Information on EC 3.2.1.93 - alpha,alpha-phosphotrehalase

for references in articles please use BRENDA:EC3.2.1.93
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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
3.2.1.93
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RECOMMENDED NAME
GeneOntology No.
alpha,alpha-phosphotrehalase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
trehalose degradation I (low osmolarity)
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metabolism of disaccharids
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Starch and sucrose metabolism
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SYSTEMATIC NAME
IUBMB Comments
alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
54576-93-1
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
in symbiosis Glycine max
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-nitrophenyl alpha-glucopyranoside + H2O
4-nitrophenol + alpha-D-glucose
show the reaction diagram
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-
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-
?
alpha,alpha-trehalose 6-phosphate + H2O
alpha-D-glucose + alpha-D-glucose 6-phosphate
show the reaction diagram
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?
alpha,alpha-trehalose 6-phosphate + H2O
D-glucose + D-glucose 6-phosphate
show the reaction diagram
additional information
?
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regulatory function on sugar influx
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha,alpha-trehalose 6-phosphate + H2O
D-glucose + D-glucose 6-phosphate
show the reaction diagram
additional information
?
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-
regulatory function on sugar influx
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NaCl
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6fold stimulation at 1 mM with 4-nitrophenyl alpha-glucopyranoside as substrate, no stimulation with alpha-trehalose 6-phosphate
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
fructose
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glycerol
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moderate
mannitol
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Sucrose
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moderate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.8
alpha,alpha-trehalose 6-phosphate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2.83
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 7
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7
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assay at
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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bacteroids
Manually annotated by BRENDA team
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / NBRC 12200 / NCIMB 9375 / NRRL NRS-1264 / Gibson 46)
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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Show AA Sequence (1523 entries)
Please use the Sequence Search for a specific query.
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LINKS TO OTHER DATABASES (specific for EC-Number 3.2.1.93)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)