Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.2.2.29 - thymine-DNA glycosylase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, E.-J.; Um, S.-J.
Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins
Biochem. Biophys. Res. Commun.
377
838-842
2008
Homo sapiens
Manually annotated by BRENDA team
Sibghat-Ullah; Gallinari, P.; Xu, Y.Z.; Goodman, M.F.; Bloom, L.B.; Jiricny, J.; Day, R.S. 3rd.
Base analog and neighboring base effects on substrate specificity of recombinant human G:T mismatch-specific thymine DNA-glycosylase
Biochemistry
35
12926-12932
1996
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Neddermann, P.; Gallinari, P.; Lettieri, T.; Schmid, D.; Truong, O.; Hsuan, J.J.; Wiebauer, K.; Jiricny, J.
Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase
Biol. Chem.
271
12767-12774
1996
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Hang, B.; Guliaev, A.B.
Substrate specificity of human thymine-DNA glycosylase on exocyclic cytosine adducts
Chem. Biol. Interact.
165
230-238
2007
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Cortazar, D.; Kunz, C.; Saito, Y.; Steinacher, R.; Schr, P.
The enigmatic thymine DNA glycosylase
DNA Repair
6
489-504
2007
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Bennett, M.T.; Rodgers, M.T.; Hebert, A.S.; Ruslander, L.E.; Eisele, L.; Drohat, A.C.
Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability
J. Am. Chem. Soc.
128
12510-12519
2006
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Neddermann, P.; Jiricny, J.
The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells
J. Biol. Chem.
268
21218-21224
1993
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Waters, T.R.
Swann, P.F.: Kinetics of the action of thymine DNA glycosylase
J. Biol. Chem.
273
20007-20014
1998
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Abu, M.; Waters, T.R.
The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine
J. Biol. Chem.
278
8739-8744
2003
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Morgan, M.T.; Bennett, M.T.; Drohat, A.C.
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG
J. Biol. Chem.
282
27578-27586
2007
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Zhou, J.; Blue, E.K.; Hu, G.; Herring, B.P.
Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding.
J. Biol. Chem.
283
35383-35392
2008
Mus musculus
Manually annotated by BRENDA team
Baba, D.; Maita, N.; Jee, J.G.; Uchimura, Y.; Saitoh, H.; Sugasawa, K.; Hanaoka, F.; Tochio, H.; Hiroaki, H.; Shirakawa, M.
Crystal structure of SUMO-3-modified thymine-DNA glycosylase
J. Mol. Biol.
359
137-147
2006
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Mohan, R.D.; Rao, A.; Gagliardi, J.; Tini, M.
SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment
Mol. Cell. Biol.
27
229-243
2007
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Waters, T.R.; Swann, P.F.
Thymine-DNA glycosylase and G to A transition mutations at CpG sites
Mutat. Res.
462
137-147
2000
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Baba, D.; Maita, N.; Jee, J.G.; Uchimura, Y.; Saitoh, H.; Sugasawa, K.; Hanaoka. F.; Tochio, H.; Hiroaki, H.; Shirakawa, M.
Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.
Nature
435
979-982
2005
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Hardeland, U.; Bentele, M.; Jiricny, J.; Schaer, P.
The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs
Nucleic Acids Res.
31
2261-2271
2003
Homo sapiens (Q13569), Homo sapiens, Drosophila melanogaster (Q9V4D8), Drosophila melanogaster
Manually annotated by BRENDA team
Yoon, J.H.; Iwai, S.; O'Connor, T.R.; Pfeifer, G.P.
Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair
Nucleic Acids Res.
31
5399-5404
2003
Homo sapiens
Manually annotated by BRENDA team
Li, Y.Q.; Zhou, P.Z.; Zheng, X.D.
Walsh, C.P.; Xu, G.L.: Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
Nucleic Acids Res.
35
390-400
2007
Mus musculus
Manually annotated by BRENDA team
Niederreither, K.; Harbers, M.; Chambon, P.; Dolle, P.
Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis
Oncogene
17
1577-1585
1998
Mus musculus
Manually annotated by BRENDA team
Kunz, C.; Focke, F.; Saito, Y.; Schuermann, D.; Lettieri, T.; Selfridge, J.; Schr, P.
Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil
PLoS Biol.
7
e91
2009
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Maiti, A.; Morgan, M.T.; Pozharski, E.; Drohat, A.C.
Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition
Proc. Natl. Acad. Sci. USA
105
8890-8895
2008
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Neddermann, P.; Jiricny, J.
Efficient removal of uracil from GNU mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells
Proc. Natl. Acad. Sci. USA
91
1642-1646
1994
Homo sapiens
Manually annotated by BRENDA team
Saparbaev, M.; Laval, J.
3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase
Proc. Natl. Acad. Sci. USA
95
8508-8513
1998
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Li, S.; Huang, Q.; Wang, L.; Lan, Y.; Zhang, X.; Yang, B.; Du, P.; Hua, Z.
A convenient spectrometric assay system for intracellular quantitative measurement of DNA glycosylase activity
Acta Biochim. Biophys. Sin. (Shanghai)
42
381-387
2010
Mus musculus
Manually annotated by BRENDA team
Aziz, M.A.; Schupp, J.E.; Kinsella, T.J.
Modulation of the activity of methyl binding domain protein 4 (MBD4/MED1) while processing iododeoxyuridine generated DNA mispairs
Cancer Biol. Ther.
8
1156-1163
2009
Homo sapiens
Manually annotated by BRENDA team
Maiti, A.; Morgan, M.T.; Drohat, A.C.
Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase
J. Biol. Chem.
284
36680-36688
2009
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Mohan, R.D.; Litchfield, D.W.; Torchia, J.; Tini, M.
Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase
Nucleic Acids Res.
38
1135-1148
2010
Mus musculus
Manually annotated by BRENDA team
Visnes, T.; Doseth, B.; Pettersen, H.; Hagen, L.; Sousa, M.; Akbari, M.; Otterlei, M.; Kavli, B.; Slupphaug, G.; Krokan, H.
Uracil in DNA and its processing by different DNA glycosylases
Philos. Trans. R. Soc. Lond. B Biol. Sci.
364
563-568
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Liu, X.P.; Li, C.P.; Hou, J.L.; Liu, Y.F.; Liang, R.B.; Liu, J.H.
Expression and characterization of thymine-DNA glycosylase from Aeropyrum pernix
Protein Expr. Purif.
70
1-6
2010
Aeropyrum pernix
Manually annotated by BRENDA team
Yang, H.; Fitz-Gibbon, S.; Marcotte, E.M.; Tai, J.H.; Hyman, E.C.; Miller, J.H.
Characterization of a thermostable DNA glycosylase specific for U/G and T/G mismatches from the hyperthermophilic archaeon Pyrobaculum aerophilum
J. Bacteriol.
182
1272-1279
2000
Pyrobaculum aerophilum (Q9P9L6), Pyrobaculum aerophilum
Manually annotated by BRENDA team
da Costa, N.M.; Hautefeuille, A.; Cros, M.P.; Melendez, M.E.; Waters, T.; Swann, P.; Hainaut, P.; Pinto, L.F.
Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53
Cell Cycle
11
4570-4578
2012
Homo sapiens
Manually annotated by BRENDA team
Chen, C.; Zhou, D.; Tang, H.; Liang, M.; Jiang, J.
A sensitive, homogeneous fluorescence assay for detection of thymine DNA glycosylase activity based on exonuclease-mediated amplification
Chem. Commun. (Camb. )
49
5874-5876
2013
Homo sapiens
Manually annotated by BRENDA team
Hashimoto, H.; Zhang, X.; Cheng, X.
Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH
DNA Repair
12
535-540
2013
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Goto, M.; Shinmura, K.; Matsushima, Y.; Ishino, K.; Yamada, H.; Totsuka, Y.; Matsuda, T.; Nakagama, H.; Sugimura, H.
Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts
Free Radic. Biol. Med.
76
136-146
2014
Homo sapiens
Manually annotated by BRENDA team
Xu, X.; Yu, T.; Shi, J.; Chen, X.; Zhang, W.; Lin, T.; Liu, Z.; Wang, Y.; Zeng, Z.; Wang, C.; Li, M.; Liu, C.
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer
J. Biol. Chem.
289
8881-8890
2014
Homo sapiens
Manually annotated by BRENDA team
Ma, J.Y.; Zhao, K.; OuYang, Y.C.; Wang, Z.B.; Luo, Y.B.; Hou, Y.; Schatten, H.; Shen, W.; Sun, Q.Y.
Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes
Mol. Hum. Reprod.
21
186-194
2015
Mus musculus
Manually annotated by BRENDA team
Zhang, L.; Lu, X.; Lu, J.; Liang, H.; Dai, Q.; Xu, G.L.; Luo, C.; Jiang, H.; He, C.
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
Nat. Chem. Biol.
8
328-330
2012
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Hashimoto, H.; Hong, S.; Bhagwat, A.S.; Zhang, X.; Cheng, X.
Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
Nucleic Acids Res.
40
10203-10214
2012
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
van de Klundert, M.A.; van Hemert, F.J.; Zaaijer, H.L.; Kootstra, N.A.
The hepatitis B virus X protein inhibits thymine DNA glycosylase initiated base excision repair
PLoS ONE
7
e48940
2012
Homo sapiens
Manually annotated by BRENDA team
Bai, W.; Wei, Y.; Zhang, Y.; Bao, L.; Li, Y.
Label-free and amplified electrogenerated chemiluminescence biosensing for the detection of thymine DNA glycosylase activity using DNA-functionalized gold nanoparticles triggered hybridization chain reaction
Anal. Chim. Acta
1061
101-109
2019
Homo sapiens
Manually annotated by BRENDA team
Pidugu, L.S.; Flowers, J.W.; Coey, C.T.; Pozharski, E.; Greenberg, M.M.; Drohat, A.C.
Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase
Biochemistry
55
6205-6208
2016
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Henry, R.A.; Mancuso, P.; Kuo, Y.M.; Tricarico, R.; Tini, M.; Cole, P.A.; Bellacosa, A.; Andrews, A.J.
Interaction with the DNA repair protein thymine DNA glycosylase regulates histone acetylation by p300
Biochemistry
55
6766-6775
2016
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Kanaan, N.; Imhof, P.
Interactions of the DNA repair enzyme human thymine DNA glycosylase with cognate and noncognate DNA
Biochemistry
57
5654-5665
2018
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Wang, L.J.; Wang, Z.Y.; Zhang, Q.; Tang, B.; Zhang, C.Y.
Cyclic enzymatic repairing-mediated dual-signal amplification for real-time monitoring of thymine DNA glycosylase
Chem. Commun. (Camb.)
53
3878-3881
2017
Homo sapiens
Manually annotated by BRENDA team
Nakamura, T.; Murakami, K.; Tada, H.; Uehara, Y.; Nogami, J.; Maehara, K.; Ohkawa, Y.; Saitoh, H.; Nishitani, H.; Ono, T.; Nishi, R.; Yokoi, M.; Sakai, W.; Sugasawa, K.
Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms
Genes Cells
22
392-405
2017
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Kanaan, N.; Crehuet, R.; Imhof, P.
Mechanism of the glycosidic bond cleavage of mismatched thymine in human thymine DNA glycosylase revealed by classical molecular dynamics and quantum mechanical/molecular mechanical calculations
J. Phys. Chem. B
119
12365-12380
2015
Homo sapiens (Q13569), Homo sapiens
Manually annotated by BRENDA team
Naydenova, E.; Dietschreit, J.C.B.; Ochsenfeld, C.
Reaction mechanism for the N-glycosidic bond cleavage of 5-formylcytosine by thymine DNA glycosylase
J. Phys. Chem. B
123
4173-4179
2019
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Malik, S.S.; Coey, C.T.; Varney, K.M.; Pozharski, E.; Drohat, A.C.
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA
Nucleic Acids Res.
43
9541-9552
2015
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Coey, C.T.; Malik, S.S.; Pidugu, L.S.; Varney, K.M.; Pozharski, E.; Drohat, A.C.
Structural basis of damage recognition by thymine DNA glycosylase Key roles for N-terminal residues
Nucleic Acids Res.
44
10248-10258
2016
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Coey, C.T.; Drohat, A.C.
Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase
Nucleic Acids Res.
46
5159-5170
2018
Homo sapiens (Q13569)
Manually annotated by BRENDA team
Mancuso, P.; Tricarico, R.; Bhattacharjee, V.; Cosentino, L.; Kadariya, Y.; Jelinek, J.; Nicolas, E.; Einarson, M.; Beeharry, N.; Devarajan, K.; Katz, R.A.; Dorjsuren, D.G.; Sun, H.; Simeonov, A.; Giordano, A.; Testa, J.R.; Davidson, G.; Davidson, I.; Larue, L.; Sobol, R.W.; Yen, T.J.; Bellacosa, A.
Thymine DNA glycosylase as a novel target for melanoma
Oncogene
38
3710-3728
2019
Homo sapiens
Manually annotated by BRENDA team