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Information on EC 3.4.17.13 - Muramoyltetrapeptide carboxypeptidase

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UNIPROT: Q2G8F3 not found.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-lysyl-/-D-alanine
Synonyms
ld-carboxypeptidase, carboxypeptidase ii, ldca1, l,d-carboxypeptidase a, l-lysyl-d-alanine carboxypeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Carboxypeptidase II
-
-
-
-
Carboxypeptidase IIW
-
-
-
-
Carboxypeptidase, lysyl-D-alanine
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-
-
-
Carboxypeptidase, muramoyltetrapeptide
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-
-
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L-Lysyl-D-alanine carboxypeptidase
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-
-
-
LD-Carboxypeptidase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
CAS REGISTRY NUMBER
COMMENTARY hide
60063-80-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
L-Ala-gamma-D-Glu-meso-diaminopimelyl + D-Ala
show the reaction diagram
-
-
-
?
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelyl-D-Ala + H2O
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
show the reaction diagram
-
-
-
?
UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
show the reaction diagram
-
-
-
?
additional information
?
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enzyme prefers tetrapeptide substrates and can discriminate between tetrapeptide and pentapeptide substrates, but is less selective toward the N-terminal sugar moiety. No substrate: UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala, poor substrate: N-acetylmuramyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
no divalent cation required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Zn2+
2 mM, more than 95% inhibition
additional information
not inhibitory: EDTA at 2.5 mM
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.17
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala
pH 8.0, 37°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
160
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala
pH 8.0, 37°C
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
230
substrate L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala, pH 8.0, 37°C
24.5
substrate UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala, pH 8.0, 37°C
30
substrate N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelyl-D-Ala, pH 8.0, 37°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q2G8F3_NOVAD
Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199)
273
0
29311
TrEMBL
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 1.89 A resolution, abd modeling of interaction with substrate
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Das, D.; Herve, M.; Elsliger, M.A.; Kadam, R.U.; Grant, J.C.; Chiu, H.J.; Knuth, M.W.; Klock, H.E.; Miller, M.D.; Godzik, A.; Lesley, S.A.; Deacon, A.M.; Mengin-Lecreulx, D.; Wilson, I.A.
Structure and function of a novel LD-carboxypeptidase a involved in peptidoglycan recycling
J. Bacteriol.
195
5555-5566
2013
Novosphingobium aromaticivorans (Q2G8F3), Novosphingobium aromaticivorans DSM 12444 (Q2G8F3), Novosphingobium aromaticivorans DSM 12444
Manually annotated by BRENDA team