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Information on EC 3.4.11.18 - methionyl aminopeptidase and Organism(s) Rickettsia prowazekii and UniProt Accession Q9ZCD3

for references in articles please use BRENDA:EC3.4.11.18
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.18 methionyl aminopeptidase
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Select one or more organisms in this record: ?
This record set is specific for:
Rickettsia prowazekii
UNIPROT: Q9ZCD3 not found.
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Word Map
The taxonomic range for the selected organisms is: Rickettsia prowazekii
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
map-2, metap2, metap, methionine aminopeptidase, metap-2, metap1, methionine aminopeptidase 2, methionine aminopeptidase-2, metap-1, methionyl aminopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminopeptidase, methionine
-
-
-
-
initiation factor 2 associated 67 kDa glycoprotein
-
-
-
-
L-methionine aminopeptidase
-
-
-
-
MAP
-
-
-
-
MetAP
-
-
-
-
MetAP-1
-
-
-
-
MetAP-2
-
-
-
-
MetAP1
-
-
-
-
MetAP2
-
-
-
-
methionine aminopeptidase
-
-
-
-
p67
-
-
-
-
p67eIF2
-
-
-
-
peptidase M
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
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-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
CAS REGISTRY NUMBER
COMMENTARY hide
61229-81-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Met-7-amido-4-methylcoumarin + H2O
Met + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
-
5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
most potent compound in the host-cell viability assay
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0005
2-(prop-1-en-2-yl)-5-[2-(trifluoromethyl)phenyl]furan
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 2.1
0.03
5-[[(4-chlorophenyl)methyl]sulfanyl]-4H-1,2,4-triazol-3-amine
Rickettsia prowazekii
pH 7.0, 30°C, Hill slope 1.6
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
molecular docking of inhibitors
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Helgren, T.R.; Chen, C.; Wangtrakuldee, P.; Edwards, T.E.; Staker, B.L.; Abendroth, J.; Sankaran, B.; Housley, N.A.; Myler, P.J.; Audia, J.P.; Horn, J.R.; Hagen, T.J.
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents
Bioorg. Med. Chem.
25
813-824
2017
Rickettsia prowazekii (Q9ZCD3), Rickettsia prowazekii, Rickettsia prowazekii Madrid E (Q9ZCD3)
Manually annotated by BRENDA team