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EC Tree
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
map-2, metap2, metap, methionine aminopeptidase, metap-2, metap1, methionine aminopeptidase 2, methionine aminopeptidase-2, metap-1, methionyl aminopeptidase,
more
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methionine aminopeptidase type-2
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methionine aminopeptidase-2
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aminopeptidase, methionine
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initiation factor 2 associated 67 kDa glycoprotein
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L-methionine aminopeptidase
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methionine aminopeptidase
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-
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methionine aminopeptidase type 2
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-
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hydrolysis of peptide bond
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-
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-
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Met-peptide + H2O
Met + peptide
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-
-
?
Met-Ala-Ser + H2O
Met + Ala-Ser
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-
-
-
?
Met-Lys-bradykinin + H2O
Met + Lys-bradykinin
Met-peptide + H2O
Met + peptide
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the biological function is removing the terminal methionine from nascent peptides during protein synthesis
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-
?
methionyl 2-naphthylamide + H2O
Met + 2-naphthylamine
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-
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?
additional information
?
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removes methionine from hemoglobin nascent peptides
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-
?
Met-Lys-bradykinin + H2O
Met + Lys-bradykinin
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-
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-
?
Met-Lys-bradykinin + H2O
Met + Lys-bradykinin
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i.e. Met-Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
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-
?
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Met-peptide + H2O
Met + peptide
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-
-
?
Met-peptide + H2O
Met + peptide
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the biological function is removing the terminal methionine from nascent peptides during protein synthesis
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-
?
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fumagillin
irreversible inhibition
[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro[2.5]oct-6-yl ester
PPI-2458, 5 mg/kg
p-hydroxymercuribenzoate
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[(1R)-1-carbamoyl-2-methyl-propyl]-carbamic acid-(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-but-2-enyl)-oxiranyl]-1-oxa-spiro [2.5] oct-6-yl ester
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PPI-2458, potent irreversible inhibitor
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2-mercaptoethanol
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activates
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
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membrane-bound
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brenda
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MAP2_RAT
478
0
53052
Swiss-Prot
other Location (Reliability: 1)
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Termignoni, C.; Freitas, J.O.; Guimaraes, J.A.
Removal of N-terminal methionine from haemoglobin nascent peptides by a membrane-bound rat liver methionine aminopeptidase
Biochem. J.
234
469-473
1986
Rattus norvegicus
brenda
Freitas, J.O.; Termignoni, C.; Guimaraes, J.A.
Microsomal methionine aminopeptidase: properties of the detergent-solubilized enzyme
Int. J. Biochem.
17
1285-1291
1985
Rattus norvegicus
brenda
Freitas, J.O.; Termignoni, C.; Borges, D.R.; Sampaio, C.A.M.; Prado, J.L.; Guimaraes, J.A.
Methionine aminopeptidase associated with liver mitochondria and microsomes
Int. J. Biochem.
13
991-997
1981
Rattus norvegicus
brenda
Kass, D.; Bridges, R.S.; Borczuk, A.; Greenberg, S.
Methionine aminopeptidase-2 as a selective target of myofibroblasts in pulmonary fibrosis
Am. J. Respir. Cell Mol. Biol.
37
193-201
2007
Mus musculus (O08663), Rattus norvegicus (P38062), Homo sapiens (P50579)
brenda
Hannig, G.; Bernier, S.G.; Hoyt, J.G.; Doyle, B.; Clark, E.; Karp, R.M.; Lorusso, J.; Westlin, W.F.
Suppression of inflammation and structural damage in experimental arthritis through molecular targeted therapy with PPI-2458
Arthritis Rheum.
56
850-860
2007
Rattus norvegicus
brenda
Lazarus, D.D.; Doyle, E.G.; Bernier, S.G.; Rogers, A.B.; Labenski, M.T.; Wakefield, J.D.; Karp, R.M.; Clark, E.J.; Lorusso, J.; Hoyt, J.G.; Thompson, C.D.; Hannig, G.; Westlin, W.F.
An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis
Inflamm. Res.
57
18-27
2008
Rattus norvegicus (P38062)
brenda