Neurodegenerative Diseases
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.
Neurodegenerative Diseases
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
Neurodegenerative Diseases
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Neurodegenerative Diseases
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Neurodegenerative Diseases
Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Neurodegenerative Diseases
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Neurodegenerative Diseases
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
Neurodegenerative Diseases
Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease.
Neurodegenerative Diseases
Expression in the mammalian retina of parkin and UCH-L1, two components of the ubiquitin-proteasome system.
Neurodegenerative Diseases
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.
Neurodegenerative Diseases
Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment.
Neurodegenerative Diseases
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3.
Neurodegenerative Diseases
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
Neurodegenerative Diseases
Functions of SAGA in development and disease.
Neurodegenerative Diseases
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Neurodegenerative Diseases
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Neurodegenerative Diseases
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
Neurodegenerative Diseases
Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4.
Neurodegenerative Diseases
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Neurodegenerative Diseases
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Neurodegenerative Diseases
Heterogeneous intracellular localization and expression of ataxin-3.
Neurodegenerative Diseases
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Neurodegenerative Diseases
Identification and functional dissection of localization signals within ataxin-3.
Neurodegenerative Diseases
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Neurodegenerative Diseases
Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease.
Neurodegenerative Diseases
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Neurodegenerative Diseases
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Neurodegenerative Diseases
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Neurodegenerative Diseases
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Neurodegenerative Diseases
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Neurodegenerative Diseases
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Neurodegenerative Diseases
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Neurodegenerative Diseases
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Neurodegenerative Diseases
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Neurodegenerative Diseases
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Neurodegenerative Diseases
Modeling the Effect of Monomer Conformational Change on the Early Stage of Protein Self-Assembly into Fibrils.
Neurodegenerative Diseases
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Neurodegenerative Diseases
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Neurodegenerative Diseases
Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.
Neurodegenerative Diseases
Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
Neurodegenerative Diseases
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Neurodegenerative Diseases
Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with A?1-42, PrP106-126, and ataxin-3 oligomers.
Neurodegenerative Diseases
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Neurodegenerative Diseases
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Neurodegenerative Diseases
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Neurodegenerative Diseases
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Neurodegenerative Diseases
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Neurodegenerative Diseases
Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Neurodegenerative Diseases
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Neurodegenerative Diseases
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Neurodegenerative Diseases
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
Neurodegenerative Diseases
p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.
Neurodegenerative Diseases
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Neurodegenerative Diseases
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Neurodegenerative Diseases
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Neurodegenerative Diseases
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Neurodegenerative Diseases
Phenotyping of tianma-stimulated differentiated rat neuronal b104 cells by quantitative proteomics.
Neurodegenerative Diseases
Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.
Neurodegenerative Diseases
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Neurodegenerative Diseases
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Neurodegenerative Diseases
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Neurodegenerative Diseases
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Neurodegenerative Diseases
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
Neurodegenerative Diseases
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Neurodegenerative Diseases
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Neurodegenerative Diseases
Proteasome inhibition arrests neurite outgrowth and causes "dying-back" degeneration in primary culture.
Neurodegenerative Diseases
Protection against neurodegenerative disease on Earth and in space.
Neurodegenerative Diseases
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Neurodegenerative Diseases
Proteomic characterization of aggregating proteins after the inhibition of the ubiquitin proteasome system.
Neurodegenerative Diseases
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Neurodegenerative Diseases
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Neurodegenerative Diseases
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Neurodegenerative Diseases
Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.
Neurodegenerative Diseases
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
Neurodegenerative Diseases
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Neurodegenerative Diseases
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Neurodegenerative Diseases
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Neurodegenerative Diseases
Structural and functional analysis of ataxin-2 and ataxin-3.
Neurodegenerative Diseases
Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3.
Neurodegenerative Diseases
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Neurodegenerative Diseases
Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1.
Neurodegenerative Diseases
SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.
Neurodegenerative Diseases
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Neurodegenerative Diseases
Systematic Assessment of 10 Biomarker Candidates Focusing on ?-Synuclein-Related Disorders.
Neurodegenerative Diseases
Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).
Neurodegenerative Diseases
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
Neurodegenerative Diseases
The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1.
Neurodegenerative Diseases
The functions of UCH-L1 and its relation to neurodegenerative diseases.
Neurodegenerative Diseases
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
Neurodegenerative Diseases
The josephin domain of ataxin-3 contains two distinct ubiquitin binding sites.
Neurodegenerative Diseases
The Machado-Joseph disease-associated expanded form of ataxin-3: Overexpression, purification, and preliminary biophysical and structural characterization.
Neurodegenerative Diseases
The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.
Neurodegenerative Diseases
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.
Neurodegenerative Diseases
The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.
Neurodegenerative Diseases
The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.
Neurodegenerative Diseases
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.
Neurodegenerative Diseases
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity.
Neurodegenerative Diseases
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
Neurodegenerative Diseases
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Neurodegenerative Diseases
Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP.
Neurodegenerative Diseases
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells.
Neurodegenerative Diseases
Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
Neurodegenerative Diseases
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.
Neurodegenerative Diseases
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Neurodegenerative Diseases
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Neurodegenerative Diseases
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Neurodegenerative Diseases
Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases.
Neurodegenerative Diseases
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Neurodegenerative Diseases
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.
Neurodegenerative Diseases
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Neurodegenerative Diseases
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
Neurodegenerative Diseases
UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis.
Neurodegenerative Diseases
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Neurodegenerative Diseases
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Neuroectodermal Tumor, Melanotic
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy.
Neuroectodermal Tumors
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Neuroectodermal Tumors, Primitive
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Neuroectodermal Tumors, Primitive
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.
Neuroectodermal Tumors, Primitive
Protein gene product (PGP) 9.5 as a reliable marker in primitive neuroectodermal tumours--an immunohistochemical study of 21 childhood cases.
Neuroectodermal Tumors, Primitive
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Neuroectodermal Tumors, Primitive
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Paraganglioma of the cauda equina. A case report and review of the literature.
Neuroendocrine Tumors
PGP 9.5, a new marker for human neuroendocrine tumours.
Neuroendocrine Tumors
Prognostic relevance of UCH-L1 and ?-internexin in pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.
Neuroendocrine Tumors
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neurofibroma
Mast cell and lymphoreticular infiltrates in neurofibromas. Comparison with nerve sheath tumors.
Neurofibromatoses
Molecular pathogenesis of malignant mesothelioma.
Neurofibromatosis 2
Molecular pathogenesis of malignant mesothelioma.
Neurofibrosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Neurofibrosarcoma
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Neuroinflammatory Diseases
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Neuroinflammatory Diseases
OTUB1 inhibits CNS autoimmunity by preventing IFN-?-induced hyperactivation of astrocytes.
Neuroinflammatory Diseases
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Neuroinflammatory Diseases
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25.
Neuroma
Neuropeptide- and tyrosine hydroxylase-immunoreactive nerve fibers in painful Morton's neuromas.
Neurothekeoma
An infiltrative variant of non-neural granular cell tumor: a case report.
Neurothekeoma
Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma.
Neurothekeoma
Classic neurothekeoma (nerve sheath myxoma) and cellular neurothekeoma of the oral mucosa: immunohistochemical profiles.
Neurothekeoma
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Neurothekeoma
Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy.
Neurothekeoma
PGP9.5: a marker for cellular neurothekeoma.
Nevus, Blue
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Non-alcoholic Fatty Liver Disease
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.
Non-alcoholic Fatty Liver Disease
Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease.
Obesity
Proteomic analysis of fetal programming-related obesity markers.
Obesity
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
Optic Atrophy
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Optic Nerve Injuries
Distribution of protein gene product 9.5 (PGP 9.5) in the vertebrate retina: evidence that immunoreactivity is restricted to mammalian horizontal and ganglion cells.
Osteoarthritis
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Osteoarthritis, Knee
Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis.
Osteochondrosis
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Osteoporosis
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Osteosarcoma
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
Osteosarcoma
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.
Osteosarcoma
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell.
Osteosarcoma
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Osteosarcoma
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
Osteosarcoma
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Osteosarcoma
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Osteosarcoma
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Ototoxicity
Downregulated UCHL1 Accelerates Gentamicin-Induced Auditory Cell Death via Autophagy.
Out-of-Hospital Cardiac Arrest
Ultra-early serum concentrations of neuronal and astroglial biomarkers predict poor neurological outcome after out-of-hospital cardiac arrest-a pilot neuroprognostic study.
Ovarian Neoplasms
A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells.
Ovarian Neoplasms
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
Ovarian Neoplasms
Analysis of protein profiles in human epithelial ovarian cancer tissues by proteomic technology.
Ovarian Neoplasms
Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression.
Ovarian Neoplasms
Correction: Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression.
Ovarian Neoplasms
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Ovarian Neoplasms
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Ovarian Neoplasms
Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer.
Ovarian Neoplasms
MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.
Ovarian Neoplasms
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.
Ovarian Neoplasms
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.
Ovarian Neoplasms
The non-coding RNA OTUB1-isoform2 promotes ovarian tumour progression and predicts poor prognosis.
Ovarian Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Ovarian Neoplasms
UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance.
Ovarian Neoplasms
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-?B pathway.
Pancreatic Neoplasms
Analysis of transcription profile to reveal altered signaling pathways following the overexpression of human desumoylating isopeptidase 2 in pancreatic cancer cells.
Pancreatic Neoplasms
Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patients.
Pancreatic Neoplasms
Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.
Pancreatic Neoplasms
MicroRNA-29c Increases the Chemosensitivity of Pancreatic Cancer Cells by Inhibiting USP22 Mediated Autophagy.
Pancreatic Neoplasms
PGP9.5 as a marker for invasive colorectal cancer.
Pancreatic Neoplasms
PGP9.5 as a prognostic factor in pancreatic cancer.
Pancreatic Neoplasms
Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer.
Pancreatic Neoplasms
The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.
Pancreatic Neoplasms
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Pancreatic Neoplasms
Tumor innervation and clinical outcome in pancreatic cancer.
Pancreatic Neoplasms
Ubiquitin?specific protease 22?induced autophagy is correlated with poor prognosis of pancreatic cancer.
Pancreatic Neoplasms
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
Pancreatic Neoplasms
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
Pancreatic Neoplasms
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
Pancreatic Neoplasms
USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1.
Pancreatitis, Chronic
Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patients.
Paralysis
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Parathyroid Neoplasms
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
Parathyroid Neoplasms
Parafibromin, Galectin-3, PGP9.5, Ki67, and Cyclin D1: Using an Immunohistochemical Panel to Aid in the Diagnosis of Parathyroid Cancer.
Parathyroid Neoplasms
Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics.
Parkinson Disease
A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.
Parkinson Disease
A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population.
Parkinson Disease
ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onset.
Parkinson Disease
Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.
Parkinson Disease
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
Parkinson Disease
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
Parkinson Disease
An Ile93Met substitution in the UCH-L1 gene is not a disease-causing mutation for idiopathic Parkinson's disease.
Parkinson Disease
Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.
Parkinson Disease
Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease.
Parkinson Disease
Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis.
Parkinson Disease
Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.
Parkinson Disease
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms.
Parkinson Disease
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Parkinson Disease
Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.
Parkinson Disease
Backbone assignments of the 26 kDa neuron-specific ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1).
Parkinson Disease
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.
Parkinson Disease
Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.
Parkinson Disease
Case-control study of UCHL1 S18Y variant in Parkinson's disease.
Parkinson Disease
Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering.
Parkinson Disease
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Parkinson Disease
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Parkinson Disease
Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish.
Parkinson Disease
Complex interactions in Parkinson's disease: a two-phased approach.
Parkinson Disease
CSF ?-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.
Parkinson Disease
Cutaneous Alpha-Synuclein is Correlated with Autonomic Impairment in Isolated REM Sleep Behavior Disorder.
Parkinson Disease
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
Parkinson Disease
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Parkinson Disease
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Parkinson Disease
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.
Parkinson Disease
Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
Parkinson Disease
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Parkinson Disease
Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
Parkinson Disease
Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor.
Parkinson Disease
Excess ?-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1.
Parkinson Disease
Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease.
Parkinson Disease
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease.
Parkinson Disease
Failure to find mutations in ubiquitin carboxy-terminal hydrolase L1 gene in familial Parkinson's disease.
Parkinson Disease
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.
Parkinson Disease
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.
Parkinson Disease
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Parkinson Disease
Genetic causes of Parkinson's disease: UCHL-1.
Parkinson Disease
Genetics and Parkinson's disease.
Parkinson Disease
Genetics of Parkinson's disease.
Parkinson Disease
Identification of tyrosine nitration in UCH-L1 and GAPDH.
Parkinson Disease
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.
Parkinson Disease
Improving synaptic function in a mouse model of AD.
Parkinson Disease
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Parkinson Disease
Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy.
Parkinson Disease
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.
Parkinson Disease
Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.
Parkinson Disease
Lack of Association of the UCHL-1 gene with Parkinson's disease in a greek cohort: A haplotype-tagging approach.
Parkinson Disease
Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.
Parkinson Disease
Lack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.
Parkinson Disease
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Parkinson Disease
Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.
Parkinson Disease
Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.
Parkinson Disease
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Parkinson Disease
Mechanistic studies of ubiquitin C-terminal hydrolase l1.
Parkinson Disease
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Parkinson Disease
Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.
Parkinson Disease
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Parkinson Disease
Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.
Parkinson Disease
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
Parkinson Disease
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
Parkinson Disease
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Parkinson Disease
No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease.
Parkinson Disease
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Parkinson Disease
Parkinson's disease-associated mutations in ?-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1.
Parkinson Disease
Parkinson's genetics--creating exciting new insights.
Parkinson Disease
Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease.
Parkinson Disease
Porcine UCHL1: genomic organization, chromosome localization and expression analysis.
Parkinson Disease
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Parkinson Disease
Production of polyclonal anti-dUCH (Drosophila Ubiquitin Carboxyl-terminal Hydrolase) antibodies.
Parkinson Disease
Progress in familial Parkinson's disease.
Parkinson Disease
Protective and toxic roles of dopamine in Parkinson's disease.
Parkinson Disease
Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells.
Parkinson Disease
Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1.
Parkinson Disease
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
Parkinson Disease
S-nitrosylation of UCHL1 induces its structural instability and promotes ?-synuclein aggregation.
Parkinson Disease
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.
Parkinson Disease
S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship.
Parkinson Disease
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Parkinson Disease
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Parkinson Disease
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Parkinson Disease
Substrate recognition and catalysis by UCH-L1.
Parkinson Disease
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
Parkinson Disease
The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1.
Parkinson Disease
The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease.
Parkinson Disease
The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates.
Parkinson Disease
The long non-coding RNAs in neurodegenerative diseases: novel mechanisms of pathogenesis.
Parkinson Disease
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
Parkinson Disease
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
Parkinson Disease
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells.
Parkinson Disease
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
Parkinson Disease
The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.
Parkinson Disease
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
Parkinson Disease
The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.
Parkinson Disease
Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.
Parkinson Disease
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Parkinson Disease
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Parkinson Disease
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
Parkinson Disease
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron.
Parkinson Disease
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Parkinson Disease
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Parkinson Disease
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.
Parkinson Disease
UCH-L1 S18Y variant and risk of Parkinson's disease in Asian populations: an updated meta-analysis.
Parkinson Disease
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
Parkinson Disease
UCHL-1 is not a Parkinson's disease susceptibility gene.
Parkinson Disease
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein.
Parkinson Disease
UCHL1 is a Parkinson's disease susceptibility gene.
Parkinson Disease
UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.
Parkinson Disease
UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.
Parkinson Disease
[Association of the ubiquitin carboxy-terminal hydrolase-L1 genetic polymorphism with the susceptibility of Parkinson's disease.]
Parkinson Disease
[Association of two polymorphisms in ubiquitin carboxy-terminal hydrolase-L1 gene with Parkinson's disease in Shanghai]
Parkinson Disease
[Parkinson's disease: what have we learned from the genes responsible for familial forms?]
Parkinson Disease
[The ubiquitin-proteasome system and neurodegeneration]
Parkinsonian Disorders
Analysis of alpha-synuclein, parkin, tau, and UCH-L1 in a Japanese family with autosomal dominant parkinsonism.
Parkinsonian Disorders
CSF ?-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.
Parkinsonian Disorders
Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
Parkinsonian Disorders
New endemic familial parkinsonism in south Moravia, Czech Republic and its genetical background.
Parkinsonian Disorders
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Parkinsonian Disorders
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Parkinsonian Disorders
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.
Parkinsonian Disorders
[Parkinson's disease: what have we learned from the genes responsible for familial forms?]
Parkinsonian Disorders
[The genetics of Parkinson syndrome]
Periodontitis
Comparison of NK-cell (Leu-7+ and Leu-11b+) populations in clinically healthy gingiva, chronic gingivitis and chronic adult periodontitis.
Peripheral Nervous System Diseases
Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.
Peripheral Nervous System Diseases
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Peripheral Nervous System Diseases
Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments.
Pheochromocytoma
Disseminated pheochromocytoma in a North American river otter (Lontra canadensis).
Phyllodes Tumor
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Pinealoma
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Pituitary Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Pneumonia
The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
Pneumothorax
Familial spontaneous pneumothorax and Machado-Joseph disease.
Polyneuropathies
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Porcine Reproductive and Respiratory Syndrome
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotypic analysis of acute lymphoblastic leukemia using routinely processed bone marrow specimens.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
New marker of B lymphocytes, MB2: comparison with other lymphocyte subset markers active in conventionally processed tissue sections.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Role of ubiquitin carboxyl terminal hydrolase in the differentiation of human acute lymphoblastic leukemia cell line, Reh.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia.
Prostatic Hyperplasia
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
Prostatic Neoplasms
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Prostatic Neoplasms
Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer.
Prostatic Neoplasms
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Prostatic Neoplasms
Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A.
Prostatic Neoplasms
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
Prostatic Neoplasms
Localization of protein gene product 9.5 immunoreactivity in derivatives of the human Wolffian duct and in prostate cancer.
Prostatic Neoplasms
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.
Prostatic Neoplasms
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Prostatic Neoplasms
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
Prostatic Neoplasms
Survey of differentially methylated promoters in prostate cancer cell lines.
Prostatic Neoplasms
The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.
Prostatic Neoplasms
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
Prostatic Neoplasms
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
Prostatic Neoplasms
The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.
Prostatic Neoplasms
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Prostatic Neoplasms
Tumor Suppressor Function of PGP9.5 Is Associated with Epigenetic Regulation in Prostate Cancer--Novel Predictor of Biochemical Recurrence after Radical Surgery.
Prostatic Neoplasms
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Prostatic Neoplasms
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Prostatic Neoplasms
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation.
Prostatic Neoplasms
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
Prostatic Neoplasms
USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair.
Prostatic Neoplasms
USP2a activation of MYC in prostate cancer.
Prostatic Neoplasms
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Proteinuria
Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice.
Proteinuria
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
Proteinuria
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Prurigo
Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis.
Pseudolymphoma
Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.
Pseudolymphoma
Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections.
Psoriasis
Dithranol abolishes UCH-L1 immunoreactivity in the nerve fibers of the rat orofacial skin.
Psoriasis
Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.
Psoriasis
[Role of the skin expression of neuropeptides, neurotrophins and their receptors in the pathogenesis of dermatoses].
Pulmonary Disease, Chronic Obstructive
Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model.
Pulmonary Disease, Chronic Obstructive
OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers.
Pulmonary Fibrosis
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGF?-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis.
Rabies
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
Rectal Neoplasms
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Rectal Neoplasms
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
Reperfusion Injury
Knockdown EZH2 attenuates cerebral ischemia-reperfusion injury via regulating microRNA-30d-3p methylation and USP22.
Reperfusion Injury
USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death.
Retinal Degeneration
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice.
Retinal Detachment
RNA Interference Reveals the Coregulatory Effects of Cylindromatosis on Apoptosis and Necroptosis of Photoreceptor Cells in Experimental Retinal Detachment.
Retinal Diseases
UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2.
Retinoblastoma
Disseminated retinoblastoma successfully treated with myeloablative chemotherapy--implication for molecular detection of minimal residual disease.
Retinoblastoma
microRNA-362-3p targets USP22 to retard retinoblastoma growth via reducing deubiquitination of LSD1.
Retinoblastoma
PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours.
Retinoblastoma
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Retinoblastoma
The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.
Retinoblastoma
The double dealing of cyclin D1.
Retinoblastoma
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Retinoblastoma
USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway.
Rhabdomyolysis
Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.
Rhabdomyosarcoma
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Rhabdomyosarcoma
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Rhabdomyosarcoma, Alveolar
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Rhabdomyosarcoma, Embryonal
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Rhinitis
Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.
Rubella
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Rubella
Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses.
Salivary Gland Neoplasms
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Salmonella Infections
Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.
Sandhoff Disease
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Sarcoma
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Sarcoma
Classification of Canine Nonangiogenic, Nonlymphogenic, Gastrointestinal Sarcomas Based on Microscopic, Immunohistochemical, and Molecular Characteristics.
Sarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Sarcoma
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Sarcoma
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Sarcoma, Ewing
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.
Sarcoma, Ewing
USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.
Sarcoma, Kaposi
PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi's sarcoma.
Sarcoma, Myeloid
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Sarcoma, Myeloid
Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues.
Sarcoma, Synovial
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Scleroderma, Systemic
Deficiency of calcitonin gene-related peptide in Raynaud's phenomenon.
Seizures
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Seizures
Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Seizures
Correction to: Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Seizures
Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy.
Seizures
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
Seizures
Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures.
Seizures
Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.
Seizures
The diagnostic value of serum UCHL-1 and S100-B levels in differentiate epileptic seizures from psychogenic attacks.
Seizures
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
Seizures
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Seizures
Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure.
Seizures
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Seminoma
Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas.
Seminoma
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Sepsis
Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication.
Sepsis-Associated Encephalopathy
Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication.
Severe Acute Respiratory Syndrome
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Severe Acute Respiratory Syndrome
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Severe Acute Respiratory Syndrome
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.
Severe Acute Respiratory Syndrome
Binding site-based classification of coronaviral papain-like proteases.
Severe Acute Respiratory Syndrome
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
Severe Acute Respiratory Syndrome
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.
Severe Acute Respiratory Syndrome
Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.
Severe Acute Respiratory Syndrome
Chemical constituents from coconut waste and their in silico evaluation as potential antiviral agents against SARS-CoV-2.
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Severe Acute Respiratory Syndrome
Crystal structure of SARS-CoV-2 papain-like protease.
Severe Acute Respiratory Syndrome
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Severe Acute Respiratory Syndrome
Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus.
Severe Acute Respiratory Syndrome
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease.
Severe Acute Respiratory Syndrome
Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches.
Severe Acute Respiratory Syndrome
Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity.
Severe Acute Respiratory Syndrome
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
Severe Acute Respiratory Syndrome
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
Severe Acute Respiratory Syndrome
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Severe Acute Respiratory Syndrome
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Severe Acute Respiratory Syndrome
Molecular Dynamic Studies of Interferon and Innate Immunity Resistance in MERS CoV Non-Structural Protein 3.
Severe Acute Respiratory Syndrome
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Severe Acute Respiratory Syndrome
Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities.
Severe Acute Respiratory Syndrome
Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits.
Severe Acute Respiratory Syndrome
Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition.
Severe Acute Respiratory Syndrome
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Severe Acute Respiratory Syndrome
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Severe Acute Respiratory Syndrome
Phytochemical profile of Paulownia tomentosa (Thunb). Steud.
Severe Acute Respiratory Syndrome
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Severe Acute Respiratory Syndrome
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.
Severe Acute Respiratory Syndrome
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus.
Severe Acute Respiratory Syndrome
SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6.
Severe Acute Respiratory Syndrome
SARS-CoV-2 Papain-Like Protease Potential Inhibitors-In Silico Quantitative Assessment.
Severe Acute Respiratory Syndrome
Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme.
Severe Acute Respiratory Syndrome
Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease.
Severe Acute Respiratory Syndrome
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Severe Acute Respiratory Syndrome
Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.
Severe Acute Respiratory Syndrome
Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.
Severe Acute Respiratory Syndrome
The emerging SARS-CoV-2 papain-like protease: Its relationship with recent coronavirus epidemics.
Severe Acute Respiratory Syndrome
The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase.
Severe Acute Respiratory Syndrome
The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme.
Severe Acute Respiratory Syndrome
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.
Severe Acute Respiratory Syndrome
Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme.
Severe Acute Respiratory Syndrome
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.
Sex Cord-Gonadal Stromal Tumors
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog.
Skin Diseases
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Skin Neoplasms
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
Skin Neoplasms
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Small Cell Lung Carcinoma
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Small Fiber Neuropathy
Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?
Soft Tissue Neoplasms
Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma.
Spinal Cord Compression
Expression of the ubiquitin carboxyl-terminal hydrolase PGP 9.5 in axons following spinal cord compression trauma. An immunohistochemical study in the rat.
Spinal Cord Compression
Systemic hypothermia following spinal cord compression injury in the rat: axonal changes studied by beta-APP, ubiquitin, and PGP 9.5 immunohistochemistry.
Spinal Cord Diseases
[An autopsy case with subacute spinal cord disease showing progressive paraplegia]
Spinal Cord Injuries
Accumulation of immunoreactivity to ubiquitin carboxyl-terminal hydrolase PGP 9.5 in axons of human cases with spinal cord lesions.
Spinal Cord Injuries
Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 as a Biomarker of Human Acute Traumatic Spinal Cord Injury.
Spinal Cord Injuries
Single-step functionalization of poly-catecholamine nanofilms for ultra-sensitive immunosensing of ubiquitin carboxyl terminal hydrolase-L1 (UCHL-1) in spinal cord injury.
Spinal Cord Injuries
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Spinocerebellar Ataxias
A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic josephin domain in monomeric form, while leaving the oligomers unaffected.
Spinocerebellar Ataxias
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
Spinocerebellar Ataxias
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Spinocerebellar Ataxias
A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins.
Spinocerebellar Ataxias
A spinocerebellar ataxia family with expanded alleles in the tata-binding protein gene and ataxin-3 gene.
Spinocerebellar Ataxias
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.
Spinocerebellar Ataxias
A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats.
Spinocerebellar Ataxias
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Spinocerebellar Ataxias
Allosteric regulation of deubiquitylase activity through ubiquitination.
Spinocerebellar Ataxias
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
Spinocerebellar Ataxias
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Spinocerebellar Ataxias
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
Spinocerebellar Ataxias
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Spinocerebellar Ataxias
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
Spinocerebellar Ataxias
Ataxin-3 is subject to autolytic cleavage.
Spinocerebellar Ataxias
Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
Spinocerebellar Ataxias
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Spinocerebellar Ataxias
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Spinocerebellar Ataxias
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Spinocerebellar Ataxias
Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon.
Spinocerebellar Ataxias
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation.
Spinocerebellar Ataxias
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Axonal inclusions in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients.
Spinocerebellar Ataxias
Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.
Spinocerebellar Ataxias
Broadening the therapeutic scope for rapamycin treatment.
Spinocerebellar Ataxias
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Spinocerebellar Ataxias
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Spinocerebellar Ataxias
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Spinocerebellar Ataxias
Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3.
Spinocerebellar Ataxias
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
Spinocerebellar Ataxias
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Spinocerebellar Ataxias
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Spinocerebellar Ataxias
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Spinocerebellar Ataxias
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Spinocerebellar Ataxias
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Spinocerebellar Ataxias
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.
Spinocerebellar Ataxias
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Spinocerebellar Ataxias
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Spinocerebellar Ataxias
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Spinocerebellar Ataxias
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.
Spinocerebellar Ataxias
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Spinocerebellar Ataxias
Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3.
Spinocerebellar Ataxias
Divalproex sodium regulates ataxin-3 translocation likely by an importin ?1-dependent pathway.
Spinocerebellar Ataxias
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Spinocerebellar Ataxias
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Spinocerebellar Ataxias
Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.
Spinocerebellar Ataxias
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Spinocerebellar Ataxias
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
Spinocerebellar Ataxias
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Functional interactions as a survival strategy against abnormal aggregation.
Spinocerebellar Ataxias
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Spinocerebellar Ataxias
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
Spinocerebellar Ataxias
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Spinocerebellar Ataxias
Heterogeneous intracellular localization and expression of ataxin-3.
Spinocerebellar Ataxias
How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode.
Spinocerebellar Ataxias
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Spinocerebellar Ataxias
Identification and functional dissection of localization signals within ataxin-3.
Spinocerebellar Ataxias
Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.
Spinocerebellar Ataxias
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Spinocerebellar Ataxias
Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains.
Spinocerebellar Ataxias
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
Spinocerebellar Ataxias
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Spinocerebellar Ataxias
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Spinocerebellar Ataxias
Karyopherin ?-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Spinocerebellar Ataxias
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Spinocerebellar Ataxias
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Spinocerebellar Ataxias
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Spinocerebellar Ataxias
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Spinocerebellar Ataxias
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.
Spinocerebellar Ataxias
Modeling the Effect of Monomer Conformational Change on the Early Stage of Protein Self-Assembly into Fibrils.
Spinocerebellar Ataxias
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Spinocerebellar Ataxias
Mouse models of Machado-Joseph disease and other polyglutamine spinocerebellar ataxias.
Spinocerebellar Ataxias
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Spinocerebellar Ataxias
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
Spinocerebellar Ataxias
Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.
Spinocerebellar Ataxias
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Spinocerebellar Ataxias
N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.
Spinocerebellar Ataxias
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Spinocerebellar Ataxias
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Spinocerebellar Ataxias
Non-expanded polyglutamine proteins in intranuclear inclusions of hereditary ataxias--triple-labeling immunofluorescence study.
Spinocerebellar Ataxias
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Spinocerebellar Ataxias
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
Spinocerebellar Ataxias
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Spinocerebellar Ataxias
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Spinocerebellar Ataxias
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Spinocerebellar Ataxias
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Spinocerebellar Ataxias
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Spinocerebellar Ataxias
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Spinocerebellar Ataxias
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Spinocerebellar Ataxias
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Spinocerebellar Ataxias
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
Spinocerebellar Ataxias
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Spinocerebellar Ataxias
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Spinocerebellar Ataxias
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA-3.
Spinocerebellar Ataxias
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Spinocerebellar Ataxias
Proteotoxic stress increases nuclear localization of ataxin-3.
Spinocerebellar Ataxias
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Spinocerebellar Ataxias
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation.
Spinocerebellar Ataxias
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.
Spinocerebellar Ataxias
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Spinocerebellar Ataxias
Research on screening and identification of proteins interacting with ataxin-3.
Spinocerebellar Ataxias
Reversibility of symptoms in a conditional mouse model of Spinocerebellar Ataxia Type 3.
Spinocerebellar Ataxias
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
Spinocerebellar Ataxias
RNA toxicity is a component of ataxin-3 degeneration in Drosophila.
Spinocerebellar Ataxias
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
Spinocerebellar Ataxias
SCA3: Neurological features, pathogenesis and animal models.
Spinocerebellar Ataxias
Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Spinocerebellar Ataxias
Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions.
Spinocerebellar Ataxias
Spinocerebellar ataxia type 3 in Israel: phenotype and genotype of a Jew Yemenite subpopulation.
Spinocerebellar Ataxias
Structural and functional analysis of ataxin-2 and ataxin-3.
Spinocerebellar Ataxias
Structural modeling of ataxin-3 reveals distant homology to adaptins.
Spinocerebellar Ataxias
Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.
Spinocerebellar Ataxias
Study of subcellular localization and proteolysis of ataxin-3.
Spinocerebellar Ataxias
SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.
Spinocerebellar Ataxias
Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide.
Spinocerebellar Ataxias
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.
Spinocerebellar Ataxias
T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.
Spinocerebellar Ataxias
Targeting several CAG expansion diseases by a single antisense oligonucleotide.
Spinocerebellar Ataxias
Temperature profoundly affects ataxin-3 fibrillogenesis.
Spinocerebellar Ataxias
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
Spinocerebellar Ataxias
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
Spinocerebellar Ataxias
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Spinocerebellar Ataxias
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
Spinocerebellar Ataxias
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
Spinocerebellar Ataxias
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
Spinocerebellar Ataxias
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.
Spinocerebellar Ataxias
The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.
Spinocerebellar Ataxias
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
Spinocerebellar Ataxias
The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.
Spinocerebellar Ataxias
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis.
Spinocerebellar Ataxias
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
Spinocerebellar Ataxias
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Spinocerebellar Ataxias
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Spinocerebellar Ataxias
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Spinocerebellar Ataxias
Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
Spinocerebellar Ataxias
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Spinocerebellar Ataxias
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Spinocerebellar Ataxias
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Spinocerebellar Ataxias
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Spinocerebellar Ataxias
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Spinocerebellar Ataxias
Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients.
Spinocerebellar Ataxias
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
Spinocerebellar Ataxias
Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3.
Spinocerebellar Ataxias
Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.
Spinocerebellar Ataxias
[Screening for proteins interacting with ataxin-3, the gene product of SCA3/MJD]
Spinocerebellar Degenerations
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Squamous Cell Carcinoma of Head and Neck
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Squamous Cell Carcinoma of Head and Neck
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Squamous Cell Carcinoma of Head and Neck
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Squamous Cell Carcinoma of Head and Neck
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Squamous Cell Carcinoma of Head and Neck
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Squamous Cell Carcinoma of Head and Neck
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Starvation
A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium.
Starvation
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Starvation
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Status Epilepticus
Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.
Status Epilepticus
Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure.
Stomach Neoplasms
Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer.
Stomach Neoplasms
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Stomach Neoplasms
Correction: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Stomach Neoplasms
Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.
Stomach Neoplasms
Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.
Stomach Neoplasms
Filtering High-Dimensional Methylation Marks With Extremely Small Sample Size: An Application to Gastric Cancer Data.
Stomach Neoplasms
Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P.
Stomach Neoplasms
High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
Stomach Neoplasms
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
Stomach Neoplasms
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
Stomach Neoplasms
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
Stomach Neoplasms
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
Stomach Neoplasms
PGP9.5 methylation in diffuse-type gastric cancer.
Stomach Neoplasms
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Stomach Neoplasms
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Stomach Neoplasms
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Stomach Neoplasms
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Stomach Neoplasms
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
Stomach Neoplasms
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Stomach Neoplasms
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Stomach Neoplasms
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner.
Stomach Neoplasms
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
Stomach Neoplasms
UCHL3 stimulates metastasis of gastric cancer through upregulating IGF2.
Stomach Neoplasms
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
Stomach Neoplasms
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Strabismus
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Stroke
Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients.
Stroke
Biomarkers for acute diagnosis and management of stroke in neurointensive care units.
Stroke
Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).
Stroke
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Stroke
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Stroke
Quantitative neuroproteomics of an in vivo rodent model of focal cerebral ischemia/reperfusion injury reveals a temporal regulation of novel pathophysiological molecular markers.
Stroke
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Stroke
Stroke and Amyloid-? Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response.
Stroke
Treatment efficacy of arterial urokinase thrombolysis combined with mechanical thrombectomy for acute cerebral infarction and its influence on neuroprotective factors and factors for neurological injury.
Stroke
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Subarachnoid Hemorrhage
A Pilot Study of Novel biomarkers in neonates with Hypoxic-Ischemic Encephalopathy.
Subarachnoid Hemorrhage
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Subarachnoid Hemorrhage
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Subarachnoid Hemorrhage
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage.
Subarachnoid Hemorrhage
Increased plasma UCH-L1 after aneurysmal subarachnoid hemorrhage is associated with unfavorable neurological outcome.
Synucleinopathies
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.
Synucleinopathies
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Synucleinopathies
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Synucleinopathies
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Tauopathies
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
Tauopathies
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Tendinopathy
Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections.
Tendinopathy
The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation.
Teratoma
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Testicular Neoplasms
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Thrombosis
Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech.
Thyroid Cancer, Papillary
Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion.
Thyroid Cancer, Papillary
MiR-101 targets USP22 to inhibit the tumorigenesis of papillary thyroid carcinoma.
Thyroid Cancer, Papillary
miR-29a-3p inhibits growth, proliferation, and invasion of papillary thyroid carcinoma by suppressing NF-?B signaling via direct targeting of OTUB2.
Thyroid Cancer, Papillary
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Thyroid Neoplasms
A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.
Thyroid Neoplasms
Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion.
Thyroid Neoplasms
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
Thyroid Neoplasms
Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
Trauma, Nervous System
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Tremor
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Tremor
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Triple Negative Breast Neoplasms
USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Trophoblastic Neoplasms
Immunohistochemistry of germ cell and trophoblastic neoplasms.
Tuberculosis
Deciphering Molecular Virulence Mechanism of Mycobacterium tuberculosis Dop isopeptidase Based on Its Sequence-Structure-Function Linkage.
ubiquitinyl hydrolase 1 deficiency
Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse.
ubiquitinyl hydrolase 1 deficiency
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
ubiquitinyl hydrolase 1 deficiency
BETA-CELL DYSFUNCTIONAL ERAD/UBIQUITIN/PROTEASOME SYSTEM IN TYPE 2 DIABETES MEDIATED BY IAPP-INDUCED UCH-L1 DEFICIENCY.
ubiquitinyl hydrolase 1 deficiency
Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice.
ubiquitinyl hydrolase 1 deficiency
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
ubiquitinyl hydrolase 1 deficiency
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
ubiquitinyl hydrolase 1 deficiency
Effects of ubiquitin C-terminal hydrolase-L1 deficiency on mouse ova.
ubiquitinyl hydrolase 1 deficiency
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
ubiquitinyl hydrolase 1 deficiency
Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.
ubiquitinyl hydrolase 1 deficiency
Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.
ubiquitinyl hydrolase 1 deficiency
Preventing abnormal NF-?B activation and autoimmunity by Otub1-mediated p100 stabilization.
ubiquitinyl hydrolase 1 deficiency
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
ubiquitinyl hydrolase 1 deficiency
The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.
ubiquitinyl hydrolase 1 deficiency
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
ubiquitinyl hydrolase 1 deficiency
Ubiquitin C-terminal hydrolase L1 deficiency decreases bone mineralization.
ubiquitinyl hydrolase 1 deficiency
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
ubiquitinyl hydrolase 1 deficiency
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
ubiquitinyl hydrolase 1 deficiency
USP19 Inhibits TNF-?- and IL-1?-Triggered NF-?B Activation by Deubiquitinating TAK1.
ubiquitinyl hydrolase 1 deficiency
USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination.
ubiquitinyl hydrolase 1 deficiency
Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.
ubiquitinyl hydrolase 1 deficiency
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
ubiquitinyl hydrolase 1 deficiency
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
ubiquitinyl hydrolase 1 deficiency
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
Urinary Bladder Neoplasms
An 18-gene signature based on glucose metabolism and DNA methylation improves prognostic prediction for urinary bladder cancer.
Urinary Bladder Neoplasms
Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.
Urinary Bladder Neoplasms
MINDY1 promotes bladder cancer progression by stabilizing YAP.
Urinary Bladder Neoplasms
OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress.
Urinary Bladder Neoplasms
Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells.
Urinary Bladder, Overactive
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Uterine Cervical Neoplasms
Identification of potential target genes of USP22 via ChIP-seq and RNA-seq analysis in HeLa cells.
Uterine Cervical Neoplasms
miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer.
Uterine Cervical Neoplasms
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
Vascular Diseases
Cezanne is a critical regulator of pathological arterial remodelling by targeting ?-catenin signalling.
Vascular Diseases
The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for A? 42 Accumulation in Alzheimer's and Vascular Disease.
Ventilator-Induced Lung Injury
UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo.
Vesicular Stomatitis
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Virus Diseases
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Virus Diseases
HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Virus Diseases
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
Virus Diseases
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Virus Diseases
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Virus Diseases
Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow.
Virus Diseases
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Virus Diseases
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Virus Diseases
USP7 manipulation by viral proteins.
Virus Diseases
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.
Vitiligo
Neuropeptide and neuronal marker studies in vitiligo.
Vulvodynia
Increased innervation of the vulval vestibule in patients with vulvodynia.
Waldenstrom Macroglobulinemia
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
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