Reference on EC 3.4.16.2 - lysosomal Pro-Xaa carboxypeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tan, F.; Morris, P.W.; Skidgel, R.A.; Erdös, E.G.
Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families [published erratum appears in J Biol Chem 1993 Dec 5;268(34):26032
J. Biol. Chem.
268
16631-16638
1993
Homo sapiens
Odya, C.E.; Erdös, E.G.
Human prolylcarboxypeptidase
Methods Enzymol.
80
460-466
1981
Homo sapiens
Skidgel, R.A.; Wickstrom, E.; Kumamoto, K.; Erdös, E.G.
Rapid radioassay for prolylcarboxypeptidase (angiotensinase C)
Anal. Biochem.
118
113-119
1981
Homo sapiens
Odya, C.E.; Marinkovic, D.V.; Hammon, K.J.; Stewart, T.A.; Erdös, E.G.
Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney
J. Biol. Chem.
253
5927-5931
1978
Homo sapiens
Kakimoto, T.; Oshima, G.; Yeh, H.S.J.; Erdös, E.G.
Purification of lysosomal prolycarboxypeptidase angiotensinase C
Biochim. Biophys. Acta
302
178-182
1973
Sus scrofa
Yang, H.Y.T.; Erdös, E.G.; Chiang, T.S.
New enzymatic route for the inactivation of angiotensin
Nature
218
1224-1226
1968
Homo sapiens, Sus scrofa
Jackman, H.L.; Tan, F.; Schraufnagel, D.; Dragovic, T.; Dezsö, B.; Becker, R.P.; Erdös, E.G.
Plasma membrane-bound and lysosomal peptidases in human alveolar macrophages
Am. J. Respir. Cell Mol. Biol.
13
196-204
1995
Homo sapiens
Suga, K.; Ito, K.; Tsuru, D.; Yoshimoto, T.
Prolylcarboxypeptidase (angiotensinase C): purification and characterization of the enzyme from Xanthomanas maltophilia
Biosci. Biotechnol. Biochem.
59
298-301
1995
Stenotrophomonas maltophilia
Gacko, M.; Worowska, A.; Glowinski, S.
Activity of lysosomal carboxypeptidase in aneurysmal aortic wall
Bull. Pol. Acad. Sci. Biol. Sci.
46
107-112
1998
Homo sapiens
-
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Recombinant prolylcarboxypeptidase activates plasma prekallikrein
Blood
15
4554-4561
2004
Homo sapiens
Moreira, C.R.; Schmaier, A.H.; Mahdi, F.; da Motta, G.; Nader, H.B.; Shariat-Madar, Z.
Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator
FEBS Lett.
523
167-170
2002
Homo sapiens
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator
J. Biol. Chem.
277
17962-17969
2002
Homo sapiens
Shariat-Madar, Z.; Rahimy, E.; Mahdi, F.; Schmaier, A.H.
Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells
Am. J. Physiol.
289
H2697-H2703
2005
Homo sapiens
Shariat-Madar, Z.; Mahdi, F.; Schmaier, A.H.
Recombinant prolylcarboxypeptidase activates plasma prekallikrein
Blood
103
4554-4561
2004
Homo sapiens
Tan, F.; Erdoes, E.G.
Lysosomal Pro-X carboxypeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
2
1936-1938
2004
Sus scrofa
-
Mishra, S.; Dubey, R.S.
Inhibition of ribonuclease and protease activities in arsenic exposed rice seedlings: role of proline as enzyme protectant
J. Plant Physiol.
163
927-936
2006
Oryza sativa
Wang, L.; Feng, Y.; Zhang, Y.; Zhou, H.; Jiang, S.; Niu, T.; Wei, L.J.; Xu, X.; Xu, X.; Wang, X.
Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia
Am. J. Obstet. Gynecol.
195
162-171
2006
Homo sapiens
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of pH-dependent hydrolyses by exo-type carboxypeptidase P on a 27-MHz quartz crystal microbalance
Anal. Chem.
80
1005-1011
2008
Penicillium janthinellum
Perkins, R.; Ngo, M.D.; Mahdi, F.; Shariat-Madar, Z.
Identification of lipopolysaccharide binding site on high molecular weight kininogen
Biochem. Biophys. Res. Commun.
366
938-943
2008
Homo sapiens
Ward, G.R.; Franklin, S.O.; Gerald, T.M.; Dempsey, K.T.; Clodfelter, D.E.; Krissinger, D.J.; Patel, K.M.; Vrana, K.E.; Howlett, A.C.
Glucocorticoids plus opioids up-regulate genes that influence neuronal function
Cell. Mol. Neurobiol.
27
651-660
2007
Homo sapiens
Mallela, J.; Yang, J.; Shariat-Madar, Z.
Prolylcarboxypeptidase: A cardioprotective enzyme
Int. J. Biochem. Cell Biol.
41
477-481
2009
Homo sapiens
Lyons, P.J.; Callaway, M.B.; Fricker, L.D.
Characterization of carboxypeptidase a6, an extracellular matrix peptidase
J. Biol. Chem.
283
7054-7063
2008
Homo sapiens
Huang, X.D.; Tong, W.W.; Fan, X.L.; Li, Z.H.
Application of HPLC-ESI-ITMS in the quality control of carboxyterminal sequence confirmation for the recombinant DNA product Hirudin Variant 3
J. Pharm. Biomed. Anal.
43
533-539
2007
Penicillium janthinellum
Wang, X.; Smith, P.L.; Hsu, M.Y.; Tamasi, J.A.; Bird, E.; Schumacher, W.A.
Deficiency in thrombin-activatable fibrinolysis inhibitor (TAFI) protected mice from ferric chloride-induced vena cava thrombosis
J. Thromb. Thrombolysis
23
41-49
2007
Mus musculus
Furusawa, H.; Takano, H.; Okahata, Y.
Transient kinetic studies of protein hydrolyses by endo- and exo-proteases on a 27 MHz quartz-crystal microbalance
Org. Biomol. Chem.
6
727-731
2008
Penicillium janthinellum
Mallela, J.; Perkins, R.; Yang, J.; Pedigo, S.; Rimoldi, J.M.; Shariat-Madar, Z.
The functional importance of the N-terminal region of human prolylcarboxypeptidase
Biochem. Biophys. Res. Commun.
374
635-640
2008
Homo sapiens
Iwatsuki, M.; Koizumi, Y.; Gouda, H.; Hirono, S.; Tomoda, H.; Omura, S.
Lys17 in the lasso peptide lariatin A is responsible for anti-mycobacterial activity
Bioorg. Med. Chem. Lett.
19
2888-2890
2009
Penicillium janthinellum
Abeywickrema, P.D.; Patel, S.B.; Byrne, N.J.; Diehl, R.E.; Hall, D.L.; Ford, R.E.; Rickert, K.W.; Reid, J.C.; Shipman, J.M.; Geissler, W.M.; Pryor, K.D.; SinhaRoy, R.; Soisson, S.M.; Lumb, K.J.; Sharma, S.
Expression, purification and crystallization of human prolylcarboxypeptidase
Acta Crystallogr. Sect. F
66
702-705
2010
Homo sapiens (P42785)
Zhang, Y.; Hong, X.M.; Xing, H.X.; Li, J.P.; Huo, Y.; Xu, X.P.
E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients
Chin. Med. Sci.
122
2461-2465
2009
Homo sapiens
Qin, X.; Zeng, S.; Tian, H.; Deng, S.; Ren, J.; Zheng, Y.; Li, D.; Li, Y.; Liao, D.; Chen, S.
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats
Clin. Exp. Pharmacol. Physiol.
36
319-324
2009
Rattus norvegicus (D4AA31)
Palmiter, R.D.
Reduced levels of neurotransmitter-degrading enzyme PRCP promote obesity
J. Clin. Invest.
119
2130-2133
2009
Mus musculus (Q7TMR0)
Wallingford, N.; Perroud, B.; Gao, Q.; Coppola, A.; Gyengesi, E.; Liu, Z.W.; Gao, X.B.; Diament, A.; Haus, K.A.; Shariat-Madar, Z.; Mahdi, F.; Wardlaw, S.L.; Schmaier, A.H.; Warden, C.H.; Diano, S.
Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents
J. Clin. Invest.
119
2291-2303
2009
Mus musculus
Ngo, M.L.; Mahdi, F.; Kolte, D.; Shariat-Madar, Z.
Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation
J. Inflamm.
6
1-9
2009
Homo sapiens
Zhao, X.; Southwick, K.; Cardasis, H.L.; Du, Y.; Lassman, M.E.; Xie, D.; El-Sherbeini, M.; Geissler, W.M.; Pryor, K.D.; Verras, A.; Garcia-Calvo, M.; Shen, D.M.; Yates, N.A.; Pinto, S.; Hendrickon, R.C.
Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase
Proteomics
10
2882-2886
2010
Homo sapiens
Graham, T.H.; Liu, W.; Verras, A.; Sebhat, I.K.; Xiong, Y.; Bleasby, K.; Bhatt, U.R.; Chen, Q.; Garcia-Calvo, M.; Geissler, W.M.; Gorski, J.N.; He, H.; Lassman, M.E.; Lisnock, J.; Li, X.; Shen, Z.; Tong, X.; Tung, E.C.; Wiltsie, J.; Xiao, J.; Xie, D.; Xu, S.; Hale, J.J.; Pinto, S.; Shen, D.M.
A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation
Bioorg. Med. Chem. Lett.
22
2811-2817
2012
Homo sapiens, Mus musculus
Graham, T.H.; Liu, W.; Verras, A.; Reibarkh, M.; Bleasby, K.; Bhatt, U.R.; Chen, Q.; Garcia-Calvo, M.; Geissler, W.M.; Gorski, J.N.; He, H.; Lassman, M.E.; Lisnock, J.; Li, X.; Shen, Z.; Tong, X.; Tung, E.C.; Wiltsie, J.; Xie, D.; Xu, S.; Xiao, J.; Hale, J.J.; Pinto, S.; Shen, D.M.
A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes
Bioorg. Med. Chem. Lett.
22
2818-2822
2012
Homo sapiens, Mus musculus
Graham, T.H.; Shu, M.; Verras, A.; Chen, Q.; Garcia-Calvo, M.; Li, X.; Lisnock, J.; Tong, X.; Tung, E.C.; Wiltsie, J.; Hale, J.J.; Pinto, S.; Shen, D.M.
Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors
Bioorg. Med. Chem. Lett.
24
1657-1660
2014
Homo sapiens, Mus musculus
Jeong, J.K.; Diano, S.
Prolyl carboxypeptidase mRNA expression in the mouse brain
Brain Res.
1542
85-92
2014
Mus musculus
Goptar, I.A.; Shagin, D.A.; Shagina, I.A.; Mudrik, E.S.; Smirnova, Y.A.; Zhuzhikov, D.P.; Belozersky, M.A.; Dunaevsky, Y.E.; Oppert, B.; Filippova, I.Y.; Elpidina, E.N.
A digestive prolyl carboxypeptidase in Tenebrio molitor larvae
Insect Biochem. Mol. Biol.
43
501-509
2013
Tenebrio molitor (C5H0E3), Tenebrio molitor
Duan, L.; Ying, G.; Danzer, B.; Perez, R.E.; Shariat-Madar, Z.; Levenson, V.V.; Maki, C.G.
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT
J. Biol. Chem.
289
21694-21705
2014
Homo sapiens
Kehoe, K.; Brouns, R.; Verkerk, R.; Engelborghs, S.; De Deyn, P.; Hendriks, D.; De Meester, I.
Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke
Neurochem. Res.
40
81-88
2014
Homo sapiens
Grobe, N.; Weir, N.M.; Leiva, O.; Ong, F.S.; Bernstein, K.E.; Schmaier, A.H.; Morris, M.; Elased, K.M.
Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry
Am. J. Physiol. Cell Physiol.
304
C945-C953
2013
Mus musculus
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