Reference on EC 3.4.17.23 - angiotensin-converting enzyme 2

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yan, Z.H.; Ren, K.J.; Wang, Y.; Chen, S.; Brock, T.A.; Rege, A.A.
Development of intramolecularly quenched fluorescent peptides as substrates of angiotensin-converting enzyme 2
Anal. Biochem.
312
141-147
2003
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Guy, J.L.; Jackson, R.M.; Acharya, K.R.; Sturrock, E.D.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence
Biochemistry
42
13185-13192
2003
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S.
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
Circ. Res.
87
E1-9
2000
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Zisman, L.S.; Keller, R.S.; Weaver, B.; Lin, Q.; Speth, R.; Bristow, M.R.; Canver, C.C.
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme homologue ACE2
Circulation
108
1707-1712
2003
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Tikellis, C.; Johnston, C.I.; Forbes, J.M.; Burns, W.C.; Burrell, L.M.; Risvanis, J.; Cooper, M.E.
Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy
Hypertension
41
392-397
2003
Rattus norvegicus
Manually annotated by BRENDA team
Dales, N.A.; Gould, A.E.; Brown, J.A.; Calderwood, E.F.; Guan, B.; Minor, C.A.; Gavin, J.M.; Hales, P.; Kaushik, V.K.; Stewart, M.; Tummino, P.J.; Vickers, C.S.; Ocain, T.D.; Patane, M.A.
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors
J. Am. Chem. Soc.
124
11852-11853
2002
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Tipnis, S.R.; Hooper, N.M.; Hyde, R.J.; Christie, G.; Karran, E.; Turner, A.J.
A humen homolog of angiotensin converting enzyme - cloning and functional expression as a captopril-insensitive carboxypeptidase
J. Biol. Chem.
275
33238-33243
2000
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Vickers, C.; Hales, P.; Kaushik, V.; Dick, L.; Gavin, J.; Tang, J.; Godbout, K.; Parsons, T.; Baronas, E.; Hsieh, F.; Acton, S.; Patane, M.; Nichols, A.; Tummino, P.
Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase
J. Biol. Chem.
277
14838-14843
2002
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Huang, L.; Sexton, D.J.; Skogerson, K.; Devlin, M.; Smith, R.; Sanyal, I.; Parry, T.; Kent, R.; Enright, J.; Wu, Q.L.; Conley, G.; DeOliveira, D.; Morganelli, L.; Ducar, M.; Wescott, C.R.; Ladner, R.C.
Novel peptide inhibitors of angiotensin-converting enzyme 2
J. Biol. Chem.
278
15532-15540
2003
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Stoesser, G.; Baker, W.; van den Broek, A.; Garcia-Pastor, M.; Kanz, C.; Kulikova, T.; Leinonen, R.; Lin Q.; Lombard, V.; Lopez, R.; Mancuso, R.; Nardone, F.; Stoehr, P.; Tuli, M.A.; Tzouvara, K.; Vaughan, R.
The EMBL Nucleotide Sequence Database: major new developments
Nucleic Acids Res.
31
17-22
2003
Rhipicephalus microplus (Q17248)
Manually annotated by BRENDA team
Benson, D.A.; Karsch-Mizrachi, I.; Lipman, D.J.; Ostell, J.; Wheeler, D.L.
GenBank: update
Nucleic Acids Res.
32
D23-D26
2004
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Dantas, A.P.; Sandberg, K.
Regulation of ACE2 and ANG-(1-7) in the aorta: New insights into the renin-angiotensin system in the control of vascular function
Am. J. Physiol.
289
H980-H981
2005
Rattus norvegicus
Manually annotated by BRENDA team
Gallagher, P.E.; Chappell, M.C.; Ferrario, C.M.; Tallant, E.A.
Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
Am. J. Physiol.
290
C420-C426
2006
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Li, N.; Zimpelmann, J.; Cheng, K.; Wilkins, J.A.; Burns, K.D.
The role of angiotensin converting enzyme 2 in the generation of angiotensin 1-7 by rat proximal tubules
Am. J. Physiol. Renal Physiol.
288
F353-F362
2005
Rattus norvegicus
Manually annotated by BRENDA team
Rice, G.I.; Thomas, D.A.; Grant, P.J.; Turner, A.J.; Hooper, N.M.
Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
Biochem. J.
383
45-51
2004
Homo sapiens
Manually annotated by BRENDA team
Warner, F.J.; Smith, A.I.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme-2: a molecular and cellular perspective
Cell. Mol. Life Sci.
61
2704-2713
2004
Homo sapiens
Manually annotated by BRENDA team
Danilczyk, U.; Eriksson, U.; Oudit, G.Y.; Penninger, J.M.
Physiological roles of angiotensin-converting enzyme 2
Cell. Mol. Life Sci.
61
2714-2719
2004
Homo sapiens
Manually annotated by BRENDA team
Kuhn, J.H.; Li, W.; Choe, H.; Farzan, M.
Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus
Cell. Mol. Life Sci.
61
2738-2743
2004
Chlorocebus aethiops
Manually annotated by BRENDA team
Ferrario, C.M.; Jessup, J.; Chappell, M.C.; Averill, D.B.; Brosnihan, K.B.; Tallant, E.A.; Diz, D.I.; Gallagher, P.E.
Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
Circulation
111
2605-2610
2005
Rattus norvegicus
Manually annotated by BRENDA team
Tikellis, C.; Johnston, C.I.; Forbes, J.M.; Burns, W.C.; Thomas, M.C.; Lew, R.A.; Yarski, M.; Smith, A.I.; Cooper, M.E.
Identification of angiotensin converting enzyme 2 in the rodent retina
Curr. Eye Res.
29
419-427
2004
Rattus norvegicus
Manually annotated by BRENDA team
Kuba, K.; Imai, Y.; Penninger, J.M.
Angiotensin-converting enzyme 2 in lung diseases
Curr. Opin. Pharmacol.
6
271-276
2006
Homo sapiens
Manually annotated by BRENDA team
Douglas, G.C.; OBryan, M.K.; Hedger, M.P.; Lee, D.K.; Yarski, M.A.; Smith, A.I.; Lew, R.A.
The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis
Endocrinology
145
4703-4711
2004
Homo sapiens (Q9BYF1), Rattus norvegicus
Manually annotated by BRENDA team
Katovich, M.J.; Grobe, J.L.; Huentelman, M.; Raizada, M.K.
Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension
Exp. Physiol.
90
299-305
2005
Rattus norvegicus
Manually annotated by BRENDA team
Guy, J.L.; Jackson, R.M.; Jensen, H.A.; Hooper, N.M.; Turner, A.J.
Identification of critical active-site residues in angiotensin-converting enzyme-2 (ACE2) by site-directed mutagenesis
FEBS J.
272
3512-3520
2005
Homo sapiens
Manually annotated by BRENDA team
Riviere, G.; Michaud, A.; Breton, C.; VanCamp, G.; Laborie, C.; Enache, M.; Lesage, J.; Deloof, S.; Corvol, P.; Vieau, D.
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat
Hypertension
46
1169-1174
2005
Rattus norvegicus
Manually annotated by BRENDA team
Elased, K.M.; Cunha, T.S.; Gurley, S.B.; Coffman, T.M.; Morris, M.
New mass spectrometric assay for angiotensin-converting enzyme 2 activity
Hypertension
47
1010-1017
2006
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ferrario, C.M.
Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation
Hypertension
47
515-521
2006
Rattus norvegicus
Manually annotated by BRENDA team
Rice, G.I.; Jones, A.L.; Grant, P.J.; Carter, A.M.; Turner, A.J.; Hooper, N.M.
Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study
Hypertension
48
914-920
2006
Homo sapiens
Manually annotated by BRENDA team
Lew, R.A.; Warner, F.J.; Hanchapola, I.; Smith, A.I.
Characterization of angiotensin converting enzyme-2 (ACE2) in human urine
Int. J. Pept. Res. Ther.
12
283-289
2006
Homo sapiens
-
Manually annotated by BRENDA team
Warner, F.J.; Lew, R.A.; Smith, A.I.; Lambert, D.W.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells
J. Biol. Chem.
280
39353-39362
2005
Homo sapiens
Manually annotated by BRENDA team
Campbell, D.J.; Zeitz, C.J.; Esler, M.D.; Horowitz, J.D.
Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation
J. Hypertens.
22
1971-1976
2004
Homo sapiens
Manually annotated by BRENDA team
To, K.F.; Lo, A.W.
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2)
J. Pathol.
203
740-743
2004
Homo sapiens
Manually annotated by BRENDA team
Kuba, K.; Imai, Y.; Rao, S.; Gao, H.; Guo, F.; Guan, B.; Huan, Y.; Yang, P.; Zhang, Y.; Deng, W.; Bao, L.; Zhang, B.; Liu, G.; Wang, Z.; Chappell, M.; Liu, Y.; Zheng, D.; Leibbrandt, A.; Wada, T.; Slutsky, A.S.; Liu, D.; Qin, C.; Jiang, C.; Penninger, J.M.
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury
Nat. Med.
11
875-879
2005
Mus musculus
Manually annotated by BRENDA team
Imai, Y.; Kuba, K.; Rao, S.; Huan, Y.; Guo, F.; Guan, B.; Yang, P.; Sarao, R.; Wada, T.; Leong-Poi, H.; Crackower, M.A.; Fukamizu, A.; Hui, C.C.; Hein, L.; Uhlig, S.; Slutsky, A.S.; Jiang, C.; Penninger, J.M.
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Nature
436
112-116
2005
Mus musculus
Manually annotated by BRENDA team
Valdes, G.; Neves, L.A.; Anton, L.; Corthorn, J.; Chacon, C.; Germain, A.M.; Merrill, D.C.; Ferrario, C.M.; Sarao, R.; Penninger, J.; Brosnihan, K.B.
Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies
Placenta
27
200-207
2006
Homo sapiens
Manually annotated by BRENDA team
Huentelman, M.J.; Zubcevic, J.; Katovich, M.J.; Raizada, M.K.
Cloning and characterization of a secreted form of angiotensin-converting enzyme 2
Regul. Pept.
122
61-67
2004
Homo sapiens
Manually annotated by BRENDA team
Trask, A.J.; Averill, D.B.; Ganten, D.; Chappell, M.C.; Ferrario, C.M.
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats
Am. J. Physiol. Heart Circ. Physiol.
292
H3019-H3024
2007
Rattus norvegicus
Manually annotated by BRENDA team
Li, X.; Molina-Molina, M.; Abdul-Hafez, A.; Uhal, V.; Xaubet, A.; Uhal, B.D.
Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis
Am. J. Physiol. Lung Cell Mol. Physiol.
295
L178-185
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Joyner, J.; Neves, L.A.; Granger, J.P.; Alexander, B.T.; Merrill, D.C.; Chappell, M.C.; Ferrario, C.M.; Davis, W.P.; Brosnihan, K.B.
Temporal-spatial expression of ANG-(1-7) and angiotensin-converting enzyme 2 in the kidney of normal and hypertensive pregnant rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
293
R169-R177
2007
Rattus norvegicus
Manually annotated by BRENDA team
Ho, T.Y.; Wu, S.L.; Chen, J.C.; Li, C.C.; Hsiang, C.Y.
Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
Antiviral Res.
74
92-101
2007
Homo sapiens
Manually annotated by BRENDA team
Lambert, D.W.; Hooper, N.M.; Turner, A.J.
Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system
Biochem. Pharmacol.
75
781-786
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Deaton, D.N.; Gao, E.N.; Graham, K.P.; Gross, J.W.; Miller, A.B.; Strelow, J.M.
Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite
Bioorg. Med. Chem. Lett.
18
732-737
2008
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Zhong, J.C.; Yu, X.Y.; Lin, Q.X.; Li, X.H.; Huang, X.Z.; Xiao, D.Z.; Lin, S.G.
Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression
Br. J. Pharmacol.
153
66-74
2008
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Keidar, S.; Kaplan, M.; Gamliel-Lazarovich, A.
ACE2 of the heart: From angiotensin I to angiotensin (1-7)
Cardiovasc. Res.
73
463-469
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Imai, Y.; Kuba, K.; Penninger, J.M.
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Cell. Mol. Life Sci.
64
2006-2012
2007
Mus musculus
Manually annotated by BRENDA team
Koitka, A.; Cooper, M.E.; Thomas, M.C.; Tikellis, C.
Angiotensin converting enzyme 2 in the kidney
Clin. Exp. Pharmacol. Physiol.
35
420-425
2008
Rattus norvegicus
Manually annotated by BRENDA team
Imai, Y.; Kuba, K.; Penninger, J.M.
The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice
Exp. Physiol.
93
543-548
2008
Mus musculus
Manually annotated by BRENDA team
Zulli, A.; Rai, S.; Buxton, B.F.; Burrell, L.M.; Hare, D.L.
Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques
Exp. Physiol.
93
564-569
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Guy, J.L.; Lambert, D.W.; Turner, A.J.; Porter, K.E.
Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts
Exp. Physiol.
93
579-588
2008
Homo sapiens
Manually annotated by BRENDA team
Garabelli, P.J.; Modrall, J.G.; Penninger, J.M.; Ferrario, C.M.; Chappell, M.C.
Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
Exp. Physiol.
93
613-621
2008
Mus musculus
Manually annotated by BRENDA team
Elased, K.M.; Cunha, T.S.; Marcondes, F.K.; Morris, M.
Brain angiotensin-converting enzymes: role of angiotensin-converting enzyme 2 in processing angiotensin II in mice
Exp. Physiol.
93
665-675
2008
Mus musculus
Manually annotated by BRENDA team
Lew, R.A.; Warner, F.J.; Hanchapola, I.; Yarski, M.A.; Manohar, J.; Burrell, L.M.; Smith, A.I.
Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
Exp. Physiol.
93
685-693
2008
Homo sapiens
Manually annotated by BRENDA team
Lambert, D.W.; Clarke, N.E.; Hooper, N.M.; Turner, A.J.
Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain
FEBS Lett.
582
385-390
2008
Homo sapiens
Manually annotated by BRENDA team
Yamazato, M.; Yamazato, Y.; Sun, C.; Diez-Freire, C.; Raizada, M.K.
Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats
Hypertension
49
926-931
2007
Rattus norvegicus
Manually annotated by BRENDA team
Der Sarkissian, S.; Grobe, J.L.; Yuan, L.; Narielwala, D.R.; Walter, G.A.; Katovich, M.J.; Raizada, M.K.
Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology
Hypertension
51
712-718
2008
Rattus norvegicus
Manually annotated by BRENDA team
Ye, M.; Wysocki, J.; William, J.; Soler, M.J.; Cokic, I.; Batlle, D.
Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes
J. Am. Soc. Nephrol.
17
3067-3075
2006
Mus musculus
Manually annotated by BRENDA team
Wiener, R.S.; Cao, Y.X.; Hinds, A.; Ramirez, M.I.; Williams, M.C.
Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung
J. Cell. Biochem.
101
1278-1291
2007
Mus musculus, Mus musculus (Q8R0I0)
Manually annotated by BRENDA team
Rella, M.; Rushworth, C.A.; Guy, J.L.; Turner, A.J.; Langer, T.; Jackson, R.M.
Structure-based pharmacophore design and virtual screening for novel angiotensin converting enzyme 2 inhibitors
J. Chem. Inf. Model.
46
708-716
2006
Homo sapiens
Manually annotated by BRENDA team
Herath, C.B.; Warner, F.J.; Lubel, J.S.; Dean, R.G.; Jia, Z.; Lew, R.A.; Smith, A.I.; Burrell, L.M.; Angus, P.W.
Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis
J. Hepatol.
47
387-395
2007
Rattus norvegicus
Manually annotated by BRENDA team
Zulli, A.; Burrell, L.M.; Widdop, R.E.; Black, M.J.; Buxton, B.F.; Hare, D.L.
Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques
J. Histochem. Cytochem.
54
147-150
2006
Oryctolagus cuniculus
Manually annotated by BRENDA team
Mores, A.; Matziari, M.; Beau, F.; Cuniasse, P.; Yiotakis, A.; Dive, V.
Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2
J. Med. Chem.
51
2216-2226
2008
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Fukushi, S.; Mizutani, T.; Sakai, K.; Saijo, M.; Taguchi, F.; Yokoyama, M.; Kurane, I.; Morikawa, S.
Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells
J. Virol.
81
10831-10834
2007
Rattus norvegicus
Manually annotated by BRENDA team
Guo, H.; Guo, A.; Wang, C.; Yan, B.; Lu, H.; Chen, H.
Expression of feline angiotensin converting enzyme 2 and its interaction with SARS-CoV S1 protein
Res. Vet. Sci.
84
494-496
2008
Felis silvestris (Q56H28), Homo sapiens, Homo sapiens (Q9BYF1), Mus musculus (Q8R0I0), Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Koka, V.; Huang, X.R.; Chung, A.C.; Wang, W.; Truong, L.D.; Lan, H.Y.
Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway
Am. J. Pathol.
172
1174-1183
2008
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Herath. C.B.; Lubel, J.S.; Jia, Z.; Velkoska, E.; Casley, D.; Brown, L.; Tikellis, C.; Burrell, L.M.; Angus, P.W.
Portal pressure responses and angiotensin peptide production in rat liver are determined by relative activity of angiotensin converting enzyme (ACE) and ACE2
Am. J. Physiol. Gastrointest. Liver Physiol.
297
G98-G106
2009
Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Levy, A.; Yagil, Y.; Bursztyn, M.; Barkalifa, R.; Scharf, S.; Yagil, C.
ACE2 expression and activity are enhanced during pregnancy
Am. J. Physiol. Regul. Integr. Comp. Physiol.
295
R1953-R1961
2008
Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Feng, Y.; Yue, X.; Xia, H.; Bindom, S.M.; Hickman, P.J.; Filipeanu, C.M.; Wu, G.; Lazartigues, E.
Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation
Circ. Res.
102
729-736
2008
Mus musculus, Mus musculus (Q8R0I0)
Manually annotated by BRENDA team
Lai, Z.W.; Lew, R.A.; Yarski, M.A.; Mu, F.T.; Andrews, R.K.; Smith, A.I.
The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2
Endocrinology
150
2376-2381
2009
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Rushworth, C.A.; Guy, J.L.; Turner, A.J.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis
FEBS J.
275
6033-6042
2008
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Hernandez Prada, J.A.; Ferreira, A.J.; Katovich, M.J.; Shenoy, V.; Qi, Y.; Santos, R.A.; Castellano, R.K.; Lampkins, A.J.; Gubala, V.; Ostrov, D.A.; Raizada, M.K.
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents
Hypertension
51
1312-1317
2008
Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Huang, Q.; Xie, Q.; Shi, C.C.; Xiang, X.G.; Lin, L.Y.; Gong, B.D.; Zhao, G.D.; Wang, H.; Jia, NN.
Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis
Int. J. Mol. Med.
23
717-723
2009
Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Towler, P.; Staker, B.; Prasad, S.G.; Menon, S.; Tang, J.; Parsons,T.; Ryan, D.; Fisher, M.; Williams, D.; Dales, N.A.; Patane, M.A.; Pantoliano, M.W.
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
J. Biol. Chem.
279
17996-18007
2004
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Ferreira. A.J.; Raizada, M.K.
Are we poised to target ACE2 for the next generation of antihypertensives?
J. Mol. Med.
86
685-690
2008
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Xia, H.; Lazartigues, E.
Angiotensin-converting enzyme 2 in the brain: properties and future directions
J. Neurochem.
107
1482-1494
2008
Homo sapiens (Q9BYF1), Mus musculus (Q8R0I0), Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Luhtala, S.; Vaajanen, A.; Oksala, O.; Valjakka, J.; Vapaatalo, H.
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues
J. Ocul. Pharmacol. Ther.
25
23-28
2009
Sus scrofa
Manually annotated by BRENDA team
Sluimer, J.C.; Gasc, J.M.; Hamming, I.; van Goor, H.; Michaud, A.; van den Akker, L.H.; Juetten, B.; Cleutjens, J.; Bijnens, A.P.; Corvol, P.; Daemen, M.J.; Heeneman, S.
Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesions
J. Pathol.
215
273-279
2008
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Bindom, S.M.; Lazartigues, E.
The sweeter side of ACE2: physiological evidence for a role in diabetes
Mol. Cell. Endocrinol.
302
193-202
2009
Homo sapiens (Q9BYF1), Rattus norvegicus (Q5EGZ1)
Manually annotated by BRENDA team
Oudit, G.Y.; Imai, Y.; Kuba, K.; Scholey, J.W.; Penninger, J.M.
The role of ACE2 in pulmonary diseases - relevance for the nephrologist.
Nephrol. Dial. Transplant.
24
1362-1365
2009
Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Vaz-Silva, J.; Carneiro, M.M.; Ferreira, M.C.; Pinheiro, S.V.; Silva, D.A.; Silva-Filho, A.L.; Witz, C.A.; Reis, A.M.; Santos, R.A.; Reis, F.M.
The vasoactive peptide angiotensin-(1-7), its receptor Mas and the angiotensin-converting enzyme type 2 are expressed in the human endometrium
Reprod. Sci.
16
247-256
2009
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Zhou, L.; Zhang, R.; Yao, W.; Wang, J.; Qian, A.; Qiao, M.; Zhang, Y.; Yuan, Y.
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression
Tohoku J. Exp. Med.
217
123-131
2009
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Clayton, D.; Hanchapola, I.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I.
The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs
Adv. Exp. Med. Biol.
611
559-560
2009
Homo sapiens
Manually annotated by BRENDA team
Trask, A.J.; Groban, L.; Westwood, B.M.; Varagic, J.; Ganten, D.; Gallagher, P.E.; Chappell, M.C.; Ferrario, C.M.
Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
Am. J. Hypertens.
23
687-693
2010
Rattus norvegicus
Manually annotated by BRENDA team
Iwata, M.; Silva Enciso, J.E.; Greenberg, B.H.
Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme
Am. J. Physiol. Cell Physiol.
297
C1318-C1329
2009
Cricetulus griseus, Mus musculus
Manually annotated by BRENDA team
Jia, H.P.; Look, D.C.; Tan, P.; Shi, L.; Hickey, M.; Gakhar, L.; Chappell, M.C.; Wohlford-Lenane, C.; McCray, P.B.
Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia
Am. J. Physiol. Lung Cell Mol. Physiol.
297
L84-L96
2009
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Takahashi, Y.; Haga, S.; Ishizaka, Y.; Mimori, A.
Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases
Arthritis Res. Ther.
12
R85
2010
Homo sapiens
Manually annotated by BRENDA team
Kassiri, Z.; Zhong, J.; Guo, D.; Basu, R.; Wang, X.; Liu, P.P.; Scholey, J.W.; Penninger, J.M.; Oudit, G.Y.
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
Circ. Heart Fail.
2
446-455
2009
Mus musculus
Manually annotated by BRENDA team
Huang, M.L.; Li, X.; Meng, Y.; Xiao, B.; Ma, Q.; Ying, S.S.; Wu, P.S.; Zhang, Z.S.
Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors
Clin. Exp. Pharmacol. Physiol.
37
e1-e6
2010
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, Y.; Yin, H.Q.; Yu, Q.T.; Qiao, Y.; Dai, H.Y.; Zhang, M.X.; Zhang, L.; Liu, Y.F.; Wang, L.C.; Liu, D.S.; Deng, B.P.; Zhang, Y.H.; Pang, C.M.; Song, H.D.; Qu, X.; Jiang, H.; Liu, C.X.; Lu, X.T.; Liu, B.; Gao, F.; Dong, B.
ACE2 overexpression improves left ventricular remodeling and function in rats with myocardial infarction
Hum. Gene Ther.
21
1545-1554
2010
Rattus norvegicus
Manually annotated by BRENDA team
Xia, H.; Feng, Y.; Obr, T.D.; Hickman, P.J.; Lazartigues, E.
Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice
Hypertension
53
210-216
2009
Mus musculus
Manually annotated by BRENDA team
Masson, R.; Nicklin, S.A.; Craig, M.A.; McBride, M.; Gilday, K.; Gregorevic, P.; Allen, J.M.; Chamberlain, J.S.; Smith, G.; Graham, D.; Dominiczak, A.F.; Napoli, C.; Baker, A.H.
Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2
Hypertension
53
694-700
2009
Oryctolagus cuniculus, Rattus norvegicus
Manually annotated by BRENDA team
Stewart, J.M.; Ocon, A.J.; Clarke, D.; Taneja, I.; Medow, M.S.
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome
Hypertension
53
767-774
2009
Homo sapiens
Manually annotated by BRENDA team
Yoshikawa, N.; Yoshikawa, T.; Hill, T.; Huang, C.; Watts, D.M.; Makino, S.; Milligan, G.; Chan, T.; Peters, C.J.; Tseng, C.T.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2
J. Virol.
83
5451-5465
2009
Homo sapiens
Manually annotated by BRENDA team
Fraga-Silva, R.A.; Sorg, B.S.; Wankhede, M.; Dedeugd, C.; Jun, J.Y.; Baker, M.B.; Li, Y.; Castellano, R.K.; Katovich, M.J.; Raizada, M.K.; Ferreira, A.J.
ACE2 activation promotes antithrombotic activity
Mol. Med.
16
210-215
2010
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Feng, Y.; Wan, H.; Liu, J.; Zhang, R.; Ma, Q.; Han, B.; Xiang, Y.; Che, J.; Cao, H.; Fei, X.; Qiu, W.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer
Oncol. Rep.
23
941-948
2010
Homo sapiens
Manually annotated by BRENDA team
Lin, C.S.; Pan, C.H.; Wen, C.H.; Yang, T.H.; Kuan, T.C.
Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts
Peptides
31
1334-1340
2010
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Coelho, M.S.; Lopes, K.L.; Freitas, R.d.e.A.; de Oliveira-Sales, E.B.; Bergasmaschi, C.T.; Campos, R.R.; Casarini, D.E.; Carmona, A.K.; Araujo, M.d.a..S.; Heimann, J.C.; Dolnikoff, M.S.
High sucrose intake in rats is associated with increased ACE2 and angiotensin-(1-7) levels in the adipose tissue
Regul. Pept.
162
61-67
2010
Rattus norvegicus
Manually annotated by BRENDA team
Han, S.X.; He, G.M.; Wang, T.; Chen, L.; Ning, Y.Y.; Luo, F.; An, J.; Yang, T.; Dong, J.J.; Liao, Z.L.; Xu, D.; Wen, F.Q.
Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: possible involvement of angiotensin-converting enzyme-2
Toxicol. Appl. Pharmacol.
245
100-107
2010
Rattus norvegicus
Manually annotated by BRENDA team
Cohen-Segev, R.; Francis, B.; Abu-Saleh, N.; Awad, H.; Lazarovich, A.; Kabala, A.; Aronson, D.; Abassi, Z.
Cardiac and renal distribution of ACE and ACE-2 in rats with heart failure
Acta Histochem.
116
1342-1349
2014
Rattus norvegicus
Manually annotated by BRENDA team
Lambert, D.W.; Lambert, L.A.; Clarke, N.E.; Hooper, N.M.; Porter, K.E.; Turner, A.J.
Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421
Clin. Sci.
127
243-249
2014
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Lu, C.L.; Wang, Y.; Yuan, L.; Li, Y.; Li, X.Y.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects the function of pancreatic beta cells by improving the function of islet microvascular endothelial cells
Int. J. Mol. Med.
34
1293-1300
2014
Mus musculus
Manually annotated by BRENDA team
Liu, S.; Liu, J.; Miura, Y.; Tanabe, C.; Maeda, T.; Terayama, Y.; Turner, A.J.; Zou, K.; Komano, H.
Conversion of Abeta43 to Abeta40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme
J. Neurosci. Res.
92
1178-1186
2014
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Zou, Z.; Yan, Y.; Shu, Y.; Gao, R.; Sun, Y.; Li, X.; Ju, X.; Liang, Z.; Liu, Q.; Zhao, Y.; Guo, F.; Bai, T.; Han, Z.; Zhu, J.; Zhou, H.; Huang, F.; Li, C.; Lu, H.; Li, N.; Li, D.; Jin, N.; Penninger, J.M.; Jiang, C.
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections
Nat. Commun.
5
3594
2014
Mus musculus
Manually annotated by BRENDA team
Feng, Y.; Hans, C.; McIlwain, E.; Varner, K.J.; Lazartigues, E.
Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy
PLoS ONE
7
e48910
2012
Mus musculus
Manually annotated by BRENDA team
Xiao, F.; Zimpelmann, J.; Agaybi, S.; Gurley, S.B.; Puente, L.; Burns, K.D.
Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells
PLoS ONE
9
e85958
2014
Mus musculus
Manually annotated by BRENDA team
Uri, K.; Fagyas, M.; Manyine Siket, I.; Kertesz, A.; Csanadi, Z.; Sandorfi, G.; Clemens, M.; Fedor, R.; Papp, Z.; Edes, I.; Toth, A.; Lizanecz, E.
New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure
PLoS ONE
9
e87845
2014
Homo sapiens, Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team
Yang, P.; Gu, H.; Zhao, Z.; Wang, W.; Cao, B.; Lai, C.; Yang, X.; Zhang, L.; Duan, Y.; Zhang, S.; Chen, W.; Zhen, W.; Cai, M.; Penninger, J.M.; Jiang, C.; Wang, X.
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury
Sci. Rep.
4
7027
2014
Mus musculus
Manually annotated by BRENDA team
Li, Y.; Cao, Y.; Zeng, Z.; Liang, M.; Xue, Y.; Xi, C.; Zhou, M.; Jiang, W.
Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF-kappaB pathways
Sci. Rep.
5
8209
2015
Rattus norvegicus
Manually annotated by BRENDA team