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Synonyms
purine nucleosidase, iag-nh, iu-nucleoside hydrolase, iagnh, ribonucleoside hydrolase, ssiag-nh, iag-nucleoside hydrolase, purine nucleoside hydrolase, inosine-guanosine nucleoside hydrolase, purine-specific inosine-adenosine-guanosine nucleoside hydrolase,
more
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6-oxopurine nucleosidase
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IAG nucleoside hydrolase
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-
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IAG-nucleoside hydrolase
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inosine-adenosine-guanosine nucleoside hydrolase
inosine-adenosine-guanosine-preferring nucleoside hydrolase
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inosine-guanosine nucleoside hydrolase
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inosine-guanosine-specific nucleoside hydrolase
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inosine/adenosine/guanosinepreferring NH
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IU-nucleoside hydrolase
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-
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IunH
IunH is important in moderating inosine- or adenosine-induced germination of Bacillus thuringiensis spores
N-ribosyl purine ribohydrolase
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N-ribosyl-purine ribohydrolase
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nucleoside hydrolase
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purine beta-ribosidase
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Purine nucleosidase
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purine nucleoside hydrolase
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purine nucleoside N-ribohydrolase
purine ribonucleosidase
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purine specific nucleoside hydrolase
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purine-preferring nucleoside hydrolase
purine-specific hydrolase
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purine-specific inosine-adenosine-guanosine nucleoside hydrolase
purine-specific inosineadenosine-guanosine nucleoside hydrolase
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purine-specific nucleoside hydrolase
purine-specific ribonucleoside hydrolase
ribonucleoside hydrolase
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IAG-NH

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the enzyme is specific for adenosine, guanosine and inosine
IAG-NH
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the enzyme is specific for adenosine, guanosine and inosine
-
IAGNH

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inosine-adenosine-guanosine nucleoside hydrolase

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inosine-adenosine-guanosine nucleoside hydrolase
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inosine-adenosine-guanosine nucleoside hydrolase
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inosine-adenosine-guanosine nucleoside hydrolase
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PpNRH1

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PpNRH1
Physcomitrium patens Gransden 2004
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purine NRH

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purine NRH
Physcomitrium patens Gransden 2004
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purine nucleoside N-ribohydrolase

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purine nucleoside N-ribohydrolase
Physcomitrium patens Gransden 2004
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purine nucleoside N-ribohydrolase
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purine-preferring nucleoside hydrolase

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purine-preferring nucleoside hydrolase
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purine-specific inosine-adenosine-guanosine nucleoside hydrolase

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purine-specific inosine-adenosine-guanosine nucleoside hydrolase
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purine-specific inosine-adenosine-guanosine nucleoside hydrolase
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purine-specific NH

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purine-specific nucleoside hydrolase

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purine-specific nucleoside hydrolase
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purine-specific nucleoside hydrolase
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purine-specific nucleoside hydrolase
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purine-specific nucleoside hydrolase
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purine-specific nucleoside hydrolase
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purine-specific ribonucleoside hydrolase

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purine-specific ribonucleoside hydrolase
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RihC

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SsIAG-NH

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SSO2243

locus name
Tb927.3.2960

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a purine nucleoside + H2O = D-ribose + a purine base
a purine nucleoside + H2O = D-ribose + a purine base

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a purine nucleoside + H2O = D-ribose + a purine base
main features of transition state are activation of the heterocyclic base by protonation of/or hydrogen bonding to O2, an extensively broken C-N-glycosysic bond, formation of an oxocarbenium ion in the ribose ring, C3-exo ribose ring conformation, and almost no bond formation to the attacking nucleophile
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a purine nucleoside + H2O = D-ribose + a purine base
mechanism couples loop closure to the positioning of active site residues. Relationship between the dimeric form of the enzyme and its catalytic activity
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a purine nucleoside + H2O = D-ribose + a purine base
ordered bi-bi kinetic mechanism and high forward commitment with inosine as substrate. The dominant energetic contribution towards catalysis comes from ribosyl and water activation, leaving group activation also makes a considerable contribution. The leaving group is unlikely to be protonated prior to N-glycosidic bond cleavage and active site binding interactions to the purine leaving group are required for efficient ribosyl and/or water activation
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2'-deoxyadenosine + H2O
D-ribose + ?
-
-
-
-
?
2'-O-methyladenosine + H2O
2-O-methylribose + adenine
-
-
-
-
?
2'-O-methylcytidine + H2O
2-O-methylribose + cytosine
-
-
-
-
?
2'-O-methylguanosine + H2O
2-O-methylribose + guanidine
-
-
-
-
?
2'-O-methylinosine + H2O
2-O-methylribose + hypoxanthine
-
-
-
-
?
2'-O-methyluridine + H2O
2-O-methylribose + uracil
-
-
-
-
?
2,6-diamino-9-beta-D-ribofuranosylpurine + H2O
2,6-diaminopurine + D-ribose
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76% of the activity with inosine
-
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ir
2,8-diamino-9-beta-D-ribofuranosyladenine + H2O
2,8-diaminoadenine + D-ribose
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38% of the activity with inosine
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ir
2-aminopurine riboside + H2O
2-aminopurine + D-ribose
2-hydroxy-9-beta-D-ribofuranosyladenine + H2O
2-hydroxyadenine + D-ribose
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10% of the activity with inosine
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ir
3'-AMP + H2O
adenine + D-ribose 3-phosphate
E15229
0.67% of the activity with adenosine
-
-
?
3'-deoxyadenosine + H2O
D-ribose + ?
-
-
-
-
?
3-deazaadenosine + H2O
D-ribose + 3-deazaadenine
-
-
-
-
?
4-nitrophenyl beta-D-ribofuranoside + H2O
4-nitrophenol + beta-D-ribofuranose
-
-
-
-
?
4-nitrophenyl beta-D-ribofuranoside + H2O
4-nitrophenol + D-ribose
4-nitrophenylriboside + H2O
4-nitrophenol + D-ribose
-
-
-
-
?
4-nitrophenylriboside + H2O
D-ribose + 4-nitrophenol
-
-
-
?
5'-AMP + H2O
adenine + D-ribose 5-phosphate
-
-
-
-
?
5'-deoxyadenosine + H2O
5-deoxy-D-ribose + adenine
-
-
-
-
?
5'-deoxyadenosine + H2O
D-ribose + ?
-
-
-
-
?
5'-GMP + H2O
guanine + D-ribose 5-phosphate
5'-IMP + H2O
hypoxanthine + D-ribose 5-phosphate
-
-
-
-
?
5,6-dimethyl-1-beta-D-ribofuranosylbenzimidazole + H2O
5,6-dimethylbenzimidazole + D-ribose
-
200% of the activity with inosine
-
-
ir
5-methyluridine + H2O
5-methyluracil + D-ribose
6-dimethylamino-9-beta-D-ribofuranosylbenzimidazole + H2O
6-dimethylaminobenzimidazole + D-ribose
-
30% of the activity with inosine
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-
ir
6-mercaptopurine ribonucleoside + H2O
6-mercaptopurine + ribose
-
-
-
-
?
7-methyl guanosine + H2O
D-ribose + 7-methyl guanine
7-methylguanosine + H2O
?
-
-
-
-
?
7-methylguanosine + H2O
D-ribose + 7-methylguanine
-
-
-
?
9-beta-D-ribofuranosylpurine + H2O
purine + D-ribose
-
47% of the activity with inosine
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ir
adenosine + H2O
adenine + D-ribose
adenosine + H2O
D-ribose + adenine
adenosine 5'-phosphate + H2O
?
-
31% of the activity with inosine
-
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?
cytidine + H2O
cytosine + D-ribose
cytidine + H2O
D-ribose + cytosine
cytosine + D-ribose
cytidine + H2O
-
-
-
-
r
deamino-NAD+ + H2O
?
-
-
-
-
?
ethenoadenosine + H2O
D-ribose + ethenoadenine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
guanosine + H2O
guanine + D-ribose
imidazoleacetic acid riboside + H2O
imidazoleacetate + D-ribose
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5% of the activity with inosine
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ir
inosine + H2O
D-ribose + hypoxanthine
inosine + H2O
hypoxanthine + D-ribose
NAD+ + H2O
adenine + ?
-
-
-
?
nicotinamide riboside + H2O
nicotinamide + D-ribose
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150% of the activity with inosine
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ir
p-nitrophenylriboside + H2O
4-nitrophenol + D-ribose
-
-
-
-
?
p-nitrophenylriboside + H2O
p-nitrophenol + D-ribose
-
-
-
?
purine ribonucleoside + H2O
purine + D-ribose
purine riboside + H2O
purine + D-ribose
thymidine + H2O
D-ribose + thymine
-
-
-
-
?
uridine + H2O
D-ribose + uracil
uridine + H2O
uracil + D-ribose
xanthosine + H2O
D-ribose + xanthine
xanthosine + H2O
xanthine + D-ribose
additional information
?
-
2-aminopurine riboside + H2O

2-aminopurine + D-ribose
-
-
-
-
?
2-aminopurine riboside + H2O
2-aminopurine + D-ribose
-
-
-
?
4-nitrophenyl beta-D-ribofuranoside + H2O

4-nitrophenol + D-ribose
-
-
-
-
?
4-nitrophenyl beta-D-ribofuranoside + H2O
4-nitrophenol + D-ribose
-
-
-
?
5'-GMP + H2O

guanine + D-ribose 5-phosphate
-
-
-
-
?
5'-GMP + H2O
guanine + D-ribose 5-phosphate
-
-
-
-
?
5-methyluridine + H2O

5-methyluracil + D-ribose
-
-
-
-
?
5-methyluridine + H2O
5-methyluracil + D-ribose
-
-
-
-
?
7-methyl guanosine + H2O

D-ribose + 7-methyl guanine
-
-
-
-
?
7-methyl guanosine + H2O
D-ribose + 7-methyl guanine
-
-
-
?
adenosine + H2O

adenine + D-ribose
E15229
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
-
?
adenosine + H2O
adenine + D-ribose
-
-
-
?
adenosine + H2O
adenine + D-ribose
preferred substrate
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?
adenosine + H2O

D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
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15% of the activity with inosine
-
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?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
best substrate
-
-
?
adenosine + H2O
D-ribose + adenine
-
103% of the activity with inosine
-
-
ir
adenosine + H2O
D-ribose + adenine
-
no activity
-
-
?
adenosine + H2O
D-ribose + adenine
-
IAG-NH shows higher affinity for adenosine with respect to inosine and guanosine, but the catalytic efficiency of these substrates is comparable
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
substrate for inosine-adenosine-guanosine nucleoside hydrolase
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
-
-
?
adenosine + H2O
D-ribose + adenine
-
3.6% of the activity with xanthosine
-
-
?
cytidine + H2O

cytosine + D-ribose
-
-
-
-
?
cytidine + H2O
cytosine + D-ribose
-
-
-
-
?
cytidine + H2O
cytosine + D-ribose
-
about 20% of the rate with adenosine
-
-
?
cytidine + H2O
cytosine + D-ribose
-
-
-
-
r
cytidine + H2O
cytosine + D-ribose
-
-
-
-
?
cytidine + H2O
cytosine + D-ribose
-
-
-
?
cytidine + H2O

D-ribose + cytosine
-
isoform rih1
-
-
?
cytidine + H2O
D-ribose + cytosine
-
54% of the activity with inosine
-
-
ir
cytidine + H2O
D-ribose + cytosine
-
-
-
-
?
cytidine + H2O
D-ribose + cytosine
-
-
-
-
?
cytidine + H2O
D-ribose + cytosine
-
-
-
-
?
guanosine + H2O

D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
preferred substrate
-
-
?
guanosine + H2O
D-ribose + guanine
-
33% of the activity with inosine
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
about 80% of the rate with adenosine
-
-
?
guanosine + H2O
D-ribose + guanine
-
90% of the activity with inosine
-
-
ir
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
highest activity
-
-
?
guanosine + H2O
D-ribose + guanine
-
highest activity
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
preferred substrate
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
-
-
?
guanosine + H2O
D-ribose + guanine
-
1.4% of the activity with xanthosine
-
-
?
guanosine + H2O

guanine + D-ribose
E15229
29.5% of the activity with adenosine
-
-
?
guanosine + H2O
guanine + D-ribose
-
-
-
-
?
guanosine + H2O
guanine + D-ribose
-
-
-
-
?
guanosine + H2O
guanine + D-ribose
-
-
-
-
?
guanosine + H2O
guanine + D-ribose
-
-
-
-
?
guanosine + H2O
guanine + D-ribose
-
-
-
?
guanosine + H2O
guanine + D-ribose
preferred substrate
-
-
?
inosine + H2O

D-ribose + hypoxanthine
-
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
preferred substrate
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
87% of the activity with xanthosine
-
-
?
inosine + H2O
D-ribose + hypoxanthine
Physcomitrium patens Gransden 2004
87% of the activity with xanthosine
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
preferred substrate
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
-
-
-
?
inosine + H2O
D-ribose + hypoxanthine
best substrate
-
-
?
inosine + H2O

hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
E15229
78.9% of the activity with adenosine
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
kinetic mechanism is rapid equilibrium with random product release
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
rate of hydrolysis similar to adenosine
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
ir
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
kinetic mechanism is rapid equilibrium with random product release
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
-
-
?
inosine + H2O
hypoxanthine + D-ribose
preferred substrate
-
-
?
inosine + H2O
hypoxanthine + D-ribose
-
25% of the activity with xanthosine
-
-
?
purine ribonucleoside + H2O

purine + D-ribose
-
-
-
-
?
purine ribonucleoside + H2O
purine + D-ribose
-
-
-
-
?
purine ribonucleoside + H2O
purine + D-ribose
-
-
-
-
?
purine riboside + H2O

purine + D-ribose
-
-
-
-
?
purine riboside + H2O
purine + D-ribose
-
-
-
-
?
purine riboside + H2O
purine + D-ribose
-
-
-
-
?
uridine + H2O

D-ribose + uracil