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Information on EC 3.3.2.11 - cholesterol-5,6-oxide hydrolase

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EC Tree
     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.2 Ether hydrolases
                3.3.2.11 cholesterol-5,6-oxide hydrolase
IUBMB Comments
The enzyme appears to work equally well with either epoxide as substrate . The product is a competitive inhibitor of the reaction. In vertebrates, five epoxide-hydrolase enzymes have been identified to date: EC 3.3.2.6 (leukotriene-A4 hydrolase), EC 3.3.2.7 (hepoxilin-epoxide hydrolase), EC 3.3.2.9 (microsomal epoxide hydrolase), EC 3.3.2.10 (soluble epoxide hydrolase) and EC 3.3.2.11 (cholesterol 5,6-oxide hydrolase) .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
cholesterol epoxide hydrolase, anti-estrogen binding site, cehase, cholesterol-5,6-epoxide hydrolase, cholesterol-epoxide hydrolase, cholesterol oxide hydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5alpha,6beta-triol
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5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5alpha,6beta-triol
show the reaction diagram
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