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Information on EC 3.4.14.2 - dipeptidyl-peptidase II and Organism(s) Homo sapiens and UniProt Accession Q9UHL4

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Homo sapiens
UNIPROT: Q9UHL4 not found.
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
release of an N-terminal dipeptide, Xaa-Yaa-/-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides
Synonyms
dipeptidyl peptidase, seprase, dpp ii, dipeptidyl peptidase ii, fibroblast activation protein alpha, dpp-ii, dppii, dp ii, dipeptidyl aminopeptidase ii, dipeptidylpeptidase ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
brain dipeptidyl aminopeptidase A
-
carboxytripeptidase
-
dipeptidyl aminopeptidase II
-
dipeptidyl arylamidase II
-
dipeptidyl peptidase
-
dipeptidyl peptidase II
-
quiescent cell proline dipeptidase
-
carboxytripeptidase
-
-
-
-
dipeptidyl aminopeptidase II
-
-
-
-
dipeptidyl arylamidase II
-
-
-
-
dipeptidyl peptidase
-
-
dipeptidyl peptidase 2
-
-
dipeptidyl peptidase II
dipeptidyl-aminopeptidase II
-
-
-
-
dipeptidylpeptidase II
-
-
-
-
DP II
-
-
fibroblast activation protein alpha
-
has dipeptidyl peptidase and a 170-kDa gelatinase activity
peptidase, dipeptidyl, II
-
-
-
-
quiescent cell proline dipeptidase
seprase
-
has dipeptidyl peptidase and a 170-kDa gelatinase activity
additional information
CAS REGISTRY NUMBER
COMMENTARY hide
76199-23-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
Ala-Pro + amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Arg-Pro-Lys-Pro + H2O
Arg-Pro + Lys-Pro
show the reaction diagram
fragments of substance P
-
-
?
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Asn-Pro-p-nitroanilide + H2O
Asn-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
?
casomorphin + H2O
?
show the reaction diagram
-
-
-
?
Gly-Ala-7-amido-4-methylcoumarin + H2O
Gly-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
His-Ala-p-nitroanilide + H2O
His-Ala + p-nitroaniline
show the reaction diagram
-
-
-
?
His-Pro-p-nitroanilide + H2O
His-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Lys-Ala-p-nitroanilide + H2O
Lys-Ala + p-nitroaniline
show the reaction diagram
-
-
-
?
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Lys-Pro-p-nitroanilide + H2O
Lys-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Nle-Nle-p-nitroanilide + H2O
Nle-Nle + p-nitroaniline
show the reaction diagram
-
-
-
?
Nle-Nle-rhodamine + H2O
Nle-Nle + rhodamine
show the reaction diagram
-
-
?
Nle-Pro-7-amido-4-methylcoumarin + H2O
Nle-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
Nle-Pro-rhodamine + H2O
Nle-Pro + rhodamine
show the reaction diagram
-
-
?
Phe-Pro-p-nitroanilide + H2O
Phe-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Pro-Ala-p-nitroanilide + H2O
Pro-Ala + p-nitroaniline
show the reaction diagram
-
-
-
?
Ser-Pro-p-nitroanilide + H2O
Ser-Pro + p-nitroaniline
show the reaction diagram
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
?
Tyr-Ala-p-nitroanilide + H2O
Tyr-Ala + p-nitroaniline
show the reaction diagram
-
-
-
?
Ala-Ala-4-nitroanilide + H2O
Ala-Ala + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Ala-Ala + H2O
Ala-Ala + Ala
show the reaction diagram
-
54% activity compared to Met-Ala-Ser
-
-
?
Ala-Ala-Ala-Ala + H2O
Ala-Ala + Ala-Ala
show the reaction diagram
-
39% activity compared to Met-Ala-Ser
-
-
?
Ala-Pro-2-(4-methoxy)-naphthylamine + H2O
?
show the reaction diagram
-
-
-
-
?
Ala-Pro-4-nitroanilide + H2O
Ala-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Ala-Pro-p-nitroanilide + H2O
Ala-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Arg-Pro-4-nitroanilide + H2O
Arg-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Asp-Pro-4-nitroanilide + H2O
Asp-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Glu-Pro-4-nitroanilide + H2O
Glu-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
show the reaction diagram
Gly-Pro-Ala + H2O
Gly-Pro + Ala
show the reaction diagram
-
96% activity compared to Met-Ala-Ser
-
-
?
Gly-Pro-Gly-Gly + H2O
Gly-Pro + Gly-Gly
show the reaction diagram
-
16% activity compared to Met-Ala-Ser
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-Lys-L-Ala-7-amido-4-methylcoumarin + H2O
L-Lys-L-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Lys-Ala-4-methylcoumaryl-7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
show the reaction diagram
Lys-Pro-2-(4-methoxy)-naphthylamine + H2O
?
show the reaction diagram
-
-
-
-
?
Lys-Pro-4-nitroanilide + H2O
Lys-Pro + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Lys-Pro-p-nitroanilide + H2O
Lys-Pro + p-nitroaniline
show the reaction diagram
-
-
-
-
?
Met-Ala-Ser + H2O
Met-Ala + Ser
show the reaction diagram
-
100% activity
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Arg-Pro-Lys-Pro + H2O
Arg-Pro + Lys-Pro
show the reaction diagram
fragments of substance P
-
-
?
bradykinin + H2O
?
show the reaction diagram
-
-
-
?
casomorphin + H2O
?
show the reaction diagram
-
-
-
?
Substance P + H2O
?
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Diprotin A
not selective for the enzyme
Ile cyanothiazolidide
not selective for the enzyme
Lys piperidide
not selective for the enzyme
Lys thiazolidide
not selective for the enzyme
lysyl-piperidide
-
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride
-
threo-Ile thiazolidide
not selective for the enzyme
Val pyrrolidide
not selective for the enzyme
Val thiazolidide
not selective for the enzyme
(1R,S)-(2E)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile
-
IC50: 0.0361 mM, low inhibitory potential against EC 3.4.14.5
(1R,S)-(2E)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile
-
IC50: 0.0404 mM, low inhibitory potential against EC 3.4.14.5
(1R,S)-(2Z)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile
-
IC50: 0.0329 mM, low inhibitory potential against EC 3.4.14.5
(1R,S)-(2Z)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile
-
IC50: 0.0873 mM, low inhibitory potential against EC 3.4.14.5
(3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
-
-
(3S)-4-[(3aR,6aR)-hexahydrocyclopenta[b]pyrrol-1(2H)-yl]-4-oxobutane-1,3-diamine
-
AX8819, potent and selective inhibitor of DPP II
(3S)-N1-(4-chlorobenzyl)-4-(2-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
(3S)-N1-(4-chlorobenzyl)-4-(3-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine
(3S)-N1-(4-chlorobenzyl)-4-(3-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
-
IC50: 1.13 nM
(3S)-N1-(4-chlorobenzyl)-4-(4-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine
-
IC50: 0.39 nM
(3S)-N1-(4-chlorobenzyl)-4-(4-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
-
IC50: 0.55 nM
(3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
1-((2S)-2-amino-4-((4-chlorobenzyl)amino)butanoyl)piperidin-3-ol
-
IC50: 54.7 nM
1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidin-4-ol
-
IC50: 113 nM
1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidine-2-carbonitrile
-
IC50: 6.5 nM
1-([(2-phenylethyl)amino]acetyl)-2-pyrrolidinecarbonitrile
-
0.0163 mM
1-([(4-fluorobenzyl)amino]acetyl)-2-pyrrolidinecarbonitrile
-
IC50: 0.0255 mM
1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine
-
IC50: 0.00104 mM, low inhibitory potential against EC 3.4.14.5
1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine
-
-
1-benzyl-N-(2-cyclopentylidene-2-fluoroethyl)-4-piperidinamine
-
IC50: 0.0013 mM, low inhibitory potential against EC 3.4.14.5
1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine
-
-
1-benzyl-N-[2-oxo-2-(1-piperidinyl)ethyl]-4-piperidinamine
-
IC50: 0.0031 mM, low inhibitory potential against EC 3.4.14.5
1-[(1-adamantylamino)acetyl]-2-pyrrolidinecarbonitrile
-
IC50: 0.1335 mM
1-[(2S)-2-amino-4-(benzylamino)butanoyl]piperidine-2-carbonitrile
-
IC50: 4.0 nM
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-3-ol
-
IC50: 54.7 nM
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-4-ol
-
IC50: 113 nM
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidine-2-carbonitrile
-
IC50: 6.5 nM
3-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)aminomethyl)-benzonitrile
-
IC50: 2.7 nM
4-oxo-4-(1-piperidinyl)-N1 -(4-piperidinyl)-1,3-(S)-butanedi-amine
-
IC50: 85 nM
4-oxo-4-(1-piperidinyl)-N1-(2-thienylmethyl)-1,3-(S)-butanediamine
-
IC50: 0.8 nM
4-oxo-4-(1-piperidinyl)-N1-(4-pyridinylmethyl)-1,3-(S)-butanediamine
-
IC50: 0.75 nM
4-oxo-4-(1-piperidinyl)-N3-(4-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.017 mM
4-oxo-N1-(2-phenylethyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.9 nM
4-oxo-N1-(3-phenylpropyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.91 nM
4-oxo-N1-phenyl-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.0015 mM
6-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)amino)nicotinonitrile
-
IC50: 0.0046 mM
Ala-PSI[CS-N]-pyrrolidine
-
competitive
Ala-PSI[CS-N]-thiazolidine
-
competitive
Ala-pyrrolidine
-
competitive
Ala-thiazolidine
-
competitive
benzyl 4-[(2-cyclohexylidene-2-fluoroethyl)amino]-1-piperidinecarboxylate
-
IC50: 0.0128 mM, low inhibitory potential against EC 3.4.14.5
bestatin
-
-
Cd2+
-
-
Co2+
-
-
Cu2+
-
-
diisopropyl fluorophosphate
-
-
EDTA
-
-
Hg2+
-
-
Ile-PSI[CS-N]-pyrrolidine
-
competitive
Ile-PSI[CS-N]-thiazolidine
-
competitive
Ile-pyrrolidine
-
competitive
Ile-thiazolidine
-
competitive
N-(1,3-benzodioxol-5-ylmethyl)-2-cyclohexylidene-2-fluoroethanamine
-
IC50: 0.0129 mM, low inhibitory potential against EC 3.4.14.5
N-(1,3-benzodioxol-5-ylmethyl)-2-cyclopentylideneethanamine
N-(2-cyclohexylidene-2-fluoroethyl)-1-adamantanamine
-
IC50: 0.0913 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine
-
IC50: 0.0042 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)-N-(2-phenylethyl)-amine
-
IC50: 0.011 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-fluorobenzyl)-amine
-
IC50: 0.0219 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-methoxybenzyl)amine
-
IC50: 0.0134 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)aniline
-
IC50: 0.1 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine
-
IC50: 0.5 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-phenylethyl)amine
-
IC50: 0.0272 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine
N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-fluorobenzyl)amine
-
IC50: 0.0108 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-methoxy-benzyl)amine
-
IC50: 0.0155 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine
-
IC50: 0.09 mM, low inhibitory potential against EC 3.4.14.5
N-(2-cyclopentylideneethyl)cyclohexanamine
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride
-
-
N-benzyl-2-cyclohexylidene-2-fluoroethanamine
-
IC50: 0.034 mM, low inhibitory potential against EC 3.4.14.5
N-benzyl-2-cyclopentylidene-2-fluoroethanamine
-
IC50: 0.0378 mM, low inhibitory potential against EC 3.4.14.5
N-benzyl-2-cyclopentylideneethanamine
N-benzyl-2-oxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.397 mM, low inhibitory potential against EC 3.4.14.5
N-benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
-
IC50: 0.5 mM
N-benzyl-2-thioxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.0484 mM, low inhibitory potential against EC 3.4.14.5
N-cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.177 mM, low inhibitory potential against EC 3.4.14.5
N-cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
-
IC50: 0.276 mM
N-cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.069 mM, low inhibitory potential against EC 3.4.14.5
N-cyclohexyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine
-
IC50: 0.092 mM, low inhibitory potential against EC 3.4.14.5
N-piperonyl-2-oxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.052 mM, low inhibitory potential against EC 3.4.14.5
N-piperonyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
-
IC50: 0.063 mM, low inhibitory potential against EC 3.4.14.5
N-piperonyl-2-thioxo-2-(1-piperidinyl)ethaneamine
-
IC50: 0.042 mM, low inhibitory potential against EC 3.4.14.5
N-piperonyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine
-
IC50: 0.067 mM, low inhibitory potential against EC 3.4.14.5
N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]acetamide
-
IC50: 0.0015 mM
N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]guanidine bis-(trifluoroacetate)
-
IC50: 0.0018 mM
N-[3-amino-1-(S)-(1-piperidinylcarbonyl)propyl]guanidine bis-(trifluoroacetate)
-
IC50: 0.0074 mM
N-[3-amino-4-oxo-4-(1-piperidinyl)butyl]benzamide
-
IC50: 0.0074 mM
N1 -(2-cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
-
IC50: 0.0537 mM, low inhibitory potential against EC 3.4.14.5
N1 -(4-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.66 nM
N1,N1-di(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 4.2 nM
N1,N1-dibenzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.6 nM
N1-(1-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.31 nM
N1-(2,4-dimethoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 2.7 nM
N1-(2-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.23 nM
N1-(2-cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
-
IC50: 0.0546 mM, low inhibitory potential against EC 3.4.14.5
N1-(2-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.85 nM
N1-(2-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.1 nM
N1-(3-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.34 nM
N1-(3-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.77 nM
N1-(3-nitro-2-pyridinyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.0235 mM
N1-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.48 nM
N1-(4-chlorobenzyl)-N1-methyl-4-oxo-4-(1-piperidinyl)-1,3-butanediamine
-
IC50: 0.22 nm
N1-(cyclohexylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 1.1 nM
N1-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 2.03 nM
N1-cyclohexyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 18.6 nM
N1-[2-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.39 nM
N1-[4-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
-
IC50: 0.41 nM
N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide
-
-
N3-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine dihydrobromide
-
IC50: 0.0125 mM
Phe-PSI[CS-N]-pyrrolidine
-
competitive
Phe-PSI[CS-N]-thiazolidine
-
competitive
Phe-pyrrolidine
-
competitive
Phe-thiazolidine
-
competitive
phenylmethylsulfonyl fluoride
-
-
Val-PSI[CS-N]-pyrrolidine
-
competitive
Val-PSI[CS-N]-thiazolidine
-
competitive
Val-pyrrolidine
-
competitive
Val-thiazolidine
-
competitive
[(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid
-
-
additional information
-
isomerization of the thiazolidine derivatives
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.032
Ala-Pro-amino-4-trifluoromethylcoumarin
pH 7.5, 37°C
0.009 - 0.04
Ala-Pro-p-nitroanilide
0.04
Arg-Pro-p-nitroanilide
37°C, pH 5.5
0.101
Asn-Pro-p-nitroanilide
37°C, pH 5.5
0.149
Gly-Pro-7-amido-4-methylcoumarin
pH 7.5, 37°C
0.07 - 0.21
Gly-Pro-p-nitroanilide
0.0223
His-Ala-p-nitroanilide
37°C, pH 5.5
0.083
His-Pro-p-nitroanilide
37°C, pH 5.5
0.215
Lys-Ala-7-amido-4-methylcoumarin
pH 7.5, 37°C
0.04 - 0.57
Lys-Ala-p-nitroanilide
0.011
Lys-Pro-7-amido-4-methylcoumarin
pH 7.5, 37°C
0.019
Lys-Pro-p-nitroanilide
37°C, pH 5.5
0.02
Nle-Nle-p-nitroanilide
37°C, pH 5.5
0.006
Nle-Nle-rhodamine
pH 7.5, 37°C
0.003
Nle-Pro-7-amido-4-methylcoumarin
pH 7.5, 37°C
0.003
Nle-Pro-rhodamine
pH 7.5, 37°C
0.058
Phe-Pro-p-nitroanilide
37°C, pH 5.5
1.376
Pro-Ala-p-nitroanilide
37°C, pH 5.5
0.08
Ser-Pro-p-nitroanilide
37°C, pH 5.5
0.22
Tyr-Ala-p-nitroanilide
37°C, pH 5.5
1.22
Ala-Ala-4-nitroanilide
-
-
0.0457
Ala-Pro-4-nitroanilide
-
-
0.041
Ala-Pro-p-nitroanilide
-
-
0.086
Arg-Pro-4-nitroanilide
-
-
1.16
Asp-Pro-4-nitroanilide
-
-
0.311
Glu-Pro-4-nitroanilide
-
-
0.25 - 0.282
Gly-Pro-4-nitroanilide
0.227
Gly-Pro-p-nitroanilide
-
-
0.93
L-Lys-L-Ala-7-amido-4-methylcoumarin
-
-
-
0.0457
Lys-Pro-4-nitroanilide
-
-
0.019
Lys-Pro-p-nitroanilide
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
89 - 105.4
Ala-Pro-p-nitroanilide
65.8
Arg-Pro-p-nitroanilide
37°C, pH 5.5
184.6
Asn-Pro-p-nitroanilide
37°C, pH 5.5
67.3
Gly-Pro-p-nitroanilide
37°C, pH 5.5
12.8
His-Ala-p-nitroanilide
37°C, pH 5.5
28.4
His-Pro-p-nitroanilide
37°C, pH 5.5
229.3
Lys-Ala-p-nitroanilide
37°C, pH 5.5
3 - 77.7
Lys-Pro-p-nitroanilide
18.4
Nle-Nle-p-nitroanilide
37°C, pH 5.5
93
Phe-Pro-p-nitroanilide
37°C, pH 5.5
15.3
Pro-Ala-p-nitroanilide
37°C, pH 5.5
66 - 116.9
Ser-Pro-p-nitroanilide
11
Tyr-Ala-p-nitroanilide
37°C, pH 5.5
89 - 105.4
Ala-Pro-p-nitroanilide
67.3
Gly-Pro-p-nitroanilide
-
-
3 - 77.7
Lys-Pro-p-nitroanilide
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0408
Diprotin A
pH 7.5, 37°C
0.00056
Ile cyanothiazolidide
pH 7.5, 37°C
0.00065
Lys piperidide
pH 7.5, 37°C
0.00017
Lys thiazolidide
pH 7.5, 37°C
0.000052 - 0.00264
lysyl-piperidide
0.00095 - 0.00145
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride
0.0097
threo-Ile thiazolidide
pH 7.5, 37°C
0.1
Val pyrrolidide
above, pH 7.5, 37°C
0.0153
Val thiazolidide
pH 7.5, 37°C
0.0033
Ala-PSI[CS-N]-pyrrolidine
-
pH 5.5, 30°C
0.00065
Ala-PSI[CS-N]-thiazolidine
-
pH 5.5, 30°C
0.0218
Ala-pyrrolidine
-
pH 5.5, 30°C
0.0044
Ala-thiazolidine
-
pH 5.5, 30°C
0.0048
Ile-PSI[CS-N]-pyrrolidine
-
pH 5.5, 30°C
0.0011
Ile-PSI[CS-N]-thiazolidine
-
pH 5.5, 30°C
0.0302
Ile-pyrrolidine
-
pH 5.5, 30°C
0.0071
Ile-thiazolidine
-
pH 5.5, 30°C
0.000082
N-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butane-diamine dihydrochloride
-
-
0.0073
Phe-PSI[CS-N]-pyrrolidine
-
pH 5.5, 30°C
0.0006
Phe-PSI[CS-N]-thiazolidine
-
pH 5.5, 30°C
0.0139
Phe-pyrrolidine
-
pH 5.5, 30°C
0.0032
Phe-thiazolidine
-
pH 5.5, 30°C
0.0082
Val-PSI[CS-N]-pyrrolidine
-
pH 5.5, 30°C
0.0009
Val-PSI[CS-N]-thiazolidine
-
pH 5.5, 30°C
0.0267
Val-pyrrolidine
-
pH 5.5, 30°C
0.0077
Val-thiazolidine
-
pH 5.5, 30°C
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0361
(1R,S)-(2E)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile
Homo sapiens
-
IC50: 0.0361 mM, low inhibitory potential against EC 3.4.14.5
0.0404
(1R,S)-(2E)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile
Homo sapiens
-
IC50: 0.0404 mM, low inhibitory potential against EC 3.4.14.5
0.0329
(1R,S)-(2Z)-2-(1-fluoro-2-[(2-phenylethyl)amino]ethylidene)cyclopentanecarbonitrile
Homo sapiens
-
IC50: 0.0329 mM, low inhibitory potential against EC 3.4.14.5
0.0873
(1R,S)-(2Z)-2-(1-fluoro-2-[(4-fluorobenzyl)amino]ethylidene)cyclopentanecarbonitrile
Homo sapiens
-
IC50: 0.0873 mM, low inhibitory potential against EC 3.4.14.5
0.00013
(3S)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
Homo sapiens
-
-
0.00000088
(3S)-4-[(3aR,6aR)-hexahydrocyclopenta[b]pyrrol-1(2H)-yl]-4-oxobutane-1,3-diamine
Homo sapiens
-
-
0.0000023 - 2.3
(3S)-N1-(4-chlorobenzyl)-4-(2-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
0.62
(3S)-N1-(4-chlorobenzyl)-4-(3-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine
Homo sapiens
-
IC50: 0.62 nM
0.00000113
(3S)-N1-(4-chlorobenzyl)-4-(3-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
Homo sapiens
-
IC50: 1.13 nM
0.00000039
(3S)-N1-(4-chlorobenzyl)-4-(4-fluoropiperidin-1-yl)-4-oxobutane-1,3-diamine
Homo sapiens
-
IC50: 0.39 nM
0.00000055
(3S)-N1-(4-chlorobenzyl)-4-(4-methylpiperidin-1-yl)-4-oxobutane-1,3-diamine
Homo sapiens
-
IC50: 0.55 nM
0.00000048 - 0.0000011
(3S)-N1-(4-chlorobenzyl)-4-oxo-4-piperidin-1-ylbutane-1,3-diamine
0.0000547
1-((2S)-2-amino-4-((4-chlorobenzyl)amino)butanoyl)piperidin-3-ol
Homo sapiens
-
IC50: 54.7 nM
0.000113
1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidin-4-ol
Homo sapiens
-
IC50: 113 nM
0.0000065
1-((2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl)piperidine-2-carbonitrile
Homo sapiens
-
IC50: 6.5 nM
0.0255
1-([(4-fluorobenzyl)amino]acetyl)-2-pyrrolidinecarbonitrile
Homo sapiens
-
IC50: 0.0255 mM
0.00104
1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine
Homo sapiens
-
IC50: 0.00104 mM, low inhibitory potential against EC 3.4.14.5
0.00104
1-benzyl-N-(2-cyclohexylidene-2-fluoroethyl)piperidin-4-amine
Homo sapiens
-
-
0.0013
1-benzyl-N-(2-cyclopentylidene-2-fluoroethyl)-4-piperidinamine
Homo sapiens
-
IC50: 0.0013 mM, low inhibitory potential against EC 3.4.14.5
0.0031
1-benzyl-N-(2-oxo-2-piperidin-1-ylethyl)piperidin-4-amine
Homo sapiens
-
-
0.0031
1-benzyl-N-[2-oxo-2-(1-piperidinyl)ethyl]-4-piperidinamine
Homo sapiens
-
IC50: 0.0031 mM, low inhibitory potential against EC 3.4.14.5
0.1335
1-[(1-adamantylamino)acetyl]-2-pyrrolidinecarbonitrile
Homo sapiens
-
IC50: 0.1335 mM
0.000004
1-[(2S)-2-amino-4-(benzylamino)butanoyl]piperidine-2-carbonitrile
Homo sapiens
-
IC50: 4.0 nM
0.0000547
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-3-ol
Homo sapiens
-
IC50: 54.7 nM
0.000113
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidin-4-ol
Homo sapiens
-
IC50: 113 nM
0.0000065
1-[(2S)-2-amino-4-[(4-chlorobenzyl)amino]butanoyl]piperidine-2-carbonitrile
Homo sapiens
-
IC50: 6.5 nM
0.0000027
3-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)aminomethyl)-benzonitrile
Homo sapiens
-
IC50: 2.7 nM
0.000085
4-oxo-4-(1-piperidinyl)-N1 -(4-piperidinyl)-1,3-(S)-butanedi-amine
Homo sapiens
-
IC50: 85 nM
0.0000008
4-oxo-4-(1-piperidinyl)-N1-(2-thienylmethyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.8 nM
0.00000075
4-oxo-4-(1-piperidinyl)-N1-(4-pyridinylmethyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.75 nM
0.017
4-oxo-4-(1-piperidinyl)-N3-(4-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.017 mM
0.0000009
4-oxo-N1-(2-phenylethyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.9 nM
0.00000191
4-oxo-N1-(3-phenylpropyl)-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.91 nM
0.0015
4-oxo-N1-phenyl-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.0015 mM
0.0046
6-((3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl)amino)nicotinonitrile
Homo sapiens
-
IC50: 0.0046 mM
0.0128
benzyl 4-[(2-cyclohexylidene-2-fluoroethyl)amino]-1-piperidinecarboxylate
Homo sapiens
-
IC50: 0.0128 mM, low inhibitory potential against EC 3.4.14.5
0.0129
N-(1,3-benzodioxol-5-ylmethyl)-2-cyclohexylidene-2-fluoroethanamine
Homo sapiens
-
IC50: 0.0129 mM, low inhibitory potential against EC 3.4.14.5
0.0075
N-(1,3-benzodioxol-5-ylmethyl)-2-cyclopentylideneethanamine
Homo sapiens
-
IC50: 0.0075 mM, low inhibitory potential against EC 3.4.14.5, low inhibitory potential against EC 3.4.14.5
0.0913
N-(2-cyclohexylidene-2-fluoroethyl)-1-adamantanamine
Homo sapiens
-
IC50: 0.0913 mM, low inhibitory potential against EC 3.4.14.5
0.0042
N-(2-cyclohexylidene-2-fluoroethyl)-4-piperidinamine
Homo sapiens
-
IC50: 0.0042 mM, low inhibitory potential against EC 3.4.14.5
0.011
N-(2-cyclohexylidene-2-fluoroethyl)-N-(2-phenylethyl)-amine
Homo sapiens
-
IC50: 0.011 mM, low inhibitory potential against EC 3.4.14.5
0.0219
N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-fluorobenzyl)-amine
Homo sapiens
-
IC50: 0.0219 mM, low inhibitory potential against EC 3.4.14.5
0.0134
N-(2-cyclohexylidene-2-fluoroethyl)-N-(4-methoxybenzyl)amine
Homo sapiens
-
IC50: 0.0134 mM, low inhibitory potential against EC 3.4.14.5
0.1
N-(2-cyclohexylidene-2-fluoroethyl)aniline
Homo sapiens
-
IC50: 0.1 mM, low inhibitory potential against EC 3.4.14.5
0.5
N-(2-cyclohexylidene-2-fluoroethyl)cyclohexanamine
Homo sapiens
-
IC50: 0.5 mM, low inhibitory potential against EC 3.4.14.5
0.0272
N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-phenylethyl)amine
Homo sapiens
-
IC50: 0.0272 mM, low inhibitory potential against EC 3.4.14.5
0.0096 - 0.0157
N-(2-cyclopentylidene-2-fluoroethyl)-N-(2-pyridinylethyl)amine
0.0108
N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-fluorobenzyl)amine
Homo sapiens
-
IC50: 0.0108 mM, low inhibitory potential against EC 3.4.14.5
0.0155
N-(2-cyclopentylidene-2-fluoroethyl)-N-(4-methoxy-benzyl)amine
Homo sapiens
-
IC50: 0.0155 mM, low inhibitory potential against EC 3.4.14.5
0.09
N-(2-cyclopentylidene-2-fluoroethyl)cyclohexanamine
Homo sapiens
-
IC50: 0.09 mM, low inhibitory potential against EC 3.4.14.5
0.062
N-(2-cyclopentylideneethyl)cyclohexanamine
0.034
N-benzyl-2-cyclohexylidene-2-fluoroethanamine
Homo sapiens
-
IC50: 0.034 mM, low inhibitory potential against EC 3.4.14.5
0.0378
N-benzyl-2-cyclopentylidene-2-fluoroethanamine
Homo sapiens
-
IC50: 0.0378 mM, low inhibitory potential against EC 3.4.14.5
0.026
N-benzyl-2-cyclopentylideneethanamine
0.397
N-benzyl-2-oxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.397 mM, low inhibitory potential against EC 3.4.14.5
0.5
N-benzyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
Homo sapiens
-
IC50: 0.5 mM
0.0484
N-benzyl-2-thioxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.0484 mM, low inhibitory potential against EC 3.4.14.5
0.177
N-cyclohexyl-2-oxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.177 mM, low inhibitory potential against EC 3.4.14.5
0.276
N-cyclohexyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
Homo sapiens
-
IC50: 0.276 mM
0.069
N-cyclohexyl-2-thioxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.069 mM, low inhibitory potential against EC 3.4.14.5
0.092
N-cyclohexyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine
Homo sapiens
-
IC50: 0.092 mM, low inhibitory potential against EC 3.4.14.5
0.052
N-piperonyl-2-oxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.052 mM, low inhibitory potential against EC 3.4.14.5
0.063
N-piperonyl-2-oxo-2-(1-pyrrolidinyl)ethaneamine
Homo sapiens
-
IC50: 0.063 mM, low inhibitory potential against EC 3.4.14.5
0.042
N-piperonyl-2-thioxo-2-(1-piperidinyl)ethaneamine
Homo sapiens
-
IC50: 0.042 mM, low inhibitory potential against EC 3.4.14.5
0.067
N-piperonyl-2-thioxo-2-(1-pyrrolidinyl)ethaneamine
Homo sapiens
-
IC50: 0.067 mM, low inhibitory potential against EC 3.4.14.5
0.0015
N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]acetamide
Homo sapiens
-
IC50: 0.0015 mM
0.0018
N-[3-(S)-amino-4-oxo-4-(1-piperidinyl)butyl]guanidine bis-(trifluoroacetate)
Homo sapiens
-
IC50: 0.0018 mM
0.0074
N-[3-amino-1-(S)-(1-piperidinylcarbonyl)propyl]guanidine bis-(trifluoroacetate)
Homo sapiens
-
IC50: 0.0074 mM
0.0074
N-[3-amino-4-oxo-4-(1-piperidinyl)butyl]benzamide
Homo sapiens
-
IC50: 0.0074 mM
0.0537
N1 -(2-cyclopentylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
Homo sapiens
-
IC50: 0.0537 mM, low inhibitory potential against EC 3.4.14.5
0.00000066
N1 -(4-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.66 nM
0.0000042
N1,N1-di(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 4.2 nM
0.0000006
N1,N1-dibenzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.6 nM
0.00000131
N1-(1-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.31 nM
0.0000027
N1-(2,4-dimethoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 2.7 nM
0.00000023
N1-(2-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.23 nM
0.0546
N1-(2-cyclohexylidene-2-fluoroethyl)-N3,N3-dimethyl-1,3-propanediamine
Homo sapiens
-
IC50: 0.0546 mM, low inhibitory potential against EC 3.4.14.5
0.00000185
N1-(2-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.85 nM
0.0000011
N1-(2-naphthylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.1 nM
0.00000134
N1-(3-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.34 nM
0.00000177
N1-(3-methoxybenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.77 nM
0.0235
N1-(3-nitro-2-pyridinyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.0235 mM
0.00000048
N1-(4-chlorobenzyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.48 nM
0.00000022
N1-(4-chlorobenzyl)-N1-methyl-4-oxo-4-(1-piperidinyl)-1,3-butanediamine
Homo sapiens
-
IC50: 0.22 nm
0.0000011
N1-(cyclohexylmethyl)-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 1.1 nM
0.00000203
N1-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 2.03 nM
0.0000186
N1-cyclohexyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 18.6 nM
0.00000039
N1-[2-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.39 nM
0.00000041
N1-[4-(benzyloxy)benzyl]-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine
Homo sapiens
-
IC50: 0.41 nM
0.0038
N2-cyclopentyl-N-[(diphenoxyphosphoryl)(phenyl)methyl]glycinamide
Homo sapiens
-
-
0.0125
N3-benzyl-4-oxo-4-(1-piperidinyl)-1,3-(S)-butanediamine dihydrobromide
Homo sapiens
-
IC50: 0.0125 mM
0.00000048
[(1R)-1-[[(2S)-2,4-diaminobutanoyl]amino]pentyl]boronic acid
Homo sapiens
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
70
substrate: Lys-Ala-p-nitroanilide
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5
substrate: Lys-Ala-p-nitroanilide or Ala-Pro-p-nitroanilide
5 - 5.5
enzyme from seminal fluid
5.3
enzyme from kidney
5.5
enzyme from placenta
5.3
-
hydrolysis of Lys-Ala-4-methylcoumarinamide
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.5 - 8.5
-
4 - 6
pH 4.0: about 50% of maximal activity, pH 6.0: about 40% of maximal activity, substrate: Lys-Ala-p-nitroanilide or Ala-Pro-p-nitroanilide
4 - 7
-
50% of maximal activity at pH 4 and 7
5.5 - 7
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
30
-
assay at
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.8
isoelectric focusing, enzyme from spleen and ovary
6.1
isoelectric focusing, enzyme from seminal plasma
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
highest activity in the hypothalamus
Manually annotated by BRENDA team
-
of patients with Sjorgren's syndrome and healthy subjects
Manually annotated by BRENDA team
-
increased activity in serum of cancer patients
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DPP2_HUMAN
492
0
54341
Swiss-Prot
Secretory Pathway (Reliability: 3)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000
gel filtration, enzyme from kidney
120000
55000
2 * 55000, gel filtration, enzyme from kidney
60000
116000
-
SDS-PAGE
55000
-
2 * 55000, SDS-PAGE
58000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
2 * 60000, SDS-PAGE in presence of 2-mercaptoethanol
homodimer
dimer
-
2 * 55000, SDS-PAGE
homodimer
-
2 * 58000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
glycosylation is necessary for enzyme activity
glycoprotein
-
-
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
2 h, 30% loss of activity without a stabilizer. 10% loss of activity after 4 h in presence of 1 mg/ml bovine serum albumin or 0.1% Tween 20
50
stable up to 50°C
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
in presence of stabilizing agents, the enzyme tolerates at least five subsequent freeze/thaw cycles
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, -20°C, or -80°C, purified enzyme is stable for at least 4 months in presence of 1 mg/ml bovine serum albumin
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
from placenta
purification scheme includes an inhibitor-based affinity chromatographic step
His·Bind Resin column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in 293-EBNA cells
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
the enzyme is a potential urinary marker for the biochemical detection of kidney damage
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mantle, D.
Characterization of dipeptidyl and tripeptidyl aminopeptidases in human kidney soluble fraction
Clin. Chim. Acta
196
135-142
1991
Homo sapiens
Manually annotated by BRENDA team
Sakai, T.; Kojima, K.
Rapid chromatographic purification of dipeptidyl-aminopeptidase II from human kidney
J. Chromatogr.
416
131-137
1987
Homo sapiens
Manually annotated by BRENDA team
Nagatsu, T.; Sakai, T.; Kojima, K.; Araki, E.; Sakakibara, S.; Fukasawa, K.; Harada, M.
A sensitive and specific assay for dipeptidyl-aminopeptidase II in serum and tissues by liquid chromatography-fluorometry
Anal. Biochem.
147
80-85
1985
Homo sapiens
Manually annotated by BRENDA team
Gossrau, R.; Lojda, Z.
Study on dipeptidylpeptidase II (DPP II)
Histochemistry
70
53-76
1980
Cavia porcellus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Leiting, B.; Pryor, K.D.; Wu, J.K.; Marsilio, F.; Patel, R.A.; Craik, C.S.; Ellman, J.A.; Cummings, R.T.; Thornberry, N.A.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
Biochem. J.
371
525-532
2003
Homo sapiens (Q9UHL4), Homo sapiens
Manually annotated by BRENDA team
Stoeckel-Maschek, A.; Mrestani-Klaus, C.; Stiebitz, B.; Demuth, H.U.; Neubert, K.
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases
Biochim. Biophys. Acta
1479
15-31
2000
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Sohar, N.; Sohar, I.; Hammer, H.
Lysosomal enzyme activities: new potential markers for Sjoegrens syndrome
Clin. Biochem.
38
1120-1126
2005
Homo sapiens
Manually annotated by BRENDA team
Maes, M.B.; Lambeir, A.M.; Gilany, K.; Senten, K.; Van der Veken, P.; Leiting, B.; Augustyns, K.; Scharpe, S.; De Meester, I.
Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7)
Biochem. J.
386
315-324
2005
Homo sapiens (Q9UHL4), Homo sapiens
Manually annotated by BRENDA team
Maes, M.B.; Martinet, W.; Schrijvers, D.M.; Van der Veken, P.; De Meyer, G.R.; Augustyns, K.; Lambeir, A.M.; Scharpe, S.; De Meester, I.
Dipeptidyl peptidase II and leukocyte cell death
Biochem. Pharmacol.
72
70-79
2006
Homo sapiens
Manually annotated by BRENDA team
Senten, K.; van der Veken, P.; De Meester, I.; Lambeir, A.M.; Scharpe, S.; Haemers, A.; Augustyns, K.
gamma-Amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors
J. Med. Chem.
47
2906-2916
2004
Homo sapiens
Manually annotated by BRENDA team
Van der Veken, P.; Senten, K.; Kertesz, I.; De Meester, I.; Lambeir, A.M.; Maes, M.B.; Scharpe, S.; Haemers, A.; Augustyns, K.
Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases
J. Med. Chem.
48
1768-1780
2005
Homo sapiens
Manually annotated by BRENDA team
Danilova, O.; Li, B.; Szardenings, A.K.; Huber, B.T.; Rosenblum, J.S.
Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor
Bioorg. Med. Chem. Lett.
17
507-510
2007
Homo sapiens
Manually annotated by BRENDA team
Chen, D.; Kennedy, A.; Wang, J.Y.; Zeng, W.; Zhao, Q.; Pearl, M.; Zhang, M.; Suo, Z.; Nesland, J.M.; Qiao, Y.; Ng, A.K.; Hirashima, N.; Yamane, T.; Mori, Y.; Mitsumata, M.; Ghersi, G.; Chen, W.T.
Activation of EDTA-resistant gelatinases in malignant human tumors
Cancer Res.
66
9977-9985
2006
Homo sapiens
Manually annotated by BRENDA team
Maes, M.B.; Scharpe, S.; De Meester, I.
Dipeptidyl peptidase II (DPPII), a review
Clin. Chim. Acta
380
31-49
2007
Bos taurus, Rattus norvegicus, Sus scrofa, Homo sapiens (Q9UHL4)
Manually annotated by BRENDA team
Van der Veken, P.; Haemers, A.; Augustyns, K.
Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery
Curr. Top. Med. Chem.
7
621-635
2007
Homo sapiens
Manually annotated by BRENDA team
Sentandreu, M.A.; Toldra, F.
Oligopeptides hydrolysed by muscle dipeptidyl peptidases can generate angiotensin-I converting enzyme inhibitory dipeptides
Eur. Food Res. Technol.
224
785-790
2007
Homo sapiens
Manually annotated by BRENDA team
Bista, P.; Mele, D.A.; Baez, D.V.; Huber, B.T.
Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1
Mol. Immunol.
45
3618-3623
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team