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Information on EC 3.4.17.24 - tubulin-glutamate carboxypeptidase and Organism(s) Danio rerio and UniProt Accession Q68EI3

for references in articles please use BRENDA:EC3.4.17.24
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Danio rerio
UNIPROT: Q68EI3 not found.
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The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
Synonyms
deglutamylase, ccpp-1, agbl5, cytosolic carboxypeptidase 1, ccpp-6, cytosolic carboxypeptidase 6, cytosolic carboxypeptidase ccp1, cytosolic carboxypeptidase 5, cytosolic carboxypeptidase-like protein 5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tubulinyl-Glu carboxypeptidase
-
-
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
CCP1 and CCP5 mRNAs are predominantly expressed in tissues such as the brain, olfactory placodes, and pronephric ducts
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature
physiological function
malfunction
knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature
physiological function
CCP1 and CCP5 play important roles in zebrafish embryonic development, particularly the development and functioning of cilia. Loss of the deglutamylating enzymes causes developmental defects in zebrafish
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CBPC5_DANRE
885
0
98709
Swiss-Prot
other Location (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CCP1 and CCP5 mRNAs are detectable between 2 h and 8 days postfertilization with highest levels 5-8 days postfertilization
CCP1 and CCP5 mRNAs are detectable between 2 h and 8 days postfertilization with highest levels 5-8 days postfertilization
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pathak, N.; Austin-Tse, C.A.; Liu, Y.; Vasilyev, A.; Drummond, I.A.
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function
Mol. Biol. Cell
25
1836-1844
2014
Danio rerio (Q68EI3), Danio rerio
Manually annotated by BRENDA team
Lyons, P.J.; Sapio, M.R.; Fricker, L.D.
Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development
J. Biol. Chem.
288
30454-30462
2013
Danio rerio (Q4U2V3), Danio rerio (Q68EI3)
Manually annotated by BRENDA team