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Information on EC 3.4.15.4 - Peptidyl-dipeptidase B

for references in articles please use BRENDA:EC3.4.15.4

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IUBMB Comments

A membrane-bound, zinc metallopeptidase located in mammalian atrial, but not ventricular, myocytes. Although it is capable of converting the 126-residue atriopeptin III directly to atriopeptin I by releasing a C-terminal tripeptide Phe-Arg-Tyr, it is generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it displays no Cl- dependence and shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II

The expected taxonomic range for this enzyme is: Bos taurus
Reaction Schemes
release of a C-terminal dipeptide or exceptionally a tripeptide

Synonyms
dipeptidyl carboxyhydrolase, atrial dipeptidyl carboxyhydrolase, atrial peptide convertase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
release of a C-terminal dipeptide or exceptionally a tripeptide
show the reaction diagram
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