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Information on EC 3.2.1.51 - alpha-L-fucosidase and Organism(s) Drosophila melanogaster and UniProt Accession Q9VTJ4
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3.2.1.51 alpha-L-fucosidaseSpecify your search results
Word Map
- 3.2.1.51
- lysosomal
- hydrolases
- oligosaccharide
- glycosidases
- fucosidosis
- alpha-d-mannosidase
- beta-d-galactosidase
- fucose
-
fucosylated
- lectin
-
sialic
- beta-d-glucuronidase
- neuraminidase
-
n-acetyl-beta-d-glucosaminidase
- beta-n-acetylglucosaminidase
- beta-d-glucosidase
- glycoconjugates
- alpha-d-galactosidase
-
fucose-containing
-
4-methylumbelliferyl
- alpha-d-glucosidase
- alpha-l-fucose
- angiokeratomas
-
fucosyltransferase
- i-cell
-
transglycosylation
-
exoglycosidase
- mucolipidosis
- hexosaminidase
- diagnostics
- diffusum
-
spaniel
- beta-mannosidase
- analysis
- almond
-
corporis
- medicine
- synthesis
-
springer
- food industry
-
intralysosomal
- arylsulphatase
- alpha-gal
- beta-n-acetylhexosaminidase
- europaeus
The taxonomic range for the selected organisms is: Drosophila melanogaster
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alpha-l-fucosidase, acid hydrolase, fuca1, serum alpha-l-fucosidase, serum afu, alpha-fuc, fuca2, alpha-l-fucosidase i, alphafuc, alf1_wf, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alpha-fucosidase
-
-
-
-
Alpha-L-fucoside fucohydrolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
alpha-L-fucoside fucohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
9037-65-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl-alpha-L-fucopyranoside + H2O
4-methylumbelliferone + alpha-L-fucose
-
-
-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
localized in the sperm plasma membrane over the acrosome and the tail
the enzyme is localized in the sperm plasma membrane over the acrosome and the tail
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
enzyme is involved in gamete recognition. Recombinant enzyme interacts with alpha-L-fucose residues present on the micropyle of the Drosophila melanogaster eggshell, confirming that it is a good candidate as receptor involved in gamete interactions in fruit fly
physiological function
role of this glycosidase in sperm-egg interactions in Drosophila. The oligosaccharide recognition ability of the enzyme with defined carbohydrate chains that can functionally mimic egg glycoconjugates is analzed. The enzyme binds to fucose residue and in particular it prefers N-glycans carrying core alpha1,6-linked fucose and core alpha1,3-linked fucose in N-glycans carrying only a terminal mannose residue
physiological function
the enzyme interacts with the egg coats through its core fucose residues and has a potential role in sperm-egg interactions in Drosophila
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FUCO_DROME
494
0
57723
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
57700
x * 57700, calculated, x * 80000, recombinant GFP fusion protein including His-tag, SDS-PAGE
80000
x * 57700, calculated, x * 80000, recombinant GFP fusion protein including His-tag, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
x * 57700, calculated, x * 80000, recombinant GFP fusion protein including His-tag, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
proteolytic modification
first 25 amino acids near to the N-terminus have characteristics of a signal peptide. If the signal peptide is not removed, it will function as a membrane-anchoring domain
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Intra, J.; Perotti, M.E.; Pavesi, G.; Horner, D.
Comparative and phylogenetic analysis of alpha-L-fucosidase genes
Gene
392
34-46
2007
Anopheles gambiae, Apis mellifera, Arabidopsis thaliana, Bacteroides fragilis (Q5L9F5), Bacteroides fragilis (Q5LAD6), Bacteroides fragilis (Q5LH32), Bacteroides fragilis (Q5LJ69), Bacteroides fragilis (Q64PP0), Bacteroides fragilis (Q64QR8), Bacteroides fragilis (Q64VK9), Bacteroides fragilis (Q64XY9), Bacteroides fragilis (Q650P6), Bacteroides thetaiotaomicron (Q8A1J6), Bacteroides thetaiotaomicron (Q8A6N5), Bos taurus, Caenorhabditis briggsae, Caenorhabditis elegans (P49713), Canis lupus familiaris (P48300), Caulobacter vibrioides (Q9AA16), Ciona intestinalis, Clostridium perfringens (Q8XNK9), Clostridium perfringens 13 (Q8XNK9), Cutibacterium acnes (Q6A632), Cutibacterium acnes (Q6AA53), Danio rerio (Q68EI7), Danio rerio (Q7ZW80), Dictyostelium discoideum (P10901), Drosophila ananassae, Drosophila erecta, Drosophila melanogaster, Drosophila mojavensis, Drosophila pseudoobscura, Drosophila simulans, Drosophila virilis, Drosophila yakuba, Gallus gallus, Homo sapiens (P04066), Homo sapiens (Q9BTY2), Homo sapiens, Macaca fascicularis (Q60HF8), Macaca mulatta, Microscilla sp. (Q93PB1), Microscilla sp. (Q93PB2), Microscilla sp. PRE1 (Q93PB1), Microscilla sp. PRE1 (Q93PB2), Monodelphis domestica, Mus musculus (Q99KR8), Mus musculus (Q99LJ1), Pan troglodytes, Porphyromonas gingivalis (Q7MTR2), Pyricularia oryzae 70-15, Rattus norvegicus (P17164), Rattus norvegicus (Q6AYS4), Rhodopirellula baltica (Q7UR90), Schistosoma japonicum (Q86FH9), Streptococcus gordonii (Q6QT50), Streptococcus pneumoniae (Q8CY64), Streptococcus pneumoniae TIGR4 (A0A0H2US78), Streptomyces coelicolor (Q9S2D4), Streptomyces coelicolor A3(2) (Q9S2D4), Streptomyces sp. (Q9Z4I9), Streptomyces sp. 142 (Q9Z4I9), Strongylocentrotus purpuratus, Takifugu rubripes, Tetraodon nigroviridis, Thermotoga maritima (Q9WYE2), Treponema denticola (Q73QG3), Xanthomonas axonopodis (Q8PI26), Xanthomonas campestris (A0A0H2X4Z5), Xenopus laevis (Q6IRC2), Xenopus tropicalis (Q5EAL9), Xenopus tropicalis (Q5M8I5)
Liu, S.W.; Chen, C.S.; Chang, S.S.; Mong, K.K.; Lin, C.H.; Chang, C.W.; Tang, C.Y.; Li, Y.K.
Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism
Biochemistry
48
110-120
2009
Homo sapiens (P04066), Homo sapiens, Dictyostelium discoideum (P10901), Pongo abelii (Q5RFI5), Schistosoma japonicum (Q86FH9), Halocynthia roretzi (Q8TA71), Drosophila melanogaster (Q9VTJ4), Thermotoga maritima (Q9WYE2)
Xu, Y.; Intra, J.; Zhang, C.X.; Pasini, M.E.
Recombinant expression of Drosophila melanogaster alpha-L-fucosidase in Trichoplusia ni cells
J. Insect Physiol.
57
1205-1211
2011
Drosophila melanogaster (Q9VTJ4)
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