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Information on EC 3.4.14.5 - dipeptidyl-peptidase IV and Organism(s) Homo sapiens

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Homo sapiens
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Word Map
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
Synonyms
dpp-4, dipeptidyl peptidase-4, dpp-iv, dipeptidyl peptidase iv, dpp iv, dppiv, dipeptidyl peptidase 4, dipeptidyl peptidase-iv, dp iv, dipeptidylpeptidase iv, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(GLP1)-degrading enzyme
-
ACT3
-
-
-
-
ADA binding protein
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ADA-binding protein
-
-
ADABP
adenosine deaminase binding protein
Adenosine deaminase complexing protein
-
-
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adenosine deaminase-binding protein
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amino acyl-prolyl dipeptidyl aminopeptidase
-
-
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aminopeptidase, glycylproline
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-
-
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Bile canaliculus domain-specific membrane glycoprotein
-
-
-
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CD26 peptidase
-
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dipeptidyl aminopeptidase IV
dipeptidyl peptidase 4
-
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dipeptidyl peptidase 8
-
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dipeptidyl peptidase 9
-
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dipeptidyl peptidase IV
dipeptidyl peptidase-IV
dipeptidyl-aminopeptidase IV
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dipeptidyl-peptidase 4
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dipeptidyl-peptidase IV (CD26)
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-
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dipeptidyl-peptide hydrolase
-
-
-
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dipeptidylpeptidase IV
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dipeptidylpeptidase IV/CD26
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dipeptidylpeptidase-IV
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DPP IV
DPP IV/CD26
-
-
-
-
DPP-4
DPP-IV
DPP8
-
DPP8 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPP9
-
DPP9 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPPIV
glucagon-like peptide 1-degrading enzyme
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Gly-Pro-naphthylamidase
-
-
-
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glycoprotein GP110
-
-
-
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glycylproline aminopeptidase
-
-
-
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glycylproline-dipeptidyl-aminopeptidase
-
-
-
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glycylprolyl aminopeptidase
-
-
-
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glycylprolyl dipeptidylaminopeptidase
-
-
-
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GP110 glycoprotein
-
-
-
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h-DPPIV
-
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leukocyte antigen CD26
-
-
-
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lymphocyte, antigen CD26
-
-
-
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Pep X
-
-
-
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peptidase, dipeptidyl, IV
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-
-
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postproline dipeptidyl aminopeptidase IV
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-
-
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prolyl-dipeptidyl-aminopeptidase
-
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T cell triggering molecule Tp103
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-
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T-cell activation antigen CD26
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-
-
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THAM
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-
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Thymocyte-activating molecule
-
-
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TP103
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-
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WC10
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-
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X-PDAP
-
-
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X-prolyl dipeptidyl aminopeptidase
-
-
-
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Xaa-Pro-dipeptidyl-aminopeptidase
-
-
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additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
CAS REGISTRY NUMBER
COMMENTARY hide
54249-88-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(glycyl-L-prolyl hydrazido)-N-hexyl-1,8-naphthalimide + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Ala-Pro-7-amido-4-trifluoromethyl coumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethyl coumarin
show the reaction diagram
-
-
?
Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Asn-Pro-4-nitroanilide + H2O
Asn-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
B-type natriuretic peptide (1-32) + H2O
B-type natriuretic peptide (3-32) + L-Ser-L-Pro
show the reaction diagram
-
DPP IV removes the two amino terminal amino acids (Ser-Pro) from B-type natriuretic peptide (1-32) to produce B-type natriuretic peptide (3-32)
-
-
?
B-type natriuretic peptide(1-32) + H2O
B-type natriuretic peptide(3-32) + ?
show the reaction diagram
-
-
-
-
?
B-type natriuretic propeptide (1-108) + H2O
B-type natriuretic propeptide (3-306) + ?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
BRI peptide (1-23) + H2O
?
show the reaction diagram
-
-
-
-
?
casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
corticotropin-like intermediate lobe peptide + H2O
?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
EPLGRQLTSGP + H2O
Glu-Pro + LGRQLTSGP
show the reaction diagram
-
the sequence EPLGRQLTSGP, which corresponds to the propeptide fragment of alpha-2 plasmin inhibitor
-
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
-
?
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
-
?
glucose-dependent insulinotropic polypeptide(1-42) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
-
?
glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
-
GIP-fragment, very low activity
-
?
Gly-Ala-4-nitroanilide + H2O
Gly-Ala + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
Gly-azetidine-2-carboxyl-3,5-dibromo-4-hydroxyanilide + H2O
Gly-azetidine + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-Hyp-Ala + H2O
Ala + ?
show the reaction diagram
-
-
-
?
Gly-L-hydroxyproline-3,5-dibromo-4-hydroxyanilide + H2O
Gly-L-hydroxyproline + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Phe-4-nitroanilide + H2O
Gly-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro 4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-3,5-dibromo-4-hydroxyanilide + H2O
Gly-Pro + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methoxy-2-naphthylamide
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
fluorogenic substrate
-
?
Gly-Pro-4-methoxy-2-naphthylamide + H2O
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-Pro-4-methylcoumaryl-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
Gly-Pro-glycinamide + H2O
Gly-Pro + glycinamide
show the reaction diagram
-
the anti-HIV drug Gly-Pro-glycinamide is not active as such, but rather behaves as a prodrug that must be obligatorily cleaved by VD26/DPP IV to Gly-Pro and glycinamide to exert its antiretroviral activity
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
glycyl-L-prolyl-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
H-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
His-Ala-4-nitroanilide + H2O
His-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-Phe + H2O
His-Pro + Phe
show the reaction diagram
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
-
?
Ile-Pro-4-nitroanilide + H2O
Ile-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
incretin hormone glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
?
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
kentsin + H2O
Thr-Pro + ?
show the reaction diagram
-
-
-
?
L-Ala-L-Pro 4-nitroanilide + H2O
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
L-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
L-Ala-L-Pro-p-nitroanilide + H2O
L-Ala-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-7-amido-4-methylcoumarin + H2O
L-Arg-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-p-nitroanilide + H2O
L-Arg-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asn-L-Pro-p-nitroanilide + H2O
L-Asn-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-6-aminoquinolide + H2O
L-Asp-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-p-nitroanilide + H2O
L-Asp-L-Pro + p-nitroaniline
show the reaction diagram
-
least preferred substrate
-
-
?
L-Glu-L-Pro-4-nitroanilide
L-Glu-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Glu-L-Pro-p-nitroanilide + H2O
L-Glu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Leu-L-Pro-p-nitroanilide + H2O
L-Leu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
L-Met-L-Pro-p-nitroanilide + H2O
L-Met-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ser-L-Pro-p-nitroanilide + H2O
L-Ser-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Val-L-Ala-L-Val-L-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-6-aminoquinolide + H2O
L-Val-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-doxorubicin + H2O
L-Val-L-Pro + doxorubicin
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-Ara-A + H2O
L-Val-L-Pro + L-Val-L-Pro-Ara-A
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosyladenosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosyladenosine
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
show the reaction diagram
-
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-nitroanilide + H2O
Lys-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Pro-4-methoxy-2-naphthylamide + H2O
Lys-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
show the reaction diagram
-
-
-
?
N-terminal B-type natriuretic propeptide (1-76) + H2O
N-terminal B-type natriuretic propeptide (3-76) + ?
show the reaction diagram
-
-
-
-
?
N-tosyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-tosyl-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
norleucine-Pro-7-amido-4-methylcoumarin + H2O
norleucine-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
norleucine-Pro-rhodamine + H2O
norleucine-Pro + rhodamine
show the reaction diagram
-
-
-
?
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
NPY(1-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
NPY(3-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Ala-4-nitroanilide + H2O
Phe-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Phe-Ala-Pro-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Pro-2-naphthylamide + H2O
Phe-Pro + 2-naphthylamine
show the reaction diagram
-
L-Phe-L-Pro-2-naphthylamide
-
-
?
Phe-Pro-4-nitroanilide + H2O
Phe-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
pituitary adenylate cyclase activating peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Ala-4-nitroanilide + H2O
Pro-Ala + 4-nitroaniline
show the reaction diagram
-
best substrate
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Pro-4-nitroanilide + H2O
Pro-Pro + 4-nitroaniline
show the reaction diagram
-
high activity
-
?
Pro-Pro-Gly + H2O
Gly + ?
show the reaction diagram
-
-
-
?
procasomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
procolipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
?
Substance P + H2O
?
show the reaction diagram
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
substance P + H2O
peptides SP(3-11) + SP(5-11) + ?
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
synthetic renin inhibitor + H2O
?
show the reaction diagram
-
His-Pro-Phe-His-Leu-D-Leu-Val-Tyr
-
-
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen propeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Ala-4-nitroanilide + H2O
Tyr-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-melanostatin + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-4-nitroanilide + H2O
Tyr-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Val-Ala-4-nitroanilide + H2O
Val-Ala-4-nitroaniline
show the reaction diagram
-
-
-
-
?
Val-Pro-4-nitroanilide + H2O
Val-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
VPAC2P-PEG + H2O
?
show the reaction diagram
-
VPAC2P-PEG is a VPAC2 receptor agonist peptide that acts as a glucose-dependent insulin secretagogue. Proteolysis by DPPIV may contribute to the in vivo clearance of VPAC2P-PEG. The N-terminus of VPAC2P-PEG is modified by N-terminal acetylation to impart DPPIV resistance. The acetylated peptide, Ac-VPAC2P-PEG, is a selective and potent VPAC2 agonist, resistant to DPPIV proteolysis
-
-
?
[Gly2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with glycine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Val2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with valine at position 2 in the sequence
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
-
?
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
-
?
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
neuropeptide Y + H2O
?
show the reaction diagram
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
-
CD26 may play a role in SDF-1/CXCL12 mediated functions such as chemotaxis
-
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
?
Substance P + H2O
?
show the reaction diagram
substance P + H2O
peptides SP(3-11) + SP(5-11) + ?
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
-
-
(1R)-2-([(3R,4R)-4-amino-1-[1-(4-ethynylphenyl)ethyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
(1R)-2-([(3R,4R)-4-amino-1-[2-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
(1R)-2-([(3R,4R)-4-amino-1-[3-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
(1R)-2-[[(3R,4R)-4-amino-1-(3,4-dihydro-2H-chromen-4-yl)pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
(1R)-2-[[(3R,4R)-4-amino-1-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
(1R,3S)-2-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)-3-fluorocyclopentanecarbonitrile
-
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile
-
-
(1S)-1-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethanaminium
-
(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-(3-fluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethanamine
-
-
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine
-
-
(1S,2S)-1-(4'-fluorobiphenyl-4-yl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(1H-tetrazol-1-yl)propan-2-amine
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridine carboxylic acid
i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes
(2R)-1-(2,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-methylphenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(3,4-difluorophenyl)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxobutan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(4-chlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(4-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(4-iodophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-(4-nitrophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-cyclohexyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2R)-1-[8-(trifluoromethyl)bis[1,2,4]triazolo[4,3-a:3',4'-c]pyrazin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4',3':1,2]pyrido[3,4-d]pyrimidin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-(2-benzoylpyrazolidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-1-phenyl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-4-oxo-1-pyridin-2-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-4-oxo-1-pyridin-3-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-4-oxo-1-pyridin-4-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-(3,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[2-(trifluoromethyl)phenyl]butan-2-amine
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[3-(trifluoromethyl)phenyl]butan-2-amine
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[4-(trifluoromethyl)phenyl]butan-2-amine
-
(2R)-4-oxo-4-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-oxo-4-pyrazolidin-1-yl-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
competitive
(2R)-4-oxo-4-[2-(phenylcarbonyl)tetrahydropyridazin-1(2H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
the inhibitor displays a greater than 1400fold selectivity over all the enzymes tested including DPP-8 and DPP-9
(2R)-4-oxo-4-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-oxo-4-[8-(1H-pyrazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[2-[(4-methylphenyl)sulfonyl]pyrazolidin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
-
(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
(2R)-4-[8-(1H-imidazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
-
(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
-
potent, selectiveDPP-4 inhibitor
(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,3S)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N1,N1-dimethyl-4-oxobutane-1,3-diamine
-
(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine
-
-
(2R,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate
-
best selectivity for dipeptidyl peptidase IV over dipeptidyl peptidases DPP8 and DPP9
(2R,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile
-
(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)-N-phenylpyrrolidine-2-carboxamide
-
(2R,5S)-N-(4-bromophenyl)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidine-2-carboxamide
-
(2S)-1-(((2S,5R)-5-[(1,3-benzodioxol-4-yloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(1-naphthyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(2,4-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(2,6-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(2-chloro-4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(2-chlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(2-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(4-bromophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(4-methoxyphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(4-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(((2S,5R)-5-[(benzyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-(3-furyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2S)-1-([(2S,4S)-4-[(2E)-but-2-en-1-yl]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(([2-chloro-5-(dihydroxymethyl)pyridin-3-yl]oxy)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-(([dihydroxy(phenyl)-'4-sulfanyl]amino)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-(anilinomethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-(morpholin-4-ylmethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-(phenoxymethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([(2-chloropyridin-3-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([(4-bromophenyl)amino]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([(6-bromo-1,3-benzodioxol-5-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([2,4-dichloro-5-(dihydroxyamino)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([2-bromo-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(2S,5R)-5-([2-chloro-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1-methyl-1H-pyrazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-pyrazol-5-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(2H-1,2,3-triazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(3-methyl-1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
(2S)-1-([[2-methyl-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-cyclopentyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
(2S)-1-L-prolylpyrrolidine-2-carbonitrile
-
IC50: 2.9 nmol/L
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
-
-
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-[(4R)-4-tricyclo[3.3.1.13,7]dec-2-yl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5,5-dimethyl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[3-(1,3-dihydro-2H-isoindol-2-yl)-1,1-dimethyl-3-oxopropyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[4-(1,3-dihydro-2H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-ethyl-4-hydroxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethoxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-cyclohexylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-isobutylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyanobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
(2S)-1-[[(3R,4R)-4-amino-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide
-
-
(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethoxy)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
(2S)-2-(4-[[([(4R)-3-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)-3-methylbutanoic acid
-
(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide
-
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(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide
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(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide
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(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide
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(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide
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(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide
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(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide
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(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide
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(2S)-2-[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-fluoro-2-methylphenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-(pentafluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-2-[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
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(2S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-amine
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(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
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(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide
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(2S)-{((3-Hydroxyadamantan-1-yl)amino) acetyl}pyrrolidin-2-carbonitrile
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vldagliptin is rapidly and well absorbed with an estimated absolute bioavailability of 85%. Two possible sites of absorption are identified, and the absorption rates are slower than the elimination rate, indicating a flip-flop phenomenon after oral dosing
(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
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(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
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(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[2'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-1,2,4-triazol-3-yl)biphenyl-4-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-1-yl)biphenyl-4-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-5-yl)biphenyl-4-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)phenyl]butan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(1,3,4-oxadiazol-2-yl)biphenyl-4-yl]-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(methylthio)phenyl]-1-oxobutan-2-amine
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(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxobutan-2-amine
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(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
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(2S,3S)-2-amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one
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(2S,3S)-3-(2',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2'-chlorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-pyrrolidin-1-ylbutan-2-amine
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(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-5-pyrrolidin-1-ylpentan-2-amine
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(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
(2S,3S)-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-amino-2-(2',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(2',5'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(3',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(3'-ethynylbiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-1-ol
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(1-methylethyl)-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-(1,3-thiazolidin-3-yl)butanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide
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(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide
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(2S,3S)-3-amino-4-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-4-(3,3-difluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide
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(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide
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(2S,3S)-3-amino-4-(3-fluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-4-aziridin-1-yl-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
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(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-4-oxobutanamide
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(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-3-ylphenyl)butanamide
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(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-4-ylphenyl)butanamide
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(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[3'-(2H-tetrazol-2-yl)biphenyl-4-yl]butanamide
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(2S,3S)-3-amino-N,N-diethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
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(2S,3S)-3-amino-N-(3,4-dihydro-2H-tetrazol-2-yl)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
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(2S,3S)-3-amino-N-cyclopropyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
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(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
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(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
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(2S,3S)-3-biphenyl-4-yl-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pentan-2-amine
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(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine
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(2S,3S)-3-[3'-(5-cyclopropyl-2,3-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
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(2S,3S)-3-[4-(acetylamino)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
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(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
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(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-[(phenylsulfonyl)amino]phenyl]butan-2-aminium
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(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)carbonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
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(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)sulfonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
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(2S,3S)-4-(dimethylamino)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-4-(dimethylamino)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
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(2S,3S)-4-azetidin-1-yl-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-amine
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(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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-
(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-pyrido[2,1-a]isoquinoline-2,11b-diamine
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(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
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(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-ethyl-N,N-dimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
-
-
(2S,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-((2S)-2-amino-3-methylpentanoyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-1-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-2-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclobutylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclooctylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopentylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopropylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-[2-[(5-chloropyridin-2-yl)amino]ethyl]-glycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(O-benzyl-L-threonyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-L-alloisoleucyl-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile
-
potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
(2S,4S)-1-[N-(tert-butyl)glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[(2E)-1,1-dimethyl-3-phenylprop-2-en-1-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[1-(1-benzofuran-2-yl)-1-methylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(diethylamino)-1,1-dimethylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(7-azabicyclo[2.2.1]hept-7-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(azepan-1-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[O-(tert-butyl)-L-threonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[[(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-isopropylglycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-methyl-L-isoleucyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-[(4-cyanobenzyl)amino]-1,1-dimethylethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-[(5-cyanopyridin-2-yl)-amino]ethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(O-methyl-L-threonyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-L-valyl-pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(1-methyl-1-pyridin-2-ylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-hydroxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-methoxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-hydroxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-isopropoxypropyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-methoxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(5-hydroxy-2-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(2-furyl)-1-methylethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(hydroxymethyl)cyclopentyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-methyl-1-(2-thienyl)-ethyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-(pyridin-2-ylamino)ethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(4-methylpiperazin-1-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(4-oxopiperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[[(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[[(3S)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-N-ethyl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-prop-2-yn-1-ylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-propylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-N,5-dimethylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-cyclopropyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-allyl-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N4-benzyl-N2-(cyanomethyl)-N2-ethyl-5-methylpyrrolidine-2,4-dicarboxamide
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile
-
(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine
-
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4R)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin)-2-yl]-methanone
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone
PF-00734200, potent, selective, orally active dipeptidyl peptidase IV inhibitor
(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
-
-
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
(3R)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
(3R)-3-amino-1-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(2S)-2-([[2-(trifluoromethyl)pyrimidin-4-yl]oxy]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[6-(trifluoromethyl)pyridin-3-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(cyclopropylmethoxy)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(pyrimidin-2-ylamino)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyridin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyrimidin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4S)-1-methyl-4-propyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(5R)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(5S)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[2,3-bis(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
(3R)-3-amino-1-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[2-cyclopropyl-3-(trifluoromethyl)-4,7-dihydrofuro[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
(3R)-3-amino-1-[3-(difluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(8R)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorophenyl)-3-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(2,2,2-trifluoroethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(2,2,2-trifluoroethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfanyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(trifluoromethyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,5-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(hydroxymethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(pyridin-4-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4,5-dihydro[1,2]oxazolo[3,4-c]pyridin-6(7H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,7-dihydro[1,2]oxazolo[4,3-c]pyridin-5(4H)-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(4-fluorophenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-[2-(benzyloxy)ethyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one
i.e. evogliptin
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1-(2-oxopropyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R,4R)-1-(1,3-benzothiazol-2-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-(1,3-benzothiazol-6-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(2-naphthoyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(3,4-difluorobenzyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(4-cyanopyridin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-(6-piperidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-(6-pyrrolidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-(isoquinolin-3-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrazino[2,3-b]pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinolin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinoxalin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[(5-chloro-1-benzofuran-2-yl)carbonyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[1-methyl-1-(4-nitrophenyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[2-(trifluoromethyl)[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-[5-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[6-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[6-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
(3R,4R)-3-amino-N-phenyl-4-(2,4,5-trifluorophenyl)piperidine-1-carboxamide
-
(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
-
-
(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
-
-
(3R,4R)-3-butyl-1-phenylpiperidin-4-amine
-
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylmethyl)pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-6-ylcarbonyl)pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzoyl]pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzoyl]pyrrolidin-3-amine
-
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzyl]pyrrolidin-3-amine
-
(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-acetyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
-
(3R,4S)-1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
-
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
-
-
(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
(3R,4S)-1-[6-[3-(morpholin-4-ylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
(3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
(3R,4S)-1-[6-[3-fluoro-5-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-fluorobenzyl)pyrrolidine-1-carboxamide
-
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-methoxybenzyl)-N-methylpyrrolidine-1-carboxamide
-
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethyl-N-methylpyrrolidine-1-carboxamide
-
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethylpyrrolidine-1-carboxamide
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-(6-phenylpyridin-2-yl)pyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-phenylpyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-pyridin-2-ylpyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-pyrimidin-2-ylpyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-[2-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-[4-(3-thienyl)pyrimidin-2-yl]pyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-[5-(4-methoxyphenyl)pyrimidin-2-yl]pyrrolidin-3-amine
-
(3R,4S)-4-(2,4-dichlorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
-
(3R,4S)-4-(2-chloro-4,5-difluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
-
(3R,4S)-4-(2-chloro-4-fluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
-
(3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine
-
-
(3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
-
-
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one
-
-
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-(2-fluorobenzyl)-3-methyl-1,4-diazepan-2-one
-
-
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-ethyl-3-methyl-1,4-diazepan-2-one
-
-
(3R,S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3S)-1-oxo-5-phenyl-1-(1,3-thiazolidin-3-yl)pentan-3-amine
-
(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
(3S)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
-
(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one
-
-
(3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6,6-trimethyl-1,4-diazepan-2-one
-
-
(3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
-
-
(3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
-
-
(3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
-
-
(3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
-
-
(3S,4S)-1-pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3S,4S)-1-pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3S,4S)-1-pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3S,4S)-1-pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3S,4S)-5-(dimethylamino)-2-[(3S)-3-fluoropyrrolidin-1-yl]-5-oxo-4-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)pent-1-en-3-aminium
-
(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl 4-cyanobenzoate
-
(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl benzoate
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
-
-
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
-
-
(3S,5S)-N-(2-phenylethyl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
-
-
(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3S,5S)-N-(4-methoxyphenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
-
-
(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
-
(3S,5S)-N-phenyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
-
-
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
-
-
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
-
-
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
-
-
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
-
-
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
-
-
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2-fluorobenzyl)-7-methyl-1,4-diazepan-2-one
-
-
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2-methylbenzyl)-1,4-diazepan-2-one
-
-
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one
-
-
(3S,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
-
-
(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine
-
-
(4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid
-
(4-[[([(4R)-3-[(3R)-3-amino-4-phenylbutanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid
-
(4R,5R)-5-amino-1-(2-phenylethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-(2-pyridin-4-ylethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-(3-phenylpropyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-(morpholin-4-ylmethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-benzyl-4-(2-chlorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-[(2S)-2-phenylpropyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-1-[2-[3-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
(4R,5R)-5-amino-1-[2-[4-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
(4R,5R)-5-amino-4-(2-chlorophenyl)-1-(cyclohexylmethyl)piperidin-2-one
-
(4R,5R)-5-amino-4-(2-chlorophenyl)-1-phenylpiperidin-2-one
-
(6-methylpyridin-2-yl)methyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate
-
(7R,8R)-2-methyl-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyridin-8-amine
-
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-morpholin-4-ylphenyl)amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-sulfamoyl phenyl)amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-amino benzyl amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonyl phenyl ester
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl benzyl ester
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl methyl phenyl ester
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl ester
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(pyridin-2-ylmethyl)amide
-
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-4-sulfamoyl benzyl amide
-
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino) benzoic acid ethyl ester
-
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzenesulfonic acid
-
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzoic acid
-
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid
-
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid methyl ester
-
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
-
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
-
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
-
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid ethyl ester
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S)-isopropyl acetic acid
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S)-isopropyl acetic acid ethyl ester
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
-
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
-
(S)-1-(2-(2-(2-oxo-3-(3,4,5-trimethoxyphenyl)imidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(2-oxo-3-p-tolylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(2-oxo-3-phenylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(3,4-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(3,5-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(3-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(4-chlorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-cyclohexyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-isopropyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
(S)-1-(2-(2-(3-tert-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
-
-
1-(1-methyl-6-phenyl-1H-benzimidazol-7-yl)methanamine
-
1-(2-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
-
1-(3,4-dichlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(3,4-dimethoxyphenyl)-3-(3,4-dimethylphenyl)piperidin-4-amine
-
-
1-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)piperidin-4-amine
-
-
1-(3,4-dimethoxyphenyl)-3-(3-methylphenyl)piperidin-4-amine
-
-
1-(3,4-dimethoxyphenyl)-3-(4-methylphenyl)piperidin-4-amine
-
-
1-(3,4-dimethoxyphenyl)-3-pyridin-2-ylpiperidin-4-amine
-
-
1-(3-benzyl-4-oxido-3H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-aminium
-
-
1-(3-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(3-methyl-1,2,4-thiadiazol-5-yl)-4-[[(2S,3S,5S)-2-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]piperazine
-
-
1-(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
-
1-(4-bromophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-cyanophenyl)-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea
-
1-(4-ethynylpyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-fluorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-methoxyphenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,4-diazepane
-
-
1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
-
-
1-(5-chloropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(5-nitropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(6-chloro-2-isobutyl-4-phenyl-3,4-dihydroquinolin-3-yl)methanamine
-
-
1-(diphenylmethyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-(L-alanyl)pyrrolidine
-
reversible
1-(L-cyclohexylalanyl)piperidine
-
reversible
1-(L-cyclohexylalanyl)pyrrolidine
-
reversible
1-(L-isoleucyl)-1,2,5,6-tetrahydropyridine
-
reversible
1-(L-isoleucyl)-3(R,S)-azidopyrrolidine
-
reversible
1-(L-isoleucyl)-3(R,S)-chloropyrrolidine
-
reversible
1-(L-isoleucyl)-3(R,S)-hydroxypyrrolidine
-
reversible
1-(L-isoleucyl)-3-pyrroline
-
reversible
1-(L-isoleucyl)hexamethyleneimine
-
reversible
1-(L-isoleucyl)piperidine
-
reversible
1-(L-isoleucyl)pyrrolidine
-
reversible
1-(L-lysyl)piperidine
-
reversible
1-(L-lysyl)pyrrolidine
-
reversible
1-(L-phenylalanyl)pyrrolidine
-
reversible
1-(L-prolyl)pyrrolidine
-
reversible
1-(L-tyrosyl)pyrrolidine
-
reversible
1-(L-valyl)pyrrolidine
-
reversible
1-([(5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methyl)-3-phenylurea
-
1-benzyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-cyclohexyl-2-oxo-2-(1,3-thiazolidin-3-yl)ethanaminium 2,2,2-trifluoro-1-oxoethanide
-
1-methyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-phenyl-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea
-
1-phenyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-pyridin-2-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-pyridin-4-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
-
-
1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4,4-dimethyl-1-oxopentan-2-amine
-
-
1-[(2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
-
1-[(2R)-4,4-difluoro-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
-
1-[(2R,4R)-4-fluoro-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
-
1-[(2S)-2-amino-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butyl]piperidin-2-one
-
-
1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide
-
-
1-[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]indane-5-carbonitrile
-
1-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
-
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-benzyl-L-prolinamide
-
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(1H-1,2,3-triazol-4-yl)butyl]-L-prolinamide
-
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2,3-dihydro-1H-tetrazol-5-yl)butyl]-L-prolinamide
-
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(trifluoromethyl)benzyl]-L-prolinamide
-
1-[(3S,4S)-4-amino-1-[4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-4,4-difluoropiperidin-2-one
-
-
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,2,3,4-tetrahydroquinoline
-
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]piperazine
-
-
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine
-
-
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
-
-
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
-
-
1-[(4R)-4-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]tetrahydrothiophen-3-yl]-2-(tricyclo[3.3.1.13,7]dec-1-ylamino)ethanone
-
-
1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano(S)-pyrrolidine
-
competitive
1-[1-(2-chlorobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
-
-
1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium
-
-
1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
-
potent and selective DPPIV inhibitor, but it showed a significant loss of activity in the presence of plasma
1-[1-(2-cyanobenzyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
-
-
1-[1-(2-cyanobenzyl)-6-methyl-7-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
-
-
1-[1-(3-cyanobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
-
-
1-[1-benzyl-6-(2-chlorophenyl)-1H-benzimidazol-7-yl]methanamine
-
1-[1-methyl-6-(2-methylphenyl)-1H-benzimidazol-7-yl]methanamine
-
1-[1-[3-(cyanomethyl)benzyl]-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
-
-
1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxopropyl]-4-[benzothiazol-2-yl]piperazine
-
-
1-[4,9-dioxo-1-[2-(trifluoromethyl)benzyl]-4,9-dihydro-1H-naphtho[2,3-d]imidazol-2-yl]piperidin-3-aminium
-
-
1-[5-benzyl-1-(3-cyanobenzyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
-
-
1-[5-bromo-6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethoxy)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
-
-
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethyl)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
-
-
1-[6-(2,4-dichlorophenyl)-1-ethyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2,4-dichlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2,4-dichlorophenyl)-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2,4-difluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chloro-5-fluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-1,2-dimethyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-1-methyl-1H-1,2,3-benzotriazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-1-methyl-2-pyridin-3-yl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-2-ethyl-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-chlorophenyl)-2-methoxy-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[6-(2-methoxyphenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
-
1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium
-
-
1-[7-fluoro-6-methoxy-1-[2-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]piperidin-3-aminium
-
-
1-[amino(cyclohexyl)acetyl]pyrrolidine-2-carbonitrile
-
-
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine
-
vildagliptin, reversible inhibitor
1-[[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazin-8-yl]methyl]cyclopropanol
-
-
2,2-bis(4-chlorophenyl)-N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]acetamide
-
-
2-(2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxoethylsulfanyl)-4-hydroxy-6-phenyl-pyrimidine-5-carbonitrile
-
single dose of 10 mg/kg of the compound significantly reduces glucose excursion during oral glucose tolerance test in streptozotocin-induced diabetic rat model
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-4-cyano-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(2-oxo-2-phenylethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11R)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11S)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
-
-
2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide
-
-
2-(3-but-2-yn-1-yl-4-oxo-2-piperazin-1-yl-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl)benzonitrile
-
-
2-(4-[(3R,5S)-5-[(3,3,4,4-tetrafluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
-
2-(4-[(3R,5S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
-
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole
-
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrazine
-
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyridine-3-carbonitrile
-
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
-
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)[1,3]oxazolo[5,4-b]pyridine
-
2-(4-[(3R,5S)-5-[(3-fluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
-
2-(N-tert-butylglycyl-L-prolyl)-5-(1-methylcyclohexyl)-1,3,4-oxadiazole
-
-
2-(N-tert-butylglycyl-L-prolyl)-5-(2,4,6-trimethylphenyl)-1,3,4-oxadiazole
-
-
2-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-4-carbonitrile
-
-
2-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]carbonyl)isoindoline
-
-
2-([2-(4-aminopiperidin-1-yl)-2-oxoethyl]sulfanyl)-4-hydroxy-6-phenylpyrimidine-5-carbonitrile
-
single dose of 10 mg/kg of the compound significantly reduces glucose excursion during oral glucose tolerance test in streptozotocin-induced diabetic rat model
2-([2-[(1R,3S)-3-aminocyclohexyl]-5-benzyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl)benzonitrile
-
-
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
-
-
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
2-([6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl)benzonitrile
2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile
-
-
2-([8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl]methyl)benzonitrile
most potent inhibitor tested, exhibits moderate antihyperglycemic activity as compared to the standard antidiabetic drug Linagliptin in ther oral glucose tolerance test. The compound effectively improves the pathological state of diet-induced obesity mice. IC50 value with isoforms DPP-8 and DPP-9 is above 0.1 mM
2-cyanopyrrolidines
-
-
-
2-ethoxy-4-[2-(methylsulfanyl)ethyl]-1,3,2-oxazaphospholidine 2-sulfide
-
2-mercaptoethanol
-
-
2-methyl-2-[(2-[(2S)-2-[(5-methyl-1,2,4-oxadiazol-3-yl)carbonyl]pyrrolidin-1-yl]-2-oxoethyl)amino]propanoic acid
-
-
2-tert-butyl-5-(N-tert-butylglycyl-L-prolyl)-1,3,4-oxadiazole
-
-
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole
-
the inhibitor shows good potency against DPPIV, and good selectivity against DPPII, DPPVIII, and elastase
2-tert-butyl-5-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-L-prolyl]-1,3,4-oxadiazole
-
-
2-tert-butyl-5-[N-[2-(4-fluorophenyl)-1,1-dimethylethyl]glycyl-(4S)-4-fluoro-L-prolyl]-1,3,4-oxadiazole
-
-
2-[(2-aminoethyl)(methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
-
2-[(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-methylpyrrolidin-3-yl]-N,N-dimethylacetamide
-
-
2-[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]-1-[(2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]cyclopentyl]ethanone
-
-
2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenylpyrazolidine-1-carboxamide
-
-
2-[(3R)-3-aminopiperidin-1-yl]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
-
-
2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide
-
-
2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
2-[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetamide
-
2-[(7-but-2-yn-1-yl-2-methoxy-6-oxo-8-piperazin-1-yl-6,7-dihydro-1H-purin-1-yl)methyl]benzonitrile
-
-
2-[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide
-
2-[(8S)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide
-
2-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile
-
-
2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
-
-
2-[4-[(3R,5S)-5-(azetidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3R,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3R,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3R,5S)-5-[[(3R,4R)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3R,5S)-5-[[(3R,4S)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3R,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
-
2-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile
-
-
2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
-
2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]benzamide
-
2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenol
-
2-[7-(aminomethyl)-6-(2-chlorophenyl)-1H-benzimidazol-1-yl]ethanol
-
2-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-5-(1,1-dimethylpropyl)-1,3,4-oxadiazole
-
-
2-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-5-cyclohexyl-1,3,4-oxadiazole
-
-
2-[[(2S)-2-aminopropyl](methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
2-[[(3S)-3-[[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]acetamide
-
-
2-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]-5-(trifluoromethyl)isoindoline
-
-
2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
2-[[(3S,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline
-
-
2-[[(3S,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline
-
-
2-[[2-(3-aminopiperidin-1-yl)-4-oxoquinazolin-3(4H)-yl]methyl]benzonitrile
-
-
2-[[2-(3-aminopiperidin-1-yl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-1-yl]methyl]benzonitrile
-
-
2-[[2-(3-aminopiperidin-1-yl)-5-methyl-4,6-dioxo-5,6-dihydropyrrolo[3,4-d]imidazol-1(4H)-yl]methyl]benzonitrile
-
-
3,4-dichloroisocoumarin
-
-
3-((2S,4S)-4-anilino-2-pyrrolidinylcarbonyl)-1,3-thiazolidine
-
IC50: 147 nmol/L
3-(1-amino-2-oxo-2-pyrrolidin-1-ylethyl)tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,2,4-oxadiazolidin-5-one
-
3-(aminomethyl)-2-isobutyl-4-phenylisoquinolin-1(2H)-one
-
-
3-(aminomethyl)-4-(2,4-dichlorophenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridin-2-amine
-
-
3-(aminomethyl)-4-(2,4-dichlorophenyl)quinolin-2-amine
-
-
3-(N-tert-butylglycyl-L-prolyl)-5-(2-methylcyclohexyl)-1,2,4-oxadiazole
-
-
3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide
-
-
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-(pyridin-2-yl)butanamide
-
-
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide
-
-
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-cyclopentyl-3-methylbutanamide
-
-
3-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
-
3-bromo-4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
-
3-but-2-yn-1-yl-2-(1,4-diazepan-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
3-but-2-yn-1-yl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
-
-
3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
-
selective and competitive dipeptidyl peptidase-IV inhibitor
3-butyl-1-(5,6,7,8-tetrahydronaphthalen-1-yl)piperidin-4-amine
-
-
3-butyl-1-(diphenylmethyl)piperidin-4-amine
-
-
3-butyl-1-naphthalen-1-ylpiperidin-4-amine
-
-
3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
-
-
3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
-
-
3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
3-chloro-4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
-
3-L-prolyl-1,3-thiazolidine
-
IC50: 538 nmol/L
3-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
-
3-[(2S)-pyrrolidin-2-ylcarbonyl]-1,3-thiazolidine
3-[(2S,4S)-4-(2-chloro-4-cyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 18.2 nmol/L
3-[(2S,4S)-4-(2-cyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 24.1 nmol/L
3-[(2S,4S)-4-(3,4-dicyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 8.4 nmol/L
3-[(2S,4S)-4-(3,4-methylenedioxyphenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 29.0 nmol/L
3-[(2S,4S)-4-(3-chloro-4-cyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 11.1nmol/L
3-[(2S,4S)-4-(3-chloro-4-methoxyphenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 19.9 nmol/L
3-[(2S,4S)-4-(4-aminophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 105 nmol/L
3-[(2S,4S)-4-(4-chlorophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 45.4 nmol/L
3-[(2S,4S)-4-(4-cyanophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 25.2 nmol/L
3-[(2S,4S)-4-(4-methanesulfonylphenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 52.3 nmol/L
3-[(2S,4S)-4-(4-nitrophenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 19.2 nmol/L
3-[(2S,4S)-4-(5-cyano-2-pyridyl)amino-2-pyrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 25.4 nmol/L
3-[(2S,4S)-4-(p-anisidino)-2-pyrrolidinylcarbonyl]-1,3-thiazolidine
-
IC50: 51.5 nmol/L
3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide
-
-
3-[1-amino-2-(2H-isoindol-2-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[1-amino-2-(4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[1-amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[1-amino-2-[(1R,5S)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
-
-
3-[2-[(4R,5R)-5-amino-2-oxo-4-(2,4,5-trifluorophenyl)piperidin-1-yl]ethyl]benzoic acid
-
3-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]phenyl methanesulfonate
-
-
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]-N,N-dimethylbenzamide
-
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
-
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenol
-
-
3-[6-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
-
4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
-
-
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylic acid
-
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-sulfonamide
-
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylic acid
-
4,4'-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]imino]dimethanediyl)dibenzonitrile
-
4-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,3-dihydro-2H-imidazol-2-one
-
4-(4-nitrophenyl)-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
-
-
4-([(1-methylethyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
-
4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)-3-methoxybenzoic acid
-
4-([1-[(2-oxo-2-thiophen-3-ylethyl)amino]cyclopentyl]methoxy)benzamide
-
-
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzamide
-
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzenesulfonamide
-
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
-
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]sulfonyl)benzoic acid
-
4-([butyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
-
4-([methyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
-
4-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
-
4-bromo-3-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
-
4-chloro-3-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
-
4-cyano-N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
-
4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
-
4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzenesulfonamide
-
4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate
-
-
4-phenyl-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
-
-
4-[(1-[[2-oxo-2-(3-thienyl)ethyl]amino]cyclopentyl)methoxy]benzamide
-
4-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
-
4-[(2S)-2-amino-3-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-oxopropyl]phenol
-
-
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-(4-methylphenyl)-1,4-diazepane-1-carboxamide
-
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenyl-1,4-diazepane-1-carboxamide
-
4-[(3R)-3-[(2-oxo-2-phenylethyl)amino]butyl]benzamide
-
4-[(3R)-3-[[2-(2-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide
-
4-[(3R)-3-[[2-(3,4-difluorophenyl)-2-oxoethyl]amino]butyl]benzamide
-
4-[(3R)-3-[[2-(4-chlorophenyl)-2-oxoethyl]amino]butyl]benzamide
-
4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide
4-[(3R)-3-[[2-oxo-2-(3-thienyl)ethyl]amino]butyl]benzamide
-
4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]morpholine
-
-
4-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]benzoic acid
-
4-[2-(methylsulfanyl)ethyl]-2-phenoxy-1,3,2-oxazaphospholidine 2-sulfide
-
4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]benzene-1,2-dicarbonitrile
-
-
4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
-
4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
-
-
4-[[(2R)-2-[[2-oxo-2-(3-thienyl)ethyl]amino]propyl]oxy]benzamide
-
4-[[(2R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-2-yl]methoxy]-3-(1-methylethyl)benzoic acid
-
-
4-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]benzonitrile
-
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-diethylbenzonitrile
-
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-dimethylbenzonitrile
-
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2-methylbenzonitrile
-
4-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]benzonitrile
-
4-[[2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-4-oxo-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl]methyl]naphthalene-1-carbonitrile
-
-
5,6-dichloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-4H-1,2,4-triazole-3-carboxamide
-
-
5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-4H-1,2,4-triazole-3-carboxamide
-
-
5-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)-1,2,4-triazolidin-3-one
-
5-(aminomethyl)-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine
-
-
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine
-
-
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine
-
-
5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine
-
-
5-(aminomethyl)-6-(2,4-dichlrophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine
base compound for inhibitor design, form hydrogen bonds with residues Arg125, Glu205, Glu206, Tyr547, Ser630, Tyr662 and His740
5-(aminomethyl)-6-(4-chlorophenyl)-2-phenylpyrimidin-4-amine
-
-
5-(aminomethyl)-6-[2-chloro-4-(trifluoromethyl)phenyl]-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine
proposed inhibitor, displays three hydrogen bonds with Ser209, two with Glu205 and His740 each, and one with each of the amino acids Arg358 and Tyr662. Compounds is predicted to have good oral absorption and bioavailability
5-([2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]amino)tricyclo[3.3.1.13,7]decane-1,3-diol
-
-
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-2-carboxylic acid
-
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-3-carboxylic acid
-
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)tetrahydrofuran-2-carboxylic acid
-
5-bromo-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
5-chloro-2-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
-
5-chloro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
5-chloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
5-chloro-6-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)nicotinic acid
-
5-fluoro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
5-fluoro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
5-methoxy-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
5-methyl-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
-
-
5-nitro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
-
5-tert-butyl-3-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-(4S)-4-fluoro-L-prolyl]-1,2,4-oxadiazole
-
-
5-tert-butyl-3-[N-(2-hydroxy-1,1-dimethylethyl)glycyl-L-prolyl]-1,2,4-oxadiazole
-
-
5-tert-butyl-3-[N-tert-butylglycyl-(4S)-4-fluoro-L-prolyl]-1,2,4-oxadiazole
-
-
5-[1-amino-2-(3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
-
-
5-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
-
-
5-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]-2-fluorobenzonitrile
-
6-(aminomethyl)-1,3-dimethyl-7-(1-methylpiperazinium)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
compound exhibits low exposure, high clearance, high selectivity for dipeptidyl peptidase IV over dipeptidyleptidase DPP8
6-(aminomethyl)-1,3-dimethyl-7-(morpholin-4-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
compound exhibits excellent exposure, low clearance, high selectivity for dipeptidyl peptidase IV over dipeptidyleptidase DPP8
6-(aminomethyl)-5-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
-
6-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-3-carbonitrile
-
-
6-([(3S,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-3-yl]amino)pyridine-3-carbonitrile
-
IC50: 0.25 nmol/L
6-([2-((2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl)amino)ethyl]amino)pyridine-3-carbonitrile
-
IC50: 1.4 nmol/L
6-[(2-([2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]amino)ethyl)amino]pyridine-3-carbonitrile
-
IC50: 270 nmol/L
6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-N,N-diethylpyrimidin-4-amine
-
6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)(methyl)amino]pyridine-3-carbonitrile
-
-
6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile
-
-
6-[4-([2-[(2R,5S)-2,5-dicyanopyrrolidin-1-yl]-2-oxoethyl]amino)-4-methylpiperidin-1-yl]pyridine-3-carboxylic acid
-
6-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile
-
-
6-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]nicotinonitrile
-
6-[[2-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinonitrile
-
-
6-[[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinamide
-
-
6-[[4-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]nicotinonitrile
-
6-[[4-([2-[(2S,5R)-2-cyano-5-ethynylpyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]pyridine-3-carbonitrile
-
6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile
-
i.e. KR-62436, IC50: 0.00014 mM, selective competitive inhibitor, good lead compound for further development as a new anti-diabetic agent, almost completely inhibits DPP-IV mediated degradation of glucagon-like peptide-1
6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile
-
-
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
-
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile
-
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carboxamide
-
7-amino-6-(aminomethyl)-5-(2-bromo-5-fluorophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
compound exhibits good exposure, moderate clearance, high selctivity for dipeptidyl peptidase IV over dipeptidyleptidase DPP8
7-amino-6-(aminomethyl)-5-(2-fluoro-6-methoxyphenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
compound exhibits good exposure, moderate clearance, high selectivity for dipeptidyl peptidase IV over dipeptidyleptidase DPP8
7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione
-
-
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one
-
a competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one trifluoroacetate
-
-
7-[(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)amino]-N-[(3R)-1-[3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperidin-3-yl]heptanamide
fluorescent probe based on inhibitor alogliptin
7-[(2E)-but-2-en-1-yl]-8-(3,3-dimethylpiperazin-1-yl)-3-methyl-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione
-
-
7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-tert-butyl-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide
-
7-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2H-pyrimido[1,2-b]pyridazin-2-one
-
-
7-[(3R,4R)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
-
7-[(3R,4S)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
-
7-[(3R,4S)-3-amino-4-(3,4-dichlorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
-
7-[(3R,4S)-3-amino-4-(4-fluorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
-
7-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
-
-
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione
a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. Potential for once-daily treatment of type 2 diabetics
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-(naphthalen-1-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione
-
-
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3R)-3-aminopiperidin-1-yl]-1-[(1,3-benzothiazol-2-yl)methyl]-3-methyl-7-(3-methylbut-2-en-1-yl)-3,7-dihydro-1H-purine-2,6-dione
IC50 value with isoforms DPP-8 and DPP-9 is above 0.1 mM
8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione
-
-
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
-
linagliptin
ABT-341
-
-
Ala-Ala-Leu-Glu-Gln-Thr-Glu-Arg
-
inhibitory peptide from hydrolysate of Hypophthalmichthys molitrix muscle
Ala-cyanopyrrolidide
-
-
alogliptin
alpha-amino boronic acid analogues of pyrrolidides
-
-
-
alpha-amino boronic acid analogues of thiazolidides
-
-
-
ALS 2-0426
-
-
AMG-222
-
ALS-2-0426
ARI-2243
-
-
-
ASP-8497
-
(2S,4S)-4-fluoro-1-([[4-methyl-1-(methylsulfonyl)piperidin-4-yl]amino]acetyl)pyrrolidine-2-carbonitrile monofumarate, selective and competitive inhibitor of DPP-IV, ASP8497 is a DPP-IV inhibitor with long-acting antidiabetic effect that might be a potential agent for type 2 diabetes
ASP8497
benzyl 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carboxylate
-
benzyl 6-([5-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-(4S)-4-amino-5-oxopentanoyl]amino)hexanoate
-
-
benzyl [(5S)-5-amino-6-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-6-oxohexyl]carbamate
-
-
benzyloxycarbonyl-Pro-prolinal
-
-
Berberine
-
bestatin
-
-
BI 1356
bis(4-acetamidophenyl) 1-((S)-prolyl)pyrrolidine-2(R,S)-phosphonate
-
i.e. AB192
bis(4-acetamidophenyl) 1-(S)-prolylpyrrolidine-2(R,S)-phosphonate
-
AB-192, irreversible inhibitor
bis(4-[(ethoxycarbonyl)-methylaminocarbonyl]-phenyl) 1-((S)-prolyl)pyrrolidine-2-(R,S)-phosphonate
-
i.e. AB207
bis-(4-nitrophenylphosphate)
-
-
Bl-1356
-
ondero or linagliptin, competitive, reversible, and long-lasting inhibition
BMS-477118
-
saxagliptin, the proprietary name is Onglyza, covalently bound and reversible inhibitor
BMS-686117
-
-
cis-(2S)-1-([(2S)-5-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
cis-(2S)-1-([(2S)-5-ethylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
cis-(2S)-1-([(2S)-5-methylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
cis-(2S)-1-([(2S)-5-phenylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
cis-(2S)-1-([(2S)-5-prop-2-yn-1-ylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
cis-(2S)-1-([(2S)-5-propylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
Co2+
-
-
CR-14025
-
-
-
Cu2+
-
-
cyclohexylglycine thiazolidide
-
-
D-Val-L-boroPro
-
-
denagliptin
-
-
des-fluoro-sitagliptin
-
sitagliptin analogue, reversible inhibition
diaryl phosphonates
-
-
-
diisopropyl fluorophosphate
-
-
dipeptide-derived diphenyl phosphonate esters
-
mechanism-based inhibitors. Formation of a fairly weak initial complex, followed by a slow irreversible inactivation. Due to their stability and the irreversible nature of the inhibition, the diphenyl phosphonate ester promise to be useful tools in the continuing investigation of the physiological function of the dipeptidyl peptidase IV
-
Diprotin A
Diprotin B
-
-
diprotinin A
-
-
di{4-[(erythrocarbonyl)methylaminoacrbonyl]-phenyl} 1-((S)-prolyl)pyrrolidine-2(R,S)-phosphonate
irreversible
DP-893
-
reversible inhibition
E-3024
-
-
epsilon-(4-nitrobenzyloxycarbonyl)-L-Lys thiazolidide
-
-
ER-319711-15
-
-
ethyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate
-
ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylate
-
ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylate
-
ethyl 4-[3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanoyl]piperazine-1-carboxylate
-
-
ethyl 7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate
-
ethyl 7-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate
-
ethyl N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]glycinate
-
ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml
ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml
glypican-3
-
Simpson-Golabi-Behmel syndrome is an X-linked condition shown to be the result of deletions of the glypican-3 gene. Glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. Inhibition of CD26 reduces the rate of cell proliferation. A number of physical findings observed in SGBS patients may be a consequence of a direct interaction of GPC3 with CD26
-
GRC 8200
-
melogliptin
GRC8200
-
-
GSK-823093C
-
denagliptin
GW-1853
-
-
-
H-(S)-alaninyl-(R)-boro-proline
-
-
H-(S)-Glu-(R)-boro-alanine
-
-
H-(S)-glutaminyl-(R)-boro-alanine
-
-
H-(S)-glutamyl-(R)-boro-proline
-
-
H-(S)-valinyl-(R)-boro-alanine
-
-
H-(S)-valinyl-(R)-boro-proline
-
-
H-glycyl-(R)-boro-proline
-
-
human HIV-1 Gly3-Tat(1-9) peptide
-
amino acid sequence MDGVDPNIE, parabolic mixed type inhibition
-
human HIV-1 Ile3-Tat(1-9) peptide
-
amino acid sequence MDIVDPNIE, parabolic mixed type inhibition
-
human HIV-1 Lys2-Tat(1-9) peptide
-
amino acid sequence MKPVDPNIE, linear mixed type inhibition
-
human HIV-1 Tat protein
-
viral protein, inhibits the enzyme activity and cell proliferation
-
human HIV-1 Tat(1-9) peptide
-
amino acid sequence MDPVDPNIE, N-terminal peptide of the viral Tat protein, inhibits the enzyme activity and cell proliferation, parabolic mixed type inhibition
-
human HIV-1 Trp1-Tat(1-9) peptide
-
amino acid sequence WDPVDPNIE, parabolic mixed type inhibition
-
human HIV-1 Trp2-Tat(1-9) peptide
-
amino acid sequence MWPVDPNIE, linear mixed type inhibition
-
Ile cyanothiazolidide
-
-
Ile-Pro
-
competitive
Ile-Pro-Ile
i.e. diprotin A, inhibition mechanism, binds covalently to Ser630
Ile-pyridine
-
-
Ile-pyrrolidide
-
competitive
Ile-thiazolidide
interleukin-2 peptide Met-IL-2(1-12)
-
amino acid sequence MAPTSSSTKKTQL, linear mixed type inhibition
-
interleukin-2 peptide Met-TRp1-IL-2(1-8)
-
amino acid sequence MWPTSSSTK, competitive inhibition
-
IP-10.C8
-
-
-
isoleucine thiazolidide
-
-
isoleucyl-(2)-cyanopyrrolidine
-
-
isoleucyl-thiazolidine
-
-
K-579
-
reversibile and long-lasting inhibition
KRP-104
-
-
-
L-isoleucinepyrrolidine
-
IC50: 0.022 mM
L-Val-L-boroPro
-
-
LAF-237
-
vildagliptin, potent, selective DPP IV inhibitor, the proprietary name is Galvus, covalently bound and reversible inhibitor
LC-150444
-
reversible inhibition
LC15-0444
-
selective and competitive inhibitor of dipeptidyl peptidase IV, more than 80% inhibition of DPP IV activity from baseline is sustained for more than 24 h in all dose groups (200, 400 or 600 mg of LC15-0444 once daily for 10 days)
linagliptin
LY-2463665
-
reversible inhibition
Lys piperidide
-
-
Lys thiazolidide
-
-
Lys-Ala-Val-Gly-Glu-Pro-Pro-Leu-Phe
-
inhibitory peptide from hydrolysate of Hypophthalmichthys molitrix muscle, exhibits the dual inhibition against both DPP-IV and angiotensin-converting enzyme
Lys-pyrrolidide
-
-
Lys[benzyloxycarbonyl(NO2)]-thiazolidide
-
-
Lys[Z(NO2)]-pyrrolidide
Lys[Z(NO2)]-thiazolidide
-
the dipeptidyl peptidase IV inhibitor suppresses proliferation, enhances terminal differentiation and slightly decreases total neutral lipid production in sebocytes
MCB3937
-
-
Met-Trp-Pro
-
competitive inhibition
Met-Trp-Val
-
linear-mixed type inhibition
Met-Trp1-G-CSF(1-8) peptide
-
amino acid sequence MWPLGPASS, G-CSF is the granulocyte colony stimulating factor, linear mixed type inhibition
methyl (2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate
-
methyl (4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetate
-
methyl 4-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]benzenesulfinate
-
methyl 4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]benzoate
-
MK-0431
-
sitagliptin, potent, selective DPP IV inhibitor, the proprietary name is Januvia, reversible and long-lasting inhibition
Mn2+
-
-
MP-513
-
IDDBCP161883
N,N-diallyl-3-(bicyclo[3.2.0]hept-6-ylsulfonyl)-1H-1,2,4-triazole-1-carboxamide
-
-
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,1,1-trifluoromethanesulfonamide
-
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)methanesulfonamide
-
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)methanesulfonamide
-
N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-b-alanine
-
N-(4-nitrobenzyloxycarbonyl)-L-Ile thiazolidide
-
-
N-(H-Phe-Pro-)-O-(4-nitrobenzoyl)hydroxylamine hydrochloride
-
irreversible
N-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methyl)benzamide
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoro-N-methylmethanesulfonamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoromethanesulfonamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1-(trifluoromethyl)cyclopropanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2,2-trifluoroethanesulfonamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoro-N-methylpropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluorocyclopropanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoropropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-dimethylpropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-fluoro-2-methylpropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-3,3,3-trifluoropropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N,2,2-trimethylpropanamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-cyclopropyl-1,1,1-trifluoromethanesulfonamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-methylcyclopropanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclobutanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclopentanecarboxamide
-
-
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)methanesulfonamide
-
-
N-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]methyl)-3-[(4-methyl-1,3-thiazol-2-yl)sulfamoyl]benzamide
-
-
N-acetyl-(S)-valinyl-(R)-boro-proline
-
-
N-Ala-Pro-O-(4-nitrobenzoyl)hydroxylamine
-
-
N-isoleucyl-3-fluoro-pyrrolidine
reversible
N-terminal nonapeptide of HIV-1 Tat protein
-
wild-type is a strong inhibitor, mutant exchange variants Ile5 and Leu6 show highly reduced inhibitory activity, replacement of Asp2 with Gly or Lys lead to enhanced inhibitory potency compared to the wild-type peptide, study of structure-function relationship
-
N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]-3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanamide
-
-
N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
-
good enzyme inhibitory activity and excellent selectivity for isoform DPP4 over dipeptidyl peptidase family homologues DPP8 and DPP9. Compound shows efficacy similar to that of sitagliptin in the oral glucose tolerance test
N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
-
N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzenesulfonamide
-
N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-1-methylcyclohexanecarboxamide
-
-
N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-2,2-dimethylpropanamide
-
-
N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-N-methyl-5-oxoprolinamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-1,2,3-benzotriazole-5-carboxamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-benzimidazole-5-carboxamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2,3-dihydro-1-benzofuran-5-carboxamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-(4-cyanobenzyl)benzamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-isobutylbenzamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-methylbenzenesulfonamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzenesulfonamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]pyridine-2-carboxamide
-
-
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]thiophene-2-carboxamide
-
-
N-[3-[(2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]ethyl)amino]phenyl]methanesulfonamide
-
-
N-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]methyl]-1,3-thiazole-4-carboxamide
-
-
nateglinide
-
prevents the degradation of glucagon-like peptide-1 in a time and concentration-dependent manner
Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro
-
competitive
Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide
-
competitive
Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide
-
competitive
Ngamma-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-Arg-cyanopyrrolidine
-
-
NVP DPP 728
-
-
NVP DPP728
NVP-DPP728
P-[(3S)-3-amino-2-oxopyrrolidin-1-yl]phosphonic diamide
-
-
P32/P98
-
isoleucine thiazolidide DPPIV, reversible inhibition
peptides
-
diacylhydroxylamine derivatives of Xaa-Pro or Xaa-Ala peptides. Different oligopeptides with N-terminal Xaa-Pro-sequences
PF-00734200
-
potent, competitive DPP-IV inhibitor, complete inhibition of DPP-IV for over 24 h after treatment with one single dose of 300 mg PF-00734200
Phe-Pro-PSI[P(OEt)2]
-
diastereomeric mixture, competitive
phenylmethylsulfonyl fluoride
-
-
PHX 1149
-
-
PHX-1149
-
dutogliptin tartrate, reversible inhibition
PHX1149
Pro-Pro-[OPh-4 Cl]2
-
irreversible
PSN-9301
PSN9301
-
-
PT-630
-
-
pyrrolidine-carbonitrile derivatives
-
-
-
R-1438
-
aminomethylpyridine derivate
R-1579
-
carmegliptin, reversible inhibition
R1438
-
-
RO-0730699
-
-
S-40010
-
-
-
saxagliptin
sitagliptin
SK-0403
-
-
SrCl2
-
-
SSR-162369
SYR-322
-
2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrile monobenzoate, also called alogliptin or TAK-322, reversible inhibition
SYR322
-
-
TA-6666
-
-
-
TAK-100
-
-
threo-Ile thiazolidide
-
-
thromboxane A2 receptor peptide TXA2-R(1-9)
-
N-terminal MWP sequence motif MWPNGSSLG, potent competitive inhibitor, possibly functionally involved in antigen presentation by inhibiting T-cell expressed enzyme
-
trans-(2S)-1-([(2S)-5-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
trans-(2S)-1-([(2S)-5-ethylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
trans-(2S)-1-([(2S)-5-prop-2-yn-1-ylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
TRC-XXXX
-
-
-
Trp-Pro
-
linear mixed-type
Trp-pyrrolidide
-
competitive
Trp-thiazolidide
-
competitive
Trp2,Ile3-Tat(1-9) peptide
-
amino acid sequence MWIVDPNIE, competitive inhibition
-
TS-021
-
-
Val pyrrolidide
-
-
Val thiazolidide
-
-
Val-pyrrolidide
-
-
valine-pyrrolidine
-
vildagliptin
[(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]pyrrolidin-2-yl]boronic acid
-
-
[(2R,4R)-1-(L-arginyl)-4-hydroxypyrrolidin-2-yl]boronic acid
-
most potent inhibitor tested
[(2S)-1-([[2-(4-fluorophenyl)-1,1-dimethylethyl]amino]acetyl)pyrrolidin-2-yl](1,2,4-oxadiazol-3-yl)methanone
-
-
[(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidin-2-yl]methanol
-
-
[(2S)-1-[(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoyl]pyrrolidin-2-yl]methanol
-
-
[(2S)-1-[(tert-butylamino)acetyl]pyrrolidin-2-yl][5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]methanone
-
-
[(2S)-1-[[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]pyrrolidin-2-yl](5-methyl-1,2,4-oxadiazol-3-yl)methanone
-
-
[(2S)-1-[[(2-hydroxy-1,1-dimethylethyl)amino]acetyl]pyrrolidin-2-yl](5-methyl-1,3,4-oxadiazol-2-yl)methanone
-
-
[(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid
-
-
[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid
-
-
[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetic acid
-
[(R)-amino[(3S)-3-amino-2-oxoazepan-1-yl]phosphoryl]sulfamic acid
-
-
[(R)-amino[(3S)-3-amino-2-oxopiperidin-1-yl]phosphoryl]sulfamic acid
-
-
[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[2-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenyl]methanol
-
[3-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[3-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]acetic acid
-
[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Gln
-
activates
Glu
-
activates
glucose
-
increases enzyme expression in glucose-treated glomerular endothelial cells, glucose effect on the enzyme is probably responsible for the reduction of glucagon-like peptide-1 in type II diabetic patients
Gly-X dipeptides
-
enhance activity
glycine methylesters
-
activates
Phospholipid
-
activates
Ser
-
activates
additional information
-
CCL11 application leads to an up-regulation of DPPIV, which is not associated with negative feedback inhibition via DPPIV-cleaved CCL11(3-74)
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.82 - 1
Ala-Ala-2-naphthylamide
2.74
Ala-Ala-4-nitroanilide
-
pH 7.6, 30°C, recombinant soluble enzyme
0.013 - 0.022
Ala-Pro-7-amido-4-methylcoumarin
0.0148 - 0.0172
Ala-Pro-7-amido-4-trifluoromethyl coumarin
0.013 - 0.015
Ala-Pro-7-amido-4-trifluoromethylcoumarin
0.014
BRI peptide (1-23)
-
in 40 mM HEPES-buffer, pH 7.4, at 37°C
-
0.102
Gly-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.66
Gly-Pro-2-naphthylamide
-
-
0.17
Gly-Pro-3,5-dibromo-4-hydroxyanilide
-
-
0.018
Gly-Pro-4-methoxy-2-naphthylamide
-
-
0.131 - 44.08
Gly-Pro-4-nitroanilide
0.063
Gly-Pro-7-amido-4-methylcoumarin
0.159
Gly-Pro-glycinamide
-
-
0.05 - 0.09
Gly-Pro-p-nitroanilide
0.099 - 0.432
L-Ala-L-Pro-p-nitroanilide
0.014
L-Arg-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.337
L-Asn-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.524
L-Asp-L-Pro-6-aminoquinolide
-
purified CD26
1.244
L-Glu-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.014 - 0.127
L-Leu-L-Pro-p-nitroanilide
0.008 - 0.073
L-Lys-L-Pro-p-nitroanilide
0.018
L-Met-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.189
L-Ser-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
0.025
L-Val-L-Pro-6-aminoquinolide
-
purified CD26
0.03
L-Val-L-Pro-doxorubicin
-
purified CD26
0.056
L-Val-L-Pro-L-Val-L-Pro-Ara-A
-
purified CD26
0.016
Lys-Pro-4-methoxy-2-naphthylamide
-
-
0.035
Lys-Pro-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.125
N-tosyl-Gly-L-Pro-7-amido-4-methylcoumarin
-
-
0.034
norleucine-Pro-7-amido-4-methylcoumarin
-
pH 7.5, 37°C
0.035
norleucine-Pro-rhodamine
-
pH 7.5, 37°C
0.02
Phe-Ala-Pro-2-naphthylamide
-
-
0.019
Phe-Pro-2-naphthylamide
-
-
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3 - 42
Ala-Pro-7-amido-4-methylcoumarin
37.3 - 43.1
Ala-Pro-7-amido-4-trifluoromethyl coumarin
9 - 19
Ala-Pro-7-amido-4-trifluoromethylcoumarin
5.2
BRI peptide (1-23)
-
in 40 mM HEPES-buffer, pH 7.4, at 37°C
-
20.3
Gly-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
810
Gly-Pro-3,5-dibromo-4-hydroxyanilide
-
-
10 - 279000
Gly-Pro-4-nitroanilide
0.05 - 87
Gly-Pro-p-nitroanilide
0.6 - 33
L-Ala-L-Pro-p-nitroanilide
7.7
L-Arg-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
11
L-Asn-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
7
L-Glu-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
1.9 - 6.3
L-Leu-L-Pro-p-nitroanilide
0.4 - 5
L-Lys-L-Pro-p-nitroanilide
8.7
L-Met-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
18
L-Ser-L-Pro-p-nitroanilide
-
wild type enzyme, in PBS, pH 8.0
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000008
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile
-
-
0.000001
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid
-
0.000003
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile
-
0.00128
(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)-N-phenylpyrrolidine-2-carboxamide
pH 7.5
0.00131
(2R,5S)-N-(4-bromophenyl)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidine-2-carboxamide
pH 7.5
0.0000027
(2S)-1-(((2S,5R)-5-[(1,3-benzodioxol-4-yloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000025
(2S)-1-(((2S,5R)-5-[(1-naphthyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000016
(2S)-1-(((2S,5R)-5-[(2,4-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000076
(2S)-1-(((2S,5R)-5-[(2,6-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000006
(2S)-1-(((2S,5R)-5-[(2-chloro-4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00000085
(2S)-1-(((2S,5R)-5-[(2-chlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000035
(2S)-1-(((2S,5R)-5-[(2-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000046
(2S)-1-(((2S,5R)-5-[(4-bromophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000044
(2S)-1-(((2S,5R)-5-[(4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000011
(2S)-1-(((2S,5R)-5-[(4-methoxyphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000072
(2S)-1-(((2S,5R)-5-[(4-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00003
(2S)-1-(((2S,5R)-5-[(benzyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000068
(2S)-1-([(2S,5R)-5-(([2-chloro-5-(dihydroxymethyl)pyridin-3-yl]oxy)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000044
(2S)-1-([(2S,5R)-5-(([dihydroxy(phenyl)-'4-sulfanyl]amino)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000012
(2S)-1-([(2S,5R)-5-(anilinomethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00161
(2S)-1-([(2S,5R)-5-(morpholin-4-ylmethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000068
(2S)-1-([(2S,5R)-5-(phenoxymethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00000072
(2S)-1-([(2S,5R)-5-([(2-chloropyridin-3-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000089
(2S)-1-([(2S,5R)-5-([(4-bromophenyl)amino]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00000041
(2S)-1-([(2S,5R)-5-([(6-bromo-1,3-benzodioxol-5-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00000063
(2S)-1-([(2S,5R)-5-([2,4-dichloro-5-(dihydroxyamino)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00000068
(2S)-1-([(2S,5R)-5-([2-bromo-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000014
(2S)-1-([(2S,5R)-5-([2-chloro-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000004
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile
-
0.00000003
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
0.000001
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
0.000002
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
0.00002
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
pH 7.5
0.0000022
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile
-
-
0.000011
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile
-
0.00001
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile
-
0.000399
(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide
-
-
0.000188
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide
-
-
0.000027
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide
-
-
0.000074
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide
-
-
0.000673
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide
-
-
0.000037
(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide
-
-
0.004422
(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide
-
-
0.000513
(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide
-
-
0.000023
(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide
-
-
0.000018
(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide
-
-
0.000507
(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide
-
-
0.00026
(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide
-
-
0.00014
(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide
-
-
0.001311
(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide
-
-
0.000003
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide
-
-
0.000182
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide
-
-
0.000212
(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide
-
-
0.00041
(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine
-
-
0.000096
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000008
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000097
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile
-
0.000024
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
0.0038
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile
-
0.000008
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000049
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile
-
0.00003
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
0.000079
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000022
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000959
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
0.000025
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000062
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
0.00009
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
0.000811
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile
-
0.0000023
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
0.0000012
(3R)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
0.0000061
(3R,4R)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.000011
(3R,4R)-1-(6-piperidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.0000023
(3R,4R)-1-(6-pyrrolidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.000013
(3R,4R)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.0000016
(3R,4R)-1-[6-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.000003
(3R,4R)-1-[6-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.000004
(3R,4R)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
0.00014
(3R,4R)-3-amino-N-phenyl-4-(2,4,5-trifluorophenyl)piperidine-1-carboxamide
-
0.0000021
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
-
-
0.0011
(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
0.0000023
(3S)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
-
0.000017
(4R,5R)-5-amino-1-(2-phenylethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.000024
(4R,5R)-5-amino-1-(2-pyridin-4-ylethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.00027
(4R,5R)-5-amino-1-(3-phenylpropyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.00059
(4R,5R)-5-amino-1-(morpholin-4-ylmethyl)-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.00044
(4R,5R)-5-amino-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.0014
(4R,5R)-5-amino-1-benzyl-4-(2-chlorophenyl)piperidin-2-one
-
0.0000833
(4R,5R)-5-amino-1-[(2S)-2-phenylpropyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.0000071
(4R,5R)-5-amino-1-[2-(1,3-benzodioxol-5-yl)ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.000004
(4R,5R)-5-amino-1-[2-[3-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
0.000012
(4R,5R)-5-amino-1-[2-[4-(methylsulfonyl)phenyl]ethyl]-4-(2,4,5-trifluorophenyl)piperidin-2-one
-
0.00093
(4R,5R)-5-amino-4-(2-chlorophenyl)-1-(cyclohexylmethyl)piperidin-2-one
-
0.0016
(4R,5R)-5-amino-4-(2-chlorophenyl)-1-phenylpiperidin-2-one
-
0.000015
1-([(5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methyl)-3-phenylurea
-
0.000001
2-([8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]methyl)benzonitrile
-
-
0.000012
2-[[2-(3-aminopiperidin-1-yl)-5,6-dimethyl-4,7-dioxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-d]pyridazin-1-yl]methyl]benzonitrile
-
-
0.000002
2-[[2-(3-aminopiperidin-1-yl)-5-methyl-4,6-dioxo-5,6-dihydropyrrolo[3,4-d]imidazol-1(4H)-yl]methyl]benzonitrile
-
-
0.00000066
3-bromo-4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
pH 7.5
0.00000093
3-chloro-4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
pH 7.5
0.0000038
3-[2-[(4R,5R)-5-amino-2-oxo-4-(2,4,5-trifluorophenyl)piperidin-1-yl]ethyl]benzoic acid
-
0.000004
3-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]phenyl methanesulfonate
-
-
0.0000016
4-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)-3-methoxybenzoic acid
pH 7.5
0.000001
4-bromo-3-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
pH 7.5
0.00000082
4-chloro-3-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
pH 7.5
0.0000031
4-[[(2R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-2-yl]methoxy]-3-(1-methylethyl)benzoic acid
-
-
0.00001
5-chloro-2-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)benzoic acid
pH 7.5
0.00000045
5-chloro-6-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methoxy)nicotinic acid
pH 7.5
0.000012
6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-N,N-diethylpyrimidin-4-amine
-
0.000001
6-[4-([2-[(2R,5S)-2,5-dicyanopyrrolidin-1-yl]-2-oxoethyl]amino)-4-methylpiperidin-1-yl]pyridine-3-carboxylic acid
-
0.000004
6-[[4-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]nicotinonitrile
-
0.000005
6-[[4-([2-[(2S,5R)-2-cyano-5-ethynylpyrrolidin-1-yl]-2-oxoethyl]amino)cyclohexyl]oxy]pyridine-3-carbonitrile
-
0.000001
ABT-279
-
-
0.0000013
ABT-341
-
-
0.0000052
ASP8497
-
median inhibition concentration, in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% bovine serum albumin, at pH 7.3 and 25°C
0.000001
BI 1356
-
-
0.000001
Bl-1356
-
-
0.0000006
BMS-477118
-
-
0.000764
cis-(2S)-1-([(2S)-5-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000033
cis-(2S)-1-([(2S)-5-ethylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.0000083
cis-(2S)-1-([(2S)-5-methylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.00072
cis-(2S)-1-([(2S)-5-phenylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000021
cis-(2S)-1-([(2S)-5-prop-2-yn-1-ylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000317
cis-(2S)-1-([(2S)-5-propylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000044
cyclohexylglycine thiazolidide
-
pH 7.5, 37°
0.0035
Diprotin A
-
pH 7.5, 37°
0.000022
GSK-823093C
-
-
0.000000027
H-(S)-alaninyl-(R)-boro-proline
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.0000083
H-(S)-Glu-(R)-boro-alanine
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.000017
H-(S)-glutaminyl-(R)-boro-alanine
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.0000018
H-(S)-glutamyl-(R)-boro-proline
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.0000039
H-(S)-valinyl-(R)-boro-alanine
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.000000018
H-(S)-valinyl-(R)-boro-proline
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.0000004
H-glycyl-(R)-boro-proline
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.487
human HIV-1 Gly3-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
1.75
human HIV-1 Ile3-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.043
human HIV-1 Lys2-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.23 - 0.267
human HIV-1 Tat(1-9) peptide
-
0.15
human HIV-1 Trp1-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.002
human HIV-1 Trp2-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.000001
Ile cyanothiazolidide
-
pH 7.5, 37°
0.0292
Ile-Pro
-
-
0.0046
Ile-Pro-Ile
pH 7.8, 25°C, glycosylated recombinant soluble enzyme ectodomain
0.00055
Ile-pyrrolidide
-
-
0.00022
Ile-thiazolidide
-
-
0.269
interleukin-2 peptide Met-IL-2(1-12)
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.016
interleukin-2 peptide Met-TRp1-IL-2(1-8)
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.0000038
isoleucyl-(2)-cyanopyrrolidine
-
pH 7.6, 30°C, recombinant soluble enzyme
0.000085
isoleucyl-thiazolidine
-
pH 7.6, 30°C, recombinant soluble enzyme
0.00000018
L-Val-L-boroPro
-
-
0.000017
LAF-237
-
-
0.000007
LY-2463665
-
-
0.00067
Lys piperidide
-
pH 7.5, 37°
0.0002
Lys thiazolidide
-
pH 7.5, 37°
0.025
Met-Trp-Pro
-
pH 7.6, 30°C, recombinant, soluble enzyme
0.2
Met-Trp-Val
-
pH 7.6, 30°C, recombinant, soluble enzyme
0.012
Met-Trp1-G-CSF(1-8) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
0.000009
MK-0431
-
-
0.00002
N-([(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidin-2-yl]methyl)benzamide
pH 7.5
0.0000017
N-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]methyl)-3-[(4-methyl-1,3-thiazol-2-yl)sulfamoyl]benzamide
-
-
0.0033
N-acetyl-(S)-valinyl-(R)-boro-proline
-
in 0.1 M HEPES, 0.14 M NaCl, pH 8.0, at 25°C
0.000005
N-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]methyl]-1,3-thiazole-4-carboxamide
-
-
0.0247
Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro
-
-
0.00042
Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide
-
-
0.00014
Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide
-
-
0.000011
NVP DPP728
-
-
0.000006
NVP-DPP728
pH 7.8, 25°C, glycosylated recombinant soluble enzyme ectodomain
0.000126
P32/98
-
-
0.00008
P32/P98
-
-
0.136
Phe-Pro-PSI[P(OEt)2]
-
-
0.0000001
R-1438
-
-
0.0000006
saxagliptin
-
-
0.00022
threo-Ile thiazolidide
-
pH 7.5, 37°
0.005
thromboxane A2 receptor peptide TXA2-R(1-9)
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.000867
trans-(2S)-1-([(2S)-5-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000103
trans-(2S)-1-([(2S)-5-ethylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.000143
trans-(2S)-1-([(2S)-5-prop-2-yn-1-ylpyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
pH 7.5
0.185
Trp-Pro
-
-
0.0186
Trp-pyrrolidide
-
-
0.0079
Trp-thiazolidide
-
-
0.044
Trp2,Ile3-Tat(1-9) peptide
-
pH 7.6, 30°C, recombinant, soluble enzyme
-
0.00089
Val pyrrolidide
-
pH 7.5, 37°
0.00028
Val thiazolidide
-
pH 7.5, 37°
additional information
additional information
-
inhibition kinetics
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000013
(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00022
(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0013
(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
Homo sapiens
-
-
0.000107
(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
Homo sapiens
-
-
0.000253
(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
Homo sapiens
-
-
0.0000055
(1R)-2-([(3R,4R)-4-amino-1-[1-(4-ethynylphenyl)ethyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
Homo sapiens
-
0.0000038
(1R)-2-([(3R,4R)-4-amino-1-[2-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
Homo sapiens
-
0.000046
(1R)-2-([(3R,4R)-4-amino-1-[3-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
Homo sapiens
-
0.0000035
(1R)-2-[[(3R,4R)-4-amino-1-(3,4-dihydro-2H-chromen-4-yl)pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
Homo sapiens
-
0.000003
(1R)-2-[[(3R,4R)-4-amino-1-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
Homo sapiens
-
0.0000053
(1R,3S)-2-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)-3-fluorocyclopentanecarbonitrile
Homo sapiens
-
0.00032
(1R,4R,6S,10S)-6,10-dihydroxy-4-methyl-2-oxabicyclo[4.3.1]dec-7-ene-8-carboxylic acid
Homo sapiens
-
pH 8.0, 37°C
0.000048
(1S)-1-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethanaminium
Homo sapiens
0% human serum
0.000039 - 0.000073
(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine
0.00017
(1S)-1-cyclohexyl-2-(3-fluoropyrrolidin-1-yl)-2-oxoethanamine
Homo sapiens
-
pH 8.0, 37°C
0.00011
(1S)-1-cyclohexyl-2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethanamine
Homo sapiens
-
pH 8.0, 37°C
0.000021
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine
Homo sapiens
-
-
0.00000019
(1S,2S)-1-(4'-fluorobiphenyl-4-yl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(1H-tetrazol-1-yl)propan-2-amine
Homo sapiens
-
0.0000034
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
Homo sapiens
-
-
0.00000059
(2R)-1-(2,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.00000027 - 0.00027
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
0.00000093
(2R)-1-(2-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000098
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
Homo sapiens
-
-
0.00000098
(2R)-1-(2-methylphenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000002
(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.0000017
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000002
(2R)-1-(3-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000003
(2R)-1-(4-chlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.0000031
(2R)-1-(4-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000011
(2R)-1-(4-iodophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.0000015
(2R)-1-(4-nitrophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000033
(2R)-1-cyclohexyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.021
(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
Homo sapiens
-
pH 2
0.00144
(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.00035
(2R)-4-(2-benzoylpyrazolidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000071
(2R)-4-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00003
(2R)-4-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.0034
(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.000387
(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.0064
(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.0001
(2R)-4-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000003
(2R)-4-oxo-1-phenyl-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.00004
(2R)-4-oxo-1-pyridin-2-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000045
(2R)-4-oxo-1-pyridin-3-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000051
(2R)-4-oxo-1-pyridin-4-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.00000012
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-(3,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.0000022
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[2-(trifluoromethyl)phenyl]butan-2-amine
Homo sapiens
-
0.0000036
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[3-(trifluoromethyl)phenyl]butan-2-amine
Homo sapiens
-
0.0000078
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[4-(trifluoromethyl)phenyl]butan-2-amine
Homo sapiens
-
0.000068
(2R)-4-oxo-4-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000087
(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.000423
(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.00385
(2R)-4-oxo-4-pyrazolidin-1-yl-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000004
(2R)-4-oxo-4-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000005
(2R)-4-oxo-4-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00007
(2R)-4-oxo-4-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
competitive
0.00005
(2R)-4-oxo-4-[2-(phenylcarbonyl)tetrahydropyridazin-1(2H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
the inhibitor displays a greater than 1400fold selectivity over all the enzymes tested including DPP-8 and DPP-9
0.000059
(2R)-4-oxo-4-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000018
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00051
(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.00041
(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.000004
(2R)-4-oxo-4-[8-(1H-pyrazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
mixture of diastereomers at position 9
0.000019
(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000004
(2R)-4-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000007
(2R)-4-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000025
(2R)-4-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000011 - 0.000018
(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000274
(2R)-4-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000045
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.0005
(2R)-4-[2-[(4-methylphenyl)sulfonyl]pyrazolidin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00049
(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
Homo sapiens
-
0.0000058
(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.0031
(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.00035
(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.0015
(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.000405
(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
0.000002
(2R)-4-[8-(1H-imidazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
mixture of diastereomers at position 8
0.000004
(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00000018
(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000025
(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.0000043
(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.0044
(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
Homo sapiens
-
-
0.0006
(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.000046
(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
Homo sapiens
-
-
0.00011
(2R,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.0000016
(2R,3S)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N1,N1-dimethyl-4-oxobutane-1,3-diamine
Homo sapiens
-
0.00938
(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00005
(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00513
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000032
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.01059
(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00027
(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00099
(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00007
(2R,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000016
(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate
Homo sapiens
-
pH 7.8, temperature not specified in the publication
0.0003
(2R,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
IC50 above 0.0003 mM
0.0003
(2R,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
IC50 above 0.0003 mM
0.0003
(2R,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
IC50 above 0.0003 mM
0.000246
(2R,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000047
(2S)-1-(3-furyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.000027
(2S)-1-([(2S,4S)-4-[(2E)-but-2-en-1-yl]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.00000013
(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00001
(2S)-1-([(3R,4R)-4-amino-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.00001
(2S)-1-([(3R,4R)-4-amino-1-[4-(1-methyl-1H-pyrazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000032
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000067
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-pyrazol-5-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000054
(2S)-1-([(3R,4R)-4-amino-1-[4-(2H-1,2,3-triazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000053
(2S)-1-([(3R,4R)-4-amino-1-[4-(3-methyl-1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000085
(2S)-1-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
0.000071
(2S)-1-([[2-methyl-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000028
(2S)-1-cyclopentyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
0.003653
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine
Homo sapiens
-
-
0.003257
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
Homo sapiens
-
-
0.000356
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
Homo sapiens
-
-
0.000877
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
Homo sapiens
-
-
0.001065
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
Homo sapiens
-
-
0.000112
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
Homo sapiens
-
-
0.00000054 - 0.0014
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
0.00002
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
0.0098
(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
Homo sapiens
-
-
0.000047
(2S)-1-[(4R)-4-tricyclo[3.3.1.13,7]dec-2-yl-L-prolyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000984
(2S)-1-[(4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5,5-dimethyl-L-prolyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000011
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000008
(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000018
(2S)-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0187
(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000015
(2S)-1-[N-[3-(1,3-dihydro-2H-isoindol-2-yl)-1,1-dimethyl-3-oxopropyl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000015
(2S)-1-[N-[4-(1,3-dihydro-2H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000003
(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000013
(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000091
(2S)-1-[[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000089
(2S)-1-[[(2S,4R)-4-(2-ethyl-4-hydroxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000038
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000091
(2S)-1-[[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000053
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000022
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000049 - 0.0000071
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000039
(2S)-1-[[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000023
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethoxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000033
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000083
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000025
(2S)-1-[[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000038
(2S)-1-[[(2S,4R)-4-cyclohexylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.00006
(2S)-1-[[(2S,4R)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000017
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000083
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000004
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000063
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000043
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000049
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000056
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000048
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000035 - 0.000038
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.00004
(2S)-1-[[(2S,4S)-4-isobutylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.000017
(2S)-1-[[(2S,4S)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
37°C, pH 7.4
0.0000034 - 0.00005
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000056
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000013
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00002
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000013
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000065
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000062
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000051
(2S)-1-[[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000051
(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000033 - 0.0000036
(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
0.0000013
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000024
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyanobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000062
(2S)-1-[[(3R,4R)-4-amino-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
0.0000000095
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
Homo sapiens
-
0.00000000083
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
Homo sapiens
-
0.0000003
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethoxy)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
Homo sapiens
-
0.000000012
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
Homo sapiens
-
0.0000000003
(2S)-2-(4-[[([(4R)-3-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)-3-methylbutanoic acid
Homo sapiens
-
0.0000072
(2S)-2-[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.00000048
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
-
0.000000013
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.00000000048
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.0000000017
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.0000000018
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.000000012 - 0.000000081
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid
0.0000000016
(2S)-2-[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.0000000016
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.000000033
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-fluoro-2-methylphenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.0000000081
(2S)-2-[4-[([1-[(3S)-3-amino-4-(pentafluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.000000018
(2S)-2-[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
Homo sapiens
-
0.00000098
(2S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-amine
Homo sapiens
-
0.000731
(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
Homo sapiens
-
-
0.0011
(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.0018
(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
Homo sapiens
-
-
0.00011
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
Homo sapiens
-
-
0.0000014
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-amine
Homo sapiens
-
0.00000013
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[2'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
Homo sapiens
-
0.000000098
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-1,2,4-triazol-3-yl)biphenyl-4-yl]butan-2-amine
Homo sapiens
-
0.00000014
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-1-yl)biphenyl-4-yl]butan-2-amine
Homo sapiens
-
0.000000006
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-5-yl)biphenyl-4-yl]butan-2-amine
Homo sapiens
-
0.00000051
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
Homo sapiens
-
0.0000006
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)phenyl]butan-2-amine
Homo sapiens
-
0.00044 - 0.00347
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
0.00000011
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
Homo sapiens
-
0.00000015
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
Homo sapiens
-
0.00000013
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
Homo sapiens
-
0.00000039
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
Homo sapiens
-
0.00000078
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)-1-oxobutan-2-amine
Homo sapiens
-
0.000027 - 0.000097
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium
0.000074 - 0.00021
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium
0.000000069
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(1,3,4-oxadiazol-2-yl)biphenyl-4-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000011
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000042
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000036
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(methylthio)phenyl]-1-oxobutan-2-amine
Homo sapiens
-
0.000054
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxobutan-2-amine
Homo sapiens
-
0.00053
(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
Homo sapiens
-
-
0.000000037
(2S,3S)-3-(2',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000015
(2S,3S)-3-(2',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.000000085
(2S,3S)-3-(2'-chlorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000001
(2S,3S)-3-(2'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000042
(2S,3S)-3-(2,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.000002
(2S,3S)-3-(2-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000011
(2S,3S)-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000006
(2S,3S)-3-(3',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000024
(2S,3S)-3-(3',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000011
(2S,3S)-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000037
(2S,3S)-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000028
(2S,3S)-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000011
(2S,3S)-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000037
(2S,3S)-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.0000000091
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-pyrrolidin-1-ylbutan-2-amine
Homo sapiens
-
0.0000035
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-5-pyrrolidin-1-ylpentan-2-amine
Homo sapiens
-
0.000000065 - 0.000064
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.000064
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
Homo sapiens
-
0.00000025 - 0.000245
(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.00000048
(2S,3S)-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000028
(2S,3S)-3-(4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00046 - 0.00149
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
0.00033 - 0.00051
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
0.00016 - 0.0003
(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
0.000000013
(2S,3S)-3-amino-2-(2',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000056
(2S,3S)-3-amino-2-(2',5'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000021
(2S,3S)-3-amino-2-(3',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000043
(2S,3S)-3-amino-2-(3'-ethynylbiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.00000003
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.00000039
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-1-ol
Homo sapiens
-
0.00000011
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
Homo sapiens
-
0.0000000066
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid
Homo sapiens
-
0.000000068
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide
Homo sapiens
-
0.000000012
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.0000001
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(1-methylethyl)-4-oxobutanamide
Homo sapiens
-
0.000000093
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide
Homo sapiens
-
0.000000045
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide
Homo sapiens
-
0.000000037
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
Homo sapiens
-
0.00000052
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide
Homo sapiens
-
0.0000000091
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-(1,3-thiazolidin-3-yl)butanamide
Homo sapiens
-
0.00000055
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide
Homo sapiens
-
0.0000000074
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide
Homo sapiens
-
0.00000023
(2S,3S)-3-amino-4-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000029
(2S,3S)-3-amino-4-(3,3-difluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000027
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.0000088
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide
Homo sapiens
-
-
0.0000048
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide
Homo sapiens
-
-
0.000000017
(2S,3S)-3-amino-4-(3-fluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.0000001
(2S,3S)-3-amino-4-aziridin-1-yl-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
Homo sapiens
-
0.000000021
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-4-oxobutanamide
Homo sapiens
-
0.000000019
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-3-ylphenyl)butanamide
Homo sapiens
-
0.00000002
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-4-ylphenyl)butanamide
Homo sapiens
-
0.0000000022
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[3'-(2H-tetrazol-2-yl)biphenyl-4-yl]butanamide
Homo sapiens
-
0.000000059
(2S,3S)-3-amino-N,N-diethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
Homo sapiens
-
0.000000011
(2S,3S)-3-amino-N-(3,4-dihydro-2H-tetrazol-2-yl)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
Homo sapiens
-
0.000000071
(2S,3S)-3-amino-N-cyclopropyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
Homo sapiens
-
0.00000011
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
Homo sapiens
-
0.00000002
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
Homo sapiens
-
0.00000012
(2S,3S)-3-biphenyl-4-yl-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.00000014
(2S,3S)-3-[3'-(5-cyclopropyl-2,3-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
0.000615
(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
-
0.00004
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
-
0.000071
(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
Homo sapiens
-
-
0.0006
(2S,3S)-3-[4-(acetylamino)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
Homo sapiens
-
0.000022 - 0.000047
(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
0.000016 - 0.00004
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
0.000029 - 0.00019
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
0.00021
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
Homo sapiens
-
0.00015
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
Homo sapiens
-
0.00036 - 0.00128
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
0.00087
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-[(phenylsulfonyl)amino]phenyl]butan-2-aminium
Homo sapiens
-
0.000025
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)carbonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
Homo sapiens
-
0.00043
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)sulfonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
Homo sapiens
-
0.000012
(2S,3S)-4-(dimethylamino)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
Homo sapiens
-
0.000022 - 0.0002
(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
0.000028
(2S,3S)-4-(dimethylamino)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
Homo sapiens
-
0.000000044
(2S,3S)-4-azetidin-1-yl-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-amine
Homo sapiens
-
0.0000046
(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0000017
(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00373
(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000004 - 0.0000042
(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.000038
(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000061
(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00052
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-pyrido[2,1-a]isoquinoline-2,11b-diamine
Homo sapiens
-
pH 8.0, 37°C
0.0000005
(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0000012
(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00065
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000004 - 0.0000046
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
0.00037
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000019
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0002
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.00152
(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0055
(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.000016
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-ethyl-N,N-dimethylpyrrolidine-3-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.00001
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
0.000015
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.000042
(2S,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000006
(2S,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000006
(2S,4S)-1-((2S)-2-amino-3-methylpentanoyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000041
(2S,4S)-1-(N-1-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000031
(2S,4S)-1-(N-2-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000031
(2S,4S)-1-(N-cyclobutylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000033
(2S,4S)-1-(N-cyclooctylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000026
(2S,4S)-1-(N-cyclopentylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000033
(2S,4S)-1-(N-cyclopropylglycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000027
(2S,4S)-1-(N-[2-[(5-chloropyridin-2-yl)amino]ethyl]-glycyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000021
(2S,4S)-1-(O-benzyl-L-threonyl)-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000012
(2S,4S)-1-L-alloisoleucyl-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000011
(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000015
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000029
(2S,4S)-1-[N-(tert-butyl)glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000016
(2S,4S)-1-[N-[(2E)-1,1-dimethyl-3-phenylprop-2-en-1-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000088
(2S,4S)-1-[N-[1-(1-benzofuran-2-yl)-1-methylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000027
(2S,4S)-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000252
(2S,4S)-1-[N-[2-(diethylamino)-1,1-dimethylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000018
(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000066
(2S,4S)-1-[N-[4-(7-azabicyclo[2.2.1]hept-7-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00016
(2S,4S)-1-[N-[4-(azepan-1-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000049
(2S,4S)-1-[O-(tert-butyl)-L-threonyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000025
(2S,4S)-1-[[(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]-4-fluoropyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0003
(2S,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
IC50 above 0.0003 mM
0.0000006
(2S,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000078
(2S,4S)-4-fluoro-1-(N-isopropylglycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0001
(2S,4S)-4-fluoro-1-(N-methyl-L-isoleucyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
IC50 above 0.0001 mM
0.000032
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000024
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000039
(2S,4S)-4-fluoro-1-(N-[2-[(4-cyanobenzyl)amino]-1,1-dimethylethyl]glycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000011
(2S,4S)-4-fluoro-1-(N-[2-[(5-cyanopyridin-2-yl)-amino]ethyl]glycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000024
(2S,4S)-4-fluoro-1-(N-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000047
(2S,4S)-4-fluoro-1-(O-methyl-L-threonyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000027
(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000007
(2S,4S)-4-fluoro-1-L-valyl-pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000008
(2S,4S)-4-fluoro-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000022
(2S,4S)-4-fluoro-1-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000039
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00003
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00005
(2S,4S)-4-fluoro-1-[([4-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000022
(2S,4S)-4-fluoro-1-[N-(1-methyl-1-pyridin-2-ylethyl)glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000046
(2S,4S)-4-fluoro-1-[N-(2-hydroxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
potent and long-acting DPP-IV inhibitor and effective with single daily dosing
0.000013
(2S,4S)-4-fluoro-1-[N-(2-methoxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000031
(2S,4S)-4-fluoro-1-[N-(3-hydroxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000087
(2S,4S)-4-fluoro-1-[N-(3-isopropoxypropyl)glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000083
(2S,4S)-4-fluoro-1-[N-(3-methoxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000053
(2S,4S)-4-fluoro-1-[N-(5-hydroxy-2-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000086
(2S,4S)-4-fluoro-1-[N-[1-(2-furyl)-1-methylethyl]-glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000033
(2S,4S)-4-fluoro-1-[N-[1-(hydroxymethyl)cyclopentyl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000012
(2S,4S)-4-fluoro-1-[N-[1-methyl-1-(2-thienyl)-ethyl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000028
(2S,4S)-4-fluoro-1-[N-[2-(pyridin-2-ylamino)ethyl]-glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000093
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(4-methylpiperazin-1-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.00002
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000026
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(4-oxopiperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000027
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000012
(2S,4S)-4-fluoro-1-[[(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.0000017
(2S,4S)-4-fluoro-1-[[(3S)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
-
0.000011
(2S,4S,5S)-N-(cyanomethyl)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-N-ethyl-5-methylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.00006
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-prop-2-yn-1-ylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.0006
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-propylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.013
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000025
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-N,5-dimethylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000056
(2S,4S,5S)-N-(cyanomethyl)-N-cyclopropyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000024
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000024
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000017
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000016
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000041
(2S,4S,5S)-N-allyl-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
Homo sapiens
-
37°C, pH 7.4
0.000051
(2S,4S,5S)-N4-benzyl-N2-(cyanomethyl)-N2-ethyl-5-methylpyrrolidine-2,4-dicarboxamide
Homo sapiens
-
37°C, pH 7.4
0.000127
(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine
Homo sapiens
-
-
0.000338
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4R)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin)-2-yl]-methanone
Homo sapiens
-
0.0000129
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone
Homo sapiens
-
0.000032
(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
Homo sapiens
-
-
0.0000042 - 0.0000053
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.0000061
(3R)-3-amino-1-[(2S)-2-([[2-(trifluoromethyl)pyrimidin-4-yl]oxy]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.0000039
(3R)-3-amino-1-[(2S)-2-([[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.000015
(3R)-3-amino-1-[(2S)-2-([[6-(trifluoromethyl)pyridin-3-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.00001
(3R)-3-amino-1-[(2S)-2-[(cyclopropylmethoxy)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.0000054
(3R)-3-amino-1-[(2S)-2-[(pyrimidin-2-ylamino)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.0000063
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyridin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.0000071
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyrimidin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.00003
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Homo sapiens
-
-
0.000055
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
Homo sapiens
-
-
0.0000066
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000151
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000008
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000096
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000105
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-[2-(benzyloxy)ethyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000026
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000066
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000192
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.000009
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000207
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000115
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000116
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1-(2-oxopropyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.000085
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.00004
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.00012
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.00002
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000062
(3R,4R)-1-(1,3-benzothiazol-2-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000042
(3R,4R)-1-(1,3-benzothiazol-6-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000005
(3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000007
(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000008
(3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
pharmacokinetic properties
0.000079
(3R,4R)-1-(2-naphthoyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.0000012 - 0.000002
(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
0.00008
(3R,4R)-1-(3,4-difluorobenzyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000006
(3R,4R)-1-(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000006
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Homo sapiens
-
-
0.000006
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
pharmacokinetic properties
0.000014
(3R,4R)-1-(4-cyanopyridin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000008
(3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000047
(3R,4R)-1-(isoquinolin-3-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.0037
(3R,4R)-1-isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.00021
(3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000043
(3R,4R)-1-pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000013
(3R,4R)-1-pyrazino[2,3-b]pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000058
(3R,4R)-1-pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000144
(3R,4R)-1-pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000125
(3R,4R)-1-pyridin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.00013
(3R,4R)-1-pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000007
(3R,4R)-1-pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000054
(3R,4R)-1-quinolin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000012
(3R,4R)-1-quinoxalin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000086
(3R,4R)-1-[(5-chloro-1-benzofuran-2-yl)carbonyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000026
(3R,4R)-1-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
pharmacokinetic properties
0.000031
(3R,4R)-1-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000083
(3R,4R)-1-[1-methyl-1-(4-nitrophenyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000022
(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000005
(3R,4R)-1-[2-(trifluoromethyl)[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000016
(3R,4R)-1-[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000111
(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000009
(3R,4R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000067
(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000463
(3R,4R)-1-[5-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.00065
(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.0184
(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.026
(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0134
(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0052
(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.142
(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
Homo sapiens
-
-
0.0094
(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
Homo sapiens
-
-
0.0063
(3R,4R)-3-butyl-1-phenylpiperidin-4-amine
Homo sapiens
-
-
0.00049
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000027
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylmethyl)pyrrolidin-3-amine
Homo sapiens
-
0.000038
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-6-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000091
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-amine
Homo sapiens
-
0.00004
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzoyl]pyrrolidin-3-amine
Homo sapiens
-
0.000069
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-amine
Homo sapiens
-
0.00003
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzoyl]pyrrolidin-3-amine
Homo sapiens
-
0.00005
(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzyl]pyrrolidin-3-amine
Homo sapiens
-
0.00002 - 0.000021
(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000031
(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.0027
(3R,4S)-1-acetyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.0034
(3R,4S)-1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.0000021
(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.000261
(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000057
(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.00018
(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.00019
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.0029
(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
Homo sapiens
-
-
0.000051
(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000047
(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000014 - 0.00012
(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.000006 - 0.000017
(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
0.00047
(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000051
(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.00012
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.0023
(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
Homo sapiens
-
-
0.000037
(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.0000035
(3R,4S)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.0000017
(3R,4S)-1-[6-[3-(morpholin-4-ylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.0013
(3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000071
(3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
-
0.000009
(3R,4S)-1-[6-[3-fluoro-5-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
Homo sapiens
-
0.00019
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-fluorobenzyl)pyrrolidine-1-carboxamide
Homo sapiens
-
0.00022
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-methoxybenzyl)-N-methylpyrrolidine-1-carboxamide
Homo sapiens
-
0.00061
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethyl-N-methylpyrrolidine-1-carboxamide
Homo sapiens
-
0.00028
(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethylpyrrolidine-1-carboxamide
Homo sapiens
-
0.00014
(3R,4S)-4-(2,4-dichlorophenyl)-1-(6-phenylpyridin-2-yl)pyrrolidin-3-amine
Homo sapiens
-
0.0028
(3R,4S)-4-(2,4-dichlorophenyl)-1-phenylpyrrolidin-3-amine
Homo sapiens
-
0.00079
(3R,4S)-4-(2,4-dichlorophenyl)-1-pyridin-2-ylpyrrolidin-3-amine
Homo sapiens
-
0.00021
(3R,4S)-4-(2,4-dichlorophenyl)-1-pyrimidin-2-ylpyrrolidin-3-amine
Homo sapiens
-
0.013
(3R,4S)-4-(2,4-dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-amine
Homo sapiens
-
0.002
(3R,4S)-4-(2,4-dichlorophenyl)-1-[2-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
Homo sapiens
-
0.000076
(3R,4S)-4-(2,4-dichlorophenyl)-1-[4-(3-thienyl)pyrimidin-2-yl]pyrrolidin-3-amine
Homo sapiens
-
0.00043
(3R,4S)-4-(2,4-dichlorophenyl)-1-[5-(4-methoxyphenyl)pyrimidin-2-yl]pyrrolidin-3-amine
Homo sapiens
-
0.000015
(3R,4S)-4-(2,4-dichlorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
Homo sapiens
-
0.000035
(3R,4S)-4-(2-chloro-4,5-difluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
Homo sapiens
-
0.000034
(3R,4S)-4-(2-chloro-4-fluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
Homo sapiens
-
0.00079
(3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine
Homo sapiens
-
-
0.0000097
(3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000139
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.000126
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-(2-fluorobenzyl)-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000296
(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-ethyl-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000765 - 0.00105
(3R,S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Homo sapiens
-
absolute configuration of 3-methyl group not determined
0.000017
(3S)-1-oxo-5-phenyl-1-(1,3-thiazolidin-3-yl)pentan-3-amine
Homo sapiens
-
0.00046 - 0.00048
(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
0.0088
(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one
Homo sapiens
-
-
0.000142
(3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6,6-trimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0023
(3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0033
(3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine
Homo sapiens
-
-
0.0049
(3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0947
(3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
Homo sapiens
-
-
0.015
(3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0058
(3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
Homo sapiens
-
-
0.0357
(3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine
Homo sapiens
-
-
0.0186 - 0.0452
(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
0.0015
(3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
Homo sapiens
-
-
0.0021
(3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
Homo sapiens
-
-
0.0028
(3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
Homo sapiens
-
-
0.000082
(3S,4S)-1-pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000063
(3S,4S)-1-pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.00009
(3S,4S)-1-pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000037
(3S,4S)-1-pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
Homo sapiens
-
-
0.000004
(3S,4S)-5-(dimethylamino)-2-[(3S)-3-fluoropyrrolidin-1-yl]-5-oxo-4-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)pent-1-en-3-aminium
Homo sapiens
-
0.000006
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000018
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000049
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000044
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000035
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000057
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000077
(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
Homo sapiens
-
-
0.002587
(3S,5S)-N-(2-phenylethyl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
Homo sapiens
-
-
0.0000551
(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000021
(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.000171
(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.001957
(3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
Homo sapiens
-
-
0.00019
(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
Homo sapiens
-
0.00413
(3S,5S)-N-phenyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
Homo sapiens
-
-
0.000033
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000603
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.000143
(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000097
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000373
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000246
(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000151
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000277
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2-fluorobenzyl)-7-methyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000343
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.00000149
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2-methylbenzyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.000011
(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one
Homo sapiens
-
-
0.000397
(3S,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
Homo sapiens
-
-
0.0000016
(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine
Homo sapiens
-
-
0.000000037
(4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid
Homo sapiens
-
0.00000016
(4-[[([(4R)-3-[(3R)-3-amino-4-phenylbutanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid
Homo sapiens
-
0.00024
(6-methylpyridin-2-yl)methyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate
Homo sapiens
-
0.0014
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
Homo sapiens
-
0.0037
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)amide
Homo sapiens
-
0.0016
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-morpholin-4-ylphenyl)amide
Homo sapiens
-
0.0091
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid (4-sulfamoyl phenyl)amide
Homo sapiens
-
0.0013
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-amino benzyl amide
Homo sapiens
-
0.0016
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonyl phenyl ester
Homo sapiens
-
0.0027
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl benzyl ester
Homo sapiens
-
0.0019
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-methoxycarbonyl methyl phenyl ester
Homo sapiens
-
0.0056
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid amide
Homo sapiens
-
0.0016
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl amide
Homo sapiens
-
0.00071
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester
Homo sapiens
-
0.0016
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl amide
Homo sapiens
-
0.0022
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid phenyl ester
Homo sapiens
-
0.0074
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(pyridin-2-ylmethyl)amide
Homo sapiens
-
0.0031
(R)-2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-4-sulfamoyl benzyl amide
Homo sapiens
-
0.00077
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino) benzoic acid ethyl ester
Homo sapiens
-
0.0089
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzenesulfonic acid
Homo sapiens
-
0.0059
(R)-4-([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)benzoic acid
Homo sapiens
-
0.0014
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid
Homo sapiens
-
0.003
(R)-4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]benzoic acid methyl ester
Homo sapiens
-
0.0085
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
Homo sapiens
-
0.0048
(R)-[2-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
Homo sapiens
-
0.0028
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
Homo sapiens
-
0.002
(R)-[3-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
Homo sapiens
-
0.0043
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
Homo sapiens
-
0.0019
(R)-[3-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
Homo sapiens
-
0.0025
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid
Homo sapiens
-
0.0021
(R)-[4-[([2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino)methyl]phenoxy]acetic acid ethyl ester
Homo sapiens
-
0.0022
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid
Homo sapiens
-
0.0036
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(R)-isopropyl acetic acid ethyl ester
Homo sapiens
-
0.0027
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid
Homo sapiens
-
0.0026
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]-(S )-isopropyl acetic acid ethyl ester
Homo sapiens
-
0.00051
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid
Homo sapiens
-
0.00069
(R)-[4-[[2-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl]amino]phenoxy]acetic acid ethyl ester
Homo sapiens
-
0.0001656
(S)-1-(2-(2-(2-oxo-3-(3,4,5-trimethoxyphenyl)imidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000293
(S)-1-(2-(2-(2-oxo-3-p-tolylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000348
(S)-1-(2-(2-(2-oxo-3-phenylimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0001336
(S)-1-(2-(2-(3-(2-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.000002
(S)-1-(2-(2-(3-(3,4-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000204
(S)-1-(2-(2-(3-(3,5-dimethoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000601
(S)-1-(2-(2-(3-(3-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000651
(S)-1-(2-(2-(3-(3-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000258
(S)-1-(2-(2-(3-(4-chlorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000445
(S)-1-(2-(2-(3-(4-fluorophenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000824
(S)-1-(2-(2-(3-(4-methoxyphenyl)-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000535
(S)-1-(2-(2-(3-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000686
(S)-1-(2-(2-(3-cyclohexyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000478
(S)-1-(2-(2-(3-isopropyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.0000681
(S)-1-(2-(2-(3-tert-butyl-2-oxoimidazolidin-1-yl)ethylamino)acetyl)pyrrolidine-2-carbonitrile
Homo sapiens
-
in 25 mM HEPES,140 mM NaCl, 1% bovine serum albumin, 80 mM MgCl2, at 25°C
0.001
1-(1-methyl-6-phenyl-1H-benzimidazol-7-yl)methanamine
Homo sapiens
-
0.0000041
1-(2-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.00023
1-(2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
Homo sapiens
-
-
0.0000042
1-(3,4-dichlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0313
1-(3,4-dimethoxyphenyl)-3-(3,4-dimethylphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0256
1-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0006
1-(3,4-dimethoxyphenyl)-3-(3-methylphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0148
1-(3,4-dimethoxyphenyl)-3-(4-methylphenyl)piperidin-4-amine
Homo sapiens
-
-
0.0089
1-(3,4-dimethoxyphenyl)-3-pyridin-2-ylpiperidin-4-amine
Homo sapiens
-
-
0.0003
1-(3-benzyl-4-oxido-3H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-aminium
Homo sapiens
-
-
0.0000087
1-(3-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.000014
1-(3-methyl-1,2,4-thiadiazol-5-yl)-4-[[(2S,3S,5S)-2-methyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]piperazine
Homo sapiens
-
-
0.000019
1-(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
Homo sapiens
-
-
0.0000108
1-(4-bromophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000122
1-(4-chlorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000762
1-(4-cyanophenyl)-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea
Homo sapiens
-
0.000001
1-(4-ethynylpyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000135
1-(4-fluorophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000109
1-(4-methoxyphenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000029
1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,4-diazepane
Homo sapiens
-
-
0.0000082
1-(4-nitrophenyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.000016
1-(4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)ethanone
Homo sapiens
-
-
0.0000025
1-(5-chloropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.00000092
1-(5-nitropyridin-2-yl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.00071
1-(6-chloro-2-isobutyl-4-phenyl-3,4-dihydroquinolin-3-yl)methanamine
Homo sapiens
-
pH 8.0, 37°C
0.000021
1-(diphenylmethyl)-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000305
1-benzyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.00046
1-cyclohexyl-2-oxo-2-(1,3-thiazolidin-3-yl)ethanaminium 2,2,2-trifluoro-1-oxoethanide
Homo sapiens
-
0.0000575
1-methyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.000151
1-phenyl-3-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]urea
Homo sapiens
-
0.0000109
1-phenyl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000027
1-pyridin-2-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.0000031
1-pyridin-4-yl-4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazine
Homo sapiens
-
-
0.00101
1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4,4-dimethyl-1-oxopentan-2-amine
Homo sapiens
-
-
0.00012
1-[(2S)-2-amino-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butyl]piperidin-2-one
Homo sapiens
-
-
0.0019
1-[(3R)-3-amino-4-phenylbutanoyl]-N-[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]benzyl]-L-prolinamide
Homo sapiens
-
-
0.0000034
1-[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]indane-5-carbonitrile
Homo sapiens
-
0.0000052
1-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
0.00000054
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-benzyl-L-prolinamide
Homo sapiens
-
0.0000016
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(1H-1,2,3-triazol-4-yl)butyl]-L-prolinamide
Homo sapiens
-
0.000000039
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2,3-dihydro-1H-tetrazol-5-yl)butyl]-L-prolinamide
Homo sapiens
-
0.00000072
1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-N-[4-(trifluoromethyl)benzyl]-L-prolinamide
Homo sapiens
-
0.000024
1-[(3S,4S)-4-amino-1-[4-(3,3-difluoropyrrolidin-1-yl)-1,3,5-triazin-2-yl]pyrrolidin-3-yl]-4,4-difluoropiperidin-2-one
Homo sapiens
-
-
0.0000998
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-1,2,3,4-tetrahydroquinoline
Homo sapiens
-
0.0000072
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]piperazine
Homo sapiens
-
-
0.0000015
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[4-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
-
0.0000015
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
Homo sapiens
-
-
0.0000476
1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
Homo sapiens
-
-
0.000009
1-[1-(2-chlorobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000011 - 0.00045
1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium
0.000002
1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
potent and selective DPPIV inhibitor, but it showed a significant loss of activity in the presence of plasma
0.00026
1-[1-(2-cyanobenzyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000005
1-[1-(2-cyanobenzyl)-6-methyl-7-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.0012
1-[1-(3-cyanobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000102
1-[1-benzyl-6-(2-chlorophenyl)-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000098
1-[1-methyl-6-(2-methylphenyl)-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000011
1-[1-[3-(cyanomethyl)benzyl]-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000527
1-[3-[2-[2-cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-1-oxopropyl]-4-[benzothiazol-2-yl]piperazine
Homo sapiens
-
-
0.000025
1-[4,9-dioxo-1-[2-(trifluoromethyl)benzyl]-4,9-dihydro-1H-naphtho[2,3-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000029
1-[5-benzyl-1-(3-cyanobenzyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.00005
1-[5-bromo-6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000022
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethoxy)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.00001
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethyl)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000066
1-[6-(2,4-dichlorophenyl)-1-ethyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000062
1-[6-(2,4-dichlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.00063
1-[6-(2,4-dichlorophenyl)-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.00079
1-[6-(2,4-difluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.00032
1-[6-(2-chloro-5-fluorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.00016
1-[6-(2-chlorophenyl)-1,2-dimethyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000061
1-[6-(2-chlorophenyl)-1-methyl-1H-1,2,3-benzotriazol-7-yl]methanamine
Homo sapiens
-
0.000063
1-[6-(2-chlorophenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000011
1-[6-(2-chlorophenyl)-1-methyl-2-pyridin-3-yl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000097
1-[6-(2-chlorophenyl)-2-ethyl-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000066
1-[6-(2-chlorophenyl)-2-methoxy-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.002
1-[6-(2-methoxyphenyl)-1-methyl-1H-benzimidazol-7-yl]methanamine
Homo sapiens
-
0.000002
1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000057
1-[7-fluoro-6-methoxy-1-[2-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]piperidin-3-aminium
Homo sapiens
-
-
0.000012
1-[amino(cyclohexyl)acetyl]pyrrolidine-2-carbonitrile
Homo sapiens
-
pH 8.0, 37°C
0.000012 - 0.000014
1-[[(8R)-7-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazin-8-yl]methyl]cyclopropanol
0.000109
2,2-bis(4-chlorophenyl)-N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]acetamide
Homo sapiens
-
-
0.00032
2-(2-[4-(4-chloro-phenyl)-piperazin-1-yl]-2-oxoethylsulfanyl)-4-hydroxy-6-phenyl-pyrimidine-5-carbonitrile
Homo sapiens
-
pH not specified in the publication, 37°C
0.000582
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-4-cyano-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
Homo sapiens
-
-
0.000107
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
Homo sapiens
-
-
0.003059
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-methyl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
Homo sapiens
-
-
0.000099
2-(3-aminopiperidin-1-yl)-1-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-1H-imidazole-5-carboxamide
Homo sapiens
-
-
0.000014
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000026
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(2-oxo-2-phenylethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000089
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
Homo sapiens
-
-
0.000013
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000025
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11R)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000003
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(11S)-10,11-dihydrodibenzo[b,f][1,4]oxazepin-11-ylmethyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000021
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one
Homo sapiens
-
-
0.000005
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000001
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000004
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-5-[(6-methyl-1,3-benzoxazol-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000052
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-(naphthalen-1-ylmethyl)-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000019
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methoxy-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000007
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(3-methylisoquinolin-1-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000001
2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-7-methyl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000559
2-(3-aminopiperidin-1-yl)-4-bromo-1-but-2-yn-1-yl-N-(naphthalen-1-ylmethyl)-1H-imidazole-5-carboxamide
Homo sapiens
-
-
0.0000073
2-(3-but-2-yn-1-yl-4-oxo-2-piperazin-1-yl-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl)benzonitrile
Homo sapiens
-
-
0.000025
2-(4-[(3R,5S)-5-[(3,3,4,4-tetrafluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
Homo sapiens
-
0.000134
2-(4-[(3R,5S)-5-[(3,3-difluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
Homo sapiens
-
0.0000058 - 0.0000082
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)-1,3-benzoxazole
0.0000056
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrazine
Homo sapiens
-
0.0000048
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyridine-3-carbonitrile
Homo sapiens
-
0.0000087
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
Homo sapiens
-
0.0000052
2-(4-[(3R,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)[1,3]oxazolo[5,4-b]pyridine
Homo sapiens
-
0.000041
2-(4-[(3R,5S)-5-[(3-fluoroazetidin-1-yl)carbonyl]pyrrolidin-3-yl]piperazin-1-yl)pyrimidine
Homo sapiens
-
0.0000023
2-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-4-carbonitrile
Homo sapiens
-
-
0.000129
2-([(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl]carbonyl)isoindoline
Homo sapiens
-
-
0.00025
2-([2-(4-aminopiperidin-1-yl)-2-oxoethyl]sulfanyl)-4-hydroxy-6-phenylpyrimidine-5-carbonitrile
Homo sapiens
-
pH not specified in the publication, 37°C
0.000005
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
Homo sapiens
-
-
0.000004 - 0.000005
2-([2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxoquinazolin-3(4H)-yl]methyl)benzonitrile
0.000007
2-([6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl)benzonitrile
Homo sapiens
-
-
0.0000362
2-([8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl]methyl)benzonitrile
Homo sapiens
pH not specified in the publication, 37°C
0.0065
2-ethoxy-4-[2-(methylsulfanyl)ethyl]-1,3,2-oxazaphospholidine 2-sulfide
Homo sapiens
-
0.000001
2-[(2-aminoethyl)(methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.0000025
2-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
Homo sapiens
-
0.0000056
2-[(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-methylpyrrolidin-3-yl]-N,N-dimethylacetamide
Homo sapiens
-
37°C, pH 7.4
0.00099
2-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenylpyrazolidine-1-carboxamide
Homo sapiens
-
-
0.000005
2-[(3R)-3-aminopiperidin-1-yl]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.000014
2-[(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
Homo sapiens
-
-
0.0000045
2-[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylacetamide
Homo sapiens
-
-
0.0000195 - 0.000039
2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
0.0000165
2-[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetamide
Homo sapiens
-
0.0000022
2-[(7-but-2-yn-1-yl-2-methoxy-6-oxo-8-piperazin-1-yl-6,7-dihydro-1H-purin-1-yl)methyl]benzonitrile
Homo sapiens
-
-
0.0000032
2-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile
Homo sapiens
-
-
0.011
2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]-N-[3-[(methylsulfonyl)amino]phenyl]acetamide
Homo sapiens
-
-
0.000309
2-[4-[(3R,5S)-5-(azetidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.000031
2-[4-[(3R,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.000051
2-[4-[(3R,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.000309
2-[4-[(3R,5S)-5-[[(3R,4R)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.000013
2-[4-[(3R,5S)-5-[[(3R,4S)-3,4-difluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.000031
2-[4-[(3R,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]piperazin-1-yl]pyrimidine
Homo sapiens
-
0.0000012
2-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile
Homo sapiens
-
-
0.000093
2-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
Homo sapiens
-
-
0.004
2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]benzamide
Homo sapiens
-
0.0016
2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenol
Homo sapiens
-
0.000096
2-[7-(aminomethyl)-6-(2-chlorophenyl)-1H-benzimidazol-1-yl]ethanol
Homo sapiens
-
0.000002
2-[[(2S)-2-aminopropyl](methyl)amino]-3-but-2-yn-1-yl-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.0000033
2-[[(3S)-3-[[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]carbonyl]-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy]acetamide
Homo sapiens
-
-
0.000084
2-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.000073
2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]-5-(trifluoromethyl)isoindoline
Homo sapiens
-
-
0.000109
2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.000228
2-[[(3S,5S)-5-[[(3R)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.000245
2-[[(3S,5S)-5-[[(3S)-3-fluoropyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.000049
3-(1-amino-2-oxo-2-pyrrolidin-1-ylethyl)tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.000000003
3-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,2,4-oxadiazolidin-5-one
Homo sapiens
-
0.00025
3-(aminomethyl)-2-isobutyl-4-phenylisoquinolin-1(2H)-one
Homo sapiens
-
pH 8.0, 37°C
0.000007
3-(aminomethyl)-4-(2,4-dichlorophenyl)-7,8-dimethoxy-5H-indeno[1,2-b]pyridin-2-amine
Homo sapiens
-
-
0.00037
3-(aminomethyl)-4-(2,4-dichlorophenyl)quinolin-2-amine
Homo sapiens
-
pH 8.0, 37°C
0.000116
3-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide
Homo sapiens
-
-
0.000019
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methyl-N-(pyridin-2-yl)butanamide
Homo sapiens
-
-
0.000019 - 0.000027
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide
0.000029
3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-N-cyclopentyl-3-methylbutanamide
Homo sapiens
-
-
0.00005
3-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
Homo sapiens
-
0.000003
3-but-2-yn-1-yl-2-(1,4-diazepan-1-yl)-5-[(4-methylquinazolin-2-yl)methyl]-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.0001
3-but-2-yn-1-yl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one
Homo sapiens
-
-
0.0001 - 0.00013
3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate
0.0136
3-butyl-1-(5,6,7,8-tetrahydronaphthalen-1-yl)piperidin-4-amine
Homo sapiens
-
-
0.0035
3-butyl-1-(diphenylmethyl)piperidin-4-amine
Homo sapiens
-
-
0.0053
3-butyl-1-naphthalen-1-ylpiperidin-4-amine
Homo sapiens
-
-
0.0084
3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
Homo sapiens
-
-
0.0026
3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
Homo sapiens
-
-
0.00064
3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Homo sapiens
-
-
0.0000089
3-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
Homo sapiens
-
0.000538
3-[(2S)-pyrrolidin-2-ylcarbonyl]-1,3-thiazolidine
Homo sapiens
-
-
0.0000024
3-[(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]-N,N-dimethylpropanamide
Homo sapiens
-
-
0.00142
3-[1-amino-2-(2H-isoindol-2-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.003311
3-[1-amino-2-(4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.000028
3-[1-amino-2-oxo-2-(1,3-thiazolidin-3-yl)ethyl]tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.001944
3-[1-amino-2-[(1R,5S)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.0000029 - 0.000607
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]-5,7-dimethyltricyclo[3.3.1.13,7]decan-1-ol
0.00001
3-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decan-1-ol
Homo sapiens
-
-
0.000007
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]-N,N-dimethylbenzamide
Homo sapiens
-
0.0000018 - 0.000005
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
0.000037
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
Homo sapiens
-
-
0.00007
3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenol
Homo sapiens
-
-
0.0014
3-[6-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
Homo sapiens
-
-
0.000032
4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
Homo sapiens
-
-
0.0000001 - 0.0001
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide
0.000000056
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylic acid
Homo sapiens
-
0.00000014
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-sulfonamide
Homo sapiens
-
0.00000037
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylic acid
Homo sapiens
-
0.0000093
4,4'-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]imino]dimethanediyl)dibenzonitrile
Homo sapiens
-
0.00000011
4-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,3-dihydro-2H-imidazol-2-one
Homo sapiens
-
0.0000033
4-(4-nitrophenyl)-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
Homo sapiens
-
-
0.0000125
4-([(1-methylethyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
Homo sapiens
-
0.000005
4-([1-[(2-oxo-2-thiophen-3-ylethyl)amino]cyclopentyl]methoxy)benzamide
Homo sapiens
-
-
0.000067
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzamide
Homo sapiens
-
0.00026
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzenesulfonamide
Homo sapiens
-
0.000223
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)benzoic acid
Homo sapiens
-
0.00015
4-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]sulfonyl)benzoic acid
Homo sapiens
-
0.000005
4-([butyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
Homo sapiens
-
0.0000136
4-([methyl[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
Homo sapiens
-
0.0000343
4-([[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]methyl)benzonitrile
Homo sapiens
-
0.000168
4-cyano-N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
Homo sapiens
-
0.0000341
4-cyano-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
Homo sapiens
-
0.00021 - 0.214
4-nitrobenzyl[(5S)-5-amino-6-oxo-6-(1-pyrrolidinyl)hexyl]carbamate
0.0000096
4-phenyl-1-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperidine
Homo sapiens
-
-
0.000005
4-[(1-[[2-oxo-2-(3-thienyl)ethyl]amino]cyclopentyl)methoxy]benzamide
Homo sapiens
-
0.0000147
4-[(2R)-2-amino-4-oxo-4-(1,3-thiazolidin-3-yl)butyl]benzonitrile
Homo sapiens
-
0.003007
4-[(2S)-2-amino-3-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-oxopropyl]phenol
Homo sapiens
-
-
0.00005
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-(4-methylphenyl)-1,4-diazepane-1-carboxamide
Homo sapiens
-
0.001392
4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-N-phenyl-1,4-diazepane-1-carboxamide
Homo sapiens
-
0.00028
4-[(3R)-3-[(2-oxo-2-phenylethyl)amino]butyl]benzamide
Homo sapiens
-
0.0038
4-[(3R)-3-[[2-(2-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide
Homo sapiens
-
0.000039
4-[(3R)-3-[[2-(3,4-difluorophenyl)-2-oxoethyl]amino]butyl]benzamide
Homo sapiens
-
0.00082
4-[(3R)-3-[[2-(4-chlorophenyl)-2-oxoethyl]amino]butyl]benzamide
Homo sapiens
-
0.000084
4-[(3R)-3-[[2-(4-fluorophenyl)-2-oxoethyl]amino]butyl]benzamide
0.00011
4-[(3R)-3-[[2-oxo-2-(3-thienyl)ethyl]amino]butyl]benzamide
Homo sapiens
-
0.0000139
4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]morpholine
Homo sapiens
-
-
0.0000042
4-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]benzoic acid
Homo sapiens
-
0.0435
4-[2-(methylsulfanyl)ethyl]-2-phenoxy-1,3,2-oxazaphospholidine 2-sulfide
Homo sapiens
-
0.0000018
4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]benzene-1,2-dicarbonitrile
Homo sapiens
-
-
0.000085
4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzoic acid
Homo sapiens
-
0.00013
4-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]benzonitrile
Homo sapiens
-
-
0.00034
4-[[(2R)-2-[[2-oxo-2-(3-thienyl)ethyl]amino]propyl]oxy]benzamide
Homo sapiens
-
0.000081
4-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]benzonitrile
Homo sapiens
-
0.0000047
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-diethylbenzonitrile
Homo sapiens
-
0.0000011
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2,6-dimethylbenzonitrile
Homo sapiens
-
0.0000013
4-[[(3R,4R)-3-amino-4-[[(2R)-2-cyanocyclopentyl]carbonyl]pyrrolidin-1-yl]methyl]-2-methylbenzonitrile
Homo sapiens
-
0.0000336
4-[[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]benzonitrile
Homo sapiens
-
0.000004
4-[[2-(3-aminopiperidin-1-yl)-3-but-2-yn-1-yl-4-oxo-3,4-dihydro-5H-imidazo[4,5-d]pyridazin-5-yl]methyl]naphthalene-1-carbonitrile
Homo sapiens
-
-
0.000144
5,6-dichloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.000024
5-(3-aminopiperidin-1-yl)-4-but-2-yn-1-yl-N-[(3-methylisoquinolin-1-yl)methyl]-4H-1,2,4-triazole-3-carboxamide
Homo sapiens
-
-
0.000000095
5-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)-1,2,4-triazolidin-3-one
Homo sapiens
-
0.01
5-(aminomethyl)-6-(1,3-benzodioxol-5-yl)-2-phenylpyrimidin-4-amine
Homo sapiens
-
-
0.0000001
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-(3,5-dimethoxyphenyl)pyrimidin-4-amine
Homo sapiens
-
-
0.000003
5-(aminomethyl)-6-(2,4-dichlorophenyl)-2-phenylpyrimidin-4-amine
Homo sapiens
-
-
0.000009
5-(aminomethyl)-6-(2,4-dichlorophenyl)-N2-(2-methoxyethyl)-N2-methylpyrimidine-2,4-diamine
0.003081
5-([2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]amino)tricyclo[3.3.1.13,7]decane-1,3-diol
Homo sapiens
-
-
0.00015
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-2-carboxylic acid
Homo sapiens
-
0.000067
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)pyridine-3-carboxylic acid
Homo sapiens
-
0.00026
5-([4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-1-yl]carbonyl)tetrahydrofuran-2-carboxylic acid
Homo sapiens
-
0.0000107
5-bromo-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
Homo sapiens
-
0.0000134
5-chloro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
Homo sapiens
-
0.00005
5-chloro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.0000101
5-fluoro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
Homo sapiens
-
0.000073
5-fluoro-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.0000061
5-methoxy-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
Homo sapiens
-
0.000072
5-methyl-2-[[(3S,5S)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-yl]carbonyl]isoindoline
Homo sapiens
-
-
0.0000103
5-nitro-2-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]isoindoline
Homo sapiens
-
0.00027
5-[1-amino-2-(3-azabicyclo[3.1.0]hex-3-yl)-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
Homo sapiens
-
-
0.000014
5-[1-amino-2-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl]tricyclo[3.3.1.13,7]decane-1,3-diol
Homo sapiens
-
-
0.000078
5-[[(3R,4R)-3-amino-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methyl]-2-fluorobenzonitrile
Homo sapiens
-
0.0000099
6-(aminomethyl)-1,3-dimethyl-7-(1-methylpiperazinium)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000046
6-(aminomethyl)-1,3-dimethyl-7-(morpholin-4-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000002
6-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methoxy)pyridine-3-carbonitrile
Homo sapiens
-
-
0.000004
6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)(methyl)amino]pyridine-3-carbonitrile
Homo sapiens
-
-
0.0000035
6-[([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)amino]pyridine-3-carbonitrile
Homo sapiens
-
-
0.0000016
6-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]nicotinonitrile
Homo sapiens
-
-
0.000022
6-[[2-([2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinonitrile
Homo sapiens
-
pH 8.0, 37°C
0.0000024
6-[[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)ethyl]amino]nicotinamide
Homo sapiens
-
-
0.00014
6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile
Homo sapiens
-
i.e. KR-62436, IC50: 0.00014 mM, selective competitive inhibitor, good lead compound for further development as a new anti-diabetic agent, almost completely inhibits DPP-IV mediated degradation of glucagon-like peptide-1
0.000007 - 0.000022
6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile
0.000052
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1,3-dihydro-2H-benzimidazol-2-one
Homo sapiens
-
0.000008
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile
Homo sapiens
-
0.000032
7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carboxamide
Homo sapiens
-
0.0000048
7-amino-6-(aminomethyl)-5-(2-bromo-5-fluorophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00002
7-amino-6-(aminomethyl)-5-(2-fluoro-6-methoxyphenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0039
7-benzyl-3-methyl-8-piperazin-1-yl-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.000089
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one trifluoroacetate
Homo sapiens
-
-
0.0145
7-[(2-butyl-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)amino]-N-[(3R)-1-[3-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperidin-3-yl]heptanamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000001
7-[(2E)-but-2-en-1-yl]-8-(3,3-dimethylpiperazin-1-yl)-3-methyl-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.0000012
7-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2H-pyrimido[1,2-b]pyridazin-2-one
Homo sapiens
-
-
0.002
7-[(3R,4R)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Homo sapiens
-
-
0.0002
7-[(3R,4S)-3-amino-4-(2-methoxyphenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Homo sapiens
-
-
0.001
7-[(3R,4S)-3-amino-4-(3,4-dichlorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Homo sapiens
-
-
0.00014
7-[(3R,4S)-3-amino-4-(4-fluorophenyl)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Homo sapiens
-
-
0.00015
7-[(3R,4S)-3-amino-4-phenylpyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Homo sapiens
-
-
0.000015
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-(naphthalen-1-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.000002
8-(3-aminopiperidin-1-yl)-7-but-2-yn-1-yl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.0000235
8-[(3R)-3-aminopiperidin-1-yl]-1-[(1,3-benzothiazol-2-yl)methyl]-3-methyl-7-(3-methylbut-2-en-1-yl)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
pH not specified in the publication, 37°C
0.000006
8-[(3R)-3-aminopiperidin-1-yl]-3-methyl-7-(3-methylbut-2-en-1-yl)-1-(2-oxo-2-phenylethyl)-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.000001
8-[(3R)-3-aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione
Homo sapiens
-
-
0.000001
ABT-279
Homo sapiens
-
-
0.647
Ala-Ala-Leu-Glu-Gln-Thr-Glu-Arg
Homo sapiens
-
pH 8.0, 37°C
0.0000069 - 0.000024
alogliptin
0.0000053
ASP-8497
Homo sapiens
-
in 25 mM HEPES, 140 mM NaCl, 80 mM MgCl2, 0.5% BSA, pH 7, at 25°C
0.0000053 - 0.0000062
ASP8497
0.00049
benzyl 4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepane-1-carboxylate
Homo sapiens
-
0.0000007
benzyl 6-([5-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-(4S)-4-amino-5-oxopentanoyl]amino)hexanoate
Homo sapiens
-
-
0.0000014
benzyl [(5S)-5-amino-6-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-6-oxohexyl]carbamate
Homo sapiens
-
-
0.0133
Berberine
Homo sapiens
in Tris buffer (pH 7.5, 50 mM), at 37°C
0.000001
BI 1356
0.000001
Bl-1356
Homo sapiens
-
-
0.0000037
BMS-477118
Homo sapiens
-
-
0.0023
D-Val-L-boroPro
Homo sapiens
-
pH 2
0.000022
denagliptin
Homo sapiens
-
-
0.000089
ER-319711-15
Homo sapiens
-
-
0.00049
ethyl (3R,4S)-3-amino-4-(2,4-dichlorophenyl)pyrrolidine-1-carboxylate
Homo sapiens
-
0.000000076
ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxylate
Homo sapiens
-
0.00000044
ethyl 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-carboxylate
Homo sapiens
-
0.000063
ethyl 4-[3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanoyl]piperazine-1-carboxylate
Homo sapiens
-
-
0.0000153
ethyl N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]glycinate
Homo sapiens
-
0.00456
ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
Homo sapiens
pH 7.5, temperature not specified in the publication
0.0084
ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
Homo sapiens
pH 7.5, temperature not specified in the publication
0.00000161
GRC 8200
Homo sapiens
-
-
0.022
L-isoleucinepyrrolidine
Homo sapiens
-
IC50: 0.022 mM
0.0000016 - 0.0012
L-Val-L-boroPro
0.0000035
LAF-237
Homo sapiens
-
-
0.000034
LY-2463665
Homo sapiens
-
-
0.329
Lys-Ala-Val-Gly-Glu-Pro-Pro-Leu-Phe
Homo sapiens
-
pH 8.0, 37°C
0.0003
MCB3937
Homo sapiens
-
-
0.00000022
methyl (2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate
Homo sapiens
-
0.000000087
methyl (4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetate
Homo sapiens
-
0.0000036
methyl 4-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]benzenesulfinate
Homo sapiens
-
0.00000017
methyl 4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]benzoate
Homo sapiens
-
0.000018
MK-0431
Homo sapiens
-
-
0.00000135
MP-513
Homo sapiens
-
-
0.000021
N,N-diallyl-3-(bicyclo[3.2.0]hept-6-ylsulfonyl)-1H-1,2,4-triazole-1-carboxamide
Homo sapiens
-
pH 8.0, 37°C
0.000000027
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)-1,1,1-trifluoromethanesulfonamide
Homo sapiens
-
0.00000015
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-yl)methanesulfonamide
Homo sapiens
-
0.00000071
N-(4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-4-yl)methanesulfonamide
Homo sapiens
-
0.000023
N-(4-cyanobenzyl)-N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]-b-alanine
Homo sapiens
-
0.0000015
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoro-N-methylmethanesulfonamide
Homo sapiens
-
-
0.000012
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1,1,1-trifluoromethanesulfonamide
Homo sapiens
-
-
0.0000027
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-1-(trifluoromethyl)cyclopropanecarboxamide
Homo sapiens
-
-
0.0000056
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2,2-trifluoroethanesulfonamide
Homo sapiens
-
-
0.0000078
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoro-N-methylpropanamide
Homo sapiens
-
-
0.0000013
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluorocyclopropanecarboxamide
Homo sapiens
-
-
0.0000059
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-difluoropropanamide
Homo sapiens
-
-
0.0000037
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2,2-dimethylpropanamide
Homo sapiens
-
-
0.0000063
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-2-fluoro-2-methylpropanamide
Homo sapiens
-
-
0.0000035
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-3,3,3-trifluoropropanamide
Homo sapiens
-
-
0.0000068
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N,2,2-trimethylpropanamide
Homo sapiens
-
-
0.0000027
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-cyclopropyl-1,1,1-trifluoromethanesulfonamide
Homo sapiens
-
-
0.0000011
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)-N-methylcyclopropanecarboxamide
Homo sapiens
-
-
0.0000022
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclobutanecarboxamide
Homo sapiens
-
-
0.000009
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanecarboxamide
Homo sapiens
-
-
0.000008
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclohexanesulfonamide
Homo sapiens
-
-
0.0000048
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)cyclopentanecarboxamide
Homo sapiens
-
-
0.000027
N-([(2S)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]pyrrolidin-2-yl]methyl)methanesulfonamide
Homo sapiens
-
-
0.000015
N-[(1S,2R)-2-(3-chlorophenyl)cyclopropyl]-3-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-3-methylbutanamide
Homo sapiens
-
-
0.000031
N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide
Homo sapiens
-
pH 7.5, temperature not specified in the publication
0.000236
N-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]benzamide
Homo sapiens
-
0.000013
N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-1-methylcyclohexanecarboxamide
Homo sapiens
-
-
0.0000058
N-[2-([2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino)-2-methylpropyl]-2,2-dimethylpropanamide
Homo sapiens
-
-
0.0113
N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-N-methyl-5-oxoprolinamide
Homo sapiens
-
23°C, pH 7.4
0.0000015
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-1,2,3-benzotriazole-5-carboxamide
Homo sapiens
-
-
0.0000057
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-1H-benzimidazole-5-carboxamide
Homo sapiens
-
-
0.0000029
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2,3-dihydro-1-benzofuran-5-carboxamide
Homo sapiens
-
-
0.0000062
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-(4-cyanobenzyl)benzamide
Homo sapiens
-
-
0.0000073
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-isobutylbenzamide
Homo sapiens
-
-
0.000031
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-N-methylbenzenesulfonamide
Homo sapiens
-
-
0.0000045
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzamide
Homo sapiens
-
-
0.000075
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]benzenesulfonamide
Homo sapiens
-
-
0.0000082
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]pyridine-2-carboxamide
Homo sapiens
-
-
0.0000054
N-[2-[[2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]thiophene-2-carboxamide
Homo sapiens
-
-
0.011
N-[3-[(2-[4-[(2S)-2-amino-3-phenylpropyl]-3-benzylpiperazin-1-yl]ethyl)amino]phenyl]methanesulfonamide
Homo sapiens
-
-
0.000022
NVP DPP728
Homo sapiens
-
-
0.000011
P-[(3S)-3-amino-2-oxopyrrolidin-1-yl]phosphonic diamide
Homo sapiens
-
pH 8.0, 37°C
0.00042
P32/98
Homo sapiens
-
-
0.00042
P32/P98
Homo sapiens
-
-
0.0000006 - 0.00005
saxagliptin
0.00000996 - 0.000087
sitagliptin
0.000018
SSR-162369
Homo sapiens
-
-
0.000007
SYR-322
Homo sapiens
-
-
0.44
Val-pyrrolidide
Homo sapiens
-
recombinant enzyme
0.0000027 - 0.000062
vildagliptin
0.451
[(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.006871
[(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.000377
[(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0227
[(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.182
[(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.608
[(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0043
[(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.007391
[(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.00908
[(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.000068 - 0.00143
[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.0384
[(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0046
[(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0195
[(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0095
[(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]pyrrolidin-2-yl]boronic acid
Homo sapiens
-
23°C, pH 7.4
0.0000003
[(2R,4R)-1-(L-arginyl)-4-hydroxypyrrolidin-2-yl]boronic acid
Homo sapiens
-
pH 7.8, temperature not specified in the publication
0.0002
[(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidin-2-yl]methanol
Homo sapiens
-
-
0.0092
[(2S)-1-[(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoyl]pyrrolidin-2-yl]methanol
Homo sapiens
-
-
0.0000699
[(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid
Homo sapiens
-
-
0.000016
[(3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidin-3-yl]acetic acid
Homo sapiens
-
-
0.0000163
[(4-cyanobenzyl)[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]amino]acetic acid
Homo sapiens
-
0.000025
[(R)-amino[(3S)-3-amino-2-oxoazepan-1-yl]phosphoryl]sulfamic acid
Homo sapiens
-
pH 8.0, 37°C
0.000021
[(R)-amino[(3S)-3-amino-2-oxopiperidin-1-yl]phosphoryl]sulfamic acid
Homo sapiens
-
pH 8.0, 37°C
0.0000036
[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.0000012
[2-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.0004
[2-[7-(aminomethyl)-1-methyl-1H-benzimidazol-6-yl]phenyl]methanol
Homo sapiens
-
0.0000033
[3-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.0000012
[3-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.00000012
[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]acetic acid
Homo sapiens
-
0.000000054
[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.000000074
[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
0.00000051
[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenyl]acetic acid
Homo sapiens
-
additional information
alogliptin
Homo sapiens
-
50% inhibition of DPP-4 activity is observed at an alogliptin plasma concentration of 3.7 ng/ml
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.01
-
crude extract, in PBS, pH 8.0
0.8
-
after 80fold purification, in PBS, pH 8.0
12.29
-
-
19.1
-
-
32.3
-
purified recombinant soluble enzyme
41.9
purified native enzyme from serum
48.5
-
-
57.4
-
-
additional information
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 8
-
-
7.6
-
assay at
7.8
assay at
8 - 8.5
-
-
8.5
-
hydrolysis of Gly-Pro-2-naphthylamide
additional information
-
acidic pH optimum
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 8
no activity below pH 5.0, optimum at pH 8.0
7 - 9.6
-
pH 7.0: about 45% of maximal activity, pH 9.6: about 90% of maximal activity, hydrolysis of Gly-Pro-2-naphthylamide
additional information
-
the enzyme is essentially inactive at acidic pH
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22
-
assay at room temperature
25
assay at
30
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.47
-
several isozymes due to heterologous glycosylation, isoelectric focusing
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
cell surface
Manually annotated by BRENDA team
-
high activity
Manually annotated by BRENDA team
-
endothelium
Manually annotated by BRENDA team
-
neuroectodermal melanoma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
acinar cells of mucous glands
Manually annotated by BRENDA team
-
levels of tissue DPP-4 are reduced in nasal tissue of human subjects with chronic rhinosinusitis
Manually annotated by BRENDA team
the enzyme is coexpressed with fibroblast activation protein in adult humans
Manually annotated by BRENDA team
the enzyme is coexpressed with fibroblast activation protein in adult humans
Manually annotated by BRENDA team
-
from cord blood
Manually annotated by BRENDA team
-
neuroectodermal, melanoma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
squamous lung carcinoma, enzymic activity is restricted to the connective tissue stroma surrounding the dipeptidyl peptidase IV-negative tumor foci
Manually annotated by BRENDA team
-
cell surface
Manually annotated by BRENDA team
-
CEM, C8166, Molt4/C8, MT-4
Manually annotated by BRENDA team
-
neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
neuroectodermal cell line, low activity in proliferating population, quiescent population
Manually annotated by BRENDA team
-
neuroectodermal glioma cell line, proliferating and quiescent populations
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
soluble form from seminal plasma and serum
-
Manually annotated by BRENDA team
-
in P and A549 cells the enzyme is associated with the plasmalemma while in SK-MES-1 cells it is bound to intracellular membranes
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DPP4_HUMAN
766
1
88279
Swiss-Prot
Secretory Pathway (Reliability: 1)
SEPR_HUMAN
760
1
87713
Swiss-Prot
Secretory Pathway (Reliability: 1)
DPP8_HUMAN
898
0
103358
Swiss-Prot
other Location (Reliability: 2)
DPP9_HUMAN
863
0
98263
Swiss-Prot
other Location (Reliability: 1)
A0A7S4ZDQ1_HUMAN
188
1
22066
TrEMBL
Secretory Pathway (Reliability: 1)
F8WE17_HUMAN
170
1
19798
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7I2V2I2_HUMAN
296
1
34096
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7I2V3F5_HUMAN
117
1
13528
TrEMBL
Secretory Pathway (Reliability: 1)
F8WBB6_HUMAN
118
1
13630
TrEMBL
Secretory Pathway (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
103600
-
2 * 103600, recombinant soluble enzyme, MALDI-TOF mass spectrometry
104400
-
x * 104400, mass spectrometry, x * 110000, SDS-PAGE
110000
116000
-
2 * 116000, SDS-PAGE
120000
125000
-
x * 125000 + x * 135000, SDS-PAGE
130000
-
2 * 130000, SDS-PAGE
135000
-
x * 125000 + x * 135000, SDS-PAGE
143000
-
x * 143000, SDS-PAGE
189000
-
gel filtration
200000
210000
-
about, recombinant soluble enzyme, gel filtration
220000
-
gel filtration
225000
-
gel filtration
230000 - 250000
-
gel filtration
240000
-
gel filtration
264000
-
gel filtration
265000
-
gel filtration
280000
-
gel filtration
400000
-
gel filtration
84400
non-glycosylated enzyme, calculated from amino acid sequence
93500
recombinant soluble enzyme, MALDI mass spectrometry
95000
-
2 * 95000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
side-chain modification
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
10 mg/ml purified recombinant soluble enzyme ectodomain, vapour diffusion method, with 20-25% PEG 3350, 0.2 M MgCl2, Tris, pH 8.5, 15% glycerol, flash-frozen crystals for X-ray diffraction structure determination and analysis at 2.1 A resolution, also preparation and study of a mercury derivative
20 mg/ml purified soluble extracellular domain apoprotein, glycosidase endo-F treated, in 25 mM Tris, pH 7.5, 100 mM NaCl, 2 mM Tris(2-carboxyethyl)phosphine hydrochloride, i.e. TCEP, 5% glycerol, modified microbatch method, hanging drop vapour diffusion method, from 25% PEG 3350, 200 mM MgCl2, 100 mM HEPES, pH 7.5, complexing with inhibitor 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano(S)-pyrrolidine, several days, X-ray diffraction structure determination and analysis at 1.9 A resolution, in cryoprotectant solution containing 25% PEG 3350, 20% 1,6-hexanediol, at 100 K
-
20 mg/ml recombinant soluble enzyme, sitting drop vapour diffusion method, 293 K, from 180 mM Gly-NaOh, pH 9.5, with 180 mM sodium acetate and 18% PEG 4000, crystal grow 2 weeks after seeding, X-ray diffraction structure determination and analysis at 2.6 A resolution
40 mg/ml extracellular enzyme region complexed with inhibitor valine-pyrrolidine in 20 mM Tris, pH 8.0, ans 25 mM NaCl, sitting drop vapour diffusion method, mixed with equal volume of reservoir solution containing 0.3 M sodium acetate, 17-18% w/v PEG 4000, 0.1 M Tris, pH 8.0, 2-3 days, X-ray diffraction structure determination and analysis at 2.5 A resolution
crystal structure of apo hDPPIV at 1.9 A resolution, crystal structure of hDPPIV-diprotin B (Val-Pro-Leu) complex at 2.1 A resolution
-
crystal structure of apo hDPPIV at 1.9 A resolution. Crystal structure of hDPPIV-diprotin B complex at 2.1 A resolution
-
crystal structure of human CD26/dipeptidyl-peptidase IV in complex with bovine adenosine deaminase reveals a highly amphiphilic interface, structure determined at 3.0 A resolution
crystal structure of the free form of DPPIV and of the enzyme in complex with the first 10 residues of the physiological substrate neuropeptide Y (tNPY). The structure of the enzyme/tNPY complex suggests that bioactive peptides utilize the side opening unique to DPPIV to access the active site. Space group of wild-type enzyme and enzyme/tNPY complex is P2(1). The cell dimensions for wild-type enzyme are a = 121.8 A, b = 124,1 A, c = 1445 A, beta = 114.7°. The cell dimensions for the enzyme /tNPY complex are a = b = 122.5 A, c = 145.3 A, beta = 114.9°
-
dipeptidyl peptidase IV complex with diprotin A, a slowly hydrolyzed substrate at 2.2 A, space group: P2(1)2(1)2(1), cell dimensions: a = 118.02 A, b * 126.06 A, c = 136.67 A
-
hanging drop vapor diffusion method, crystallization of apoenzyme, mutant enzyme Y547F and DPP-IV in complex with diisopropyl fluorophosphate. X-ray crystal structurte analysis of the Y547 mutant reveals no overal changes compared with wild-type apoDPP-IV, except the ablation of the hydroxyl group of Tyr547 and a water molecule positioned in close proximity to Tyr547
in complex with inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one. The binding of the trifluorophenyl moiety in the S1 pocket and the piperazine-2-one moiety have hydrophobic interactions with Phe357 in the S2 extensive subsite, and the multiple hydrogen bonds made by the (R)-beta-amine group in the S2 pocket and the contacts made by the (R)-tert-butyl group with Arg125 contribute to the high potency of the inhibitor
in complex with inhibitor N-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butyl]-6-(trifluoromethyl)-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxamide, to 3.2 A resolution
-
molecular docking simulaion for compounds ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate and ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate
purified recombinant enzyme extracellular domain, wild-type or selenomethionine-form, both free, and the wild-type also complexed with the decapeptide YPSKPDNPGE, corresponding to the first 10 amino acids of neuropeptide Y, 4°C, nanovolume crystallization, over reservoir solution containing 20% PEG monomethyl ester 2000, 100 mM bicine, pH 8.0-8.5, 5 days, X-ray diffraction structure determination and analysis at 2.1-2.3 A resolution, at 100 K using 25% v/v ethylene glycol as a cryoprotectant
-
recombinant enzyme forms dimers in crystals
-
X-ray diffraction strcuture determination at 2.6 A resolution
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D708A
mutant enzyme shows less than 1% of wild-type activity
F713A
mutation disrupts dimeric DPP-IV into monomers. kcat/Km for Gly-Pro-p-nitroaniline is 27fold lower wild-type value
F730A
mutant enzyme is a mixture of monomers and dimers. With the dimeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 1.9fold lower than wild-type value. With the monomeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 241fold lower than wild-type value
F822A
-
the DPP8 mutation abolishes the enzymatic activity without disrupting its quaternary structure
F842A
-
the DPP9 mutation abolishes the enzymatic activity without disrupting its quaternary structure
H740L
mutant enzyme shows less than 1% of wild-type activity
N150A
N219A
N229A
N281A
N321A
N520A
N685A
S630A
mutant enzyme shows less than 1% of wild-type activity
V724A
mutant enzyme remains largely dimeric. With the dimeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 1.8fold lower than wild-type value. With the monomeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 138fold lower than wild-type value
W734A
mutation disrupts dimeric DPP-IV into monomers with a small fraction of dimers. With the monomeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 322fold lower than wild-type value
Y547F
mutant enzyme shows less than 1% of wild-type activity, kcat/Km is 1523fold lower than wild-type value
Y735A
mutation disrupts dimeric DPP-IV into monomers. With the monomeric mutant enzyme the kcat/Km for Gly-Pro-p-nitroaniline is 1612fold lower than wild-type value
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
65
5% remaining activity after 100 min, slightly differing thermal stability for the 3 different purified enzyme forms from serum, seminal plasma and recombinant from K562 cells
7.5 - 8
-
the activity decreases above pH 8.0 or below pH 7.5
71
5 min, 50% remaining activity, structural features responsible for the thermal stability
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, with or without glycerol, less than 10% loss of activity after 2 months
-
-80°C, purified enzyme, 1 month, no loss of activity
-
22°C, purified enzyme, 12 h, no loss of activity
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate precipitation and Sephacryl S-200 gel filtration
native from serum and seminal plasma, recombinant from K562 cell dulture medium
recombinant enzyme from insect cells, rapidly to homogeneity
-
recombinant His-tagged soluble enzyme from Sf21 insect cell culture supernatant
recombinant soluble enzyme ectodomain from Pichia pastoris, to homogeneity
recombinant soluble enzyme from insect cell culture supernatant to homogeneity
recombinant soluble extracellular domain from cell culture supernatant
-
recombinant soluble His-tagged extracellular part of the enzyme from Pichia pastoris culture medium, 534fold
-
recombinant soluble His-tagged wild-type and mutant extracellular enzyme domains from insect cell culture supernatant to homogeneity
-
recombinant soluble His-tagged wild-type and selenomethionine enzymes from insect cell culture supernatant to homogeneity
-
Strep-Tactin resin purification system
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA sequence determination and analysis, expression of enzyme ectodomain, comprising residues 31-766, in Pichia pastoris strain GS115, secretion to the culture medium
DPP9 is expressed in baculovirus-infected Sf9 insect cells
-
expressed in Pichia pastoris strain GS115
expressed using baculovirus
-
expression as soluble extracellular enzyme domain
-
expression in human K562 erythroleukemia cell line, secretion to the medium of the recombinant enzyme
expression in insect cells via baculovirus infection as secreted soluble enzyme with Asp29 to the end without any fusion tag
-
expression in of soluble His-tagged enzyme, which is secreted to the cell culture medium and comprises amino acid residues 39-766, in Spodoptera frugiperda Sf21 cells via baculovirus infection
expression of a soluble enzyme form, which comprises amino acid residues 39-766 and is secreted to the medium, in Hi5 insect cells via baculovirus infection
expression of a soluble His-tagged wild-type enzyme and glycosylation mutant extracellular domains, which comprises extracellular domain amino acid residues 39-766 and are secreted to the medium, in Trichoplusia ni Hi5 and Spodoptera frugiperda Sf9 insect cells via baculovirus infection
-
expression of soluble His-tagged enzyme wild-type and a selenomethionine forms, which comprise extracellular domain amino acid residues 39-766 and are secreted to the medium, in Trichoplusia ni Hi5 insect cells via baculovirus infection
-
expression of wild-type enzyme and mutant enzymes in Sf9 insect cells and in Hi5 insect cells
-
overexpression of the soluble His-tagged protein in Pichia pastoris strain X-33 under control of AOX1 promotor, removal of the membrane anchor, residues 1-36, secretion of the recombinant enzyme extracellular part into the cell culture medium and the periplasm
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
DPIV expression is progressively downregulated in endometrial adenocarcinoma
DPP IV activity isincreased in plasma of hypertensive patients with concomitant pulmonary hypertension and in atrial tissue of patients with chronic persistent atrial fibrillation
-
DPP-IV mRNA and protein levels are null or markedly reduced in non-small cell lung cancer cell lines, endometrial cancer, colon adenocarcinoma, and melanoma cells
-
DPP-IV protein expression is up-regulated in thyroid cancer, lung cancer, follicular thyroid cancer, and glioma
-
the activity of dipeptidyl peptidase IV is elevated up to 3fold in mucopolysacharidoses patients
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
drug development
-
a three-dimensional pharmacophore model is a useful tool for designing novel DPP-IV inhibitors
medicine
pharmacology
-
target for development of selective inhibitors for control of the enzyme's biological function
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hegen, M.; Niedobitek, G.; Klein, C.E.; Stein, H.; Fleischer, B.
The T cell triggering molecule Tp103 is associated with dipeptidyl aminopeptidase IV activity
J. Immunol.
144
2908-2914
1990
Homo sapiens
Manually annotated by BRENDA team
Caporale, C.; Fontanella, A.; Petrilli, P.; Pucci, P.; Molinaro, M.F.; Picone, D.; Auricchio, S.
Isolation and characterization of dipeptidyl peptidase IV from human meconium. Functional role of beta-casomorphins
FEBS Lett.
184
273-277
1985
Homo sapiens
Manually annotated by BRENDA team
Mentlein, R.; Heymann, E.; Scholz, W.; Feller, A.C.; Flad, H.D.
Dipeptidyl peptidase IV as a new surface marker for a subpopulation of human T-lymphocytes
Cell. Immunol.
89
11-19
1984
Homo sapiens
Manually annotated by BRENDA team
Schn, E.; Demuth, H.U.; Barth, A.; Ansorge, S.
Dipeptidyl peptidase IV of human lymphocytes. Evidence for specific hydrolysis of glycylproline p-nitroanilide in T-lymphocytes
Biochem. J.
223
255-258
1984
Homo sapiens
Manually annotated by BRENDA team
Heins, J.; Neubert, K.; Barth, A.; Canizaro, P.C.; Behal, F.J.
Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney
Biochim. Biophys. Acta
785
30-35
1984
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Saison, M.; Verlinden, J.; van Leuven, F.; Cassiman, J.J.; van den Berghe, H.
Identification of cell surface dipeptidylpeptidase IV in human fibroblasts
Biochem. J.
216
177-183
1983
Homo sapiens
Manually annotated by BRENDA team
Pschel, G.; Mentlein, R.; Heymann, E.
Isolation and characterization of dipeptidyl peptidase IV from human placenta
Eur. J. Biochem.
126
359-365
1982
Homo sapiens
Manually annotated by BRENDA team
Mentlein, R.; Heymann, E.
Dipeptidyl peptidase IV inhibits the polymerization of fibrin monomers
Arch. Biochem. Biophys.
217
748-750
1982
Homo sapiens
Manually annotated by BRENDA team
Kojima, K.; Hama, T.; Kato, T.; Nagatsu, T.
Rapid chromatographic purification of dipeptidyl peptidase IV in human submaxillary gland
J. Chromatogr.
189
233-240
1980
Homo sapiens
Manually annotated by BRENDA team
Shibuya-Saruta, H.; Kasahara, Y.; Hashimoto, Y.
Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties
J. Clin. Lab. Anal.
10
435-440
1996
Homo sapiens
Manually annotated by BRENDA team
Hendriks, D.; de Meester, I.; Umiel, T.; Vanhoof, G.; Scharpe, S.; Yaron, A.
Dipeptidy peptidas IV activity in stimulated T lymphocytes
Biochem. Soc. Trans.
16
365-366
1988
Homo sapiens
-
Manually annotated by BRENDA team
Schn, E.; Jahn, S.; Kiessig, S.T.; Demuth, H.U.; Neubert, K.; Barth, A.; von Baehr, R.; Ansorge, S.
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and immunoglobulin synthesis in vitro
Eur. J. Immunol.
17
1821-1826
1987
Homo sapiens
Manually annotated by BRENDA team
Augustyns, K.; Bal, G.; Thonus, G.; Belyaev, A.; Zhang, X.M.; Bollaert, W.; Lambeir, A.M.; Durinx, C.; Goossens, F.; Haemers, A.
The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors
Curr. Med. Chem.
6
311-327
1999
Homo sapiens, Mammalia
Manually annotated by BRENDA team
Lambeir, A.M.; Borloo, M.; de Meester, I.; Belyaev, A.; Augustyns, K.; Hendriks, D.; Scharpe, S.; Haemers, A.
Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV
Biochim. Biophys. Acta
1290
76-82
1996
Homo sapiens
Manually annotated by BRENDA team
Iwaki-Egawa, S.; Watanabe, Y.; Kikuya, Y.; Fujimoto, Y.
Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence
J. Biochem.
124
428-433
1998
Homo sapiens
Manually annotated by BRENDA team
De Meester, I.; Vanhoof, G.; Hendriks, D.; Demuth, H.U.; Yaron, A.; Scharpe, S.
Characterization of dipeptidyl peptidase IV (CD26) from human lymphocytes
Clin. Chim. Acta
210
23-24
1992
Homo sapiens
Manually annotated by BRENDA team
Misumi, Y.; Hayashi, Y.; Arakawa, F.; Ikehara, Y.
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface
Biochim. Biophys. Acta
1131
333-336
1992
Homo sapiens
Manually annotated by BRENDA team
Schn, E.; Born, I.; Demuth, H.U.; Faust, J.; Neubert, K.; Steinmetzer, T.; Barth, A.; Ansorge, S.
Dipeptidyl peptidase IV in the immune system. Effects of specific enzyme inhibitors on activity of dipeptidyl peptidase IV and proliferation of human lymphocytes
Biol. Chem. Hoppe-Seyler
372
305-311
1991
Homo sapiens
Manually annotated by BRENDA team
Chikuma, T.; Hama, T.; Nagatsu, T.; Kumegawa, M.; Kato, T.
Purification and properties of dipeptidyl peptidase IV from human urine
Biol. Chem. Hoppe-Seyler
371
325-330
1990
Homo sapiens
Manually annotated by BRENDA team
Oefner, C.; D'Arcy, A.; Mac Sweeney, A.; Pierau, S.; Gardiner, R.; Dale, G.E.
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine
Acta Crystallogr. Sect. D
59
1206-1212
2003
Homo sapiens
Manually annotated by BRENDA team
Hiramatsu, H.; Kyono, K.; Shima, H.; Fukushima, C.; Sugiyama, S.; Inaka, K.; Yamamoto, A.; Shimizu, R.
Crystallization and preliminary X-ray study of human dipeptidyl peptidase IV (DPPIV)
Acta Crystallogr. Sect. D
59
595-596
2003
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Mrestani-Klaus, C.; Fengler, A.; Faust, J.; Brandt, W.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
N-terminal HIV-1 Tat nonapeptides as inhibitors of dipeptidyl peptidase IV. Conformational characterization
Adv. Exp. Med. Biol.
477
125-129
2000
Homo sapiens
Manually annotated by BRENDA team
Kaehne, T.; Reinhold, D.; Neubert, K.; Born, I.; Faust, J.; Ansorge, S.
Signal transduction events induced or affected by inhibition of the catalytic activity of dipeptidyl peptidase IV (DP IV, CD26)
Adv. Exp. Med. Biol.
477
131-137
2000
Homo sapiens
Manually annotated by BRENDA team
Brandt, W.
Development of a tertiary-structure model of the C-terminal domain of DPP IV
Adv. Exp. Med. Biol.
477
97-101
2000
Homo sapiens
Manually annotated by BRENDA team
Baer, J.W.; Gerhartz, B.; Hoffmann, T.; Rosche, F.; Demuth, H.U.
Characterisation of human DP IV produced by a Pichia pastoris expression system
Adv. Exp. Med. Biol.
524
103-108
2003
Homo sapiens
Manually annotated by BRENDA team
Lambeir, A.M.; Rea, D.; Fulop, V.; Kumagai, Y.; Augustyns, K.; De Meester, I.; Haemers, A.; Scharpe, S.
Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis: comparison with the human enzyme
Adv. Exp. Med. Biol.
524
29-35
2003
Porphyromonas gingivalis, Homo sapiens
Manually annotated by BRENDA team
Kuehn-Wache, K.; Hoffmann, T.; Manhart, S.; Brandt, W.; Demuth, H.U.
The specificity of DP IV for natural substrates is peptide structure determined
Adv. Exp. Med. Biol.
524
57-63
2003
Homo sapiens
Manually annotated by BRENDA team
Stoeckel-Maschek, A.; Stiebitz, B.; Faust, J.; Born, I.; Kaehne, T.; Gorrell, M.D.; Neubert, K.
Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides
Adv. Exp. Med. Biol.
524
69-72
2003
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Malik, R.; Busek, P.; Mares, V.; Sevcik, J.; Kleibl, Z.; Sedo, A.
Dipeptidyl peptidase-IV activity and/or structure homologues (DASH) in transformed neuroectodermal cells
Adv. Exp. Med. Biol.
524
95-102
2003
Homo sapiens
Manually annotated by BRENDA team
Hiramatsu, H.; Kyono, K.; Higashiyama, Y.; Fukushima, C.; Shima, H.; Sugiyama, S.; Inaka, K.; Yamamoto, A.; Shimizu, R.
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold
Biochem. Biophys. Res. Commun.
302
849-854
2003
Homo sapiens
Manually annotated by BRENDA team
Pala, L.; Mannucci, E.; Pezzatini, A.; Ciani, S.; Sardi, J.; Raimondi, L.; Ognibene, A.; Cappadona, A.; Vannelli, B.G.; Rotella, C.M.
Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells
Biochem. Biophys. Res. Commun.
310
28-31
2003
Homo sapiens
Manually annotated by BRENDA team
Leiting, B.; Pryor, K.D.; Wu, J.K.; Marsilio, F.; Patel, R.A.; Craik, C.S.; Ellman, J.A.; Cummings, R.T.; Thornberry, N.A.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
Biochem. J.
371
525-532
2003
Homo sapiens
Manually annotated by BRENDA team
Rosenblum, J.S.; Kozarich, J.W.
Prolyl peptidases: a serine protease subfamily with high potential for drug discovery
Curr. Opin. Chem. Biol.
7
496-504
2003
Homo sapiens, Mammalia, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Durinx, C.; Lambeir, A.M.; Bosmans, E.; Falmagne, J.B.; Berghmans, R.; Haemers, A.; Scharpe, S.; De Meester, I.
Molecular characterization of dipeptidyl peptidase activity in serum. Soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides
Eur. J. Biochem.
267
5608-5613
2000
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Lorey, S.; Stockel-Maschek, A.; Faust, J.; Brandt, W.; Stiebitz, B.; Gorrell, M.D.; Kahne, T.; Mrestani-Klaus, C.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites
Eur. J. Biochem.
270
2147-2156
2003
Homo sapiens
Manually annotated by BRENDA team
Busek, P.; Malik, R.; Sedo, A.
Dipeptidyl peptidase IV activity and/or structure homologues (DASH) and their substrates in cancer
Int. J. Biochem. Cell Biol.
36
408-421
2004
Homo sapiens
Manually annotated by BRENDA team
Rasmussen, H.B.; Branner, S.; Wiberg, F.C.; Wagtmann, N.
Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
Nat. Struct. Biol.
10
19-25
2003
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Aertgeerts, K.; Ye, S.; Shi, L.; Prasad, S.G.; Witmer, D.; Chi, E.; Sang, B.C.; Wijnands, R.A.; Webb, D.R.; Swanson, R.V.
N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding
Protein Sci.
13
145-154
2004
Homo sapiens
Manually annotated by BRENDA team
Aertgeerts, K.; Ye, S.; Tennant, M.G.; Kraus, M.L.; Rogers, J.; Sang, B.C.; Skene, R.J.; Webb, D.R.; Prasad, G.S.
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
Protein Sci.
13
412-421
2004
Homo sapiens
Manually annotated by BRENDA team
Thoma, R.; Loffler, B.; Stihle, M.; Huber, W.; Ruf, A.; Hennig, M.
Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV
Structure
11
947-959
2003
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Longenecker, K.L.; Stewart, K.D.; Madar, D.J.; Jakob, C.G.; Fry, E.H.; Wilk, S.; Lin, C.W.; Ballaron, S.J.; Stashko, M.A.; Lubben, T.H.; Yong, H.; Pireh, D.; Pei, Z.; Basha, F.; Wiedeman, P.E.; von Geldern, T.W.; Trevillyan, J.M.; Stoll, V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Biochemistry
45
7474-7482
2006
Homo sapiens, Rattus norvegicus (P14740)
Manually annotated by BRENDA team
Hiramatsu, H.; Yamamoto, A.; Kyono, K.; Higashiyama, Y.; Fukushima, C.; Shima, H.; Sugiyama, S.; Inaka, K.; Shimizu, R.
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol. Chem.
385
561-564
2004
Homo sapiens
Manually annotated by BRENDA team
Sakashita, H.; Akahoshi, F.; Kitajima, H.; Tsutsumiuchi, R.; Hayashi, Y.
[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
Bioorg. Med. Chem.
14
3662-3671
2006
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Brandt, I.; Lambeir, A.M.; Ketelslegers, J.M.; Vanderheyden, M.; Scharpe, S.; De Meester, I.
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form
Clin. Chem.
52
82-87
2006
Homo sapiens
Manually annotated by BRENDA team
Kim, K.R.; Rhee, S.D.; Kim, H.Y.; Jung, W.H.; Yang, S.D.; Kim, S.S.; Ahn, J.H.; Cheon, H.G.
KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity
Eur. J. Pharmacol.
518
63-70
2005
Homo sapiens, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Balzarini, J.; Andersson, E.; Schols, D.; Proost, P.; Van Damme, J.; Svennerholm, B.; Horal, P.; Vahlne, A.
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2))
Int. J. Biochem. Cell Biol.
36
1848-1859
2004
Homo sapiens
Manually annotated by BRENDA team
Deacon, C.F.; Holst, J.J.
Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes
Int. J. Biochem. Cell Biol.
38
831-844
2006
Homo sapiens
Manually annotated by BRENDA team
Bjelke, J.R.; Christensen, J.; Branner, S.; Wagtmann, N.; Olsen, C.; Kanstrup, A.B.; Rasmussen, H.B.
Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
J. Biol. Chem.
279
34691-34697
2004
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Weihofen, W.A.; Liu, J.; Reutter, W.; Saenger, W.; Fan, H.
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface
J. Biol. Chem.
279
43330-43335
2004
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Pei, Z.; Li, X.; Longenecker, K.; von Geldern, T.W.; Wiedeman, P.E.; Lubben, T.H.; Zinker, B.A.; Stewart, K.; Ballaron, S.J.; Stashko, M.A.; Mika, A.K.; Beno, D.W.; Long, M.; Wells, H.; Kempf-Grote, A.J.; Madar, D.J.; McDermott, T.S.; Bhagavatula, L.; Fickes, M.G.; Pireh, D.; Solomon, L.R.; Lake, M.R.; Edalji, R.; Fry, E.H.; Sham, H.L.; Trevillyan, J.M.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors
J. Med. Chem.
49
3520-3535
2006
Homo sapiens (P27487)
Manually annotated by BRENDA team
Sharoyan, S.; Antonyan, A.; Mardanyan, S.; Lupidi, G.; Cristalli, G.
Influence of dipeptidyl peptidase IV on enzymatic properties of adenosine deaminase
Acta Biochim. Pol.
53
539-546
2006
Homo sapiens
Manually annotated by BRENDA team
Hiramatsu, H.; Kyono, K.; Yamamoto, A.; Saeki, K.; Shima, H.; Sugiyama, S.; Inaka, K.; Shimizu, R.
Crystal structures of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms
Acta Biochim. Biophys. Sin.
39
335-343
2007
Homo sapiens
Manually annotated by BRENDA team
Oefner, C.; Pierau, S.; Schulz, H.; Dale, G.E.
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV
Acta Crystallogr. Sect. D
63
975-981
2007
Homo sapiens
Manually annotated by BRENDA team
Reinhold, D.; Biton, A.; Goihl, A.; Pieper, S.; Lendeckel, U.; Faust, J.; Neubert, K.; Bank, U.; Taeger, M.; Ansorge, S.; Brocke, S.
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
Ann. N. Y. Acad. Sci.
1110
402-409
2007
Homo sapiens
Manually annotated by BRENDA team
Miller, S.; St Onge, E.L.
Sitagliptin: a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Ann. Pharmacother.
40
1336-1343
2006
Homo sapiens
Manually annotated by BRENDA team
Campbell, R.K.
Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus
Ann. Pharmacother.
41
51-60
2007
Homo sapiens
Manually annotated by BRENDA team
Ahren, B.
DPP-4 inhibitors
Best Pract. Res. Clin. Endocrinol. Metab.
21
517-533
2007
Homo sapiens
Manually annotated by BRENDA team
Chien, C.; Tsai, C.; Lin, C.; Chou, C.; Chen, X.
Identification of hydrophobic residues critical for DPP-IV dimerization
Biochemistry
45
7006-7012
2006
Homo sapiens (P27487)
Manually annotated by BRENDA team
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorg. Med. Chem.
15
2631-2650
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Kondo, T.; Sugimoto, I.; Nekado, T.; Ochi, K.; Ohtani, T.; Tajima, Y.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
15
2715-2735
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Sakashita, H.; Akahoshi, F.; Yoshida, T.; Kitajima, H.; Hayashi, Y.; Ishii, S.; Takashina, Y.; Tsutsumiuchi, R.; Ono, S.
Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors
Bioorg. Med. Chem.
15
641-655
2007
Rattus norvegicus, Homo sapiens (P27487)
Manually annotated by BRENDA team
Kondo, T.; Nekado, T.; Sugimoto, I.; Ochi, K.; Takai, S.; Kinoshita, A.; Hatayama, A.; Yamamoto, S.; Kawabata, K.; Nakai, H.; Toda, M.
Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem.
16
190-208
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Fukushima, H.; Hiratate, A.; Takahashi, M.; Mikami, A.; Saito-Hori, M.; Munetomo, E.; Kitano, K.; Chonan, S.; Saito, H.; Suzuki, A.; Takaoka, Y.; Yamamoto, K.
Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem.
16
4093-4106
2008
Homo sapiens
Manually annotated by BRENDA team
Magnin, D.R.; Taunk, P.C.; Robertson, J.G.; Wang, A.; Marcinkeviciene, J.; Kirby, M.S.; Hamann, L.G.
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1
Bioorg. Med. Chem. Lett.
16
1731-1734
2006
Homo sapiens
Manually annotated by BRENDA team
Tsai, T.Y.; Coumar, M.S.; Hsu, T.; Hsieh, H.P.; Chien, C.H.; Chen, C.T.; Chang, C.N.; Lo, Y.K.; Wu, S.H.; Huang, C.Y.; Huang, Y.W.; Wang, M.H.; Wu, H.Y.; Lee, H.J.; Chen, X.; Chao, Y.S.; Jiaang, W.T.
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
3268-3272
2006
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Kurukulasuriya, R.; Rohde, J.J.; Szczepankiewicz, B.G.; Basha, F.; Lai, C.; Jae, H.S.; Winn, M.; Stewart, K.D.; Longenecker, K.L.; Lubben, T.W.; Ballaron, S.J.; Sham, H.L.; von Geldern, T.W.
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
16
6226-6230
2006
Homo sapiens, Rattus norvegicus (P14740)
Manually annotated by BRENDA team
Tran, T.; Quan, C.; Edosada, C.Y.; Mayeda, M.; Wiesmann, C.; Sutherlin, D.; Wolf, B.B.
Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP
Bioorg. Med. Chem. Lett.
17
1438-1442
2007
Homo sapiens
Manually annotated by BRENDA team
Sheehan, S.M.; Mest, H.J.; Watson, B.M.; Klimkowski, V.J.; Timm, D.E.; Cauvin, A.; Parsons, S.H.; Shi, Q.; Canada, E.J.; Wiley, M.R.; Ruehter, G.; Evers, B.; Petersen, S.; Blaszczak, L.C.; Pulley, S.R.; Margolis, B.J.; Wishart, G.N.; Renson, B.; Hankotius, D.; Mohr, M.; Zechel, J.C.; Michael Kalbfleisch, J.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site
Bioorg. Med. Chem. Lett.
17
1765-1768
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Liang, G.B.; Qian, X.; Feng, D.; Biftu, T.; Eiermann, G.; He, H.; Leiting, B.; Lyons, K.; Petrov, A.; Sinha-Roy, R.; Zhang, B.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
Bioorg. Med. Chem. Lett.
17
1903-1907
2007
Homo sapiens
Manually annotated by BRENDA team
Backes, B.J.; Longenecker, K.; Hamilton, G.L.; Stewart, K.; Lai, C.; Kopecka, H.; von Geldern, T.W.; Madar, D.J.; Pei, Z.; Lubben, T.H.; Zinker, B.A.; Tian, Z.; Ballaron, S.J.; Stashko, M.A.; Mika, A.K.; Beno, D.W.; Kempf-Grote, A.J.; Black-Schaefer, C.; Sham, H.L.; Trevillyan, J.M.
Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Bioorg. Med. Chem. Lett.
17
2005-2012
2007
Rattus norvegicus (P14740), Homo sapiens (P27487)
Manually annotated by BRENDA team
Yoshida, T.; Sakashita, H.; Akahoshi, F.; Hayashi, Y.
[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
2618-2621
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Ahn, J.H.; Shin, M.S.; Jun, M.A.; Jung, S.H.; Kang, S.K.; Kim, K.R.; Rhee, S.D.; Kang, N.S.; Kim, S.Y.; Sohn, S.K.; Kim, S.G.; Jin, M.S.; Lee, J.O.; Cheon, H.G.; Kim, S.S.
Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors
Bioorg. Med. Chem. Lett.
17
2622-2628
2007
Homo sapiens
Manually annotated by BRENDA team
Duffy, J.L.; Kirk, B.A.; Wang, L.; Eiermann, G.J.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Petrov, A.; Scapin, G.; Wu, J.K.; Thornberry, N.A.; Weber, A.E.
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
17
2879-2885
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Luebbers, T.; Boehringer, M.; Gobbi, L.; Hennig, M.; Hunziker, D.; Kuhn, B.; Loeffler, B.; Mattei, P.; Narquizian, R.; Peters, J.U.; Ruff, Y.; Wessel, H.P.; Wyss, P.
1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
2966-2970
2007
Homo sapiens
Manually annotated by BRENDA team
Kang, N.S.; Ahn, J.H.; Kim, S.S.; Chae, C.H.; Yoo, S.E.
Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors
Bioorg. Med. Chem. Lett.
17
3716-3721
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Gao, Y.D.; Feng, D.; Sheridan, R.P.; Scapin, G.; Patel, S.B.; Wu, J.K.; Zhang, X.; Sinha-Roy, R.; Thornberry, N.A.; Weber, A.E.; Biftu, T.
Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors
Bioorg. Med. Chem. Lett.
17
3877-3879
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Koo, K.D.; Kim, M.J.; Kim, S.; Kim, K.H.; Hong, S.Y.; Hur, G.C.; Yim, H.J.; Kim, G.T.; Han, H.O.; Kwon, O.H.; Kwon, T.S.; Koh, J.S.; Lee, C.S.
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones
Bioorg. Med. Chem. Lett.
17
4167-4172
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Cox, J.M.; Harper, B.; Mastracchio, A.; Leiting, B.; Sinha Roy, R.; Patel, R.A.; Wu, J.K.; Lyons, K.A.; He, H.; Xu, S.; Zhu, B.; Thornberry, N.A.; Weber, A.E.; Edmondson, S.D.
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
4579-4583
2007
Homo sapiens
Manually annotated by BRENDA team
Wright, S.W.; Ammirati, M.J.; Andrews, K.M.; Brodeur, A.M.; Danley, D.E.; Doran, S.D.; Lillquist, J.S.; Liu, S.; McClure, L.D.; McPherson, R.K.; Olson, T.V.; Orena, S.J.; Parker, J.C.; Rocke, B.N.; Soeller, W.C.; Soglia, C.B.; Treadway, J.L.; Vanvolkenburg, M.A.; Zhao, Z.; Cox, E.D.
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Bioorg. Med. Chem. Lett.
17
5638-5642
2007
Homo sapiens
Manually annotated by BRENDA team
Kaelin, D.E.; Smenton, A.L.; Eiermann, G.J.; He, H.; Leiting, B.; Lyons, K.A.; Patel, R.A.; Patel, S.B.; Petrov, A.; Scapin, G.; Wu, J.K.; Thornberry, N.A.; Weber, A.E.; Duffy, J.L.
4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
17
5806-5811
2007
Homo sapiens
Manually annotated by BRENDA team
Kowalchick, J.E.; Leiting, B.; Pryor, K.D.; Marsilio, F.; Wu, J.K.; He, H.; Lyons, K.A.; Eiermann, G.J.; Petrov, A.; Scapin, G.; Patel, R.A.; Thornberry, N.A.; Weber, A.E.; Kim, D.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
Bioorg. Med. Chem. Lett.
17
5934-5939
2007
Homo sapiens
Manually annotated by BRENDA team
Simpkins, L.M.; Bolton, S.; Pi, Z.; Sutton, J.C.; Kwon, C.; Zhao, G.; Magnin, D.R.; Augeri, D.J.; Gungor, T.; Rotella, D.P.; Sun, Z.; Liu, Y.; Slusarchyk, W.S.; Marcinkeviciene, J.; Robertson, J.G.; Wang, A.; Robl, J.A.; Atwal, K.S.; Zahler, R.L.; Parker, R.A.; Kirby, M.S.; Hamann, L.G.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
17
6476-6480
2007
Homo sapiens
Manually annotated by BRENDA team
Corbett, J.W.; Dirico, K.; Song, W.; Boscoe, B.P.; Doran, S.D.; Boyer, D.; Qiu, X.; Ammirati, M.; Vanvolkenburg, M.A.; McPherson, R.K.; Parker, J.C.; Cox, E.D.
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Bioorg. Med. Chem. Lett.
17
6707-6713
2007
Rattus norvegicus, Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Wallace, M.B.; Feng, J.; Zhang, Z.; Skene, R.J.; Shi, L.; Caster, C.L.; Kassel, D.B.; Xu, R.; Gwaltney, S.L.
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
2362-2367
2008
Homo sapiens (P27487)
Manually annotated by BRENDA team
Bergman, A.; Mistry, G.C.; Luo, W.L.; Liu, Q.; Stone, J.; Wang, A.; Zeng, W.; Chen, L.; Dilzer, S.; Lasseter, K.; Herman, G.A.; Wagner, J.A.; Krishna, R.
Dose-proportionality of a final market image sitagliptin formulation, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
Biopharm. Drug Dispos.
28
307-313
2007
Homo sapiens
Manually annotated by BRENDA team
Bergman, A.; Ebel, D.; Liu, F.; Stone, J.; Wang, A.; Zeng, W.; Chen, L.; Dilzer, S.; Lasseter, K.; Herman, G.; Wagner, J.; Krishna, R.
Absolute bioavailability of sitagliptin, an oral dipeptidyl peptidase-4 inhibitor, in healthy volunteers
Biopharm. Drug Dispos.
28
315-322
2007
Homo sapiens
Manually annotated by BRENDA team
McIntyre, H.F.; Grant, P.
Dipeptidyl peptidase-IV inhibitors: fixing type 2 diabetes?
Br. J. Hosp. Med. (Lond. )
68
599-602
2007
Homo sapiens
Manually annotated by BRENDA team
He, Y.L.; Sadler, B.M.; Sabo, R.; Balez, S.; Wang, Y.; Campestrini, J.; Laurent, A.; Ligueros-Saylan, M.; Howard, D.
The absolute oral bioavailability and population-based pharmacokinetic modelling of a novel dipeptidylpeptidase-IV inhibitor, vildagliptin, in healthy volunteers
Clin. Pharmacokinet.
46
787-802
2007
Homo sapiens
Manually annotated by BRENDA team
Herman, G.A.; Stein, P.P.; Thornberry, N.A.; Wagner, J.A.
Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin
Clin. Pharmacol. Ther.
81
761-767
2007
Homo sapiens
Manually annotated by BRENDA team
Rosenstock, J.; Brazg, R.; Andryuk, P.J.; Lu, K.; Stein, P.; Stein, P.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Clin. Ther.
28
1556-1568
2006
Homo sapiens
Manually annotated by BRENDA team
OFarrell, A.M.; van Vliet, A.; Abou Farha, K.; Cherrington, J.M.; Campbell, D.A.; Li, X.; Hanway, D.; Li, J.; Guler, H.P.
Pharmacokinetic and pharmacodynamic assessments of the dipeptidyl peptidase-4 inhibitor PHX1149: double-blind, placebo-controlled, single- and multiple-dose studies in healthy subjects
Clin. Ther.
29
1692-1705
2007
Homo sapiens
Manually annotated by BRENDA team
Ahren, B.
GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors
Curr. Diab. Rep.
7
340-347
2007
Homo sapiens
Manually annotated by BRENDA team
Herman, G.A.; Bergman, A.; Yi, B.; Kipnes, M.; Kipnes, M.
Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
Curr. Med. Res. Opin.
22
1939-1947
2006
Homo sapiens
Manually annotated by BRENDA team
He, Y.L.; Sabo, R.; Riviere, G.J.; Sunkara, G.; Leon, S.; Ligueros-Saylan, M.; Rosenberg, M.; Dole, W.P.; Howard, D.
Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
Curr. Med. Res. Opin.
23
1131-1138
2007
Homo sapiens
Manually annotated by BRENDA team
Pratley, R.E.; Salsali, A.
Inhibition of DPP-4: a new therapeutic approach for the treatment of type 2 diabetes
Curr. Med. Res. Opin.
23
919-931
2007
Homo sapiens
Manually annotated by BRENDA team
Rosenstock, J.; Zinman, B.
Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus
Curr. Opin. Endocrinol. Diabetes Obes.
14
98-107
2007
Homo sapiens
Manually annotated by BRENDA team
Mest, H.J.
Dipeptidyl peptidase-IV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement
Curr. Opin. Investig. Drugs
7
338-343
2006
Homo sapiens
Manually annotated by BRENDA team
Epstein, B.J.
Drug evaluation: PSN-9301, a short-acting inhibitor of dipeptidyl peptidase IV
Curr. Opin. Investig. Drugs
8
331-337
2007
Homo sapiens
Manually annotated by BRENDA team
Sebokova, E.; Christ, A.D.; Boehringer, M.; Mizrahi, J.
Dipeptidyl peptidase IV inhibitors: the next generation of new promising therapies for the management of type 2 diabetes
Curr. Top. Med. Chem.
7
547-555
2007
Homo sapiens
Manually annotated by BRENDA team
Thornberry, N.A.; Weber, A.E.
Discovery of JANUVIATM (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Curr. Top. Med. Chem.
7
557-568
2007
Homo sapiens
Manually annotated by BRENDA team
Peters, J.U.
11 Years of cyanopyrrolidines as DPP-IV inhibitors
Curr. Top. Med. Chem.
7
579-595
2007
Homo sapiens
Manually annotated by BRENDA team
Vella, A.; Bock, G.; Giesler, P.D.; Burton, D.B.; Serra, D.B.; Saylan, M.L.; Dunning, B.E.; Foley, J.E.; Rizza, R.A.; Camilleri, M.
Effects of dipeptidyl peptidase-4 inhibition on gastrointestinal function, meal appearance, and glucose metabolism in type 2 diabetes
Diabetes
56
1475-1480
2007
Homo sapiens
Manually annotated by BRENDA team
Aschner, P.; Kipnes, M.S.; Lunceford, J.K.; Sanchez, M.; Mickel, C.; Williams-Herman, D.E.; Williams-Herman, D.E.
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
Diabetes Care
29
2632-2637
2006
Homo sapiens
Manually annotated by BRENDA team
Charbonnel, B.; Karasik, A.; Liu, J.; Wu, M.; Meininger, G.; Meininger, G.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
Diabetes Care
29
2638-2643
2006
Homo sapiens
Manually annotated by BRENDA team
Drucker, D.J.
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action
Diabetes Care
30
1335-1343
2007
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Rosenstock, J.; Foley, J.E.; Rendell, M.; Landin-Olsson, M.; Holst, J.J.; Deacon, C.F.; Rochotte, E.; Baron, M.A.
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
Diabetes Care
31
30-35
2008
Homo sapiens
Manually annotated by BRENDA team
McKennon, S.A.; Campbell, R.K.
The physiology of incretin hormones and the basis for DPP-4 inhibitors
Diabetes Educ.
33
55-66
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Idris, I.; Donnelly, R.
Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug
Diabetes Obes. Metab.
9
153-165
2007
Homo sapiens
Manually annotated by BRENDA team
Brazg, R.; Xu, L.; Dalla Man, C.; Cobelli, C.; Thomas, K.; Stein, P.P.
Effect of adding sitagliptin, a dipeptidyl peptidase-4 inhibitor, to metformin on 24-h glycaemic control and beta-cell function in patients with type 2 diabetes
Diabetes Obes. Metab.
9
186-193
2007
Homo sapiens
Manually annotated by BRENDA team
Nauck, M.A.; Meininger, G.; Sheng, D.; Terranella, L.; Stein, P.P.; Stein, P.P.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial
Diabetes Obes. Metab.
9
194-205
2007
Homo sapiens
Manually annotated by BRENDA team
Raz, I.; Hanefeld, M.; Xu, L.; Caria, C.; Williams-Herman, D.; Khatami, H.; Khatami, H.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus
Diabetologia
49
2564-2571
2006
Homo sapiens
Manually annotated by BRENDA team
Beconi, M.G.; Reed, J.R.; Teffera, Y.; Xia, Y.Q.; Kochansky, C.J.; Liu, D.Q.; Xu, S.; Elmore, C.S.; Ciccotto, S.; Hora, D.F.; Stearns, R.A.; Vincent, S.H.
Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs
Drug Metab. Dispos.
35
525-532
2007
Canis lupus familiaris, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Ristic, S.; Bates, P.C.
Vildagliptin: a novel DPP-4 inhibitor with pancreatic islet enhancement activity for treatment of patients with type 2 diabetes
Drugs Today
42
519-531
2006
Homo sapiens
Manually annotated by BRENDA team
Gallwitz, B.
Sitagliptin: Profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes
Drugs Today
43
13-25
2007
Homo sapiens
Manually annotated by BRENDA team
Gallwitz, B.
Sitagliptin: profile of a novel DPP-4 inhibitor for the treatment of type 2 diabetes (update)
Drugs Today
43
801-814
2007
Homo sapiens
Manually annotated by BRENDA team
He, Y.L.; Sabo, R.; Campestrini, J.; Wang, Y.; Ligueros-Saylan, M.; Lasseter, K.C.; Dilzer, S.C.; Howard, D.; Dole, W.P.
The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin
Eur. J. Clin. Pharmacol.
63
677-686
2007
Homo sapiens
Manually annotated by BRENDA team
Lu, I.L.; Tsai, K.C.; Chiang, Y.K.; Jiaang, W.T.; Wu, S.H.; Mahindroo, N.; Chien, C.H.; Lee, S.J.; Chen, X.; Chao, Y.S.; Wu, S.Y.
A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
43
1603-1611
2007
Homo sapiens
Manually annotated by BRENDA team
Jun, M.A.; Park, W.S.; Kang, S.K.; Kim, K.Y.; Kim, K.R.; Rhee, S.D.; Bae, M.A.; Kang, N.S.; Sohn, S.K.; Kim, S.G.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.; Ahn, J.H.
Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
43
1889-1902
2008
Homo sapiens (P27487)
Manually annotated by BRENDA team
Yasuda, N.; Nagakura, T.; Inoue, T.; Yamazaki, K.; Katsutani, N.; Takenaka, O.; Clark, R.; Matsuura, F.; Emori, E.; Yoshikawa, S.; Kira, K.; Ikuta, H.; Okada, T.; Saeki, T.; Asano, O.; Tanaka, I.
E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor
Eur. J. Pharmacol.
548
181-187
2006
Canis lupus familiaris, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Duffy, N.A.; Green, B.D.; Irwin, N.; Gault, V.A.; McKillop, A.M.; OHarte, F.P.; Flatt, P.R.
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1
Eur. J. Pharmacol.
568
278-286
2007
Homo sapiens
Manually annotated by BRENDA team
Deacon, C.F.
Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for type 2 diabetes
Expert Opin. Investig. Drugs
16
533-545
2007
Homo sapiens
Manually annotated by BRENDA team
Green, B.D.; Flatt, P.R.; Bailey, C.J.
Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes
Expert. Opin. Emerg. Drugs
11
525-539
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
McIntosh, C.H.
Dipeptidyl peptidase IV inhibitors and diabetes therapy
Front. Biosci.
13
1753-1773
2008
Homo sapiens
Manually annotated by BRENDA team
Deacon, C.F.; Carr, R.D.; Holst, J.J.
DPP-4 inhibitor therapy: new directions in the treatment of type 2 diabetes
Front. Biosci.
13
1780-1794
2008
Homo sapiens
Manually annotated by BRENDA team
Campbell, T.B.; Broxmeyer, H.E.
CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation
Front. Biosci.
13
1795-1805
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Pratley, R.E.; Jauffret-Kamel, S.; Galbreath, E.; Holmes, D.
Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes
Horm. Metab. Res.
38
423-428
2006
Homo sapiens
Manually annotated by BRENDA team
Byrd, J.B.; Touzin, K.; Sile, S.; Gainer, J.V.; Yu, C.; Nadeau, J.; Adam, A.; Brown, N.J.
Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema
Hypertension
51
141-147
2008
Homo sapiens
Manually annotated by BRENDA team
Barnett, A.
DPP-4 inhibitors and their potential role in the management of type 2 diabetes
Int. J. Clin. Pract.
60
1454-1470
2006
Homo sapiens
Manually annotated by BRENDA team
Yates, N.A.; Deyanova, E.G.; Geissler, W.; Wiener, M.C.; Sachs, J.R.; Wong, K.K.; Thornberry, N.A.; Sinha Roy, R.; Settlage, R.E.; Hendrickson, R.C.
Identification of peptidase substrates in human plasma by FTMS based differential mass spectrometry
Int. J. Mass Spectrom.
259
174-183
2007
Homo sapiens
-
Manually annotated by BRENDA team
Hinnen, D.; Nielsen, L.L.; Waninger, A.; Kushner, P.
Incretin mimetics and DPP-IV inhibitors: new paradigms for the treatment of type 2 diabetes
J. Am. Board. Fam. Med.
19
612-620
2006
Homo sapiens
Manually annotated by BRENDA team
Boyle, P.J.; Freeman, J.S.
Application of incretin mimetics and dipeptidyl peptidase IV inhibitors in managing type 2 diabetes mellitus
J. Am. Osteopath. Assoc.
107 Suppl
S10-S16
2007
Homo sapiens
Manually annotated by BRENDA team
Herman, G.A.; Bergman, A.; Stevens, C.; Kotey, P.; Yi, B.; Zhao, P.; Dietrich, B.; Golor, G.; Schrodter, A.; Keymeulen, B.; Lasseter, K.C.; Kipnes, M.S.; Snyder, K.; Hilliard, D.; Tanen, M.; Cilissen, C.; De Smet, M.; de Lepeleire, I.; Van Dyck, K.; Wang, A.Q.; Zeng, W.; Davies, M.J.; Tanaka, W.; Holst, J.J.
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
J. Clin. Endocrinol. Metab.
91
4612-4619
2006
Homo sapiens
Manually annotated by BRENDA team
Balas, B.; Baig, M.R.; Watson, C.; Dunning, B.E.; Ligueros-Saylan, M.; Wang, Y.; He, Y.L.; Darland, C.; Holst, J.J.; Deacon, C.F.; Cusi, K.; Mari, A.; Foley, J.E.; DeFronzo, R.A.
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
J. Clin. Endocrinol. Metab.
92
1249-1255
2007
Homo sapiens
Manually annotated by BRENDA team
Sunkara, G.; Sabo, R.; Wang, Y.; He, Y.L.; Campestrini, J.; Rosenberg, M.; Howard, D.; Dole, W.P.
Dose proportionality and the effect of food on vildagliptin, a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
J. Clin. Pharmacol.
47
1152-1158
2007
Homo sapiens
Manually annotated by BRENDA team
Mistry, G.C.; Bergman, A.J.; Luo, W.L.; Cilissen, C.; Haazen, W.; Davies, M.J.; Gottesdiener, K.M.; Wagner, J.A.; Herman, G.A.
Multiple-dose administration of sitagliptin, a dipeptidyl peptidase-4 inhibitor, does not alter the single-dose pharmacokinetics of rosiglitazone in healthy subjects
J. Clin. Pharmacol.
47
159-164
2007
Homo sapiens
Manually annotated by BRENDA team
Krishna, R.; Bergman, A.; Larson, P.; Cote, J.; Lasseter, K.; Dilzer, S.; Wang, A.; Zeng, W.; Chen, L.; Wagner, J.; Herman, G.
Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin (MK-0431), a dipeptidyl peptidase-4 inhibitor, in healthy male subjects
J. Clin. Pharmacol.
47
165-174
2007
Homo sapiens
Manually annotated by BRENDA team
He, Y.L.; Sabo, R.; Sunkara, G.; Bizot, M.N.; Riviere, G.J.; Leon, S.; Ligueros-Saylan, M.; Dole, W.P.; Howard, D.
Evaluation of pharmacokinetic interactions between vildagliptin and digoxin in healthy volunteers
J. Clin. Pharmacol.
47
998-1004
2007
Homo sapiens
Manually annotated by BRENDA team
He, Y.L.; Ligueros-Saylan, M.; Sunkara, G.; Sabo, R.; Zhao, C.; Wang, Y.; Campestrini, J.; Pommier, F.; Dole, K.; Marion, A.; Dole, W.P.; Howard, D.
Vildagliptin, a novel dipeptidyl peptidase IV inhibitor, has no pharmacokinetic interactions with the antihypertensive agents amlodipine, valsartan, and ramipril in healthy subjects
J. Clin. Pharmacol.
48
85-95
2008
Homo sapiens
Manually annotated by BRENDA team
Crepaldi, G.; Carruba, M.; Comaschi, M.; Del Prato, S.; Frajese, G.; Paolisso, G.
Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in type 2 diabetes anagement
J. Endocrinol. Invest.
30
610-614
2007
Homo sapiens
Manually annotated by BRENDA team
Thielitz, A.; Reinhold, D.; Vetter, R.; Bank, U.; Helmuth, M.; Hartig, R.; Wrenger, S.; Wiswedel, I.; Lendeckel, U.; Kaehne, T.; Neubert, K.; Faust, J.; Zouboulis, C.C.; Ansorge, S.; Gollnick, H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
J. Invest. Dermatol.
127
1042-1051
2007
Homo sapiens
Manually annotated by BRENDA team
Tsu, H.; Chen, X.; Chen, C.T.; Lee, S.J.; Chang, C.N.; Kao, K.H.; Coumar, M.S.; Yeh, Y.T.; Chien, C.H.; Wang, H.S.; Lin, K.T.; Chang, Y.Y.; Wu, S.H.; Chen, Y.S.; Lu, I.L.; Wu, S.Y.; Tsai, T.Y.; Chen, W.C.; Hsieh, H.P.; Chao, Y.S.; Jiaang, W.T.
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
J. Med. Chem.
49
373-380
2006
Homo sapiens
Manually annotated by BRENDA team
Madar, D.J.; Kopecka, H.; Pireh, D.; Yong, H.; Pei, Z.; Li, X.; Wiedeman, P.E.; Djuric, S.W.; Von Geldern, T.W.; Fickes, M.G.; Bhagavatula, L.; McDermott, T.; Wittenberger, S.; Richards, S.J.; Longenecker, K.L.; Stewart, K.D.; Lubben, T.H.; Ballaron, S.J.; Stashko, M.A.; Long, M.A.; Wells, H.; Zinker, B.A.
Discovery of (2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
J. Med. Chem.
49
6416-6420
2006
Canis lupus familiaris, Rattus norvegicus, Homo sapiens (P27487)
Manually annotated by BRENDA team
Clairmont, K.B.; Buckholz, T.M.; Pellegrino, C.M.; Buxton, J.M.; Barucci, N.; Bell, A.; Ha, S.; Li, F.; Claus, T.H.; Salhanick, A.I.; Lumb, K.J.
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal
J. Med. Chem.
49
7545-7548
2006
Homo sapiens
Manually annotated by BRENDA team
Pei, Z.; Li, X.; von Geldern, T.W.; Longenecker, K.; Pireh, D.; Stewart, K.D.; Backes, B.J.; Lai, C.; Lubben, T.H.; Ballaron, S.J.; Beno, D.W.; Kempf-Grote, A.J.; Sham, H.L.; Trevillyan, J.M.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors
J. Med. Chem.
50
1983-1987
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Lai, J.H.; Wu, W.; Zhou, Y.; Maw, H.H.; Liu, Y.; Milo, L.J.; Poplawski, S.E.; Henry, G.D.; Sudmeier, J.L.; Sanford, D.G.; Bachovchin, W.W.
Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines
J. Med. Chem.
50
2391-2398
2007
Homo sapiens
Manually annotated by BRENDA team
Eckhardt, M.; Langkopf, E.; Mark, M.; Tadayyon, M.; Thomas, L.; Nar, H.; Pfrengle, W.; Guth, B.; Lotz, R.; Sieger, P.; Fuchs, H.; Himmelsbach, F.
8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
J. Med. Chem.
50
6450-6453
2007
Canis lupus familiaris, Macaca mulatta, Rattus norvegicus, Homo sapiens (P27487)
Manually annotated by BRENDA team
Pissurlenkar, R.R.; Shaikh, M.S.; Coutinho, E.C.
3D-QSAR studies of dipeptidyl peptidase IV inhibitors using a docking based alignment
J. Mol. Model.
13
1047-1071
2007
Mus musculus, Homo sapiens (P27487)
Manually annotated by BRENDA team
Zeng, J.; Liu, G.; Tang, Y.; Jiang, H.
3D-QSAR studies on fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors by CoMFA and CoMSIA
J. Mol. Model.
13
993-1000
2007
Homo sapiens (P27487)
Manually annotated by BRENDA team
Yamazaki, K.; Yasuda, N.; Inoue, T.; Nagakura, T.; Kira, K.; Shinoda, M.; Saeki, T.; Tanaka, I.
7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity
J. Pharmacol. Exp. Ther.
319
1253-1257
2006
Homo sapiens
Manually annotated by BRENDA team
Chu, X.Y.; Bleasby, K.; Yabut, J.; Cai, X.; Chan, G.H.; Hafey, M.J.; Xu, S.; Bergman, A.J.; Braun, M.P.; Dean, D.C.; Evers, R.
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein
J. Pharmacol. Exp. Ther.
321
673-683
2007
Homo sapiens
Manually annotated by BRENDA team
Triplitt, C.; Wright, A.; Chiquette, E.
Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus
Pharmacotherapy
26
360-374
2006
Homo sapiens
Manually annotated by BRENDA team
Langley, A.K.; Suffoletta, T.J.; Jennings, H.R.
Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus
Pharmacotherapy
27
1163-1180
2007
Homo sapiens
Manually annotated by BRENDA team
Davoodi, J.; Kelly, J.; Gendron, N.H.; MacKenzie, A.E.
The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26
Proteomics
7
2300-2310
2007
Homo sapiens
Manually annotated by BRENDA team
Masur, K.; Schwartz, F.; Entschladen, F.; Niggemann, B.; Zaenker, K.S.
DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells
Regul. Pept.
137
147-155
2006
Homo sapiens
Manually annotated by BRENDA team
Campbell, T.B.; Hangoc, G.; Liu, Y.; Pollok, K.; Broxmeyer, H.E.
Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice
Stem Cells Dev.
16
347-354
2007
Homo sapiens
Manually annotated by BRENDA team
Christopherson, K.W.; Paganessi, L.A.; Napier, S.; Porecha, N.K.
CD26 inhibition on CD34+ or lineage- human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-term engraftment into NOD/SCID/Beta2null immunodeficient mice
Stem Cells Dev.
16
355-360
2007
Homo sapiens
Manually annotated by BRENDA team
Moore, K.B.; Saudek, C.D.
Therapeutic potential of dipeptidyl peptidase-IV inhibitors in patients with diabetes mellitus
Am. J. Ther.
15
484-491
2008
Homo sapiens
Manually annotated by BRENDA team
Tang, H.K.; Tang, H.Y.; Hsu, S.C.; Chu, Y.R.; Chien, C.H.; Shu, C.H.; Chen, X.
Biochemical properties and expression profile of human prolyl dipeptidase DPP9
Arch. Biochem. Biophys.
485
120-127
2009
Homo sapiens
Manually annotated by BRENDA team
Matsuyama-Yokono, A.; Tahara, A.; Nakano, R.; Someya, Y.; Nagase, I.; Hayakawa, M.; Shibasaki, M.
ASP8497 is a novel selective and competitive dipeptidyl peptidase-IV inhibitor with antihyperglycemic activity
Biochem. Pharmacol.
76
98-107
2008
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Jost, M.M.; Lamerz, J.; Tammen, H.; Menzel, C.; De Meester, I.; Lambeir, A.M.; Augustyns, K.; Scharpe, S.; Zucht, H.D.; Rose, H.; Juergens, M.; Schulz-Knappe, P.; Budde, P.
In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma
Biochem. Pharmacol.
77
228-237
2009
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Eckhardt, M.; Hauel, N.; Himmelsbach, F.; Langkopf, E.; Nar, H.; Mark, M.; Tadayyon, M.; Thomas, L.; Guth, B.; Lotz, R.
3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors
Bioorg. Med. Chem. Lett.
18
3158-3162
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Liang, G.B.; Qian, X.; Biftu, T.; Singh, S.; Gao, Y.D.; Scapin, G.; Patel, S.; Leiting, B.; Patel, R.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design
Bioorg. Med. Chem. Lett.
18
3706-3710
2008
Homo sapiens
Manually annotated by BRENDA team
Ahn, J.H.; Park, W.S.; Jun, M.A.; Shin, M.S.; Kang, S.K.; Kim, K.Y.; Rhee, S.D.; Bae, M.A.; Kim, K.R.; Kim, S.G.; Kim, S.Y.; Sohn, S.K.; Kang, N.S.; Lee, J.O.; Lee, D.H.; Cheon, H.G.; Kim, S.S.
Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
18
6525-6529
2008
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Ammirati, M.J.; Andrews, K.M.; Boyer, D.D.; Brodeur, A.M.; Danley, D.E.; Doran, S.D.; Hulin, B.; Liu, S.; McPherson, R.K.; Orena, S.J.; Parker, J.C.; Polivkova, J.; Qiu, X.; Soglia, C.B.; Treadway, J.L.; VanVolkenburg, M.A.; Wilder, D.C.; Piotrowski, D.W.
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor
Bioorg. Med. Chem. Lett.
19
1991-1995
2009
Homo sapiens (P27487)
Manually annotated by BRENDA team
Hu, C.X.; Huang, H.; Zhang, L.; Huang, Y.; Shen, Z.F.; Cheng, K.D.; Du, G.H.; Zhu, P.
A new screening method based on yeast-expressed human dipeptidyl peptidase IV and discovery of novel inhibitors
Biotechnol. Lett.
31
979-984
2009
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Fukushima, H.; Hiratate, A.; Takahashi, M.; Saito-Hori, M.; Munetomo, E.; Kitano, K.; Saito, H.; Takaoka, Y.; Yamamoto, K.
Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Chem. Pharm. Bull.
56
1110-1117
2008
Homo sapiens
Manually annotated by BRENDA team
Christopher, R.; Covington, P.; Davenport, M.; Fleck, P.; Mekki, Q.A.; Wann, E.R.; Karim, A.
Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects
Clin. Ther.
30
513-527
2008
Homo sapiens
Manually annotated by BRENDA team
Gupta, R.; Walunj, S.S.; Tokala, R.K.; Parsa, K.V.; Singh, S.K.; Pal, M.
Emerging drug candidates of dipeptidyl peptidase IV (DPP IV) inhibitor class for the treatment of type 2 diabetes
Curr. Drug Targets
10
71-87
2009
Homo sapiens
Manually annotated by BRENDA team
Pei, Z.
From the bench to the bedside: dipeptidyl peptidase IV inhibitors, a new class of oral antihyperglycemic agents
Curr. Opin. Drug Discov. Devel.
11
512-532
2008
Homo sapiens
Manually annotated by BRENDA team
Deacon, C.F.
Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes
Curr. Opin. Investig. Drugs
9
402-413
2008
Homo sapiens
Manually annotated by BRENDA team
Gwaltney, S.L.
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase IV
Curr. Top. Med. Chem.
8
1545-1552
2008
Homo sapiens
Manually annotated by BRENDA team
Garcia-Soria, G.; Gonzalez-Galvez, G.; Argoud, G.M.; Gerstman, M.; Littlejohn, T.W.; Schwartz, S.L.; OFarrell, A.M.; Li, X.; Cherrington, J.M.; Bennett, C.; Guler, H.P.
The dipeptidyl peptidase-4 inhibitor PHX1149 improves blood glucose control in patients with type 2 diabetes mellitus
Diabetes Obes. Metab.
10
293-300
2008
Homo sapiens
Manually annotated by BRENDA team
Dai, H.; Gustavson, S.M.; Preston, G.M.; Eskra, J.D.; Calle, R.; Hirshberg, B.
Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects
Diabetes Obes. Metab.
10
506-513
2008
Homo sapiens
Manually annotated by BRENDA team
Lee, B.; Shi, L.; Kassel, D.B.; Asakawa, T.; Takeuchi, K.; Christopher, R.J.
Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys
Eur. J. Pharmacol.
589
306-314
2008
Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Ahren, B.
Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes
Expert. Opin. Emerg. Drugs
13
593-607
2008
Homo sapiens
Manually annotated by BRENDA team
Gallwitz, B.
Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
IDrugs
11
906-917
2008
Homo sapiens
Manually annotated by BRENDA team
Serra, D.; He, Y.L.; Bullock, J.; Riviere, G.J.; Balez, S.; Schwartz, S.; Wang, Y.; Ligueros-Saylan, M.; Jarugula, V.; Dole, W.P.
Evaluation of pharmacokinetic and pharmacodynamic interaction between the dipeptidyl peptidase IV inhibitor vildagliptin, glyburide and pioglitazone in patients with Type 2 diabetes
Int. J. Clin. Pharmacol. Ther.
46
349-364
2008
Homo sapiens
Manually annotated by BRENDA team
Boschmann, M.; Engeli, S.; Dobberstein, K.; Budziarek, P.; Strauss, A.; Boehnke, J.; Sweep, F.C.; Luft, F.C.; He, Y.; Foley, J.E.; Jordan, J.
Dipeptidyl-peptidase-IV inhibition augments postprandial lipid mobilization and oxidation in type 2 diabetic patients
J. Clin. Endocrinol. Metab.
94
846-852
2009
Homo sapiens
Manually annotated by BRENDA team
Forssmann, U.; Stoetzer, C.; Stephan, M.; Kruschinski, C.; Skripuletz, T.; Schade, J.; Schmiedl, A.; Pabst, R.; Wagner, L.; Hoffmann, T.; Kehlen, A.; Escher, S.E.; Forssmann, W.G.; Elsner, J.; von Hoersten, S.
Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo
J. Immunol.
181
1120-1127
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Connolly, B.A.; Sanford, D.G.; Chiluwal, A.K.; Healey, S.E.; Peters, D.E.; Dimare, M.T.; Wu, W.; Liu, Y.; Maw, H.; Zhou, Y.; Li, Y.; Jin, Z.; Sudmeier, J.L.; Lai, J.H.; Bachovchin, W.W.
Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety
J. Med. Chem.
51
6005-6013
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Fuchs, H.; Tillement, J.P.; Urien, S.; Greischel, A.; Roth, W.
Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans
J. Pharm. Pharmacol.
61
55-62
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Thomas, L.; Eckhardt, M.; Langkopf, E.; Tadayyon, M.; Himmelsbach, F.; Mark, M.
(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with oth
J. Pharmacol. Exp. Ther.
325
175-182
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kuehlmann, U.C.; Chwieralski, C.E.; van den Brule, S.; Roecken, C.; Reinhold, D.; Welte, T.; Buehling, F.
Modulation of cytokine production and silica-induced lung fibrosis by inhibitors of aminopeptidase N and of dipeptidyl peptidase-IV-related proteases
Life Sci.
84
1-11
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Yilmaz, Y.; Atug, O.; Yonal, O.; Duman, D.; Ozdogan, O.; Imeryuz, N.; Kalayci, C.
Dipeptidyl peptidase IV inhibitors: therapeutic potential in nonalcoholic fatty liver disease
Med. Sci. Monit.
15
HY1-HY5
2009
Homo sapiens
Manually annotated by BRENDA team
Someya, Y.; Tahara, A.; Nakano, R.; Matsuyama-Yokono, A.; Nagase, I.; Fukunaga, Y.; Takasu, T.; Hayakawa, M.; Shibasaki, M.
Pharmacological profile of ASP8497, a novel, selective, and competitive dipeptidyl peptidase-IV inhibitor, in vitro and in vivo
Naunyn Schmiedebergs Arch. Pharmacol.
377
209-217
2008
Canis lupus familiaris, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Ahren, B.
Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
Vasc. Health Risk Manag.
4
383-394
2008
Homo sapiens
Manually annotated by BRENDA team
Pentzien, A.K.; Meisel, H.
Transepithelial transport and stability in blood serum of angiotensin-I-converting enzyme inhibitory dipeptides
Z. Naturforsch. C
63
451-459
2008
Homo sapiens
Manually annotated by BRENDA team
Nordhoff, S.; Lopez-Canet, M.; Hoffmann-Enger, B.; Bulat, S.; Cerezo-Galvez, S.; Hill, O.; Rosenbaum, C.; Rummey, C.; Thiemann, M.; Matassa, V.G.; Edwards, P.J.; Feurer, A.
From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
19
4818-4823
2009
Homo sapiens
Manually annotated by BRENDA team
Boehringer, M.; Fischer, H.; Hennig, M.; Hunziker, D.; Huwyler, J.; Kuhn, B.; Loeffler, B.M.; Luebbers, T.; Mattei, P.; Narquizian, R.; Sebokova, E.; Sprecher, U.; Wessel, H.P.
Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
20
1106-1108
2010
Homo sapiens
Manually annotated by BRENDA team
Yeh, T.K.; Tsai, T.Y.; Hsu, T.; Cheng, J.H.; Chen, X.; Song, J.S.; Shy, H.S.; Chiou, M.C.; Chien, C.H.; Tseng, Y.J.; Huang, C.Y.; Yeh, K.C.; Huang, Y.L.; Huang, C.H.; Huang, Y.W.; Wang, M.H.; Tang, H.K.; Chao, Y.S.; Chen, C.T.; Jiaang, W.T.
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
Bioorg. Med. Chem. Lett.
20
3596-3600
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Lim, K.S.; Cho, J.Y.; Kim, B.H.; Kim, J.R.; Kim, H.S.; Kim, D.K.; Kim, S.H.; Yim, H.J.; Lee, S.H.; Shin, S.G.; Jang, I.J.; Yu, K.S.
Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers
Br. J. Clin. Pharmacol.
68
883-890
2009
Homo sapiens
Manually annotated by BRENDA team
Kajiyama, H.; Shibata, K.; Ino, K.; Mizutani, S.; Nawa, A.; Kikkawa, F.
The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cells
Cancer Sci.
101
347-354
2010
Homo sapiens
Manually annotated by BRENDA team
Vanderheyden, M.; Bartunek, J.; Goethals, M.; Verstreken, S.; Lambeir, A.M.; De Meester, I.; Scharpe, S.
Dipeptidyl-peptidase IV and B-type natriuretic peptide. From bench to bedside
Clin. Chem. Lab. Med.
47
248-252
2009
Homo sapiens
Manually annotated by BRENDA team
Kuepeli, E.; Karnak, D.; Elguen, S.; Argueder, E.; Kayacan, O.
Concurrent measurement of adenosine deaminase and dipeptidyl peptidase IV activity in the diagnosis of tuberculous pleural effusion
Diagn. Microbiol. Infect. Dis.
65
365-371
2009
Homo sapiens
Manually annotated by BRENDA team
Wang, L.; Zhang, B.; Ji, J.; Li, B.; Yan, J.; Zhang, W.; Wu, Y.; Wang, X.
Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors
Eur. J. Med. Chem.
44
3318-3322
2009
Homo sapiens
Manually annotated by BRENDA team
Yu, D.M.; Yao, T.W.; Chowdhury, S.; Nadvi, N.A.; Osborne, B.; Church, W.B.; McCaughan, G.W.; Gorrell, M.D.
The dipeptidyl peptidase IV family in cancer and cell biology
FEBS J.
277
1126-1144
2010
Homo sapiens (P27487)
Manually annotated by BRENDA team
Kotackova, L.; Balaziova, E.; Sedo, A.
Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer
Folia Biol. (Praha)
55
77-84
2009
Homo sapiens
Manually annotated by BRENDA team
Jang, S.; Chung, T.Y.; Shin, J.; Lin, K.L.; Tzen, J.T.; Li, F.Y.
Docking study of the precursor peptide of matoparan onto its putative processing enzyme, dipeptidyl peptidase IV: a revisit to molecular ticketing
J. Comput. Aided Mol. Des.
24
213-224
2010
Homo sapiens
Manually annotated by BRENDA team
Al-masri, I.M.; Mohammad, M.K.; Tahaa, M.O.
Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine
J. Enzyme Inhib. Med. Chem.
24
1061-1066
2009
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Maalouf, K.; Jia, J.; Rizk, S.; Brogden, G.; Keiser, M.; Das, A.; Naim, H.Y.
A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV
J. Inherit. Metab. Dis.
33
445-449
2010
Homo sapiens
Manually annotated by BRENDA team
Diez-Torrubia, A.; Garcia-Aparicio, C.; Cabrera, S.; De Meester, I.; Balzarini, J.; Camarasa, M.J.; Velazquez, S.
Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs
J. Med. Chem.
53
559-572
2010
Bos taurus, Homo sapiens
Manually annotated by BRENDA team
Jiang, Y.K.
Molecular docking and 3D-QSAR studies on beta-phenylalanine derivatives as dipeptidyl peptidase IV inhibitors
J. Mol. Model.
16
1239-1249
2010
Homo sapiens (P27487)
Manually annotated by BRENDA team
Xu, F.; Corley, E.; Zacuto, M.; Conlon, D.A.; Pipik, B.; Humphrey, G.; Murry, J.; Tschaen, D.
Asymmetric synthesis of a potent, aminopiperidine-fused imidazopyridine dipeptidyl peptidase IV inhibitor
J. Org. Chem.
75
1343-1353
2010
Homo sapiens
Manually annotated by BRENDA team
Beesley, C.E.; Young, E.P.; Finnegan, N.; Jackson, M.; Mills, K.; Vellodi, A.; Cleary, M.; Winchester, B.G.
Discovery of a new biomarker for the mucopolysaccharidoses (MPS), dipeptidyl peptidase IV (DPP-IV; CD26), by SELDI-TOF mass spectrometry
Mol. Genet. Metab.
96
218-224
2009
Homo sapiens
Manually annotated by BRENDA team
Fletcher, M.A.; Zeng, X.R.; Maher, K.; Levis, S.; Hurwitz, B.; Antoni, M.; Broderick, G.; Klimas, N.G.
Biomarkers in chronic fatigue syndrome: evaluation of natural killer cell function and dipeptidyl peptidase IV/CD26
PLoS ONE
5
e10817
2010
Homo sapiens
Manually annotated by BRENDA team
Lawandi, J.; Toumieux, S.; Seyer, V.; Campbell, P.; Thielges, S.; Juillerat-Jeanneret, L.; Moitessier, N.
Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors
J. Med. Chem.
52
6672-6684
2009
Homo sapiens
Manually annotated by BRENDA team
Bar-Or, D.; Slone, D.S.; Mains, C.W.; Rael, L.T.
Dipeptidyl peptidase IV activity in commercial solutions of human serum albumin
Anal. Biochem.
441
13-17
2013
Homo sapiens
Manually annotated by BRENDA team
Wu, W.; Liu, Y.; Milo, L.J.; Shu, Y.; Zhao, P.; Li, Y.; Woznica, I.; Yu, G.; Sanford, D.G.; Zhou, Y.; Poplawski, S.E.; Connolly, B.A.; Sudmeier, J.L.; Bachovchin, W.W.; Lai, J.H.
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
Bioorg. Med. Chem. Lett.
22
5536-5540
2012
Homo sapiens
Manually annotated by BRENDA team
Lam, B.; Zhang, Z.; Stafford, J.A.; Skene, R.J.; Shi, L.; Gwaltney, S.L.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Bioorg. Med. Chem. Lett.
22
6628-6631
2012
Homo sapiens (P27487)
Manually annotated by BRENDA team
Zhang, X.; Wang, J.; Su, M.; Li, Z.; Li, J.; Li, J.; Liu, H.
Discovering novel alpha-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling
Chem. Biol. Drug Des.
80
843-852
2012
Homo sapiens (P27487)
Manually annotated by BRENDA team
Sharma, M.; Singh, D.; Gupta, M.
Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors
Chem. Biol. Drug Des.
81
257-264
2013
Homo sapiens
Manually annotated by BRENDA team
Zhu, L.; Li, Y.; Qiu, L.; Su, M.; Wang, X.; Xia, C.; Qu, Y.; Li, J.; Li, J.; Xiong, B.; Shen, J.
Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors
ChemMedChem
8
1104-1116
2013
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Li, Z.; Zhang, J.
Dipeptidyl peptidase IV reduces trophoblast invasion by inhibiting the activity of MMPs
Int. J. Dev. Biol.
58
349-353
2014
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Herlihy, S.E.; Pilling, D.; Maharjan, A.S.; Gomer, R.H.
Dipeptidyl peptidase IV is a human and murine neutrophil chemorepellent
J. Immunol.
190
6468-6477
2013
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Dimitrova, M.; Ivanov, I.; Todorova, R.; Stefanova, N.; Moskova-Doumanova, V.; Topouzova-Hristova, T.; Saynova, V.; Stephanova, E.
Comparison of the activity levels and localization of dipeptidyl peptidase IV in normal and tumor human lung cells
Tissue Cell
44
74-79
2012
Homo sapiens
Manually annotated by BRENDA team
Lee, H.K.; Kim, M.K.; Kim, H.D.; Kim, H.J.; Kim, J.W.; Lee, J.O.; Kim, C.W.; Kim, E.E.
Unique binding mode of evogliptin with human dipeptidyl peptidase IV
Biochem. Biophys. Res. Commun.
494
452-459
2017
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Ran, Y.; Pei, H.; Shao, M.; Chen, L.
Synthesis, biological evaluation, and molecular docking of (R)-2-((8-(3-aminopiperidin-1-yl)-3-methyl-7-(3-methylbut-2-en-1-yl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)methyl)benzonitrile as dipeptidyl peptidase IV inhibitors
Chem. Biol. Drug Des.
87
290-295
2016
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Xing, J.; Gong, Q.; Zhang, R.; Sun, S.; Zou, R.; Wu, A.
A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging
Chem. Commun. (Camb.)
54
8773-8776
2018
Homo sapiens (P27487)
Manually annotated by BRENDA team
Zhang, Y.; Liu, H.; Hong, H.; Luo, Y.
Purification and identification of dipeptidyl peptidase IV and angiotensin-converting enzyme inhibitory peptides from silver carp (Hypophthalmichthys molitrix) muscle hydrolysate
Eur. Food Res. Technol.
245
243-255
2019
Homo sapiens
-
Manually annotated by BRENDA team
Busek, P.; Hrabal, P.; Fric, P.; Sedo, A.
Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets
Histochem. Cell Biol.
143
497-504
2015
Homo sapiens (P27487)
-
Manually annotated by BRENDA team
Pereira, A.L.E.; Dos Santos, G.B.; Franco, M.S.F.; Federico, L.B.; da Silva, C.H.T.P.; Santos, C.B.R.
Molecular modeling and statistical analysis in the design of derivatives of human dipeptidyl peptidase IV
J. Biomol. Struct. Dyn.
36
318-334
2018
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team
Frenssen, F.; Croonenberghs, J.; Van den Steene, H.; Maes, M.
Prolyl endopeptidase and dipeptidyl peptidase IV are associated with externalizing and aggressive behaviors in normal and autistic adolescents
Life Sci.
136
157-162
2015
Homo sapiens (P27487), Homo sapiens
Manually annotated by BRENDA team