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Disease on EC 3.4.16.5 - carboxypeptidase C

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Calreticulin expression in neoplastic versus normal dog mammary glands: A cDNA subtraction-based study.
Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA).
Adenocarcinoma of Lung
Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells.
Aneurysm
Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm.
The relationship between the concentration of cathepsin A, D and E and the concentration of copper and zinc and the size of the aneurysmal enlargement in the wall of the abdominal aortic aneurysm.
Aortic Aneurysm
The relationship between the concentration of cathepsin A, D and E and the concentration of copper and zinc and the size of the aneurysmal enlargement in the wall of the abdominal aortic aneurysm.
Aortic Aneurysm, Abdominal
Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm.
The relationship between the concentration of cathepsin A, D and E and the concentration of copper and zinc and the size of the aneurysmal enlargement in the wall of the abdominal aortic aneurysm.
Astrocytoma
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Atrial Fibrillation
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Breast Neoplasms
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Burkholderia Infections
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
carboxypeptidase c deficiency
Cathepsin A deficiency in galactosialidosis: studies of patients and carriers in 16 families.
Genetic interactions between a pep7 mutation and the PEP12 and VPS45 genes: evidence for a novel SNARE component in transport between the Saccharomyces cerevisiae Golgi complex and endosome.
Genetic properties of mutations at the PEP4 locus in Saccharomyces cerevisiae.
Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae.
Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations.
Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiae.
Regulation of phagocytosis in macrophages by neuraminidase 1.
Carcinoma, Ductal
The prognostic significance of lysosomal protective protein (Cathepsin A) in breast ductal carcinoma in situ.
Carcinoma, Ehrlich Tumor
Nicotinamide deamidase in Ehrlich ascites tumor cells.
Carcinoma, Hepatocellular
Prognostic significance and oncogene function of cathepsin A in hepatocellular carcinoma.
Carcinoma, Intraductal, Noninfiltrating
The prognostic significance of lysosomal protective protein (Cathepsin A) in breast ductal carcinoma in situ.
Cardiomegaly
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Cardiomyopathies
Cathepsin A Mediates Ventricular Remote Remodeling and Atrial Cardiomyopathy in Rats With Ventricular Ischemia/Reperfusion.
Cardiovascular Diseases
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Cataract
Cathepsin A activity of normal bovine ocular tissues and pathological human intraocular fluids.
[Cathepsin A activity in the aqueous humor in patients with cataract, absolute glaucoma and intraocular tumors]
Chemical and Drug Induced Liver Injury
Drug-Induced Liver Injury Caused by "Khat," an Herbal Stimulant.
Congenital Abnormalities
Galactosialidosis: preclinical enzyme replacement therapy in a mouse model of the disease, a proof of concept.
Corneal Dystrophies, Hereditary
Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.
Coronary Vasospasm
The potential adverse effects of habitual use of Catha edulis (khat).
Diabetes Mellitus
Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis.
Diabetes Mellitus, Type 2
Conflicting reports on the role of the glycemic effect of Catha edulis (Khat): A systematic review and meta-analysis.
exo-alpha-sialidase deficiency
Elastogenesis in cultured dermal fibroblasts from patients with lysosomal beta-galactosidase, protective protein/cathepsin A and neuraminidase-1 deficiencies.
Gangliosidosis, GM1
Lysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients.
Processing of lysosomal beta-galactosidase. The C-terminal precursor fragment is an essential domain of the mature enzyme.
Gastritis
The potential adverse effects of habitual use of Catha edulis (khat).
Gastroenteritis
A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis.
Genetic Diseases, Inborn
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Glaucoma
Cathepsin A activity of normal bovine ocular tissues and pathological human intraocular fluids.
[Cathepsin A activity in the aqueous humor in patients with cataract, absolute glaucoma and intraocular tumors]
[Cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors]
Heart Diseases
Cathepsin A Inhibitors to Treat Heart Disease: Much Potential, Many Questions.
Heart Failure
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.
Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases.
Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.
Hepatitis
Effect on vitamin A on the development of galactosamine-induced hepatitis in rats.
[Distribution and activity of lysosomal protein catabolic-enzymes of rat liver in galactosamine hepatitis: catepsin D, cathepsin A and acid carboxypeptidase]
Herpes Simplex
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.
The herpes simplex virus type I deamidase enhances propagation but is dispensable for retrograde axonal transport into the nervous system.
Hyperglycemia
Cathinone: An alkaloid of Catha edulis (Khat) exacerbated hyperglycemia in diabetes-induced rats.
Hypertension
Catha edulis: a new differential in the diagnosis of pregnancy induced hypertension.
Expression, purification and crystallization of human prolylcarboxypeptidase.
Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.
Hypertension, Pregnancy-Induced
Catha edulis: a new differential in the diagnosis of pregnancy induced hypertension.
Infections
A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.
Characterization, expression signatures and microbial binding analysis of cathepsin A in turbot, Scophthalmus maximus L.(SmCTSA).
Legionella pneumophila balances ubiquitin transglutamination.
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
Proteomics Analysis of Porcine Serum Proteins by LC-MS/MS after Foot-and- Mouth Disease Virus (FMDV) Infection.
Pyrazinamide deamidase in tuberculous infection.
The first report of cathepsin A gene in a teleost (rock bream, Oplegnathus fasciatus): An investigation of immune functions upon infection with several pathogens.
[Urinary protein detection by iTRAQ® associated with renal transplant complications and its modification with therapy].
Leukemia
Catha edulis (Khat) induces cell death by apoptosis in leukemia cell lines.
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Liver Diseases
Khat chewing increases the risk for developing chronic liver disease: A hospital-based case-control study.
Lung Injury
Susceptibility of microtubule-associated protein 1 light chain 3? (MAP1LC3B/ LC3B) knockout mice to lung injury and fibrosis.
Lysosomal Storage Diseases
A case of galactosialidosis with a homozygous Q49R point mutation.
A case of galactosialidosis with novel mutations of the protective protein/cathepsin a gene: diagnosis prompted by trophoblast vacuolization on placental examination.
A new heterozygous compound mutation in the CTSA gene in galactosialidosis.
A Turkish case of galactosialidosis with a new homozygous mutation in CTSA gene.
Cathepsin A deficiency in galactosialidosis: studies of patients and carriers in 16 families.
Chemical chaperone treatment for galactosialidosis: Effect of NOEV on ?-galactosidase activities in fibroblasts.
Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells.
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Galactosialidosis in a Newborn with a Novel Mutation in the CTSA Gene Presenting with Transient Hyperparathyroidism.
Galactosialidosis: preclinical enzyme replacement therapy in a mouse model of the disease, a proof of concept.
Intermittent enzyme replacement therapy prevents Neu1 deficiency.
Juvenile galactosialidosis with attacks of neuropathic pain and absence of sialyloligosacchariduria.
Lysosomal high molecular weight multienzyme complex.
Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations.
New mutations in two Dutch patients with early infantile galactosialidosis.
Preclinical dose-finding study with a liver-tropic, recombinant AAV-2/8 vector in the mouse model of galactosialidosis.
Protective protein/cathepsin A loss in cultured cells derived from an early-infantile form of galactosialidosis patients homozygous for the A1184-G transition (Y395C mutation).
Proteolytic activation of human cathepsin A.
Ultrastructural change of ligamentum flavum in galactosialidosis.
Melanoma
Cathepsin A activity in primary and metastatic human melanocytic tumors.
Lactacystin inhibits cathepsin A activity in melanoma cell lines.
Memory Disorders
Mice with Catalytically Inactive Cathepsin A Display Neurobehavioral Alterations.
Metabolic Diseases
Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.
[Inherited metabolic diseases caused by the genetic defect of protective protein/cathepsin A and lysosomal sialidase]
Metabolic Syndrome
A pilot study on the effect of catha edulis frosk., (celastraceae) on metabolic syndrome in wokw rats.
Mucolipidoses
Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.
Cloning of the cDNA and gene encoding mouse lysosomal sialidase and correction of sialidase deficiency in human sialidosis and mouse SM/J fibroblasts.
Elimination of abnormal sialylglycoproteins in fibroblasts with sialidosis and galactosialidosis by normal gene transfer and enzyme replacement.
Lysosomal multienzymatic complex-related diseases: a genetic study among Portuguese patients.
Molecular basis of GM1 gangliosidosis and Morquio disease, type B. Structure-function studies of lysosomal beta-galactosidase and the non-lysosomal beta-galactosidase-like protein.
Pathogenesis, Emerging therapeutic targets and Treatment in Sialidosis.
Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.
Multiple Sclerosis
Macrophages and cathepsin A activity in multiple sclerosis brain.
Muscular Dystrophies
Arylamidase and cathepsin-A activity of normal and dystrophic human muscle.
Cathepsin A in nutritional and hereditary muscular dystrophy.
Myocardial Infarction
Acute exposure to Catha edulis depresses contractility and induces myocardial infarction in spontaneously contracting, isolated rabbit's heart.
Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.
The potential adverse effects of habitual use of Catha edulis (khat).
Neoplasm Metastasis
Leptin Modulates the Metastasis of Canine Inflammatory Mammary Adenocarcinoma Cells Through Downregulation of Lysosomal Protective Protein Cathepsin A (CTSA).
Neoplasms
Cathepsin A activity in primary and metastatic human melanocytic tumors.
Cathepsin A activity of normal bovine ocular tissues and pathological human intraocular fluids.
Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells.
Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate.
Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology.
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Lactacystin inhibits cathepsin A activity in melanoma cell lines.
Nicotinamide deamidase in Ehrlich ascites tumor cells.
Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.
V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.
[Cathepsin A activity in the aqueous humor in patients with cataract, absolute glaucoma and intraocular tumors]
[Cathepsin A activity in the vitreous body of patients with absolute glaucoma and intraocular tumors]
Nephrosis
Investigation into the toxicological effects of Catha edulis leaves: a short term study in animals.
Neuroblastoma
Expression of lysosomal protective protein/cathepsin A in a stably transformed human neuroblastoma cell line during bi-directional differentiation into neuronal and Schwannian cells.
Nicotinamide deamidase released by neuroblastoma cell cultures.
Purification and characterization of a nicotinamide deamidase released into the growth medium of neuroblastoma in vitro.
Neurodegenerative Diseases
Correction of murine galactosialidosis by bone marrow-derived macrophages overexpressing human protective protein/cathepsin A under control of the colony-stimulating factor-1 receptor promoter.
Neuronal Ceroid-Lipofuscinoses
S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.
Nevus, Pigmented
Cathepsin A activity in primary and metastatic human melanocytic tumors.
Obesity
Expression, purification and crystallization of human prolylcarboxypeptidase.
The Appetite Suppressant D-norpseudoephedrine (Cathine) Acts via D1/D2-Like Dopamine Receptors in the Nucleus Accumbens Shell.
Optic Atrophy
The presumed neurotoxic effects of Catha edulis--an exotic plant now available in the United Kingdom.
Pancreatitis
Chymotrypsin-like activity in rat tissues in experimental acute pancreatitis.
Paralysis
Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.
Pneumonia
A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation.
Pre-Eclampsia
[The activities of cathepsin A in the placenta, fetal membranes and amniotic fluid in physiologic pregnancy and pregnancy complicated by EPH gestosis]
Prostatic Neoplasms
Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells.
Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer.
Renal Insufficiency
A Brazilian galactosialidosis patient given renal transplantation: A case report.
Retinal Detachment
[Activity of cathepsin a in subretinal fluid in primary retinal detachment]
Rhinitis, Atrophic
Selective Membrane Redistribution and Depletion of G?q-Protein by Pasteurella multocida Toxin.
Seizures
Effect of Catha edulis (khat) on behaviour and its potential to induce seizures in Sprague Dawley rats.
Starvation
Metabolic rate and rates of protein turnover in food deprived cuttlefish, Sepia officinalis (Linnaeus 1758).
Modification of rat liver fructose biphosphate aldolase by lysosomal proteinases.
streptogrisin b deficiency
Protein degradation, meiosis and sporulation in proteinase-deficient mutants of Saccharomyces cerevisiae.
Tachycardia
Cathepsin A Mediates Susceptibility to Atrial Tachyarrhythmia and Impairment of Atrial Emptying Function in Zucker Diabetic Fatty Rats.
Thrombosis
Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm.
Tuberculosis
Pyrazinamide deamidase activity in tuberculous disease.
Tuberculosis, Pulmonary
Pyrazinamide deamidase activity in tuberculous disease.
Whooping Cough
Preliminary evidence for a pyridine nucleotide cycle in Bordetella pertussis.