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Disease on EC 3.4.14.1 - dipeptidyl-peptidase I

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acro-Osteolysis
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Adenocarcinoma
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
[Modern esophageal surgery and late functional results as equations with several unknowns--Hungarian Academy of Sciences Doctoral Thesis]
Adenocarcinoma of Lung
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Aggressive Periodontitis
Cathepsin C gene 5'-untranslated region mutation in papillon-lefèvre syndrome.
Cathepsin C gene variants in aggressive periodontitis.
Confirmation of oxidative stress and fatty acid disturbances in two further Papillon-Lefèvre syndrome families with identification of a new mutation.
Dermatologic, periodontal, and skeletal manifestations of Haim-Munk syndrome in two siblings.
Functional Cathepsin C mutations cause different Papillon-Lefèvre syndrome phenotypes.
Haim-Munk syndrome.
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Identification of genetic risk factors for periodontitis and possible mechanisms of action.
Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation.
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
Novel mutations in the cathepsin C gene in patients with pre-pubertal aggressive periodontitis and Papillon-Lefèvre syndrome.
Structure of the periodontium in cathepsin C-deficient mice.
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Anaphylaxis
Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Aortic Aneurysm, Abdominal
Critical role of dipeptidyl peptidase I in neutrophil recruitment during the development of experimental abdominal aortic aneurysms.
Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation.
Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms.
Arrhythmias, Cardiac
Electrophysiological and Anatomical Correlates of Sites With Postpacing Intervals Shorter Than Tachycardia Cycle Length in Atypical Atrial Flutter.
Arthritis
Dipeptidyl peptidase I activates neutrophil-derived serine proteases and regulates the development of acute experimental arthritis.
Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats.
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Arthritis, Experimental
Dipeptidyl peptidase I regulates the development of collagen-induced arthritis.
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Arthritis, Rheumatoid
Lysosomal peptidases and glycosidases in rheumatoid arthritis.
The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes.
Aspergillosis
Antifungal Treatments Delineate a Correlation between Cathepsins and Cytokines in Murine Model of Invasive Aspergillosis.
Asthma
Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to sendai virus infection.
Gene expression profiling in human asthma.
Identification of an alternative splicing variant of cathepsin C/dipeptidyl-peptidase I.
Neutrophil Extracellular Traps Enhance Early Inflammatory Response in Sendai Virus-Induced Asthma Phenotype.
Atherosclerosis
Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.
Atrial Flutter
Electrophysiological and Anatomical Correlates of Sites With Postpacing Intervals Shorter Than Tachycardia Cycle Length in Atypical Atrial Flutter.
Autoimmune Diseases
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Identification and Optimization of Novel Cathepsin C Inhibitors Derived from EGFR Inhibitors.
Therapeutic utility and medicinal chemistry of cathepsin C inhibitors.
Bacterial Infections
Mast cell dipeptidyl peptidase I mediates survival from sepsis.
Blister
Acid hydrolases in blister fluid. 3. Characterization and quantification of peptide hydrolases.
Breast Neoplasms
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Neutrophils create a fertile soil for metastasis.
Bronchiectasis
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Carcinogenesis
Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.
Carcinoma
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
Lysosomal dipeptidyl-peptidases I and II in human squamous cell lung carcinoma and lung parenchyma.
Carcinoma, Hepatocellular
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes.
Carcinoma, Papillary
Increase of endo-peptidases and exo-peptidases in thyroid-tumors.
Carcinoma, Renal Cell
Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis.
Carcinoma, Squamous Cell
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
Cholesteatoma
Gene expression analysis of human middle ear cholesteatoma using complementary DNA arrays.
Colonic Neoplasms
Effect of short-chain fatty acids on the proliferation and differentiation of the human colonic adenocarcinoma cell line Caco-2.
Colorectal Neoplasms
In vitro and in vivo studies on potentiation of curcumin-induced lysosomal-dependent apoptosis upon silencing of cathepsin C in colorectal cancer cells.
Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells.
Coronary Artery Disease
Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.
COVID-19
Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities.
Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?
Cystic Fibrosis
Inhibitors of cathepsin C (dipeptidyl peptidase I).
The Synthesis of ?,?-Disubstituted ?-Amino Acids via Ichikawa Rearrangement.
Cysts
The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia.
Demyelinating Diseases
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Correction: Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
Diabetes Mellitus
Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.
Diabetes Mellitus, Type 1
Inflammatory Serine Proteases Play a Critical Role in the Early Pathogenesis of Diabetic Cardiomyopathy.
dipeptidyl-peptidase i deficiency
Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants.
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
Leukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.
Nemaline myopathy. Evidence of dipeptidyl peptidase I deficiency.
NSP4 Is Stored in Azurophil Granules and Released by Activated Neutrophils as Active Endoprotease with Restricted Specificity.
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
Structure of the periodontium in cathepsin C-deficient mice.
Ectodermal Dysplasia
Diagnosis of Papillon-Lefèvre syndrome: review of the literature and a case report.
Ectromelia
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.
Encephalomyelitis
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.
Enteritis
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Enterocolitis, Necrotizing
Human breast milk oligosaccharides attenuate necrotizing enterocolitis in rats by suppressing mast cell accumulation, DPPI activity and TLR4 expression in ileum tissue, and regulating mitochondrial damage of Caco-2 cells.
Genetic Diseases, Inborn
Cu-sil dentures: A novel approach of Papillon-Lefèvre syndrome management.
Gingivitis
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
[Papillon-Lefèvre syndrome: A new case].
Glioma
Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration.
Glomerulonephritis, Membranous
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Granulomatosis with Polyangiitis
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Heart Failure
Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study.
Hyperglycemia
Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
Hypertension
Hydrolase activities in the rat aorta. II. Effects of hypertension alone and in combination with diabetes mellitus.
Hypotrichosis
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Infections
Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection.
Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.
Characterization of cathepsin C from orange-spotted grouper, Epinephelus coioides involved in SGIV infection.
Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D.
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Papillon-Lefévre syndrome: a highly-suspected case.
Joint Diseases
Serum based fluorescent assay for evaluating dipeptidyl peptidase I activity in collagen induced arthritis rat model.
Keratoderma, Palmoplantar
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
Cathepsin C gene 5'-untranslated region mutation in papillon-lefèvre syndrome.
Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutation.
Demonstration of altered splicing with the IVS3-1G --> a mutation of cathepsin C.
Identification of a novel cathepsin C mutation (p.W185X) in a Brazilian kindred with Papillon-Lefèvre syndrome.
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis.
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Keratosis
Confirmation of oxidative stress and fatty acid disturbances in two further Papillon-Lefèvre syndrome families with identification of a new mutation.
Liver Diseases
[Characteristics of bleeding from esophageal-gastric varices in patients with HIV infection]
Liver Neoplasms, Experimental
Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes.
Transient membrane association of the precursors of cathepsin C during their transfer into lysosomes.
Lung Diseases
Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
Neutrophilic cathepsin C is maturated by a multi-step proteolytic process and secreted by activated cells during inflammatory lung diseases.
Lymphatic Metastasis
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Malaria
Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.
Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.
Mastocytoma
Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I.
Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I.
Muscular Dystrophies
Decreased lysosomal dipeptidyl aminopeptidase I activity in cultured human skin fibroblasts in Duchenne's muscular dystrophy.
Muscular Dystrophy, Duchenne
Dipeptidyl peptidase I in cultured fibroblasts in Duchenne muscular dystrophy.
Myocardial Infarction
Meta-Analysis of the Cardiovascular Outcomes with Dipeptidyl Peptidase 4 Inhibitors: Validation of the Current FDA Mandate.
Myopathies, Nemaline
Nemaline myopathy. Evidence of dipeptidyl peptidase I deficiency.
Neoplasm Metastasis
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation.
Neutrophils create a fertile soil for metastasis.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Timosaponin AIII inhibits metastasis of renal carcinoma cells through suppressing cathepsin C expression by AKT/miR-129-5p axis.
Neoplasms
Cathepsin C Interacts with TNF-?/p38 MAPK Signaling Pathway to Promote Proliferation and Metastasis in Hepatocellular Carcinoma.
Demonstration of proteases in basal cell carcinomas. A histochemical study using amino acid-4-methoxy-2-naphthylamides as chromogenic substrates.
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cells.
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival.
Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways.
Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells.
The production of tumour necrosis factor, tissue thromboplastin, lactoferrin and cathepsin C during lipopolysaccharide stimulation in whole blood.
[Modern esophageal surgery and late functional results as equations with several unknowns--Hungarian Academy of Sciences Doctoral Thesis]
Nephritis, Interstitial
Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2?
Nephrosis, Lipoid
Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis.
Nervous System Diseases
Disinhibition of Cathepsin C Caused by Cystatin F Deficiency Aggravates the Demyelination in a Cuprizone Model.
Netherton Syndrome
Epidermal differentiation: the role of proteases and their inhibitors.
Neurodegenerative Diseases
Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
Neuroinflammatory Diseases
Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression.
Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion.
Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-?B pathway.
Correction to: Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression.
Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation.
Neuronal Ceroid-Lipofuscinoses
Dipeptidyl-peptidase I does not functionally compensate for the loss of tripeptidyl-peptidase I in the neurodegenerative disease late-infantile neuronal ceroid lipofuscinosis.
Pancreatic Neoplasms
The iron-regulated metastasis suppressor, Ndrg-1: Identification of novel molecular targets.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Papillon-Lefevre Disease
A family with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity.
A homozygous cathepsin C mutation associated with Haim-Munk syndrome.
A novel mutation in the cathepsin C (CTSC) gene in Iranian family with Papillon-Lefevre syndrome.
A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome.
A novel mutation of the cathepsin C gene in a thai family with Papillon-Lefevre syndrome.
Cathepsin C involvement in the aetiology of Papillon-Lefevre syndrome.
Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.
Epidermal differentiation: the role of proteases and their inhibitors.
Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans.
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
Papillon-Lefevre syndrome (PLS) without cathepsin C mutation: A rare early onset partially penetrant variant of PLS.
Papillon-lefevre syndrome.
Papillon-Lefevre syndrome: A report of two cases.
Structure of the periodontium in cathepsin C-deficient mice.
Whole-exome sequencing reveals a recurrent mutation in the cathepsin C gene that causes Papillon-Lefevre syndrome in a Saudi family.
[Mutational analysis of the cathepsin C gene in a family of Han nationality with Papillon-Lefevre syndrome.]
Paralysis
Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis.
Pemphigoid, Bullous
Dipeptidyl peptidase-4 inhibitors and bullous pemphigoid: A systematic review and adjusted meta-analysis.
Periodontal Diseases
Are proteinase 3 and cathepsin C enzymes related to pathogenesis of periodontitis?
Cathepsin C gene: First compound heterozygous patient with Papillon-Lefèvre syndrome and a novel symptomless mutation.
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis.
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
Periodontitis
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease.
Identification of cathepsin C mutations in ethnically diverse papillon-Lefèvre syndrome patients.
Identification of putative genetic modifying factors that influence the development of Papillon-Lefévre or Haim-Munk syndrome phenotypes.
Mutation analysis of cathepsin C gene in a Chinese patient with pre-pubertal periodontitis.
Mutations of the cathepsin C gene are responsible for Papillon-Lefèvre syndrome.
New syndrome of hypotrichosis, striate palmoplantar keratoderma, acro-osteolysis and periodontitis not due to mutations in cathepsin C.
Papillon-Lefèvre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene.
Papillon-Lefèvre Syndrome with Homozygous Nonsense Mutation of Cathepsin C Gene Presenting with Late-Onset Periodontitis.
Papillon-Lefevre syndrome: clinical presentation and a brief review.
Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre.
Role of polymorphonuclear leukocyte-derived serine proteinases in defense against Actinobacillus actinomycetemcomitans.
The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis.
Peritonitis
Dipeptidyl peptidase I controls survival from Klebsiella pneumoniae lung infection by processing surfactant protein D.
Pre-Eclampsia
Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia.
Primary Graft Dysfunction
Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation.
Proteinuria
[Peptidases in the kidney of male rats following castration and testosterone substitution]
Pulmonary Disease, Chronic Obstructive
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Discovery and In Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor.
Inhibitors of cathepsin C (dipeptidyl peptidase I).
Respiratory Distress Syndrome
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Sepsis
Mast cell dipeptidyl peptidase I mediates survival from sepsis.
Squamous Cell Carcinoma of Head and Neck
Expression of angiopoietin-like 4 and tenascin C but not cathepsin C mRNA predicts prognosis of oral tongue squamous cell carcinoma.
Stomach Neoplasms
Decursin inhibits cell growth and autophagic flux in gastric cancer via suppression of cathepsin C.
Stroke
Meta-Analysis of the Cardiovascular Outcomes with Dipeptidyl Peptidase 4 Inhibitors: Validation of the Current FDA Mandate.
Toxoplasmosis
Cathepsin Cs are key for the intracellular survival of the protozoan parasite, Toxoplasma gondii.
DNA Vaccines Encoding Toxoplasma gondii Cathepsin C 1 Induce Protection against Toxoplasmosis in Mice.
Vasculitis
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Virus Diseases
Cathepsin C limits acute viral infection independently of NK cell and CD8(+) T-cell cytolytic function.
Dipeptidyl peptidase I-dependent neutrophil recruitment modulates the inflammatory response to sendai virus infection.
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.