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EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
preferential release of dipeptides from a tetrapeptide, e.g. Ala-Gly-/-Ala-Gly. Acts more slowly on Ala-Ala-/-Ala-Ala and Gly-Gly-/-Gly-Gly
Synonyms
dipeptidyl ligase, dipeptidyl tetrapeptide hydrolase, hydrolase, dipeptidyl tetrapeptide, tetrapeptide dipeptidase,
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dipeptidyl ligase
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dipeptidyl tetrapeptide hydrolase
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hydrolase, dipeptidyl tetrapeptide
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tetrapeptide dipeptidase
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preferential release of dipeptides from a tetrapeptide, e.g. Ala-Gly-/-Ala-Gly. Acts more slowly on Ala-Ala-/-Ala-Ala and Gly-Gly-/-Gly-Gly
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dipeptidyl ligase activity
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hydrolysis of peptide bond
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exopeptidase, N-terminus, dipeptide
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Ala-Gly
Ala-Gly-Ala-Gly + H2O
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r
Ala-Gly-Ala-Gly + H2O
2 Ala-Gly
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r
Gly-Gly + H2O
Gly-Gly-Gly-Gly
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r
Gly-Gly-Gly-Gly + H2O
Gly-Gly
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r
Gly-L-Ala + H2O
Gly-Ala-Gly-Ala
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L-Ala-L-Ala + H2O
Ala-Ala-Ala-Ala
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L-Met-Gly + H2O
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very slowly
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additional information
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tetrapeptides are formed from Ala-Ala, Gly-Gly, Ala-Gly and Gly-Ala without prior activation of the carboxyl group, condensation reaction: substrate specificity for a dipeptide with either two Ala residues or one Ala and one Gly residue, not hydrolyzed: pentaglycine, no condensation reaction with: Ser-Gly, Ala-Ala-Gly, Gly-Gly-Ala, Gly-Gly-Gly, Gly-Gly-leu, beta-Ala-Gly, Gly-leu, D-Ala-L-Ala, Gly-D-Ala
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diisopropylfluorophosphate
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alone slightly and in combination with p-hydroxymercuribenzoate strong
p-hydroxymercuribenzoate
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puromycin
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0.005 M: no effect, 0.025 M: complete inhibition, Ala-Gly-Ala-Gly synthesis
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thiols
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activate, strict requirement for reduced sulfhydryl group
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6 - 8.8
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pH 6.0: about 50% of activity maximum, pH 8.8: about 5% of activity maximum
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cabbage
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brenda
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brenda
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enzyme activity is promoted by integrin subunit alpha2 blockade but decreased after subunit alpha6 blockade. Proliferative blockade using mitomycin C or hydroxyurea prevent the effects of subunit alpha2 ligation on differentiation
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Eng, F.W.H.T.
Dipeptidyl tetrapeptide hyrolase, a new enzyme with dipeptidyl ligase activity
Can. J. Biochem. Cell Biol.
62
516-528
1984
Brassica oleracea
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brenda
Basson, M.D.; Emenaker, N.J.; Sanders, M.A.
alpha Integrin subunits regulate human (Caco-2) intestinal epithelial proliferation and phenotype
Cell. Physiol. Biochem.
10
27-36
2000
Homo sapiens
brenda
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3.4.14.6 dipeptidyl-dipeptidase
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