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EC Tree
The taxonomic range for the selected organisms is: Rickettsia prowazekii
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
map-2, metap2, metap, methionine aminopeptidase, metap-2, metap1, methionine aminopeptidase 2, methionine aminopeptidase-2, metap-1, methionyl aminopeptidase,
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aminopeptidase, methionine
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initiation factor 2 associated 67 kDa glycoprotein
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L-methionine aminopeptidase
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methionine aminopeptidase
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hydrolysis of peptide bond
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Met-7-amido-4-methylcoumarin + H2O
Met + 7-amino-4-methylcoumarin
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2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
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5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
most potent compound in the host-cell viability assay
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0.0005
2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 2.1
0.03
5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 1.6
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UniProt
brenda
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molecular docking of inhibitors
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Helgren, T.R.; Chen, C.; Wangtrakuldee, P.; Edwards, T.E.; Staker, B.L.; Abendroth, J.; Sankaran, B.; Housley, N.A.; Myler, P.J.; Audia, J.P.; Horn, J.R.; Hagen, T.J.
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents
Bioorg. Med. Chem.
25
813-824
2017
Rickettsia prowazekii (Q9ZCD3), Rickettsia prowazekii, Rickettsia prowazekii Madrid E (Q9ZCD3)
brenda