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Information on EC 3.3.1.1 - adenosylhomocysteinase

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EC Tree
     3 Hydrolases
         3.3 Acting on ether bonds
             3.3.1 Thioether and trialkylsulfonium hydrolases
                3.3.1.1 adenosylhomocysteinase
IUBMB Comments
The enzyme contains one tightly bound NAD+ per subunit. This appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond (for mechanism, click here), cf. EC 5.5.1.4, inositol-3-phosphate synthase.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
s-adenosylhomocysteine hydrolase, adohcy hydrolase, s-adenosyl-l-homocysteine hydrolase, sah hydrolase, adohcyase, sahase, s-adenosylhomocysteinase, pfsahh, s-adenosyl homocysteine hydrolase, adenosylhomocysteine hydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine
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