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Information on EC 3.4.17.23 - angiotensin-converting enzyme 2 and Organism(s) Sus scrofa and UniProt Accession K7GLM4

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Sus scrofa
UNIPROT: K7GLM4 not found.
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The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Synonyms
angiotensin-converting enzyme 2, tmprss2, ace-2, angiotensin converting enzyme 2, hace2, angiotensin converting enzyme-2, sace2, ace 2, angiotensin converting enzyme ii, angiotensin-converting enzyme type 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
328404-18-8
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ile-Pro-Pro
-
inhibits EC 3.4.15.1 at one-thousandth of the concentration needed to inhibit ACE2
Leu-Pro-Pro
-
inhibits EC 3.4.15.1 at one-thousandth of the concentration needed to inhibit ACE2
Val-Pro-Pro
-
inhibits EC 3.4.15.1 at one-thousandth of the concentration needed to inhibit ACE2
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
vitreous body, retina and ciliary body. Counterbalancing interaction of ACE1 (EC 3.4.15.1) and ACE2 in physiological regulation of ocular circulation and pressure and possible protective role in certain ophthalmic disorders such as glaucoma and diabetic retinopathy
Manually annotated by BRENDA team
primary kidney fibroblast
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
yeast display-based comparison of the binding of SARS-CoV-2 spike protein to ACE2, the decreasing binding order is human > cat = pig > dog
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
K7GLM4_PIG
805
0
92268
TrEMBL
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Q42L
mutation increases binding of SARS-CoV-2 spike protein
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
TP53 mutant pigs exhibit a sex-specific patho-phenotype due to altered regulation of numerous X chromosome genes. The effect of p53 deficiency on ACE2 expression in pigs is explored. The p53 binding site in the ACE2 promoter is identified and its regulatory effect on ACE2 expression is demonstrated by luciferase assay in porcine primary kidney fibroblast cells. Quantitative PCR and western blot shows tissue- and gender-specific expression changes of ACE2 and its truncated isoform in p53-deficient pigs. mRNA expression of ACE2 is higher in female than male wild-type pigs, with the highest levels in the kidney and small intestine. However, the ACE2 protein expression in the kidney and small intestine is higher in wild-type males. This discrepancy can be explained by the posttranslational ACE2 modifications. In flTP53(R167H) females, the expression of the full-length ACE2 isoform is higher than in wild-type females in most tissues, particularly in small intestine and kidney. In flTP53R167H males, the expression of ACE2 is higher in heart, kidney and lower in small intestine than in wild-type males
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
angiotensin converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2, but only ACE2 of certain species can be utilized by SARS-CoV-2. SARS-CoV-2 tends to utilize ACE2 of various mammals, except murines, and some birds, such as pigeon. This prediction may help to screen the intermediate hosts of SARS-CoV-2. SARS-CoV-2 has a high genetic relationship with a bat coronavirus (BatCoV RaTG13) with a 96% genomic nucleotide sequence identity. The close phylogenetic relationship to Bat RaTG13 provides evidence for a bat origin of SARS-CoV-2. Direct transmission of the virus from bats to humans is unlikely due to the lack of direct contact between bats and humans (in Wuhan, China). There are probably intermediate hosts transmitting SARS-CoV-2 to humans. Combined phylogenetic analysis and critical site marking is used to predict the utilizing capability of ACE2 from different animal species by SARS-CoV-2. It is confirmed that pangolin (Manis javanica), cat (Felis catus), cow (Bos taurus), buffalo (Bubalus bubalis), goat (Capra hircus), sheep (Ovis aries) and pigeon (Columba livia) ACE2 might be utilized by SARS-CoV-2, indicating potential interspecies transmission of the virus from bats to these animals and among these animals
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Luhtala, S.; Vaajanen, A.; Oksala, O.; Valjakka, J.; Vapaatalo, H.
Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues
J. Ocul. Pharmacol. Ther.
25
23-28
2009
Sus scrofa
Manually annotated by BRENDA team
Qiu, Y.; Zhao, Y.B.; Wang, Q.; Li, J.Y.; Zhou, Z.J.; Liao, C.H.; Ge, X.Y.
Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2
Microbes Infect.
22
221-225
2020
Columba livia (A0A2I0MLI2), Sus scrofa (K7GLM4), Felis catus (Q56H28), Paguma larvata (Q56NL1), Mus musculus (Q8R0I0), Homo sapiens (Q9BYF1), Homo sapiens, Rhinolophus sinicus (U5WHY8), Capra hircus (W6CG84), Bos taurus (XP_005228485.1), Bubalus bubalis (XP_006041602.1), Ovis aries (XP_011961657.1), Manis javanica (XP_017505752.1)
Manually annotated by BRENDA team
Zhang, Y.; Niu, G.; Flisikowska, T.; Schnieke, A.; Flisikowski, K.
A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs
Biochem. Biophys. Res. Commun.
553
25-29
2021
Sus scrofa (B1PZW5)
Manually annotated by BRENDA team
Heinzelman, P.; Greenhalgh, J.C.; Romero, P.A.
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species
Protein Eng. Des. Sel.
35
gzab035
2022
Canis lupus familiaris (E2RR65), Sus scrofa (K7GLM4), Felis catus (Q56H28), Homo sapiens (Q9BYF1)
Manually annotated by BRENDA team