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Information on EC 3.2.1.212 - endo-(1->4)-fucoidanase

for references in articles please use BRENDA:EC3.2.1.212

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IUBMB Comments

The enzyme specifically hydrolyses (1→4)-α-L-fucoside linkages in fucan. Fucans are found mainly in different species of seaweed and are sulfated polysaccharides with a backbone of (1→3)-linked or alternating (1→3)- and (1→4)-linked α-L-fucopyranosyl residues. In the literature, the sulfated polysaccharides are often called fucoidans. Fucoidans include polysaccharides with a relatively low proportion of fucose and some polysaccharides that have a backbone composed of other saccharides with fucose in the branching side chains. The sulfation of the α-L-fucopyranosyl residues may occur at positions 2 and 3. The enzyme degrades fucan to sulfated α-L-fucooligosaccharides but neither L-fucose nor small fucooligosaccharides are produced.

The enzyme appears in viruses and cellular organisms

Synonyms
EC 3.2.1.44, endo-1,4-fucoidanase, FFA2, poly[(1->4)-alpha-L-fucoside-2-sulfate] glycanohydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
[alpha-L-Fucp(2,3OSO3-)-(1->3)-alpha-L-Fucp(2OSO3-)-(1->4)]n-alpha-L-Fucp(2OSO3-) + H2O = [alpha-L-Fucp(2,3OSO3-)-(1->3)-alpha-L-Fucp(2OSO3-)-(1->4)]n-m-alpha-L-Fucp(2OSO3-) + [alpha-L-Fucp(2,3OSO3-)-(1->3)-alpha-L-Fucp(2OSO3-)-(1->4)]m-alpha-L-Fucp(2OSO3-)
show the reaction diagram
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