Reference on EC 3.4.13.20 - beta-Ala-His dipeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lenney, J.F.; George, R.P.; Weiss, A.M.; Kucera, C.M.; Chan, P.W.H.; Rinzler, G.S.
Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium
Clin. Chim. Acta
123
221-231
1982
Homo sapiens
Jackson, M.C.; Kucera, C.M.; Lenney, J.F.
Purification and properties of human serum carnosinase
Clin. Chim. Acta
196
193-206
1991
Homo sapiens
Lenney, J.F.; Peppers, S.C.; Kucera, C.M.; Ottar, S.
Homocarnosinosis: lack of serum carnosinase is the defect probably responsible for elevated brain and CSF homocarnosine
Clin. Chim. Acta
132
157-165
1983
Homo sapiens
Schoen, P.; Everts, H.; de Boer, T.; van Oeveren, W.
Serum carnosinase activity in plasma and serum: validation of a method and values in cardiopulmonary bypass surgery
Clin. Chem.
49
1930-1932
2003
Homo sapiens
Wassif, W.S.; Sherwood, R.A.; Amir, A.; Idowu, B.; Summers, B.; Leigh, N.; Peters, T.J.
Serum carnosinase activities in central nervous system disorders
Clin. Chim. Acta
225
57-64
1994
Homo sapiens
Cacciatore, I.; Cocco, A.; Costa, M.; Fontana, M.; Lucente, G.; Pecci, L.; Pinnen, F.
Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation
Amino Acids
28
77-83
2005
Homo sapiens
Zhang, H.; Chen, J.; Waldherr, C.; Hinni, K.; Waser, B.; Reubi, J.C.; Maecke, H.R.
Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors
Cancer Res.
64
6707-6715
2004
Homo sapiens
Janssen, B.; Hohenadel, D.; Brinkkoetter, P.; Peters, V.; Rind, N.; Fischer, C.; Rychlik, I.; Cerna, M.; Romzova, M.; de Heer, E.; Baelde, H.; Bakker, S.J.; Zirie, M.; Rondeau, E.; Mathieson, P.; Saleem, M.A.; Meyer, J.; Koeppel, H.; Sauerhoefer, S.; Bartram, C.R.; Nawroth, P.; Hammes, H.P.; Yard, B.A.; Zschocke, J.; van der Woude, F.J.
Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1
Diabetes
54
2320-2327
2005
Homo sapiens
Bauer, K.
X-His dipeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
1022-1024
2004
Homo sapiens, Mus musculus
-
Otani, H.; Okumura, N.; Hashida-Okumura, A.; Nagai, K.
Identification and characterization of a mouse dipeptidase that hydrolyzes L-carnosine
J. Biochem.
137
167-175
2005
Mus musculus
Vistoli, G.; Pedretti, A.; Cattaneo, M.; Aldini, G.; Testa, B.
Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate
J. Med. Chem.
49
3269-3277
2006
Homo sapiens
Balion, C.M.; Benson, C.; Raina, P.S.; Papaioannou, A.; Patterson, C.; Ismaila, A.S.
Brain type carnosinase in dementia: a pilot study
BMC Neurol.
7
38
2007
Homo sapiens
Riedl, E.; Koeppel, H.; Brinkkoetter, P.; Sternik, P.; Steinbeisser, H.; Sauerhoefer, S.; Janssen, B.; van der Woude, F.J.; Yard, B.A.
A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells
Diabetes
56
2410-2413
2007
Homo sapiens
Sauerhoefer, S.; Yuan, G.; Braun, G.S.; Deinzer, M.; Neumaier, M.; Gretz, N.; Floege, J.; Kriz, W.; van der Woude, F.; Moeller, M.J.
L-carnosine, a substrate of carnosinase-1, influences glucose metabolism
Diabetes
56
2425-2432
2007
Homo sapiens
Teufel, M.; Saudek, V.; Ledig, J.P.; Bernhardt, A.; Boularand, S.; Carreau, A.; Cairns, N.J.; Carter, C.; Cowley, D.J.; Duverger, D.; Ganzhorn, A.J.; Guenet, C.; Heintzelmann, B.; Laucher, V.; Sauvage, C.; Smirnova, T.
Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase
J. Biol. Chem.
278
6521-31
2002
Homo sapiens (Q96KN2), Homo sapiens
Kurata, H.; Fujii, T.; Tsutsui, H.; Katayama, T.; Ohkita, M.; Takaoka, M.; Tsuruoka, N.; Kiso, Y.; Ohno, Y.; Fujisawa, Y.; Shokoji, T.; Nishiyama, A.; Abe, Y.; Matsumura, Y.
Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats
J. Pharmacol. Exp. Ther.
319
640-647
2006
Rattus norvegicus
Zschocke, J.; Nebel, A.; Wicks, K.; Peters, V.; El Mokhtari, N.E.; Krawczak, M.; van der Woude, F.; Janssen, B.; Schreiber, S.
llelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease
Mech. Ageing Dev.
127
817-820
2006
Homo sapiens
Otani, H.; Okumura, A.; Nagai, K.; Okumura, N.
Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus
Neurosci. Lett.
445
166-169
2008
Rattus norvegicus
Vistoli, G.; Orioli, M.; Pedretti, A.; Regazzoni, L.; Canevotti, R.; Negrisoli, G.; Carini, M.; Aldini, G.
Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species
ChemMedChem
4
967-975
2009
Homo sapiens
Unno, H.; Yamashita, T.; Ujita, S.; Okumura, N.; Otani, H.; Okumura, A.; Nagai, K.; Kusunoki, M.
Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2
J. Biol. Chem.
283
27289-27299
2008
Mus musculus
Min, J.; Senut, M.C.; Rajanikant, K.; Greenberg, E.; Bandagi, R.; Zemke, D.; Mousa, A.; Kassab, M.; Farooq, M.U.; Gupta, R.; Majid, A.
Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia
J. Neurosci. Res.
86
2984-2991
2008
Mus musculus
Araujo, E.C.; Suen, V.M.; Marchini, J.S.; Vannucchi, H.
Muscle mass gain observed in patients with short bowel syndrome subjected to resistance training
Nutr. Res.
28
78-82
2008
Homo sapiens
Bompard-Gilles, C.; Villeret, V.; Fanuel, L.; Joris, B.; Frre, J.M.; Van Beeumen, J.
Crystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis
Acta Crystallogr. Sect. D
55
699-701
1999
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Peters, V.; Kebbewar, M.; Jansen, E.W.; Jakobs, C.; Riedl, E.; Koeppel, H.; Frey, D.; Adelmann, K.; Klingbeil, K.; Mack, M.; Hoffmann, G.F.; Janssen, B.; Zschocke, J.; Yard, B.A.
Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity
Amino Acids
38
1607-1615
2010
Homo sapiens
Yeum, K.J.; Orioli, M.; Regazzoni, L.; Carini, M.; Rasmussen, H.; Russell, R.M.; Aldini, G.
Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans
Amino Acids
38
847-858
2010
Homo sapiens (Q96KN2), Homo sapiens
Bellia, F.; Calabrese, V.; Guarino, F.; Cavallaro, M.; Cornelius, C.; De Pinto, V.; Rizzarelli, E.
Carnosinase levels in aging brain: redox state induction and cellular stress response
Antioxid. Redox Signal.
11
2759-2775
2009
Homo sapiens
Inaba, C.; Higuchi, S.; Morisaka, H.; Kuroda, K.; Ueda, M.
Synthesis of functional dipeptide carnosine from nonprotected amino acids using carnosinase-displaying yeast cells
Appl. Microbiol. Biotechnol.
86
1895-1902
2010
Homo sapiens (Q96KN2)
Fanuel, L.; Goffin, C.; Cheggour, A.; Devreese, B.; Van Driessche, G.; Joris, B.; Van, Beeumen, J.; Frre, J.M.
The DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family
Biochem. J.
341
147-155
1999
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Fanuel, L.; Thamm, I.; Kostanjevecki, V.; Samyn, B.; Joris, B.; Goffin, C.; Brannigan, J.; van Beeumen, J.; Frre, J.M.
Two new aminopeptidases from Ochrobactrum anthropi active on D-alanyl-p-nitroanilide
Cell. Mol. Life Sci.
55
812-818
1999
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Stvolinsky, S.L.; Bulygina, E.R.; Fedorova, T.N.; Meguro, K.; Sato, T.; Tyulina, O.V.; Abe, H.; Boldyrev, A.A.
Biological activity of novel synthetic derivatives of carnosine
Cell. Mol. Neurobiol.
30
395-404
2010
Homo sapiens
Heck, T.; Limbach, M.; Geueke, B.; Zacharias, M.; Gardiner, J.; Kohler, H.P.; Seebach, D.
Enzymatic degradation of beta- and mixed alpha,beta-oligopeptides
Chem. Biodivers.
3
1325-1348
2006
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Heck, T.; Kohler, H.P.; Limbach, M.; Flgel, O.; Seebach, D.; Geueke, B.
Enzyme-catalyzed formation of beta-peptides: beta-peptidyl aminopeptidases BapA and DmpA acting as beta-peptide-synthesizing enzymes
Chem. Biodivers.
4
2016-2030
2007
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Komeda, H.; Asano, Y.
A DmpA-homologous protein from Pseudomonas sp. is a dipeptidase specific for beta-alanyl dipeptides
FEBS J.
272
3075-3084
2005
Pseudomonas sp. (Q4R9M3), Pseudomonas sp. MCI3434 (Q4R9M3)
Bompard-Gilles, C.; Villeret, V.; Davies, G.J.; Fanuel, L.; Joris, B.; Frre, J.M.; Van Beeumen, J.
A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi
Structure
8
153-162
2000
Brucella anthropi (Q59632), Brucella anthropi LMG7991 (Q59632)
Zhang, S.; Albrecht, T.; Rodriguez-Nino, A.; Qiu, J.; Schnuelle, P.; Peters, V.; Schmitt, C.P.; van den Born, J.; Bakker, S.J.L.; Lammert, A.; Kraemer, B.K.; Yard, B.A.; Hauske, S.J.
Carnosinase concentration, activity, and CNDP1 genotype in patients with type 2 diabetes with and without nephropathy
Amino Acids
51
611-617
2019
Homo sapiens (Q96KN2), Homo sapiens
Peters, V.; Schmitt, C.P.; Weigand, T.; Klingbeil, K.; Thiel, C.; van den Berg, A.; Calabrese, V.; Nawroth, P.; Fleming, T.; Forsberg, E.; Wagner, A.H.; Hecker, M.; Vistoli, G.
Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift
J. Enzyme Inhib. Med. Chem.
32
1102-1110
2017
Mus musculus (Q8BUG2)
Zhang, S.; Lindner, H.; Kabtni, S.; Van Den Born, J.; Bakker, S.; Navis, G.; Kraemer, B.; Yard, B.; Hauske, S.
Monoclonal antibody RYSK173 recognizes the dinuclear Zn center of serum carnosinase 1 (CN-1) Possible consequences of Zn binding for CN-1 recognition by RYSK173
PLoS ONE
11
e0146831
2016
Homo sapiens (Q96KN2), Homo sapiens
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