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Disease on EC 3.2.1.50 - alpha-N-acetylglucosaminidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Ascidian eggs release glycosidase activity which aids in the block against polyspermy.
Glycosylation inhibitors in biology and medicine.
Role of BgaA as a Pneumococcal Virulence Factor Elucidated by Molecular Evolutionary Analysis.
Adenocarcinoma
Alterations of glycosidases in human colonic adenocarcinoma.
Glycosyltransferase and glycosidase activities in cultured human fetal and colonic adenocarcinoma cell lines.
Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer.
alpha-Mannosidosis
A lysosomal storage disease induced by Ipomoea carnea in goats in Mozambique.
alpha-n-acetylglucosaminidase deficiency
A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs.
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB.
Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher disease.
Sanfilippo B disease: a re-examination of a particular sibship after 12 years.
The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.
The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis.
The enzymatic determination of lactic acid in faeces in glycosidase deficiency.
[Biochemical characteristics and diagnosis of lysosomal diseases related to hereditary glycosidase deficiency]
[Metabolic disorders of glycoproteins in congenital glycosidase deficiencies]
Alzheimer Disease
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
[Effects of Xixin decoction on enzymes related to O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease].
Anemia
Antigenic reactivity of the major glycoprotein of equine infectious anemia virus, a retrovirus.
Increased plasma glycosidase and protease activity in uraemia: possible role in the aetiology of the anaemia of chronic renal failure.
Arthritis, Rheumatoid
Gene expression and activity of cartilage-degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Azoospermia
Seminal plasma hexosaminidase in patients with normal and abnormal spermograms.
Bacterial Infections
Anionic amino acids support hydrolysis of poly-?-(1,6)-N-acetylglucosamine exopolysaccharides by the biofilm dispersing glycosidase Dispersin B.
Synthesis and antibacterial profiles of targeted triclosan derivatives.
Blast Crisis
[Acid glycosidases in leukocytes of patients with chronic and acute myeloid leukemias]
Borna Disease
N-glycosylated protein(s) are important for the infectivity of Borna disease virus (BDV).
Brain Diseases
Alkaloidal glycosidase inhibitors (AGIs) as the cause of sporadic scrapie, and the potential treatment of both transmissible spongiform encephalopathies (TSEs) and human immunodeficiency virus (HIV) infection.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Breast Neoplasms
22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.
Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential.
Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting ?-Mannosidase 2C1.
Burkitt Lymphoma
Significance of glycosidase patterns in lymphoid cells.
Bursitis
In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy.
Carcinoma
Acinar cell carcinoma of rat pancreas. Glycoprotein composition and glycosidase activities.
Biochemical characterization of CD39L4.
Biosynthesis of alpha-N-acetylglucosaminidase in cultured human kidney carcinoma cells.
Carcinoma, Acinar Cell
Acinar cell carcinoma of rat pancreas. Glycoprotein composition and glycosidase activities.
Carcinoma, Ehrlich Tumor
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Carcinoma, Hepatocellular
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis.
N-glycan in the scavenger receptor cysteine-rich domain of hepsin promotes intracellular trafficking and cell surface expression.
Structural differences between complex-type Asn-linked glycan chains of glycoproteins in rat hepatocytes and Zajdela hepatoma cells.
[Value of serum glycosidase spectrum in the diagnosis of hepatocellular carcinoma]
Carcinoma, Non-Small-Cell Lung
Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer.
Cataract
Variation in glycosidase activity in soluble fractions in ICR/f rat lenses with the progression of cataract formation.
Variation in the glycosidase activity of human lens during aging and with advance of senile cataract.
Cholelithiasis
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Cholestasis
Triton-polyacrylamide gel electrophoresis and leucine aminopeptidase activity staining detect Triton-slowed bands including high-molecular-mass aminopeptidase N (CD13) isoform in cholestatic patient sera.
Chronic Periodontitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Colonic Neoplasms
Heparin--a unique stimulator of human colon cancer cells' growth.
Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.
COVID-19
How glycobiology can help us treat and beat the COVID-19 pandemic.
Creutzfeldt-Jakob Syndrome
Brain glycosidases in Creutzfeldt-Jakob disease.
Cystic Fibrosis
Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.
Synthesis of sulfated oligosaccharides by cystic fibrosis trachea epithelial cells.
Cysts
N-acetyl-D-glucosamine is present in cysts and trophozoites of Giardia lamblia and serves as receptor for wheatgerm agglutinin.
Deficiency Diseases
The 1.9 A structure of alpha-N-acetylgalactosaminidase: molecular basis of glycosidase deficiency diseases.
Dental Plaque
Rapid screening method for detecting highly pathogenic Streptococcus intermedius strains carrying a mutation in the lacR gene.
Diabetes Mellitus
Comparative evaluation for phytochemical composition and regulation of blood glucose, hepatic oxidative stress and insulin resistance in mice and HepG2 models of four typical Chinese dark teas.
Kinetics studies on the inhibition mechanism of pancreatic ?-amylase by glycoconjugated 1H-1,2,3-triazoles: a new class of inhibitors with hypoglycemiant activity.
Serum and urine glycosidase activities in diabetes mellitus.
Serum glycosidase activity in diabetes mellitus.
[Glycosidases of mammals: association of activities and changes of levels in some disorders]
Diabetes Mellitus, Experimental
Effect of streptozotocin diabetes on acid phosphatase and selected glycosidase activities of serum and various rat organs.
Diabetes Mellitus, Type 2
Comparative evaluation for phytochemical composition and regulation of blood glucose, hepatic oxidative stress and insulin resistance in mice and HepG2 models of four typical Chinese dark teas.
Kinetics studies on the inhibition mechanism of pancreatic ?-amylase by glycoconjugated 1H-1,2,3-triazoles: a new class of inhibitors with hypoglycemiant activity.
Digestive System Diseases
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Endocarditis
Effect of mucin and glucose on proteolytic and glycosidic activities of Streptococcus oralis.
Modulation of glycosidase and protease activities by chemostat growth conditions in an endocarditis strain of Streptococcus sanguis.
Fabry Disease
Fluorescent probes for selective protein labeling in lysosomes: a case of ?-galactosidase A.
Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.
Favism
[Genetic improvement in Vicia and favism. II. Glycosidase activity]
Fibroadenoma
[Glycosidase activity measured in tumor tissue. The N-acetylglucosaminidase (NAFA) activity of breast fibroadenomas in relation to the stage of tumor development]
Gallbladder Neoplasms
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Gallstones
Weaving betaKlotho into bile acid metabolism.
Gangliosidosis, GM1
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis.
Gaucher Disease
Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.
Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors.
Multiple carbohydrate-cleaving specificities in human acidic and neutral glycosidases.
Multiple glycosidase deficiencies in a case of juvenile (type 3) Gaucher disease.
Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.
Genetic Diseases, Inborn
A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype.
alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype.
An overview of activity-based probes for glycosidases.
Glycosidase inhibitors: update and perspectives on practical use.
Identification of mutations in the alpha-L-iduronidase gene (IDUA) that cause Hurler and Scheie syndromes.
Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations.
Purification and characterization of recombinant human alpha-N-acetylglucosaminidase secreted by Chinese hamster ovary cells.
Gingivitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Hepatitis
Activities of serum enzymes in patients with viral hepatitis B, posthepatitic cirrhosis and hepatocellular carcinoma.
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.
Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors.
[Value of serum glycosidase spectrum in the diagnosis of hepatocellular carcinoma]
Hepatolenticular Degeneration
[A patient with Sanfilippo syndrome type B and Wilson disease born to unrelated parents]
Hyperglycemia
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.
Hypersensitivity
A novel family of cell wall-related proteins regulated differently during the yeast life cycle.
Hypertension
Increased serum glycosidase activity in human hypertension.
Infections
Alkaloidal glycosidase inhibitors (AGIs) as the cause of sporadic scrapie, and the potential treatment of both transmissible spongiform encephalopathies (TSEs) and human immunodeficiency virus (HIV) infection.
Antigenic reactivity of the major glycoprotein of equine infectious anemia virus, a retrovirus.
Glycosidase activities in plasma of naive and schistosome-infected Biomphalaria glabrata (Gastropoda).
Glycosylation-related gene expression profiling in brain and spleen of scrapie-affected mouse.
Host glycosylation pathways and the unfolded protein response contribute to the infection by Francisella.
Role of Glycosylation/Deglycolysation Processes in Francisella tularensis Pathogenesis.
Surface biochemical changes accompanying primary infection with Rous sarcoma virus. II. Proteolytic and glycosidase activity and sublethal autolysis.
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells.
Infertility
On some glycosidases (beta-D-mannosidase, alpha-L-fucosidase, N-acetyl-beta-D-glucosaminidase) of human seminal plasma.
Infertility, Male
[Association of 8-hydroxyguanine glycosidase OGG1 Ser326Cys polymorphysm with male infertility].
Influenza, Human
Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.
Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase.
Insulin Resistance
Comparative evaluation for phytochemical composition and regulation of blood glucose, hepatic oxidative stress and insulin resistance in mice and HepG2 models of four typical Chinese dark teas.
Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity.
Intellectual Disability
Identification of 12 novel mutations in the alpha-N-acetylglucosaminidase gene in 14 patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB).
Joint Diseases
A GLYCOSIDASE ABNORMALITY IN SYNOVIAL MEMBRANE IN JOINT DISEASE.
Kidney Failure, Chronic
Increased plasma glycosidase and protease activity in uraemia: possible role in the aetiology of the anaemia of chronic renal failure.
l-iduronidase deficiency
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB.
Leg Ulcer
Wound debridement potential of glycosidases of the wound-healing maggot, Lucilia sericata.
Leishmaniasis
Characterization of Glycoside Hydrolase Families 13 and 31 Reveals Expansion and Diversification of ?-Amylase Genes in the Phlebotomine Lutzomyia longipalpis and Modulation of Sandfly Glycosidase Activities by Leishmania Infection.
Leukemia
Altered glycosidase levels in drug-resistant mouse leukemias.
Gangliosides of human acute leukemia cells.
Gangliosides of human chronic lymphocytic leukemia and hairy cells.
Neutral glycosphingolipids in hairy cell leukemia.
Role of carbohydrate in determining the immunochemical properties of the major glycoprotein (gp71) of Friend murine leukemia virus.
Leukemia, Hairy Cell
Neutral glycosphingolipids in hairy cell leukemia.
Liver Cirrhosis
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Liver Diseases
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Comparison of carbohydrate structures of serum alpha-fetoprotein by sequential glycosidase digestion and lectin affinity electrophoresis.
[Value of serum glycosidase spectrum in the diagnosis of hepatocellular carcinoma]
Lung Neoplasms
Correlation analysis of mRNA expression and prognosis of hOGG1 gene polymorphism in patients with non-small cell lung cancer.
Lupus Erythematosus, Systemic
Binding of rheumatoid and lupus synovial fluids and sera-derived human IgG rheumatoid factor to degalactosylated IgG.
Lysosomal Storage Diseases
A comparison of alternative sample preparation procedures for the analysis of swainsonine using LC-MS/MS.
A novel missense mutation in lysosomal sulfamidase is the basis of MPS III A in a spontaneous mouse mutant.
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB.
An exonic insertion in the NAGLU gene causing Mucopolysaccharidosis IIIB in Schipperke dogs.
Clinical and genetic features of 13 patients with mucopolysaccarhidosis type IIIB: Description of two novel NAGLU gene mutations.
Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice.
Innate and adaptive immune activation in the brain of MPS IIIB mouse model.
Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Mucopolysaccharidosis IIIB: Oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis.
Restoration of central nervous system alpha-N-acetylglucosaminidase activity and therapeutic benefits in mucopolysaccharidosis IIIB mice by a single intracisternal recombinant adeno-associated viral type 2 vector delivery.
Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice.
[Intestinal lymphangiectasia in a patient with Sanfilippo B syndrome].
Macular Degeneration
Corneal alpha-galactosidase deficiency in macular corneal dystrophy.
Malaria
Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms.
Mannosidase Deficiency Diseases
Lysosomal glycosidase activities in human hair roots.
Melanoma
A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma.
Increase of sialylated tetraantennary sugar chains in parallel to the higher lung-colonizing abilities of mouse melanoma clones.
Melanoma, Experimental
Increase of sialylated tetraantennary sugar chains in parallel to the higher lung-colonizing abilities of mouse melanoma clones.
Mucopolysaccharidoses
A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype.
A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs.
alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype.
An exonic insertion in the NAGLU gene causing Mucopolysaccharidosis IIIB in Schipperke dogs.
Bovine mucopolysaccharidosis type IIIB.
Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions.
Characterization of sulfated oligosaccharides in mucopolysaccharidosis type IIIA by electrospray ionization mass spectrometry.
Clinical and genetic features of 13 patients with mucopolysaccarhidosis type IIIB: Description of two novel NAGLU gene mutations.
Concomitant occurrence of mucopolysaccharidosis IIIB and Glanzmann's thrombasthenia. Further evidence of a hyperactive alpha-N-acetylglucosaminidase-producing allele.
Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer.
Diversity of mutations and distribution of single nucleotide polymorphic alleles in the human alpha-L-iduronidase (IDUA) gene.
Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice.
Genotype-phenotype correspondence in Sanfilippo syndrome type B.
Hemiatrophy of the Spinal Cord in a Patient With Mucopolysaccharidosis Type IIIB.
Heparan N-sulfatase gene: two novel mutations and transient expression of 15 defects.
Identification of mutations in the alpha-L-iduronidase gene (IDUA) that cause Hurler and Scheie syndromes.
Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I.
Innate and adaptive immune activation in the brain of MPS IIIB mouse model.
Is Sanfilippo type B in your mind when you see adults with mental retardation and behavioral problems?
Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.
Molecular analysis of mucopolysaccharidosis type IIIB in Portugal: evidence of a single origin for a common mutation (R234C) in the Iberian Peninsula.
Molecular analysis of the alpha-N-acetylglucosaminidase gene in seven Japanese patients from six unrelated families with mucopolysaccharidosis IIIB (Sanfilippo type B), including two novel mutations.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Mucopolysaccharidosis type IIIB (Sanfilippo B): identification of 18 novel alpha-N-acetylglucosaminidase gene mutations.
Mucopolysaccharidosis type IIIB: characterisation and expression of wild-type and mutant recombinant alpha-N-acetylglucosaminidase and relationship with sanfilippo phenotype in an attenuated patient.
Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations.
Protein misfolding as an underlying molecular defect in mucopolysaccharidosis III type C.
Purification and partial characterization of alpha-N-acetylglucosaminidase from human liver.
Restoration of central nervous system alpha-N-acetylglucosaminidase activity and therapeutic benefits in mucopolysaccharidosis IIIB mice by a single intracisternal recombinant adeno-associated viral type 2 vector delivery.
Retrovirally transduced bone marrow has a therapeutic effect on brain in the mouse model of mucopolysaccharidosis IIIB.
Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys.
Sanfilippo B in an elderly female psychiatric patient: a rare but relevant diagnosis in presenile dementia.
Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase (HGSNAT) gene.
Serum MIP-1 alpha level: a biomarker for the follow-up of lentiviral therapy in mucopolysaccharidosis IIIB mice.
Significantly increased lifespan and improved behavioral performances by rAAV gene delivery in adult mucopolysaccharidosis IIIB mice.
Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
[Intestinal lymphangiectasia in a patient with Sanfilippo B syndrome].
Mucopolysaccharidosis I
A clinical trial of fibroblast transplantation for the treatment of mucopolysaccharidoses.
A common mutation for mucopolysaccharidosis type I associated with a severe Hurler syndrome phenotype.
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB.
alpha-L-iduronidase mutations (Q70X and P533R) associate with a severe Hurler phenotype.
Diversity of mutations and distribution of single nucleotide polymorphic alleles in the human alpha-L-iduronidase (IDUA) gene.
Identification of mutations in the alpha-L-iduronidase gene (IDUA) that cause Hurler and Scheie syndromes.
Increased longevity and metabolic correction following syngeneic BMT in a murine model of mucopolysaccharidosis type I.
Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations.
Mucopolysaccharidosis III
A model of mucopolysaccharidosis IIIB (Sanfilippo syndrome type IIIB): N-acetyl-alpha-D-glucosaminidase deficiency in Schipperke dogs.
A novel missense mutation in lysosomal sulfamidase is the basis of MPS III A in a spontaneous mouse mutant.
Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB.
BMN 250, a fusion of lysosomal alpha-N-acetylglucosaminidase with IGF2, exhibits different patterns of cellular uptake into critical cell types of Sanfilippo syndrome B disease pathogenesis.
Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions.
Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer.
Differential Uptake of NAGLU-IGF2 and Unmodified NAGLU in Cellular Models of Sanfilippo Syndrome Type B.
From hypertransaminasemia to mucopolysaccharidosis IIIA.
Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice.
Genotype-phenotype correspondence in Sanfilippo syndrome type B.
Hemiatrophy of the Spinal Cord in a Patient With Mucopolysaccharidosis Type IIIB.
Heparan N-sulfatase gene: two novel mutations and transient expression of 15 defects.
Identification and characterization of a novel homozygous deletion in the alpha-N-acetylglucosaminidase gene in a patient with Sanfilippo type B syndrome (mucopolysaccharidosis IIIB).
Identification of 12 novel mutations in the alpha-N-acetylglucosaminidase gene in 14 patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB).
Iminosugar C-Glycosides Work as Pharmacological Chaperones of NAGLU, a Glycosidase Involved in MPS IIIB Rare Disease*.
Improved behavior and neuropathology in the mouse model of Sanfilippo type IIIB disease after adeno-associated virus-mediated gene transfer in the striatum.
Intravenous administration of human umbilical cord blood cells in an animal model of MPS III B.
Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B.
Maternal transplantation of human umbilical cord blood cells provides prenatal therapy in Sanfilippo type B mouse model.
Molecular analysis of mucopolysaccharidosis type IIIB in Portugal: evidence of a single origin for a common mutation (R234C) in the Iberian Peninsula.
Molecular analysis of the alpha-N-acetylglucosaminidase gene in seven Japanese patients from six unrelated families with mucopolysaccharidosis IIIB (Sanfilippo type B), including two novel mutations.
Molecular defects in Sanfilippo syndrome type B (mucopolysaccharidosis IIIB).
Molecular defects in the alpha-N-acetylglucosaminidase gene in Italian Sanfilippo type B patients.
Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Mucopolysaccharidosis type IIIB (Sanfilippo B): identification of 18 novel alpha-N-acetylglucosaminidase gene mutations.
Mucopolysaccharidosis type IIIB: characterisation and expression of wild-type and mutant recombinant alpha-N-acetylglucosaminidase and relationship with sanfilippo phenotype in an attenuated patient.
NAGLU mutations underlying Sanfilippo syndrome type B.
Protein misfolding as an underlying molecular defect in mucopolysaccharidosis III type C.
Purification and characterization of recombinant human alpha-N-acetylglucosaminidase secreted by Chinese hamster ovary cells.
Sanfilippo syndrome type C: mutation spectrum in the heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase (HGSNAT) gene.
Sanfilippo syndrome: profound deficiency of alpha-acetylglucosaminidase activity in organs and skin fibroblasts from type-B patients.
Short-term enzyme replacement in the murine model of Sanfilippo syndrome type B.
Structural characterization of the ?-N-Acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.
The molecular basis of Sanfilippo syndrome type B.
Transplantation of human umbilical cord blood cells benefits an animal model of Sanfilippo syndrome type B.
Whole Body and CNS Biodistribution of rhHNS in Cynomolgus Monkeys after Intrathecal Lumbar Administration: Treatment Implications for Patients with MPS IIIA.
[A patient with Sanfilippo syndrome type B and Wilson disease born to unrelated parents]
[Intestinal lymphangiectasia in a patient with Sanfilippo B syndrome].
Myotonia Congenita
Carbohydrate composition of erythrocyte membranes and glycosidase activities in serum in patients with myotonic dystrophy, limb-girdle dystrophy and congenital myotonia.
Myotonic Dystrophy
Carbohydrate composition of erythrocyte membranes and glycosidase activities in serum in patients with myotonic dystrophy, limb-girdle dystrophy and congenital myotonia.
Neoplasm Metastasis
Bio-recognition and functional lipidomics by glycosphingolipid transfer technology.
Synthesis, Molecular Docking and ?-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives.
Neoplasms
A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma.
A simple and specific assay of glycosyltransferase and glycosidase activities by an enzyme-linked immunosorbent assay method, and its application to assay of galactosyltransferase activity in sera from patients with cancer.
Alterations in human breast cancer adhesion-motility in response to changes in cell surface glycoproteins displaying alpha-L-fucose moieties.
Bile lysosomal enzymes: characteristics and pathological significance for various hepatobiliary disorders.
Bio-recognition and functional lipidomics by glycosphingolipid transfer technology.
Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry.
Combinatorial approaches to iminosugars as glycosidase and glycosyltransferase inhibitors.
Comparison of different glycosidase activities in conditions of cancer.
Cross-linking CTX, a novel thymocyte-specific molecule, inhibits the growth of lymphoid tumor cells in Xenopus.
Developments in Carbohydrate-Based Cancer Therapeutics.
Effect of some glycosidase inhibitors on experimental tumours in the mouse.
Effects of Sponge-Derived Alkaloids on Activities of the Bacterial ?-D-Galactosidase and Human Cancer Cell ?-N-Acetylgalactosaminidase.
Elevation of acid glycosidase activities in thyroid and gastric tumors.
Gene expression and activity of cartilage-degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Glycoproteins in the Sera of Oncological Patients.
Glycosidase activated release of fluorescent 1,8-naphthalimide probes for tumor cell imaging from glycosylated 'pro-probes'.
Glycosidase inhibitors: update and perspectives on practical use.
Glycosidases in cancer and invasion.
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Glycosidases of Ehrlich ascites tumor cells and ascitic fluid--purification and substrate specificity of alpha-N-acetylgalactosaminidase and alpha-galactosidase: comparison with coffee bean alpha-galactosidase.
Glycosylation inhibitors in biology and medicine.
Glycosylation markers in cancer.
Glycosylation pathways as drug targets for cancer: glycosidase inhibitors.
Ligand-directed immunoaffinity purification and properties of the one-carbon, reduced folate transporter. Interspecies immuno-cross-reactivity and expression of the native transporter in murine and human tumor cells and their transport-altered variants.
Melanoma cell CD44 interaction with the alpha 1(IV)1263-1277 region from basement membrane collagen is modulated by ligand glycosylation.
Monoclonal antibodies to the human mammary gland: III. Monoclonal antibody LICR-LON-M18 identifies impaired expression and excess sialylation of the I(Ma) cell-surface antigen by primary breast carcinoma cells.
p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death.
Potentiation of epidermal growth factor-mediated oncogenic transformation by sialidase NEU3 leading to Src activation.
Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential.
Rapid and Sensitive Detection of Cancer Cells with Activatable Fluorescent Probes for Enzyme Activity.
Role of glycosidases in human ovarian carcinoma cell mediated degradation of subendothelial extracellular matrix.
Synthesis, Molecular Docking and ?-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives.
The effect of plant lectins on the survival and malignant behaviors of thyroid cancer cells.
[Glycosidase activity measured in tumor tissue. The N-acetylglucosaminidase (NAFA) activity of breast fibroadenomas in relation to the stage of tumor development]
Nervous System Diseases
Mucopolysaccharidosis IIIB: Oxidative damage and cytotoxic cell involvement in the neuronal pathogenesis.
Neurodegenerative Diseases
Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B.
Neurologic Manifestations
Innate and adaptive immune activation in the brain of MPS IIIB mouse model.
Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.
Restoration of central nervous system alpha-N-acetylglucosaminidase activity and therapeutic benefits in mucopolysaccharidosis IIIB mice by a single intracisternal recombinant adeno-associated viral type 2 vector delivery.
Obesity
Enzymatic glycosidase activities in experimental obesity.
Osteoarthritis
Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-beta-Hexosaminidase Inhibitors.
Gene expression and activity of cartilage-degrading glycosidases in human rheumatoid arthritis and osteoarthritis synovial fibroblasts.
Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.
Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.
Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation.
Otitis Media
Experimental alteration of chinchilla middle ear mucosae by bacterial neuraminidase.
Otitis Media with Effusion
Experimental alteration of chinchilla middle ear mucosae by bacterial neuraminidase.
Ovarian Neoplasms
A turn on fluorescent assay for real time determination of ?-galactosidase and its application in living cell imaging.
Glycosyltransferase and glycosidase activities in ovarian cancer patients.
Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers.
Periodontal Diseases
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Periodontitis
Glycosidase activities in gingival crevicular fluid in subjects with adult periodontitis or gingivitis.
Metabolomics Reveals Elevated Macromolecular Degradation in Periodontal Disease.
Prion Diseases
Alkaloidal glycosidase inhibitors (AGIs) as the cause of sporadic scrapie, and the potential treatment of both transmissible spongiform encephalopathies (TSEs) and human immunodeficiency virus (HIV) infection.
Sarcoma, Avian
Glycosidases in normal and regenerating chicken liver, hepatoma Mc-29, Rous sarcoma, in turkey poult liver and hemocytoblastomes, provoked by the leukosis virus strain Mc-31.
Rous sarcoma virus glycoproteins contain hybrid-type oligosaccharides.
Surface biochemical changes accompanying primary infection with Rous sarcoma virus. II. Proteolytic and glycosidase activity and sublethal autolysis.
Transformation-dependent alterations in the oligosaccharides of Prague C Rous sarcoma virus glycoproteins.
Scrapie
Alkaloidal glycosidase inhibitors (AGIs) as the cause of sporadic scrapie, and the potential treatment of both transmissible spongiform encephalopathies (TSEs) and human immunodeficiency virus (HIV) infection.
Glycosidase histochemistry in normal and scrapie mice, rats, sheep and goats.
Thrombasthenia
Concomitant occurrence of mucopolysaccharidosis IIIB and Glanzmann's thrombasthenia. Further evidence of a hyperactive alpha-N-acetylglucosaminidase-producing allele.
Trypanosomiasis
Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms.
Vaginosis, Bacterial
Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis.
Impact of bacterial vaginosis, as assessed by nugent criteria and hormonal status on glycosidases and lectin binding in cervicovaginal lavage samples.
Virus Diseases
Brain lysosomal glycosidase activity in mice during the immune response to an encephalitogenic virus infection.
Glycosidase inhibitors: a patent review (2008-2013).
Glycosidase inhibitors: update and perspectives on practical use.
Imino sugars and glycosyl hydrolases Historical context, current aspects, emerging trends.
Localization and measurement of extracellular plant galactosidases.