Information on EC 3.4.17.22 - metallocarboxypeptidase D and Organism(s) Mus musculus and UniProt Accession O89001

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Mus musculus
UNIPROT: O89001
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The taxonomic range for the selected organisms is: Mus musculus

The enzyme appears in selected viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.4.17.22
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RECOMMENDED NAME
GeneOntology No.
metallocarboxypeptidase D
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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CAS REGISTRY NUMBER
COMMENTARY hide
153967-26-1
not distinguished from EC 3.4.16.6 in Chemical Abstracts
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
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does not interact with duck hepatitis B virus preS
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
siRNA
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downregulates CpD by about 80% in RAW 264.7 cells
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
transforming growth factor-beta
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upregulates CpD in ANA-1 cells and RAW 264.7 cells
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cpd and CPE are strictly co-localized in the mouse placenta from late mid-gestation to term. While there is no strict overlap between Cpe and Cpd transcripts at the early developmental stages, E8 and E10, from E12 onwards there is no obvious difference in the expression patterns of the two genes. Just like Cpe, Cpd is expressed primarily in decidua and in chorionic plate and yolk sac, with weak expression in the labyrinth. At E18, Cpd is expressed at a level higher than Cpe. In interspecies hybrid placental dysplasia placentas, the expression of Cpd overlapps with that of Cpe. There is no difference in the pattern of expression of Cpd in wild-type and fat placentas at E18. Strong expression in decidua and yolk sac, but weak and diffuse expression in the labyrinth
Manually annotated by BRENDA team
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baseline expression
Manually annotated by BRENDA team
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it is demonstrated that CpD is up-regulated by TGF-beta in murine macrophage cell lines ANA-1 and RAW 264.7 but HepG2 cells - cells not primarily associated with innate immune responses- show only minimal regulation of CpD by TGF-beta
Manually annotated by BRENDA team
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
CPE, probably in combination with CPD, has a functional role in normal placental development, specifically in control of giant cell and glycogen cell growth. In addition, Cpe together with Cpd is an upstream determinant of interspecies hybrid placental dysplasia, whose lack produces placental phenotypes reminiscent of interspecies hybrid placental dysplasia. Pathways regulated by these enzymes are not only important in placentation, but potentially also for speciation in the genus Mus
medicine
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CpD is part of an autoregulatory feedback loop in which it is both upstream and downstream of transforming growth factor-beta signaling