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Information on EC 3.2.1.36 - hyaluronoglucuronidase
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3.2.1.36 hyaluronoglucuronidaseSpecify your search results
Word Map
- 3.2.1.36
-
hyaluronic
- glycosaminoglycans
- collagenase
- collagen
- venom
- chondroitin
- chondroitinase
- cartilage
- sperm
- proteoglycans
- testicular
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filler
- pain
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anesthesia
- phospholipase
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cumulus
- edema
- bupivacaine
- heparan
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alcian
- lidocaine
- cataract
- neuraminidase
- spermatozoa
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vitreous
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acrosomal
- pellucida
- hydrogel
- glycocalyx
- dermatan
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mucopolysaccharide
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akinesia
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ophthalmic
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pericellular
- pronase
- antivenoms
- acrosin
- myotoxicity
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aesthetic
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snakebite
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4-sulfate
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orbicularis
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vitreoretinal
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3hglucosamine
- heparitinase
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subconjunctival
- medicine
- eyelid
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phacoemulsification
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intralesional
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myxoid
The enzyme appears in viruses and cellular organisms
Synonyms
hyaluronidase, haase, hyase, haase-b, vest2a, vest2b, lhase, hyaluronate lyase hylp2, hyaluronoglucuronidase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
glucuronoglucosaminoglucan hyaluronate lyase
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-
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HAase-B
hyaluronate lyase HylP2
hyaluronate lyase HylP3
hyaluronidase
HYase
orgelase
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-
-
-
hyaluronidase
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-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
hyaluronic acid hexasaccharide + H2O = GlcAbeta(1-3)GlcNAcbeta(1-4)GlcA + GlcNAcbeta(1-4)GlcAbeta(1-3)GlcNAc
random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of O-glycosyl bond
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-
-
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SYSTEMATIC NAME
IUBMB Comments
hyaluronate 3-glycanohydrolase
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CAS REGISTRY NUMBER
COMMENTARY
37288-34-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dermatan sulfate + H2O
?
-
chondroitin sulfate B, low activity
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-
?
hyaluronan + H2O
hyaluronan tetrasaccharides + hyaluronan hexasaccharides
hyaluronan is mainly degraded into hyaluronan tetrasaccharides and hyaluronan hexasaccharides. The proportion of hyaluronan tetrasaccharides and hyaluronan hexasaccharides is accurately controlled by amount of enzyme. Higher yield of hyaluronan tetrasaccharides is achieved with higher activity of the enzyme
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-
?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
chondroitin sulfate A + H2O
?
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39% activity compared to hyaluronan
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?
chondroitin sulfate A + H2O
?
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39% activity compared to hyaluronan
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-
?
chondroitin sulfate A + H2O
oligosaccharides + ?
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low activity
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-
?
chondroitin sulfate C + H2O
?
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13.5% activity compared to hyaluronan
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-
?
chondroitin sulfate C + H2O
?
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13.5% activity compared to hyaluronan
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?
chondroitin sulfate D + H2O
?
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37.1% activity compared to hyaluronan
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-
?
chondroitin sulfate D + H2O
?
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37.1% activity compared to hyaluronan
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-
?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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?
hyaluronan + 2 H2O
N-acetyl-beta-D-glucosamine + D-glucuronate + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
(N-acetylglucosamine)-(glucuronic acid)-(N-acetylglucosamine)-(glucuronic acid) + ?
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?
hyaluronic acid + H2O
?
Clostridium welchii
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further hydrolysis of the end-products from bovine testicular enzyme
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?
hyaluronic acid + H2O
?
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major pathogenic factor of serological group B streptococci
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?
hyaluronic acid + H2O
?
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further hydrolysis of the end-products from bovine testicular enzyme
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?
hyaluronic acid + H2O
hyaluronic acid oligomers
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?
additional information
?
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no activity with dermatan sulfate, heparin sodium, heparan sulfate, sodium alginate, chitosan, chitin, sodium carboxymethyl cellulose, dextran, carboxymethyl dextran, xanthan gum, gellan gum, soluble starch, carrageenan, Konjac glucomannan, synanthrin, gumacabic powder, glycogen, or pectin
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?
additional information
?
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no activity with dermatan sulfate, heparin sodium, heparan sulfate, sodium alginate, chitosan, chitin, sodium carboxymethyl cellulose, dextran, carboxymethyl dextran, xanthan gum, gellan gum, soluble starch, carrageenan, Konjac glucomannan, synanthrin, gumacabic powder, glycogen, or pectin
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?
additional information
?
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not: chondroitin, heparan sulfate, chondroitin sulfate
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?
additional information
?
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not: chondroitin, heparan sulfate, chondroitin sulfate
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
hyaluronic acid + H2O
?
Clostridium welchii
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further hydrolysis of the end-products from bovine testicular enzyme
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?
hyaluronic acid + H2O
?
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major pathogenic factor of serological group B streptococci
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?
hyaluronic acid + H2O
?
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further hydrolysis of the end-products from bovine testicular enzyme
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?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Co2+
K+
Li+
Mg2+
Mn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
polymer from hydroxysulfonic acid
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with formaldehyde, nearly complete inhibition at 0.01 mg/ml
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Triton X-100
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moderately inhibits enzyme activity by 3%-30% at different concentrations
Tween 80
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moderately inhibits enzyme activity by 3%-30% at different concentrations
polymer from gentisic acid
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with formaldehyde, nearly complete inhibition at 0.01 mg/ml
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE