Reference on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levin, W.; Michaud, D.P.; Thomas, P.E.; Jerina, D.M.
Distinct rat hepatic microsomal epoxide hydrolases catalyze the hydration of cholesterol 5,6alpha-oxide and certain xenobiotic alkene and arene oxides
Arch. Biochem. Biophys.
220
485-494
1983
Rattus norvegicus
Nashed, N.T.; Michaud, D.P.; Levin, W.; Jerina, D.M.
Properties of liver microsomal cholesterol 5,6-oxide hydrolase
Arch. Biochem. Biophys.
241
149-162
1985
Oryctolagus cuniculus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus
Watabe, T.; Ozawa, N.; Ishii, H.; Chiba, K.; Hiratsuka, A.
Hepatic microsomal cholesterol epoxide hydrolase: selective inhibition by detergents and separation from xenobiotic epoxide hydrolase
Biochem. Biophys. Res. Commun.
140
632-637
1986
Mus musculus
Palakodety, R.B.; Vaz, A.D.; Griffin, M.J.
Microsomal cholesterol epoxide hydrolase activity in 2-acetylaminofluorene-induced rat liver hyperplastic nodules
Biochem. Pharmacol.
36
2424-2427
1987
Rattus norvegicus
Astroem, A.; Eriksson, M.; Eriksson, L.C.; Birberg, W.; Pilotti, A.; DePierre, J.W.
Subcellular and organ distribution of cholesterol epoxide hydrolase in the rat
Biochim. Biophys. Acta
882
359-366
1986
Rattus norvegicus
Oesch, F.; Timms, C.W.; Walker, C.H.; Guenthner, T.M.; Sparrow, A.; Watabe, T.; Wolf, C.R.
Existence of multiple forms of microsomal epoxide hydrolases with radically different substrate specificities
Carcinogenesis
5
7-9
1984
Oryctolagus cuniculus, Rattus norvegicus
Nashed, N.T.; Michaud, D.P.; Levin, W.; Jerina, D.M.
7-Dehydrocholesterol 5,6 beta-oxide as a mechanism-based inhibitor of microsomal cholesterol oxide hydrolase
J. Biol. Chem.
261
2510-2513
1986
Rattus norvegicus
Sevanian, A.; McLeod, L.L.
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase
J. Biol. Chem.
261
54-59
1986
Rattus norvegicus
de Medina, P.; Paillasse, M.R.; Segala, G.; Poirot, M.; Silvente-Poirot, S.
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
Proc. Natl. Acad. Sci. USA
107
13520-13525
2010
Homo sapiens, Rattus norvegicus
Segala, G.; de Medina, P.; Iuliano, L.; Zerbinati, C.; Paillasse, M.R.; Noguer, E.; Dalenc, F.; Payre, B.; Jordan, V.C.; Record, M.; Silvente-Poirot, S.; Poirot, M.
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells
Biochem. Pharmacol.
86
175-189
2013
Homo sapiens
Poirot, M.; Silvente-Poirot, S.
Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer
Biochimie
95
622-631
2013
Rattus norvegicus
Silvente-Poirot, S.; Poirot, M.
Cholesterol epoxide hydrolase and cancer
Curr. Opin. Pharmacol.
12
696-703
2012
Homo sapiens
Voisin, M.; de Medina, P.; Mallinger, A.; Dalenc, F.; Huc-Claustre, E.; et, al.
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Proc. Natl. Acad. Sci. USA
114
E9346-E9355
2017
Homo sapiens
Poirot, M.; Soules, R.; Mallinger, A.; Dalenc, F.; Silvente-Poirot, S.
Chemistry, biochemistry, metabolic fate and mechanism of action of 6-oxo-cholestan-3beta,5alpha-diol (OCDO), a tumor promoter and cholesterol metabolite
Biochimie
153
139-149
2018
Homo sapiens
Griffiths, W.J.; Yutuc, E.; Abdel-Khalik, J.; Crick, P.J.; Hearn, T.; Dickson, A.; Bigger, B.W.; Hoi-Yee Wu, T.; Goenka, A.; Ghosh, A.; Jones, S.A.; Covey, D.F.; Ory, D.S.; Wang, Y.
Metabolism of non-enzymatically derived oxysterols clues from sterol metabolic disorders
Free Radic. Biol. Med.
144
124-133
2019
Homo sapiens
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