Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.2.2.27 - uracil-DNA glycosylase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.
Adenocarcinoma of Lung
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Anemia
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia.
Anemia, Megaloblastic
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia.
Anemia, Pernicious
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia.
Astrocytoma
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Blast Crisis
Uracil-DNA glycosylase activity in human acute leukemia.
Blister
Enzymatic repair of premutagenic DNA lesions in human epidermis. Quantitation of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activities.
Bloom Syndrome
Abnormal regulation of uracil-DNA glycosylase induction during cell cycle and cell passage in Bloom's syndrome fibroblasts.
Increased levels of 5-fluorouracil-induced DNA lesions in Bloom's syndrome.
Normal uracil-DNA glycosylase activity in Bloom's syndrome cells.
Brain Injuries
Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase.
Breast Neoplasms
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.
Carcinogenesis
Differential role of Wnt signaling and base excision repair pathways in gastric adenocarcinoma aggressiveness.
Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues.
Carcinoma
Association of SMUG1 SNPs in Intron Region and Linkage Disequilibrium with Occurrence of Cervical Carcinoma and HPV Infection in Chinese Population.
Significant Contribution of DNA Repair Human 8-Oxoguanine DNA N-Glycosylase 1 Genotypes to Renal Cell Carcinoma.
Carcinoma, Hepatocellular
Comparison at the molecular level of uracil-DNA glycosylases from different origins.
dUTP pyrophosphatase and uracil-DNA glycosylase in rat liver and hepatomas.
Carcinoma, Ovarian Epithelial
Germline whole exome sequencing and large-scale replication identifies FANCM as a likely high grade serous ovarian cancer susceptibility gene.
Carcinoma, Renal Cell
Significant Contribution of DNA Repair Human 8-Oxoguanine DNA N-Glycosylase 1 Genotypes to Renal Cell Carcinoma.
Carcinoma, Squamous Cell
Association of SMUG1 SNPs in Intron Region and Linkage Disequilibrium with Occurrence of Cervical Carcinoma and HPV Infection in Chinese Population.
Cataract
Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
Colonic Neoplasms
Functional interaction of Ugene and EBV infection mediates tumorigenic effects.
Identification of different mutational profiles in cancers arising in specific colon segments by next generation sequencing.
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts.
Colorectal Neoplasms
Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Esophageal Neoplasms
Uracil-DNA glycosylase (UNG) rs246079 G/A polymorphism is associated with decreased risk of esophageal cancer in a Chinese population.
Gastritis, Atrophic
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia.
Glioblastoma
Fidelity and mutational specificity of uracil-initiated base excision DNA repair synthesis in human glioblastoma cell extracts.
Uracil-initiated base excision DNA repair synthesis fidelity in human colon adenocarcinoma LoVo and Escherichia coli cell extracts.
Glioma
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Graves Disease
The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease.
Hepatitis B
Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus.
Hepatitis C
[Utilization of Uracil-DNA glycosylase for combining reverse transcription and anti-contamination with polymerase chain reaction in hepatitis C virus]
Herpes Simplex
A 3' coterminal gene cluster in pseudorabies virus contains herpes simplex virus UL1, UL2, and UL3 gene homologs and a unique UL3.5 open reading frame.
A kinetic analysis of substrate recognition by uracil-DNA glycosylase from herpes simplex virus type 1.
Cloning and expression of the uracil-DNA glycosylase inhibitor (UGI) from bacteriophage PBS-1 and crystallization of a uracil-DNA glycosylase-UGI complex.
Computational rationale for the selective inhibition of the herpes simplex virus type 1 uracil-DNA glycosylase enzyme.
Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1.
Direct measurement of the substrate preference of uracil-DNA glycosylase.
DNA glycosylases.
Gene UL2 of herpes simplex virus type 1 encodes a uracil-DNA glycosylase.
Herpes simplex virus type 1 (HSV-1) uracil-DNA glycosylase: functional expression in Escherichia coli, biochemical characterization, and selective inhibition by 6-(p-n-octylanilino)uracil.
Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.
Identification of the coding sequence for herpes simplex virus uracil-DNA glycosylase.
Induction of uracil-DNA glycosylase and dUTP nucleotidohydrolase activity in herpes simplex virus-infected human cells.
Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase.
Isolation of a herpes simplex virus cDNA encoding the DNA repair enzyme uracil-DNA glycosylase.
Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase.
Purification and characterization of the herpes simplex virus type 2-encoded uracil-DNA glycosylase.
Selective inhibition of herpes simplex virus type-1 uracil-DNA glycosylase by designed substrate analogs.
The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?
Uracil-DNA glycosylase (UNG) influences the melting temperature (T(m)) of herpes simplex virus (HSV) hybridization probes.
Use of the PBS2 uracil-DNA glycosylase inhibitor to differentiate the uracil-DNA glycosylase activities encoded by herpes simplex virus types 1 and 2.
Hyper-IgM Immunodeficiency Syndrome
Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype.
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Hypersensitivity
Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.
Infections
Characterization of human cytomegalovirus uracil DNA glycosylase (UL114) and its interaction with polymerase processivity factor (UL44).
Clinical Features and Genetic Analysis of Taiwanese Patients with the Hyper IgM Syndrome Phenotype.
Early events after infection of Escherichia coli by bacteriophage T5. III. Inhibition of uracil-DNA glycosylase activity.
Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1.
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome.
Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription.
Laryngeal Neoplasms
The Cys326 allele of the 8-oxoguanine DNA N-glycosylase 1 gene as a risk factor in smoking- and drinking-associated larynx cancer.
Leukemia
The DNA-repair enzyme uracil-DNA glycosylase in the human hematopoietic system.
Uracil DNA-glycosylase. Purification and properties of this enzyme isolated from blast cells of acute myelocytic leukemia patients.
Uracil-DNA glycosylase activity in human acute leukemia.
Leukemia L5178
Excision of uracil from bromodeoxyuridine-substituted and U.V.-irradiated DNA in cultured mouse lymphoma cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Uracil-DNA glycosylase activity in human acute leukemia.
Uracil-DNA glycosylase in benign and malignant maturing human hematopoietic cells.
Leukemia, Myeloid
Uracil DNA-glycosylase. Purification and properties of this enzyme isolated from blast cells of acute myelocytic leukemia patients.
Leukemia, Myeloid, Acute
Uracil DNA-glycosylase. Purification and properties of this enzyme isolated from blast cells of acute myelocytic leukemia patients.
Uracil-DNA glycosylase activity in human acute leukemia.
Liver Neoplasms, Experimental
dUTP pyrophosphatase and uracil-DNA glycosylase in rat liver and hepatomas.
Lung Neoplasms
DNA repair activity for oxidative damage and risk of lung cancer.
Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.
The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk.
Uracil-DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed.
Lymphoma, B-Cell
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.
Lymphoproliferative Disorders
Uracil-DNA glycosylase activity in chronic lymphoproliferative disorders.
Macular Degeneration
ASSOCIATION BETWEEN POLYMORPHISM OF THE DNA REPAIR SMUG1 AND UNG GENES AND AGE-RELATED MACULAR DEGENERATION.
Association of the DNA repair SMUG1 rs3087404 polymorphism and its interaction with high sensitivity C-reactive protein for age-related macular degeneration in Iranian patients.
Interactions among different genetic loci in age-related macular degeneration.
Mesothelioma
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Mesothelioma, Malignant
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Monkeypox
Substrate Specificity of Homogeneous Monkeypox Virus Uracil-DNA Glycosylase.
Mouth Neoplasms
The joint effect of smoking and hOGG1 genotype on oral cancer in Taiwan.
Myelodysplastic Syndromes
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia.
Neoplasms
A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer.
A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues.
Adverse prognostic and predictive significance of low DNA-dependent protein kinase catalytic subunit (DNA-PKcs) expression in early-stage breast cancers.
Association of SMUG1 SNPs in Intron Region and Linkage Disequilibrium with Occurrence of Cervical Carcinoma and HPV Infection in Chinese Population.
Clinicopathological significance of ATM-Chk2 expression in sporadic breast cancers: a comprehensive analysis in large cohorts.
Erratum: The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID.
Excision Repair-Initiated Enzyme-Assisted Bicyclic Cascade Signal Amplification for Ultrasensitive Detection of Uracil-DNA Glycosylase.
Genetic polymorphisms of the DNA repair gene UNG are associated with the susceptibility of rheumatoid arthritis.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Genome-wide expression profile of sporadic gastric cancers with microsatellite instability.
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.
Increased uracil-DNA glycosylase, AP-DNA binding protein and deoxyribonuclease activities in tumor and SV40-transformed cell lines of human origin.
Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs.
Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification.
Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner.
Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.
Next-generation sequencing identifies recurrent copy number variations in invasive breast carcinomas from Ghana.
Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population.
Single nucleotide polymorphisms in uracil-processing genes, intake of one-carbon nutrients and breast cancer risk.
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy.
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
The Multiple Cellular Roles of SMUG1 in Genome Maintenance and Cancer.
The role of deoxyuridine triphosphate nucleotidohydrolase, uracil-DNA glycosylase, and DNA polymerase alpha in the metabolism of FUdR in human tumor cells.
The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID.
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Neuroblastoma
DNA synthesis enzymes and proliferating cell nuclear antigen in normal and neoplastic nerve cells.
Osteosarcoma
E2F-1 and a cyclin-like DNA repair enzyme, uracil-DNA glycosylase, provide evidence for an autoregulatory mechanism for transcription.
Ovarian Neoplasms
A common SNP in the uracil-DNA glycosylase gene UNG decreases ovarian cancer risk in BRCA2 mutation carriers.
Pancreatic Neoplasms
A Transcriptome-Wide Association Study (TWAS) Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer.
Papillomavirus Infections
Association of SMUG1 SNPs in Intron Region and Linkage Disequilibrium with Occurrence of Cervical Carcinoma and HPV Infection in Chinese Population.
Paraproteinemias
Uracil-DNA glycosylase activity in chronic lymphoproliferative disorders.
Photosensitivity Disorders
Roles of uracil-DNA glycosylase and apyrimidinic endonucleases in the molecular 5-bromo-2'-deoxyuridine photosensitization in Escherichia coli K-12.
Uracil-DNA glycosylase causes 5-bromodeoxyuridine photosensitization in Escherichia coli K-12.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Uracil-DNA glycosylase activity in human acute leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Uracil-DNA glycosylase activity in human acute leukemia.
Prostatic Neoplasms
A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer.
Pulmonary Disease, Chronic Obstructive
Cigarette Smoke Induces Nucleic Acid Oxidation in Lung Fibroblasts.
Stomach Neoplasms
Berzosertib (VE-822) inhibits gastric cancer cell proliferation via base excision repair system.
Induction of miR-31 causes increased sensitivity to 5-FU and decreased migration and cell invasion in gastric adenocarcinoma.
Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21.
Tuberculosis
Complexes of the uracil-DNA glycosylase inhibitor protein, Ugi, with Mycobacterium smegmatis and Mycobacterium tuberculosis uracil-DNA glycosylases.
Structural plasticity in Mycobacterium tuberculosis uracil-DNA glycosylase (MtUng) and its functional implications.
Structure of uracil-DNA glycosylase from Mycobacterium tuberculosis: insights into interactions with ligands.
Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources.
uracil-dna glycosylase deficiency
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.
Uracil-DNA glycosylase causes 5-bromodeoxyuridine photosensitization in Escherichia coli K-12.
Vaccinia
A Conserved Tripeptide Sequence at the C Terminus of the Poxvirus DNA Processivity Factor D4 Is Essential for Protein Integrity and Function.
Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase.
Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase.
Crystal structure of the vaccinia virus DNA polymerase holoenzyme subunit d4 in complex with the a20 N-terminal domain.
Crystal Structure of the Vaccinia Virus Uracil-DNA Glycosylase in Complex with DNA.
Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly.
Mutations in active-site residues of the uracil-DNA glycosylase encoded by vaccinia virus are incompatible with virus viability.
Structural analysis of point mutations at the Vaccinia virus A20/D4 interface.
Virus Diseases
Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.
Vitiligo
Association of Leukotrichia in Vitiligo and Asp148Glu Polymorphism of Apurinic/Apyrimidinic Endonuclease 1.
Waldenstrom Macroglobulinemia
Uracil-DNA glycosylase activity in chronic lymphoproliferative disorders.
Xeroderma Pigmentosum
Association Between Polymorphisms of DNA Repair Genes and Risk of Schizophrenia.