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Information on EC 3.4.14.5 - dipeptidyl-peptidase IV and Organism(s) Homo sapiens

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Homo sapiens
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
Synonyms
(GLP1)-degrading enzyme, ACT3, ADA binding protein, ADA-binding protein, ADABP, adenosine deaminase binding protein, Adenosine deaminase complexing protein, adenosine deaminase-binding protein, amino acyl-prolyl dipeptidyl aminopeptidase, aminopeptidase, glycylproline, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(GLP1)-degrading enzyme
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ACT3
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ADA binding protein
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ADA-binding protein
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ADABP
adenosine deaminase binding protein
Adenosine deaminase complexing protein
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adenosine deaminase-binding protein
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amino acyl-prolyl dipeptidyl aminopeptidase
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aminopeptidase, glycylproline
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Bile canaliculus domain-specific membrane glycoprotein
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CD26 peptidase
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dipeptidyl aminopeptidase IV
dipeptidyl peptidase 8
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dipeptidyl peptidase 9
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dipeptidyl peptidase IV
dipeptidyl-aminopeptidase IV
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dipeptidyl-peptidase 4
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dipeptidyl-peptidase IV (CD26)
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dipeptidyl-peptide hydrolase
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dipeptidylpeptidase IV
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dipeptidylpeptidase IV/CD26
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dipeptidylpeptidase-IV
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DPIV
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DPP IV
DPP IV/CD26
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DPP-IV
DPP8
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DPP8 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPP9
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DPP9 is a prolyl dipeptidases, cleaving the peptide bond after the penultimate proline residue
DPPIV
glucagon-like peptide 1-degrading enzyme
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Gly-Pro-naphthylamidase
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glycoprotein GP110
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glycylproline aminopeptidase
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glycylproline-dipeptidyl-aminopeptidase
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glycylprolyl aminopeptidase
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glycylprolyl dipeptidylaminopeptidase
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GP110 glycoprotein
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h-DPPIV
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leukocyte antigen CD26
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lymphocyte, antigen CD26
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Pep X
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peptidase, dipeptidyl, IV
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postproline dipeptidyl aminopeptidase IV
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prolyl-dipeptidyl-aminopeptidase
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T cell triggering molecule Tp103
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T-cell activation antigen CD26
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THAM
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Thymocyte-activating molecule
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TP103
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WC10
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X-PDAP
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X-prolyl dipeptidyl aminopeptidase
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Xaa-Pro-dipeptidyl-aminopeptidase
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additional information
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline
show the reaction diagram
CAS REGISTRY NUMBER
COMMENTARY hide
54249-88-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-(glycyl-L-prolyl hydrazido)-N-hexyl-1,8-naphthalimide + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Ala-2-naphthylamide + H2O
Ala-Ala + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
Ala-Pro-7-amido-4-methylcoumarin + H2O
Ala-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Ala-Pro-7-amido-4-trifluoromethyl coumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethyl coumarin
show the reaction diagram
-
-
-
?
Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O
Ala-Pro + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Asn-Pro-4-nitroanilide + H2O
Asn-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
show the reaction diagram
-
low activity
-
?
B-type natriuretic peptide (1-32) + H2O
B-type natriuretic peptide (3-32) + L-Ser-L-Pro
show the reaction diagram
-
DPP IV removes the two amino terminal amino acids (Ser-Pro) from B-type natriuretic peptide (1-32) to produce B-type natriuretic peptide (3-32)
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?
B-type natriuretic peptide(1-32) + H2O
B-type natriuretic peptide(3-32) + ?
show the reaction diagram
-
-
-
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?
B-type natriuretic propeptide (1-108) + H2O
B-type natriuretic propeptide (3-306) + ?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
BRI peptide (1-23) + H2O
?
show the reaction diagram
-
-
-
-
?
casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
corticotropin-like intermediate lobe peptide + H2O
?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
EPLGRQLTSGP + H2O
Glu-Pro + LGRQLTSGP
show the reaction diagram
-
the sequence EPLGRQLTSGP, which corresponds to the propeptide fragment of alpha-2 plasmin inhibitor
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-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
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?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
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?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
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?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
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-
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?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
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-
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?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
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?
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
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?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
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?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
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?
glucose-dependent insulinotropic polypeptide(1-42) peptide + H2O
?
show the reaction diagram
-
GIP-fragment
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?
glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
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GIP-fragment, very low activity
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?
Gly-Ala-4-nitroanilide + H2O
Gly-Ala + 4-nitroaniline
show the reaction diagram
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low activity
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?
Gly-azetidine-2-carboxyl-3,5-dibromo-4-hydroxyanilide + H2O
Gly-azetidine + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
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-
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?
Gly-Hyp-Ala + H2O
Ala + ?
show the reaction diagram
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-
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?
Gly-L-hydroxyproline-3,5-dibromo-4-hydroxyanilide + H2O
Gly-L-hydroxyproline + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
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-
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?
Gly-L-Pro-4-nitroanilide
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
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?
Gly-L-Pro-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
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-
-
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?
Gly-L-Pro-7-amido-4-methylcoumarin + H2O
Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
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-
-
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?
Gly-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
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?
Gly-Phe-4-nitroanilide + H2O
Gly-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
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?
Gly-Pro 4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
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?
Gly-Pro-2-naphthylamide + H2O
Gly-Pro + 2-naphthylamine
show the reaction diagram
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-
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?
Gly-Pro-3,5-dibromo-4-hydroxyanilide + H2O
Gly-Pro + 3,5-dibromo-4-hydroxyaniline
show the reaction diagram
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-
-
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?
Gly-Pro-4-methoxy-2-naphthylamide
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
fluorogenic substrate
-
?
Gly-Pro-4-methoxy-2-naphthylamide + H2O
Gly-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
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-
-
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?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-Pro-4-methylcoumaryl-7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
Gly-Pro-glycinamide + H2O
Gly-Pro + glycinamide
show the reaction diagram
-
the anti-HIV drug Gly-Pro-glycinamide is not active as such, but rather behaves as a prodrug that must be obligatorily cleaved by VD26/DPP IV to Gly-Pro and glycinamide to exert its antiretroviral activity
-
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?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
glycyl-L-prolyl-4-nitroanilide + H2O
Gly-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
H-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
H-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
His-Ala-4-nitroanilide + H2O
His-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-4-nitroanilide + H2O
His-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-Phe + H2O
His-Pro + Phe
show the reaction diagram
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
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?
Ile-Pro-4-nitroanilide + H2O
Ile-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
incretin hormone glucagon-like peptide 1 + H2O
?
show the reaction diagram
-
i.e. GLP-1, degradation, regulation of activity
-
?
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
kentsin + H2O
Thr-Pro + ?
show the reaction diagram
-
-
-
?
L-Ala-L-Pro 4-nitroanilide + H2O
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-4-nitroanilide
L-Ala-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O
L-Ala-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Ala-L-Pro-p-nitroanilide + H2O
L-Ala-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-7-amido-4-methylcoumarin + H2O
L-Arg-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
L-Arg-L-Pro-p-nitroanilide + H2O
L-Arg-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asn-L-Pro-p-nitroanilide + H2O
L-Asn-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-6-aminoquinolide + H2O
L-Asp-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Asp-L-Pro-p-nitroanilide + H2O
L-Asp-L-Pro + p-nitroaniline
show the reaction diagram
-
least preferred substrate
-
-
?
L-Glu-L-Pro-4-nitroanilide
L-Glu-L-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Glu-L-Pro-p-nitroanilide + H2O
L-Glu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Leu-L-Pro-p-nitroanilide + H2O
L-Leu-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-p-nitroanilide + H2O
Gly-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Pro-p-nitroanilide + H2O
L-Lys-L-Pro + p-nitroaniline
show the reaction diagram
-
most preferred substrate
-
-
?
L-Met-L-Pro-p-nitroanilide + H2O
L-Met-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Ser-L-Pro-p-nitroanilide + H2O
L-Ser-L-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Val-L-Ala-L-Val-L-Pro + H2O
?
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-6-aminoquinolide + H2O
L-Val-L-Pro + 6-aminoquinoline
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-doxorubicin + H2O
L-Val-L-Pro + doxorubicin
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosyladenosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosyladenosine
show the reaction diagram
-
-
-
-
?
L-Val-L-Pro-L-Val-L-Pro-beta-D-arabinofuranosylcytosine + H2O
L-Val-L-Pro-L-Val-L-Pro + beta-D-arabinofuranosylcytosine
show the reaction diagram
-
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-nitroanilide + H2O
Lys-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Pro-4-methoxy-2-naphthylamide + H2O
Lys-Pro + 4-methoxy-2-naphthylamine
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
show the reaction diagram
-
-
-
?
N-terminal B-type natriuretic propeptide (1-76) + H2O
N-terminal B-type natriuretic propeptide (3-76) + ?
show the reaction diagram
-
-
-
-
?
N-tosyl-Gly-L-Pro-7-amido-4-methylcoumarin + H2O
N-tosyl-Gly-L-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
norleucine-Pro-7-amido-4-methylcoumarin + H2O
norleucine-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
norleucine-Pro-rhodamine + H2O
norleucine-Pro + rhodamine
show the reaction diagram
-
-
-
?
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
NPY(1-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
NPY(3-36) peptide + H2O
?
show the reaction diagram
-
peptide derived from the neuropeptide-Y
-
?
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Ala-4-nitroanilide + H2O
Phe-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Phe-Ala-Pro-2-naphthylamide + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Pro-2-naphthylamide + H2O
Phe-Pro + 2-naphthylamine
show the reaction diagram
-
L-Phe-L-Pro-2-naphthylamide
-
-
?
Phe-Pro-4-nitroanilide + H2O
Phe-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
pituitary adenylate cyclase activating peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Ala-4-nitroanilide + H2O
Pro-Ala + 4-nitroaniline
show the reaction diagram
-
best substrate
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-Pro-4-nitroanilide + H2O
Pro-Pro + 4-nitroaniline
show the reaction diagram
-
high activity
-
?
Pro-Pro-Gly + H2O
Gly + ?
show the reaction diagram
-
-
-
?
procasomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
procolipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
Ser-Pro-4-nitroanilide + H2O
Ser-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
substance P + H2O
Arg-Pro + Lys-Pro + ?
show the reaction diagram
substance P + H2O
peptides SP(3-11) + SP(5-11)
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
synthetic renin inhibitor + H2O
?
show the reaction diagram
-
His-Pro-Phe-His-Leu-D-Leu-Val-Tyr
-
-
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen propeptide + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Ala-4-nitroanilide + H2O
Tyr-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tyr-D-Ala-Gly-Phe-Met-NH2 + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-melanostatin + H2O
?
show the reaction diagram
-
-
-
-
?
Tyr-Pro-4-nitroanilide + H2O
Tyr-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
Val-Ala-4-nitroanilide + H2O
Val-Ala-4-nitroaniline
show the reaction diagram
-
-
-
-
?
Val-Pro-4-nitroanilide + H2O
Val-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
VPAC2P-PEG + H2O
?
show the reaction diagram
-
VPAC2P-PEG is a VPAC2 receptor agonist peptide that acts as a glucose-dependent insulin secretagogue. Proteolysis by DPPIV may contribute to the in vivo clearance of VPAC2P-PEG. The N-terminus of VPAC2P-PEG is modified by N-terminal acetylation to impart DPPIV resistance. The acetylated peptide, Ac-VPAC2P-PEG, is a selective and potent VPAC2 agonist, resistant to DPPIV proteolysis
-
-
?
[Gly2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with glycine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Ser2]glucose-dependent insulinotropic polypeptide(1-6) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with serine at position 2 in the sequence
-
?
[Val2]glucose-dependent insulinotropic polypeptide(1-30) peptide + H2O
?
show the reaction diagram
-
GIP-fragment with valine at position 2 in the sequence
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha1-microglobulin + H2O
?
show the reaction diagram
-
-
-
-
?
aprotinin + H2O
?
show the reaction diagram
-
-
-
-
?
beta-casomorphin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
-
?
CCL11 + H2O
CCL11(3-74) + ?
show the reaction diagram
-
-
-
-
?
enterostatin + H2O
?
show the reaction diagram
-
-
-
-
?
eotaxin + H2O
?
show the reaction diagram
-
i.e. CCL11, chemokine
-
?
gastrin releasing peptide + H2O
?
show the reaction diagram
gastrin-releasing peptide + H2O
?
show the reaction diagram
-
-
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 (7-37) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 1 + H2O
?
show the reaction diagram
glucagon-like peptide 2 (1-33) + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide 2 + H2O
?
show the reaction diagram
-
i.e. GLP 2
-
?
glucagon-like peptide-1 (7-36)-amide + H2O
?
show the reaction diagram
-
-
-
-
?
glucagon-like peptide-1 + H2O
?
show the reaction diagram
glucose-dependent insulinotropic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
glucose-dependent insulinotropic polypeptide + H2O
?
show the reaction diagram
Gly-Pro-glycinamide + H2O
?
show the reaction diagram
-
CD26 plays a direct regulatory and indispensable role in the eventual antiretroviral activity of small synthetic molecules such as the antiretroviral prodrug Gly-Pro-glycinamide
-
-
?
growth hormone releasing factor + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-29) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone releasing hormone (1-44) + H2O
?
show the reaction diagram
-
-
-
-
?
growth hormone-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
human chorionic gonadotropin alpha + H2O
?
show the reaction diagram
-
-
-
-
?
IFN-gamma-inducible protein 10 + H2O
?
show the reaction diagram
-
i.e. IP-10 or CXCL10, chemokine
-
?
IFN-inducible T-cell alpha-chemoattractant + H2O
?
show the reaction diagram
-
i.e. I-TAC or CXCL11, chemokine
-
?
insulin-like growth factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
interferon-gamma-inducible protein-10 + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin 1-beta + H2O
?
show the reaction diagram
-
-
-
-
?
interleukin-2 + H2O
?
show the reaction diagram
-
-
-
-
?
leutinising hormone alpha chain + H2O
?
show the reaction diagram
-
-
-
-
?
macrophage-derived chemokine + H2O
?
show the reaction diagram
monocyte chemotactic protein-1 + H2O
?
show the reaction diagram
-
-
-
-
?
monocyte chemotactic protein-2 + H2O
?
show the reaction diagram
-
-
-
-
?
monokine induced by IFN-gamma + H2O
?
show the reaction diagram
-
i.e. MIg or CXCL9, chemokine
-
?
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
NPY + H2O
?
show the reaction diagram
-
important step in the neuropeptide-Y NPY-mediated angiogenesis
-
?
peptide YY (1-36) + H2O
?
show the reaction diagram
-
-
-
-
?
peptide YY + H2O
?
show the reaction diagram
-
-
-
-
?
pro-colipase + H2O
?
show the reaction diagram
-
-
-
-
?
prolactin + H2O
?
show the reaction diagram
-
-
-
-
?
promastoparan + H2O
mastoparan + ?
show the reaction diagram
-
-
-
-
?
RANTES + H2O
?
show the reaction diagram
-
i.e. CCL5 or regulated on activation normal T-cell expressed and secreted, chemokine
-
?
RANTES protein + H2O
?
show the reaction diagram
-
-
-
-
?
SDF-1/CXCL12 + H2O
?
show the reaction diagram
-
CD26 may play a role in SDF-1/CXCL12 mediated functions such as chemotaxis
-
-
?
stromal cell derived factor 1 + H2O
?
show the reaction diagram
-
i.e. SDF-1 or CXCL12, chemokine
-
?
stromal cell-derived factor 1alpha + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor 1beta + H2O
?
show the reaction diagram
-
-
-
-
?
stromal cell-derived factor-1 + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
-
?
substance P + H2O
peptides SP(3-11) + SP(5-11)
show the reaction diagram
-
i.e. SP, sequential cleavage of full length substance P
both fragments are still active
?
thyrotropin + H2O
?
show the reaction diagram
-
-
-
-
?
Trypsinogen + H2O
?
show the reaction diagram
-
-
-
-
?
trypsinogen pro-peptide + H2O
?
show the reaction diagram
-
-
-
-
?
vasostatin-1 + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
-
-
(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
-
-
(1R)-2-([(3R,4R)-4-amino-1-[1-(4-ethynylphenyl)ethyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-([(3R,4R)-4-amino-1-[2-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-([(3R,4R)-4-amino-1-[3-methyl-4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)cyclopentanecarbonitrile
-
-
(1R)-2-[[(3R,4R)-4-amino-1-(3,4-dihydro-2H-chromen-4-yl)pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
-
(1R)-2-[[(3R,4R)-4-amino-1-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]pyrrolidin-3-yl]carbonyl]cyclopentanecarbonitrile
-
-
(1R,3S)-2-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)-3-fluorocyclopentanecarbonitrile
-
-
(1R,3S)-2-[(2S)-2-amino-2-cyclopentylacetyl]-3-ethynylcyclopentanecarbonitrile
-
-
(1S)-1-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-2-[(3S)-3-fluoropyrrolidin-1-yl]-2-oxoethanaminium
-
-
(1S)-1-cyclohexyl-2-(3,3-difluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-(3-fluoropyrrolidin-1-yl)-2-oxoethanamine
-
-
(1S)-1-cyclohexyl-2-oxo-2-(3,3,4,4-tetrafluoropyrrolidin-1-yl)ethanamine
-
-
(1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine
-
-
(1S,2S)-1-(4'-fluorobiphenyl-4-yl)-3-[(3S)-3-fluoropyrrolidin-1-yl]-3-oxo-1-(1H-tetrazol-1-yl)propan-2-amine
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(1S,3S,5S)-2-[(2S)-2-amino-2-[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
-
-
(2-(4-((2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-4-pyridine carboxylic acid
-
i. e. ABT-279, a very potent, selective, effective, and well-tolerated inhibitor useful for the treatment of diabetes
(2R)-1-(2,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(2-methylphenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-dichlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxobutan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(3,4-difluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
-
(2R)-1-(3-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-chlorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-fluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-iodophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-(4-nitrophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-cyclohexyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2R)-1-[8-(trifluoromethyl)bis[1,2,4]triazolo[4,3-a:3',4'-c]pyrazin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[9-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4',3':1,2]pyrido[3,4-d]pyrimidin-3-yl]-3-(2,4,5-trifluorophenyl)propan-2-amine
-
-
(2R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2R)-4-(1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(2-benzoylpyrazolidin-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(3-methyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-acetyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-benzyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(4-ethyl-1,4-diazepan-1-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-1-phenyl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-2-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-3-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-1-pyridin-4-yl-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-(3,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[2-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[3-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(1,3-thiazolidin-3-yl)-1-[4-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2R)-4-oxo-4-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(4-pyrazin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-(4-pyrimidin-2-yl-1,4-diazepan-1-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-pyrazolidin-1-yl-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[2-(phenylcarbonyl)-1,2-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
competitive
(2R)-4-oxo-4-[2-(phenylcarbonyl)tetrahydropyridazin-1(2H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
the inhibitor displays a greater than 1400fold selectivity over all the enzymes tested including DPP-8 and DPP-9
(2R)-4-oxo-4-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
(2R)-4-oxo-4-[4-(phenylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[4-(pyridin-3-ylcarbonyl)-1,4-diazepan-1-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-oxo-4-[8-(1H-pyrazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(2R)-2-benzylpiperazin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8R)-8-[(1-fluorocyclopropyl)methyl]-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[2-[(4-methylphenyl)sulfonyl]pyrazolidin-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine hydrochloride
-
-
(2R)-4-[4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-(methylsulfonyl)-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-methylphenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-methylpiperazin-1-yl)carbonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[4-[(4-nitrophenyl)sulfonyl]-1,4-diazepan-1-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(1H-imidazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R)-4-[8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
-
(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
-
potent, selectiveDPP-4 inhibitor
(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
-
(2R,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,3S)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N1,N1-dimethyl-4-oxobutane-1,3-diamine
-
-
(2R,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2R,3S,5R)-5-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine
-
-
(2R,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate
-
best selectivity for dipeptidyl peptidase IV over dipeptidyl peptidases DPP8 and DPP9
(2R,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2R,5S)-1-[N-[1-(5-cyanopyridin-2-yl)-4-methylpiperidin-4-yl]glycyl]pyrrolidine-2,5-dicarbonitrile
-
-
(2R,5S)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)-N-phenylpyrrolidine-2-carboxamide
-
-
(2R,5S)-N-(4-bromophenyl)-5-([(2S)-2-cyanopyrrolidin-1-yl]carbonyl)pyrrolidine-2-carboxamide
-
-
(2S)-1-(((2S,5R)-5-[(1,3-benzodioxol-4-yloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(1-naphthyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2,4-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2,6-dichlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-chloro-4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-chlorophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(2-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-bromophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-cyanophenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-methoxyphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(4-methylphenoxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(((2S,5R)-5-[(benzyloxy)methyl]pyrrolidin-2-yl)carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-(3-furyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-([(2S,4S)-4-[(2E)-but-2-en-1-yl]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,4S)-4-[(3-chloro-4-cyanophenyl)amino]pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(([2-chloro-5-(dihydroxymethyl)pyridin-3-yl]oxy)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(([dihydroxy(phenyl)-'4-sulfanyl]amino)methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(anilinomethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(morpholin-4-ylmethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-(phenoxymethyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(2-chloropyridin-3-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(4-bromophenyl)amino]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([(6-bromo-1,3-benzodioxol-5-yl)oxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2,4-dichloro-5-(dihydroxyamino)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2-bromo-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(2S,5R)-5-([2-chloro-4-(methylsulfonodithioyl)phenoxy]methyl)pyrrolidin-2-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1-methyl-1H-pyrazol-4-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(1H-pyrazol-5-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(2H-1,2,3-triazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(3-methyl-1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([(3R,4R)-4-amino-1-[4-(5-methyl-1,3,4-oxadiazol-2-yl)benzyl]pyrrolidin-3-yl]carbonyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([[(1R,3S,5S)-3-hydroxytricyclo[3.3.1.13,7]dec-1-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-([[2-methyl-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S)-1-cyclopentyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-L-prolylpyrrolidine-2-carbonitrile
-
IC50: 2.9 nmol/L
(2S)-1-[(1-adamantylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxo-3-phenylpropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-1-oxohexan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3,3-dimethyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-(4-chlorophenyl)-1-oxopropan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxobutan-2-amine
-
-
(2S)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-4-methyl-3-(1-methylethyl)-1-oxopentan-2-amine
-
-
(2S)-1-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-1-oxopropan-2-aminium
-
-
(2S)-1-[(2R)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(2S,3S)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
-
(2S)-1-[(4R)-4-tricyclo[3.3.1.13,7]dec-2-yl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5,5-dimethyl-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(4S)-4-(azocan-1-ylcarbonyl)-L-prolyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(cyclopentylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[(tert-butylamino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[3-([2-[(5-nitropyridin-2-yl)amino]ethyl]amino)propanoyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[3-(1,3-dihydro-2H-isoindol-2-yl)-1,1-dimethyl-3-oxopropyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[N-[4-(1,3-dihydro-2H-isoindol-2-yl)-2-methyl-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,3S,5R,7R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(1R,5R)-tricyclo[3.3.1.13,7]dec-2-ylamino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-ethyl-4-hydroxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(2-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,4,6-trimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(3-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethoxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2,6-dimethylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxy-2-methoxy-6-methylphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-(4-hydroxyphenyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-cyclohexylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4R)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azepan-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(azetidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(hydroxymethyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-allylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-isobutylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-phenylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S)-4-propylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-4-(azetidin-1-ylcarbonyl)-5-methylpyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(2S,4S,5S)-5-methyl-4-(thiomorpholin-4-ylcarbonyl)pyrrolidin-2-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(3-cyano-4-fluorobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyano-3-methylbenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(4-cyanobenzyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-1-[[(3R,4R)-4-amino-1-(quinolin-3-ylmethyl)pyrrolidin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(1-cyanoethyl)acetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-cyclopropylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-ethylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-methylacetamide
-
-
(2S)-2-(1-adamantyl)-2-amino-N-(cyanomethyl)-N-propylacetamide
-
-
(2S)-2-(1-adamantyl)-N-allyl-2-amino-N-(cyanomethyl)acetamide
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2,5-difluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-4-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethoxy)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[(1-[(3S)-3-amino-4-[2-fluoro-5-(trifluoromethyl)phenyl]butanoyl]-L-prolyl)amino]methyl]phenoxy)-3-methylbutanoic acid
-
-
(2S)-2-(4-[[([(4R)-3-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)-3-methylbutanoic acid
-
-
(2S)-2-amino-N-(1-cyanoethyl)-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(1-cyanoethyl)-N,3,3-trimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-2-(3,5-dihydroxy-1-adamantyl)-N-methylacetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-2-(3-hydroxy-1-adamantyl)-N-methylacetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N,3,3-trimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-cyclobutyl-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-cyclopropyl-3,3-dimethylbutanamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-2-(3-hydroxy-1-adamantyl)acetamide
-
-
(2S)-2-amino-N-(cyanomethyl)-N-ethyl-3,3-dimethylbutanamide
-
-
(2S)-2-[2-[([1-[(2S)-2-amino-2-cyclohexylacetyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2,5-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-chloro-4-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]propanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(3,4-difluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-chloro-2-fluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(5-fluoro-2-methylphenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-(pentafluorophenyl)butanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-2-[4-[([1-[(3S)-3-amino-4-phenylbutanoyl]-L-prolyl]amino)methyl]phenoxy]-3-methylbutanoic acid
-
-
(2S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-amine
-
-
(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
-
-
(2S)-N-allyl-2-amino-N-(cyanomethyl)-3,3-dimethylbutanamide
-
-
(2S)-{((3-Hydroxyadamantan-1-yl)amino) acetyl}pyrrolidin-2-carbonitrile
-
vldagliptin is rapidly and well absorbed with an estimated absolute bioavailability of 85%. Two possible sites of absorption are identified, and the absorption rates are slower than the elimination rate, indicating a flip-flop phenomenon after oral dosing
(2S,3R)-1-[(1S,5R)-2-azabicyclo[3.1.0]hex-2-yl]-3-methyl-1-oxopentan-2-amine
-
-
(2S,3R,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-phenylbutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[2'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-1,2,4-triazol-3-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-1-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[3'-(1H-tetrazol-5-yl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4'-(trifluoromethyl)biphenyl-4-yl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-(trifluoromethyl)phenyl]butan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(2'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methoxybiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4'-methylbiphenyl-4-yl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl](methyl)amino]cyclohexyl)-1-oxobutan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[[(4-methoxyphenyl)carbonyl]amino]cyclohexyl)-1-oxobutan-2-aminium
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(1,3,4-oxadiazol-2-yl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4'-(methylsulfonyl)biphenyl-4-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(methylthio)phenyl]-1-oxobutan-2-amine
-
-
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]-1-oxobutan-2-amine
-
-
(2S,3S)-2-amino-1-((1S,5S)-2-azabicyclo[3.1.0]hexan-2-yl)-3-methylpentan-1-one
-
-
(2S,3S)-2-amino-3-methyl-1-(thiazolidin-3-yl)pentan-1-one
-
-
(2S,3S)-3-(2',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2'-chlorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3',4'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3',5'-difluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-pyrrolidin-1-ylbutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-5-pyrrolidin-1-ylpentan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-(4-[[(2,4-difluorophenyl)sulfonyl]amino]cyclohexyl)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-amino-2-(2',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(2',5'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(3',4'-difluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(3'-ethynylbiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-1-ol
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(1-methylethyl)-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-(1,3-thiazolidin-3-yl)butanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide
-
-
(2S,3S)-3-amino-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide
-
-
(2S,3S)-3-amino-4-(1,1-dioxido-1,3-thiazolidin-3-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(trans-4-[1,2,4]triazolo[1,5-a]pyridin-6-ylcyclohexyl)butanamide
-
-
(2S,3S)-3-amino-4-(3-fluoroazetidin-1-yl)-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-aziridin-1-yl-2-(4'-fluorobiphenyl-4-yl)-N,N-dimethyl-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-3-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyridin-4-ylphenyl)butanamide
-
-
(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[3'-(2H-tetrazol-2-yl)biphenyl-4-yl]butanamide
-
-
(2S,3S)-3-amino-N,N-diethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-(3,4-dihydro-2H-tetrazol-2-yl)-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-cyclopropyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide
-
-
(2S,3S)-3-amino-N-ethyl-2-(4'-fluorobiphenyl-4-yl)-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide
-
-
(2S,3S)-3-biphenyl-4-yl-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-methyl-1-oxo-1-(1,3-thiazolidin-3-yl)pentan-2-amine
-
-
(2S,3S)-3-methyl-1-oxo-1-pyrrolidin-1-ylpentan-2-amine
-
-
(2S,3S)-3-[3'-(5-cyclopropyl-2,3-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
-
(2S,3S)-3-[4-(acetylamino)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[(cyclopropylcarbonyl)(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]cyclohexyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-aminium
-
-
(2S,3S)-3-[4-[acetyl(methyl)amino]phenyl]-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-([[4-(trifluoromethoxy)phenyl]sulfonyl]amino)cyclohexyl]butan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-3-[4-[(phenylsulfonyl)amino]phenyl]butan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)carbonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-[methyl[(4-methylphenyl)sulfonyl]amino]phenyl)-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4-[[(3-fluorophenyl)carbonyl]amino]cyclohexyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-(dimethylamino)-3-(4-[[(4-fluorophenyl)carbonyl](methyl)amino]phenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-aminium
-
-
(2S,3S)-4-azetidin-1-yl-3-(4'-fluorobiphenyl-4-yl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-amine
-
-
(2S,3S)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(2,5-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3,4-dimethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-cyclopropylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-(3-ethylphenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-pyrido[2,1-a]isoquinoline-2,11b-diamine
-
-
(2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-3-[4-(fluoromethyl)pyridin-2-yl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(3-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylphenyl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-(4-methylpyridin-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-phenyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-pyridin-2-yl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,11bS)-9,10-dimethoxy-3-[3-(propan-2-yl)phenyl]-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-2-ethyl-N,N-dimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N,2-trimethylpyrrolidine-3-carboxamide
-
-
(2S,3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N,2-dimethylpyrrolidine-3-carboxamide
-
-
(2S,4R)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4R)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-((2S)-2-amino-3-methylpentanoyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-1-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-2-adamantylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclobutylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclooctylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopentylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-cyclopropylglycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(N-[2-[(5-chloropyridin-2-yl)amino]ethyl]-glycyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-(O-benzyl-L-threonyl)-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-L-alloisoleucyl-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[(2S)-2-amino-2-cyclohexylacetyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile
-
potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
(2S,4S)-1-[N-(tert-butyl)glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[(2E)-1,1-dimethyl-3-phenylprop-2-en-1-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[1-(1-benzofuran-2-yl)-1-methylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(3,4-dimethoxyphenyl)ethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[2-(diethylamino)-1,1-dimethylethyl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(3,6-dihydropyridin-1(2H)-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(7-azabicyclo[2.2.1]hept-7-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[N-[4-(azepan-1-yl)-2-methyl-4-oxobutan-2-yl]glycyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[O-(tert-butyl)-L-threonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-1-[[(3S)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]-4-fluoropyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-D-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(3-methyl-L-valyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-isopropylglycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-methyl-L-isoleucyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[(2R)-2-methylpyrrolidin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-methyl-4-[4-(methylsulfonyl)piperazin-1-yl]-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-[(4-cyanobenzyl)amino]-1,1-dimethylethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[2-[(5-cyanopyridin-2-yl)-amino]ethyl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(N-[4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]glycyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-(O-methyl-L-threonyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-([[2-methyl-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]amino]acetyl)pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-L-valyl-pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(2S)-pyrrolidin-2-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[(3S)-1,2,3,4-tetrahydroisoquinolin-3-ylcarbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-fluoropyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3R)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[([4-[(3S)-3-hydroxypyrrolidin-1-yl]-2-methyl-4-oxobutan-2-yl]amino)acetyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(1-methyl-1-pyridin-2-ylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-hydroxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(2-methoxy-1,1-dimethylethyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-hydroxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-isopropoxypropyl)glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(3-methoxy-1-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-(5-hydroxy-2-adamantyl)-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(2-furyl)-1-methylethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-(hydroxymethyl)cyclopentyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[1-methyl-1-(2-thienyl)-ethyl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-(pyridin-2-ylamino)ethyl]-glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(4-methylpiperazin-1-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-(morpholin-4-yl)-4-oxobutan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(4-oxopiperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[N-[2-methyl-4-oxo-4-(piperidin-1-yl)butan-2-yl]glycyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[[(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S)-4-fluoro-1-[[(3S)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-3-yl]carbonyl]pyrrolidine-2-carbonitrile
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-N-ethyl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-prop-2-yn-1-ylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methyl-N-propylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-4-isobutyryl-N,5-dimethylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-cyclopropyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(morpholin-4-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(piperidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-(cyanomethyl)-N-ethyl-5-methyl-4-(pyrrolidin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N-allyl-N-(cyanomethyl)-4-isobutyryl-5-methylpyrrolidine-2-carboxamide
-
-
(2S,4S,5S)-N4-benzyl-N2-(cyanomethyl)-N2-ethyl-5-methylpyrrolidine-2,4-dicarboxamide
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclohexylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-2-cyclopentylacetyl]-5-vinylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2R)-2-amino-4-methylpentanoyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclohexylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(cyclopentylamino)acetyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[(tert-butylamino)acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]-5-prop-1-yn-1-ylpyrrolidine-2-carbonitrile
-
-
(2S,5R)-1-[[(cis-1-ethyl-4-hydroxycyclohexyl)amino]acetyl]-5-ethynylpyrrolidine-2-carbonitrile
-
-
(2S,5S)-1-[(cyclopentylamino)acetyl]-5-methylpyrrolidine-2-carbonitrile
-
-
(3'S,5'S)-5'-(1,3-thiazolidin-3-ylcarbonyl)-1,3'-bipyrrolidine
-
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4R)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin)-2-yl]-methanone
-
-
(3,3-difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl)-piperazin-1-yl)-pyrrolidin-2-yl]-methanone
-
PF-00734200, potent, selective, orally active dipeptidyl peptidase IV inhibitor
(3-[6-[(3R,4S)-3-amino-4-(2,4,5-trifluorophenyl)pyrrolidin-1-yl]pyrimidin-4-yl]phenyl)methanol
-
-
(3R)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
-
-
(3R)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
-
-
(3R)-3-amino-1-(2-cyclopropyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(2-phenyl-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(3-cyclopropyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(3-ethyl-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-(5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[2-(trifluoromethyl)pyrimidin-4-yl]oxy]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[4-(trifluoromethyl)pyrimidin-2-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-([[6-(trifluoromethyl)pyridin-3-yl]amino]methyl)pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(cyclopropylmethoxy)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[(pyrimidin-2-ylamino)methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyridin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(2S)-2-[[(5-fluoropyrimidin-2-yl)amino]methyl]pyrrolidin-1-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4R)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-1-methyl-4-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-1-methyl-4-propyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-4-(4-fluorobenzyl)-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(4S)-4-ethyl-1-methyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(5R)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(5S)-5-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-2-(trifluoromethyl)-8-[4-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(1H-1,2,4-triazol-1-ylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-3-(trifluoromethyl)-8-[2-(trifluoromethyl)benzyl]-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(2-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(4-fluorobenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(4-methoxybenzyl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-(prop-2-en-1-yl)-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-benzyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2,3-bis(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[2-cyclopropyl-3-(trifluoromethyl)-4,7-dihydrofuro[2,3-c]pyridin-6(5H)-yl]-4-(2,5-difluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[3-(difluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(2-phenyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4R)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(4S)-1,4-dimethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[(8R)-8-ethyl-3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorobenzyl)-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-(4-fluorophenyl)-3-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-ethyl-2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(2,2,2-trifluoroethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(4-fluorophenyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(2,2,2-trifluoroethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfanyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(methylsulfonyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-[4-(trifluoromethyl)phenyl]-6,7-dihydro[1,3]thiazolo[4,5-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-trifluoroethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,5-difluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorobenzyl)-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(hydroxymethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(pyridin-4-yl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-4,7-dihydrothieno[2,3-c]pyridin-6(5H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4,5-dihydro[1,2]oxazolo[3,4-c]pyridin-6(7H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,7-dihydro[1,2]oxazolo[4,3-c]pyridin-5(4H)-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-ethyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(4-fluorophenyl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
-
-
(3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-methyl-2-(trifluoromethyl)-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]butan-1-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-[2-(benzyloxy)ethyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-[(2-methylpropan-2-yl)oxymethyl]piperazin-2-one
-
i.e. evogliptin
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-1-ethyl-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1-(2-oxopropyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
-
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
-
(3R,4R)-1-(1,3-benzothiazol-2-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(1,3-benzothiazol-6-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(2-methyl-3-oxo-2,3-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(2-methyl-4-oxo-4H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(2-naphthoyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(2-oxo-2H-pyrimido[1,2-b]pyridazin-7-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
; pharmacokinetic properties
(3R,4R)-1-(3,4-difluorobenzyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
pharmacokinetic properties
(3R,4R)-1-(4-cyanopyridin-2-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(4-cyclopropylpyrido[3,2-d]pyrimidin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(6-piperidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(6-pyrrolidin-1-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine
-
-
(3R,4R)-1-(isoquinolin-3-ylcarbonyl)-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-phenyl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrazino[2,3-b]pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyridin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinolin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-quinoxalin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
-
-
(3R,4R)-1-[(5-chloro-1-benzofuran-2-yl)carbonyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
-
-
(3R,4R)-1-[1,2,4]triazolo[4,3-a]pyrimidin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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pharmacokinetic properties
(3R,4R)-1-[1,2,4]triazolo[4,3-b]pyridazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[1-methyl-1-(4-nitrophenyl)ethyl]-4-(pyrrolidin-1-ylcarbonyl)pyrrolidin-3-amine
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(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[2-(trifluoromethyl)[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[3-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
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(3R,4R)-1-[5-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[6-(3,3-difluoropyrrolidin-1-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
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(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3R,4R)-1-[6-[2-(trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
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(3R,4R)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
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(3R,4R)-3-amino-N-phenyl-4-(2,4,5-trifluorophenyl)piperidine-1-carboxamide
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(3R,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
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(3R,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
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(3R,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
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(3R,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
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(3R,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
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(3R,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
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(3R,4R)-3-butyl-1-phenylpiperidin-4-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylcarbonyl)pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-3-ylmethyl)pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinolin-6-ylcarbonyl)pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1,2,3-thiadiazol-4-yl)benzyl]pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzoyl]pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-1,2,4-triazol-1-yl)benzyl]pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzoyl]pyrrolidin-3-amine
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(3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-[4-(1H-tetrazol-1-yl)benzyl]pyrrolidin-3-amine
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(3R,4S)-1-(6-phenylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-(6-pyridin-3-ylpyrimidin-4-yl)-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-acetyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-benzyl-4-(2,4-dichlorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[4-[3-(methylsulfonyl)phenyl]-1,3,5-triazin-2-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
(3R,4S)-1-[6-(2-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(2-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(2-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(3-chlorophenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
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(3R,4S)-1-[6-(3-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(3-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(3-nitrophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(3-thienyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(4-chlorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(4-fluorophenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-(4-methoxyphenyl)pyrimidin-4-yl]-4-phenylpyrrolidin-3-amine
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(3R,4S)-1-[6-(6-methoxypyridin-3-yl)pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-[3-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-[3-(morpholin-4-ylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-[3-(trifluoromethoxy)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-[3-(trifluoromethyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-1-[6-[3-fluoro-5-(methylsulfonyl)phenyl]pyrimidin-4-yl]-4-(2,4,5-trifluorophenyl)pyrrolidin-3-amine
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(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-fluorobenzyl)pyrrolidine-1-carboxamide
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(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-(3-methoxybenzyl)-N-methylpyrrolidine-1-carboxamide
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(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethyl-N-methylpyrrolidine-1-carboxamide
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(3R,4S)-3-amino-4-(2,4-dichlorophenyl)-N-ethylpyrrolidine-1-carboxamide
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(3R,4S)-4-(2,4-dichlorophenyl)-1-(6-phenylpyridin-2-yl)pyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-phenylpyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-pyridin-2-ylpyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-pyrimidin-2-ylpyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-[(4-methylphenyl)sulfonyl]pyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-[2-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-[4-(3-thienyl)pyrimidin-2-yl]pyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-[5-(4-methoxyphenyl)pyrimidin-2-yl]pyrrolidin-3-amine
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(3R,4S)-4-(2,4-dichlorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
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(3R,4S)-4-(2-chloro-4,5-difluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
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(3R,4S)-4-(2-chloro-4-fluorophenyl)-1-[6-(3-thienyl)pyrimidin-4-yl]pyrrolidin-3-amine
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(3R,4S)-4-phenyl-1-(6-phenylpyrimidin-4-yl)pyrrolidin-3-amine
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(3R,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
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(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one
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(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-(2-fluorobenzyl)-3-methyl-1,4-diazepan-2-one
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(3R,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-ethyl-3-methyl-1,4-diazepan-2-one
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(3R,S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
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(3S)-1-oxo-5-phenyl-1-(1,3-thiazolidin-3-yl)pentan-3-amine
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(3S)-1-[(1R)-1-(dihydroxyboranyl)ethyl]-2-oxopyrrolidin-3-aminium
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(3S)-1-[6-[(3R,4R)-3-amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimidin-4-yl]pyrrolidin-3-ol
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(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one
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(3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6,6-trimethyl-1,4-diazepan-2-one
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(3S,4R)-3-butyl-1-(3,4,5-trimethoxyphenyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(3,4-dichlorophenyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(3,4-dimethoxyphenyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(4-methylphenyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(4-phenoxyphenyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(6-methoxybiphenyl-3-yl)piperidin-4-amine
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(3S,4R)-3-butyl-1-(diphenylmethyl)piperidin-4-amine
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(3S,4R)-3-butyl-1-cyclohexylpiperidin-4-amine
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(3S,4R)-3-butyl-1-naphthalen-2-ylpiperidin-4-amine
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(3S,4R)-3-butyl-1-[3-methoxy-5-(trifluoromethyl)phenyl]piperidin-4-amine
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(3S,4R)-3-butyl-1-[4-chloro-3-(trifluoromethyl)phenyl]piperidin-4-amine
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(3S,4S)-1-pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3S,4S)-1-pyridazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3S,4S)-1-pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3S,4S)-1-pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-aminium
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(3S,4S)-5-(dimethylamino)-2-[(3S)-3-fluoropyrrolidin-1-yl]-5-oxo-4-(4-[1,2,4]triazolo[1,5-a]pyridin-6-ylphenyl)pent-1-en-3-aminium
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(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl 4-cyanobenzoate
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(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl benzoate
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-diethylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N,N-dimethylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethyl-N-methylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-ethylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-methylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]-N-propylpyrrolidine-3-carboxamide
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(3S,5S)-5-[[(2S)-2-cyanopyrrolidin-1-yl]carbonyl]pyrrolidine-3-carboxamide
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(3S,5S)-N-(2-phenylethyl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
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(3S,5S)-N-(4-chlorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
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(3S,5S)-N-(4-methoxyphenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
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(3S,5S)-N-(4-nitrophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
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(3S,5S)-N-benzyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
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(3S,5S)-N-benzyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
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(3S,5S)-N-phenyl-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-amine
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(3S,5S)-N-phenyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidine-3-carboxamide
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(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
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(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
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(3S,6R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
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(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
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(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
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(3S,6S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
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(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
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(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2-fluorobenzyl)-7-methyl-1,4-diazepan-2-one
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(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
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(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(2-methylbenzyl)-1,4-diazepan-2-one
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(3S,7R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-7-methyl-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one
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(3S,7S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
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(4-[4-[(3S,5S)-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-3-yl]piperazin-1-yl]phenyl)ethynamine
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(4-[[([(4R)-3-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidin-4-yl]carbonyl)amino]methyl]phenyl)acetic acid
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