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Information on EC 3.4.11.18 - methionyl aminopeptidase and Organism(s) Rattus norvegicus and UniProt Accession P38062

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.18 methionyl aminopeptidase
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This record set is specific for:
Rattus norvegicus
UNIPROT: P38062 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
map-2, metap2, metap, methionine aminopeptidase, metap-2, metap1, methionine aminopeptidase 2, methionine aminopeptidase-2, metap-1, methionyl aminopeptidase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methionine aminopeptidase type-2
-
methionine aminopeptidase-2
-
aminopeptidase, methionine
-
-
-
-
initiation factor 2 associated 67 kDa glycoprotein
-
-
-
-
L-methionine aminopeptidase
-
-
-
-
MAP
-
-
-
-
MetAP
-
-
-
-
MetAP-1
-
-
-
-
MetAP-2
-
-
-
-
MetAP1
-
-
-
-
MetAP2
-
-
-
-
methionine aminopeptidase
-
-
-
-
methionine aminopeptidase type 2
-
-
p67
-
-
-
-
p67eIF2
-
-
-
-
peptidase M
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -
CAS REGISTRY NUMBER
COMMENTARY hide
61229-81-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
-
-
?
Met-Ala-Ser + H2O
Met + Ala-Ser
show the reaction diagram
-
-
-
-
?
Met-Lys-bradykinin + H2O
Met + Lys-bradykinin
show the reaction diagram
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
the biological function is removing the terminal methionine from nascent peptides during protein synthesis
-
-
?
methionyl 2-naphthylamide + H2O
Met + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
removes methionine from hemoglobin nascent peptides
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
-
-
?
Met-peptide + H2O
Met + peptide
show the reaction diagram
-
the biological function is removing the terminal methionine from nascent peptides during protein synthesis
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
fumagillin
irreversible inhibition
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester
PPI-2458, 5 mg/kg
p-hydroxymercuribenzoate
-
-
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro [2.5] oct-6-yl ester
-
PPI-2458, potent irreversible inhibitor
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
activates
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
membrane-bound
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MAP2_RAT
478
0
53052
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Termignoni, C.; Freitas, J.O.; Guimaraes, J.A.
Removal of N-terminal methionine from haemoglobin nascent peptides by a membrane-bound rat liver methionine aminopeptidase
Biochem. J.
234
469-473
1986
Rattus norvegicus
Manually annotated by BRENDA team
Freitas, J.O.; Termignoni, C.; Guimaraes, J.A.
Microsomal methionine aminopeptidase: properties of the detergent-solubilized enzyme
Int. J. Biochem.
17
1285-1291
1985
Rattus norvegicus
Manually annotated by BRENDA team
Freitas, J.O.; Termignoni, C.; Borges, D.R.; Sampaio, C.A.M.; Prado, J.L.; Guimaraes, J.A.
Methionine aminopeptidase associated with liver mitochondria and microsomes
Int. J. Biochem.
13
991-997
1981
Rattus norvegicus
Manually annotated by BRENDA team
Kass, D.; Bridges, R.S.; Borczuk, A.; Greenberg, S.
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
Am. J. Respir. Cell Mol. Biol.
37
193-201
2007
Mus musculus (O08663), Rattus norvegicus (P38062), Homo sapiens (P50579)
Manually annotated by BRENDA team
Hannig, G.; Bernier, S.G.; Hoyt, J.G.; Doyle, B.; Clark, E.; Karp, R.M.; Lorusso, J.; Westlin, W.F.
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458
Arthritis Rheum.
56
850-860
2007
Rattus norvegicus
Manually annotated by BRENDA team
Lazarus, D.D.; Doyle, E.G.; Bernier, S.G.; Rogers, A.B.; Labenski, M.T.; Wakefield, J.D.; Karp, R.M.; Clark, E.J.; Lorusso, J.; Hoyt, J.G.; Thompson, C.D.; Hannig, G.; Westlin, W.F.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
Inflamm. Res.
57
18-27
2008
Rattus norvegicus (P38062)
Manually annotated by BRENDA team