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Information on EC 3.2.1.51 - alpha-L-fucosidase and Organism(s) Mus musculus and UniProt Accession Q99KR8

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This record set is specific for:
Mus musculus
UNIPROT: Q99KR8 not found.
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The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
alpha-l-fucosidase, acid hydrolase, fuca1, serum alpha-l-fucosidase, serum afu, alpha-fuc, fuca2, alpha-l-fucosidase i, alphafuc, alf1_wf, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
alpha-L-fucosidase 2
-
alpha-L-fucoside fucohydrolase 2
-
alpha-fucosidase
-
-
-
-
alpha-L-fucosidase I
-
Alpha-L-fucoside fucohydrolase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of O-glycosyl bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
alpha-L-fucoside fucohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9037-65-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-methylumbelliferyl-alpha-L-fucopyranoside + H2O
4-methylumbelliferone + alpha-L-fucose
show the reaction diagram
4-nitrophenyl-alpha-L-fucopyranoside + H2O
4-nitrophenol + alpha-L-fucose
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.05 - 0.08
4-methylumbelliferyl-alpha-L-fucopyranoside
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.84
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.8
-
broad optimum
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 5
-
low activity between
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
precursor; comparative and phylogenetic analysis of alpha-L-fucosidase genes
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FUCO2_MOUSE
461
0
53645
Swiss-Prot
Secretory Pathway (Reliability: 1)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glycoprotein
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50
-
from mouse liver: more labile against inactivation than from human liver or mouse placental enzymes
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
2-4°C, 29 days
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
near homogeneity, antibody affinity chromatography
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Levvy, G.A.; McAllan, A.
Mammalian fucosidases. 2. alpha-L-fucosidase
Biochem. J.
80
435-439
1961
Bos taurus, Mus musculus, no activity in Trichomonas foetus, Patella vulgata, Rattus sp., Sus scrofa
Manually annotated by BRENDA team
Shoarinejad, F.; Alhadeff, J.A.
Rodent tissue alpha-L-fucosidases: analysis of brain and spleen isoforms and characterization of the purified hamster liver enzyme
Comp. Biochem. Physiol. B
105
523-528
1993
Cavia porcellus, Mesocricetus auratus, Mus musculus, Rattus sp.
Manually annotated by BRENDA team
Johnson, S.W.; Alhadeff, J.A.
Isoform, kinetic and immunochemical characterization of rodent liver alpha-L-fucosidases
Comp. Biochem. Physiol. B
97
713-717
1990
Cavia porcellus, Mesocricetus auratus, Mus musculus, Rattus sp.
Manually annotated by BRENDA team
Laury-Kleintop, L.D.; Damjanov, I.; Alhadeff, J.A.
Antibody-affinity purification of novel alpha-L-fucosidase from mouse liver
Biochem. J.
245
589-593
1987
Mus musculus
Manually annotated by BRENDA team
Laury-Kleintop, L.D.; Damjanov, I.; Alhadeff, J.A.
Characterization of mouse liver alpha-L-fucosidase. Demonstration of unusual basic isoelectric forms of the enzyme that appear to be developmentally regulated
Biochem. J.
230
75-82
1985
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Cordero, O.J.; Merino, A.; De la Cadena, M.P.; Bugia, B.; Nogueira, M.; Vinuela, J.E.; Martinez-Zorzano, V.S.; De Carlos, A.; Rodriguez-Berrocal, F.J.
Cell surface human alpha-L-fucosidase
Eur. J. Biochem.
268
3321-3331
2001
Chlorocebus aethiops, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Intra, J.; Perotti, M.E.; Pavesi, G.; Horner, D.
Comparative and phylogenetic analysis of alpha-L-fucosidase genes
Gene
392
34-46
2007
Anopheles gambiae, Apis mellifera, Arabidopsis thaliana, Bacteroides fragilis (Q5L9F5), Bacteroides fragilis (Q5LAD6), Bacteroides fragilis (Q5LH32), Bacteroides fragilis (Q5LJ69), Bacteroides fragilis (Q64PP0), Bacteroides fragilis (Q64QR8), Bacteroides fragilis (Q64VK9), Bacteroides fragilis (Q64XY9), Bacteroides fragilis (Q650P6), Bacteroides thetaiotaomicron (Q8A1J6), Bacteroides thetaiotaomicron (Q8A6N5), Bos taurus, Caenorhabditis briggsae, Caenorhabditis elegans (P49713), Canis lupus familiaris (P48300), Caulobacter vibrioides (Q9AA16), Ciona intestinalis, Clostridium perfringens (Q8XNK9), Clostridium perfringens 13 (Q8XNK9), Cutibacterium acnes (Q6A632), Cutibacterium acnes (Q6AA53), Danio rerio (Q68EI7), Danio rerio (Q7ZW80), Dictyostelium discoideum (P10901), Drosophila ananassae, Drosophila erecta, Drosophila melanogaster, Drosophila mojavensis, Drosophila pseudoobscura, Drosophila simulans, Drosophila virilis, Drosophila yakuba, Gallus gallus, Homo sapiens (P04066), Homo sapiens (Q9BTY2), Homo sapiens, Macaca fascicularis (Q60HF8), Macaca mulatta, Microscilla sp. (Q93PB1), Microscilla sp. (Q93PB2), Microscilla sp. PRE1 (Q93PB1), Microscilla sp. PRE1 (Q93PB2), Monodelphis domestica, Mus musculus (Q99KR8), Mus musculus (Q99LJ1), Pan troglodytes, Porphyromonas gingivalis (Q7MTR2), Pyricularia oryzae 70-15, Rattus norvegicus (P17164), Rattus norvegicus (Q6AYS4), Rhodopirellula baltica (Q7UR90), Schistosoma japonicum (Q86FH9), Streptococcus gordonii (Q6QT50), Streptococcus pneumoniae (Q8CY64), Streptococcus pneumoniae TIGR4 (A0A0H2US78), Streptomyces coelicolor (Q9S2D4), Streptomyces coelicolor A3(2) (Q9S2D4), Streptomyces sp. (Q9Z4I9), Streptomyces sp. 142 (Q9Z4I9), Strongylocentrotus purpuratus, Takifugu rubripes, Tetraodon nigroviridis, Thermotoga maritima (Q9WYE2), Treponema denticola (Q73QG3), Xanthomonas axonopodis (Q8PI26), Xanthomonas campestris (A0A0H2X4Z5), Xenopus laevis (Q6IRC2), Xenopus tropicalis (Q5EAL9), Xenopus tropicalis (Q5M8I5)
Manually annotated by BRENDA team