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Information on EC 3.4.19.1 - acylaminoacyl-peptidase

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.1 acylaminoacyl-peptidase
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This record set is specific for:
UNIPROT: O58323 not found.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide
Synonyms
apaap, acylpeptide hydrolase, acylaminoacyl peptidase, acylamino acid-releasing enzyme, acyl-peptide hydrolase, spaap, aphdr, acyl peptide hydrolase, apaph, aare/oph, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acylaminoacyl peptidase
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Acyl-peptide hydrolase
-
-
-
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acylamino-acid-releasing enzyme
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-
-
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Acylaminoacyl-peptidase
-
-
-
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alpha-N-acylpeptide hydrolase
-
-
-
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DNF15S2 protein
-
-
-
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N-acylaminoacyl-peptide hydrolase
-
-
-
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N-acylpeptide hydrolase
-
-
-
-
N-formylmethionine (fMet) aminopeptidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
hydrolysis of peptide bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
73562-30-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Abz-EFSPF(NO2)RA + H2O
?
show the reaction diagram
-
-
-
?
Abz-GFEPF(NO2)RA + H2O
?
show the reaction diagram
-
-
-
?
Abz-KARVLF(NO2)EANle + H2O
?
show the reaction diagram
-
-
-
?
Abz-SAVLQSGF(NO2)A + H2O
?
show the reaction diagram
-
-
-
?
Ac-Ala-7-amido-4-methylcoumarin + H2O
N-acetyl-L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Ac-Leu-4-nitroanilide + H2O
N-acetyl-L-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ac-Phe-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
?
Ac-Phe-2-naphthylamide + H2O
N-acetyl-L-Phe + 2-naphthylamine
show the reaction diagram
-
-
-
?
Ac-Phe-4-nitroanilide + H2O
N-acetyl-L-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
?
Gly-Phe-2-naphthylamide + H2O
Gly-Phe + 2-naphthylamine
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
O58323_PYRHO
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
622
0
73231
TrEMBL
other Location (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
73230
calculated, monomer
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexamer
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystals are grown at 20°C by the hanging drop method
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
into the vector pET15b for expression in Escherichia coli Rosetta DE3 cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Szeltner, Z.; Kiss, A.L.; Domokos, K.; Harmat, V.; Naray-Szabo, G.; Polgar, L.
Characterization of a novel acylaminoacyl peptidase with hexameric structure and endopeptidase activity
Biochim. Biophys. Acta
1794
1204-1210
2009
Pyrococcus horikoshii (O58323), Pyrococcus horikoshii
Manually annotated by BRENDA team
Menyhard, D.K.; Kiss-Szeman A.; Tichy-Racs, E.; Hornung, B.; Radi, K.; Szeltner, Z.; Domokos, K., Szamosi, I.; Naray-Szabo, G.; Polgar, L.; Harmat, V.
A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization
J. Biol. Chem.
288
17884-17894
2013
Pyrococcus horikoshii (O58323), Pyrococcus horikoshii DSM 12428 (O58323)
Manually annotated by BRENDA team